Article
Chemistry, Multidisciplinary
Xingyun Li, Sai Zhang, Yuan Chen, Shanshan Wang, Qingchi Xu, Jun Xu
Summary: In this work, a novel gold nanocapsule with an anisotropic ellipsoidal shape and cavity structure was successfully prepared by self-assembly of ultrathin Au nanowires. The assembly mechanism was studied by tuning the assembly conditions, and the nanocapsules showed great drug loading ability and pH-responsive drug release behavior.
Review
Pharmacology & Pharmacy
Maria John Newton Amaldoss, Jia-Lin Yang, Pramod Koshy, Ashwin Unnikrishnan, Charles C. Sorrell
Summary: Inorganic nanoparticles used for drug delivery in cancer treatment offer numerous advantages, such as maximizing therapeutic effect through targeting ligands and minimizing side-effects. They have shown promising combined therapeutic capabilities, including anticancer effects and inhibition of cancer cell signaling pathways. Inorganic nanoparticles serve as synergistic platforms for RNA interference and as drug delivery agents for targeting cancer cell signaling pathways.
DRUG DISCOVERY TODAY
(2022)
Article
Biophysics
Lianjiang Tan, Changyu He
Summary: The review highlights the development of functionalized colloidal nanovehicles for NO delivery, utilizing various nanomaterials as carriers for NO donors to achieve controlled NO release. These nanovehicles hold great potential in various therapeutic applications, including cancer therapy.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Chemistry, Analytical
Jose Luis Carreon Gonzalez, Perla Elvia Garcia Casillas, Christian Chapa Gonzalez
Summary: The use of gold nanoparticles coated with silica and PEG has shown potential as drug delivery systems due to their improved stability and drug loading capacity. The coatings significantly enhanced the nanoparticles' ability to deliver drugs and extended their circulation time in the body. These findings suggest that gold nanoparticles coated with silica and PEG could be further developed as targeted and controlled release drug delivery systems.
Article
Nanoscience & Nanotechnology
Houman Alimoradi, Ansa Thomas, Daniel D. B. Lyth, Anita Barzegar-Fallah, Siddharth S. Matikonda, Allan B. Gamble, Gregory Giles
Summary: A newly developed smart polymer is capable of releasing nitric oxide (NO) in response to a photostimulus, enhancing drug uptake and delivery. This polymer shows highly photoresponsive NO release and can utilize endogenous NO signaling pathways to smuggle therapeutic cargo into target tissue.
Article
Chemistry, Inorganic & Nuclear
Hasan Arkaban, Javad Jaberi, Ali Bahramifar, Reza Zolfaghari Emameh, Gholamreza Farnoosh, Mehdi Arkaban, Ramezan Ali Taheri
Summary: Coronavirus is the main cause of common colds and spreads in a similar way to other respiratory viruses. This study successfully synthesized Fe(III)-mSiO2 nanoparticles for therapeutic applications and demonstrated their potential as a treatment system.
INORGANIC CHEMISTRY COMMUNICATIONS
(2023)
Review
Biochemistry & Molecular Biology
Ying Kuang, Junjun Zhai, Qinjian Xiao, Si Zhao, Cao Li
Summary: Mesoporous silica nanoparticles (MSNs) play a significant role in drug delivery systems, and natural polysaccharides are widely used as gate materials, providing good biocompatibility and important biological functions.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Pharmacology & Pharmacy
Bianca de Melo Santana, Joana Claudio Pieretti, Rafael Nunes Gomes, Giselle Cerchiaro, Amedea Barozzi Seabra
Summary: Combining nitric oxide (NO) donor and silica nanoparticles loaded with cisplatin into a polymeric matrix can create a drug-delivery system that provides sustained and localized drug release against tumor cells.
Article
Pharmacology & Pharmacy
Yang Chen, Xun Feng
Summary: This review summarizes the application of gold nanoparticles as drug carriers for skin drug delivery. Factors influencing the penetration behaviors of gold nanoparticles, such as size, surface chemistry, and shape, are discussed. Drug loading, release, and penetration patterns are analyzed to implicate the design of gold nanoparticles for dermal or transdermal drug delivery. Physical methods, including microneedles and iontophoresis, are presented for enhancing the delivery efficacy of gold nanoparticles. The inherent activities of gold nanoparticles, especially their application in the treatment of skin disease, are also discussed.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Chemistry, Multidisciplinary
Jingyi Zhang, Lin Zhang, Yuhan Zhang, Rong Ju, Guoqing Wei
Summary: This study developed an ultrasound-controllable nanoplatform to enhance antimicrobial therapy. By encapsulating FOT and Fe3O4 nanoparticles within ICG-modified liposomes, the control over the infection microenvironment and rapid O-2 depletion during therapy was achieved. The results showed the potential of this platform in eradicating MDR bacterial infections.
Article
Chemistry, Multidisciplinary
Jun Hou, Yanbao Zhao, Lei Sun, Xueyan Zou
Summary: Gold nanomaterials with surface features have gained significant interest in cancer research. In this study, gold nanostar carriers coated with mesoporous silica were developed for controlled drug release and showed photothermal-chemo therapeutic effect.
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
(2022)
Article
Pharmacology & Pharmacy
Kevin McLean, Wenbo Zhan
Summary: Nanoparticle-mediated topical delivery has the potential to significantly improve drug exposure in deep skin tissue. Adequate and long-term drug-skin contact is important for effective drug deposition. The release rate of nanoparticles should be controlled to achieve optimal drug accumulation in different skin layers.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Biochemistry & Molecular Biology
Birandra K. Sinha
Summary: Since the discovery of the cytotoxicity of high concentrations of nitric oxide (NO) to cancer cells, as well as its potential role in cancer treatment, numerous NO-donors have been developed to deliver NO to tumors. NO also enhances the effectiveness of anticancer drugs and reverses multi-drug resistance in tumor cells. This study explores various strategies for delivering NO to tumors using NO-donors, aiming to achieve targeted and efficient treatment with minimal toxicity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Physical
Li-Hao Chang, Teh-Min Hu
Summary: The study successfully demonstrates the feasibility of co-delivering CPT and NO using hybrid colloidal particle carriers, leading to augmented anticancer activities. Three formulations with different ratios of CPT and NO were prepared, showing increased cytotoxicity against various cancer cell lines.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2022)
Review
Biochemistry & Molecular Biology
Lu Wang, Yunfeng Yan
Summary: RNA interference (RNAi) has potential in treating cancer and genetic disorders, but safe delivery methods remain a challenge. pH-responsive hybrid nanoparticles offer promise for siRNA delivery, with unique properties and potential benefits for therapeutic applications.
MACROMOLECULAR BIOSCIENCE
(2021)
Article
Biotechnology & Applied Microbiology
Neha R. Dhoke, Komal Kaushik, Amitava Das
Article
Oncology
Lavanya Reddy, Suja T. Dharmabalan, Kanakaraju Manupati, Ragini Yeeravalli, Lakshmi D. Vijay, Kavitha Donthiboina, Vadithe Lakshma Naik, Amitava Das
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
(2020)
Article
Endocrinology & Metabolism
Komal Kaushik, Amitava Das
Review
Oncology
Swathi R. Shetty, Ragini Yeeravalli, Tanya Bera, Amitava Das
Summary: EGFR, a crucial transmembrane protein with tyrosine kinase activity, is overexpressed in various cancers triggering tumor progression and drug resistance; Inhibition of EGFR modulates chemosensitivity in breast cancer stem cells, serving as a potential drug target for breast cancer mitigation; Tyrosine kinase inhibitors and monoclonal antibodies targeting EGFR have been developed and approved for clinical use against breast cancer.
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
(2021)
Review
Cell & Tissue Engineering
Subholakshmi Choudhury, Amitava Das
Summary: This article highlights the latest approaches in developing skin equivalents, different models for studying skin diseases and properties, as well as current therapeutic applications of skin substitutes.
Article
Cell Biology
Subholakshmi Choudhury, Nidhi Surendran, Amitava Das
Summary: The review discusses the current treatment strategies for chronic wounds and challenges, as well as the application of iPSC technology in the field of regenerative therapy. It also highlights the advantages of using iPSCs for skin cell generation and skin disease modeling over existing clinical therapies.
WOUND REPAIR AND REGENERATION
(2021)
Article
Biochemistry & Molecular Biology
Ragini Yeeravalli, Komal Kaushik, Amitava Das
Summary: The study demonstrates the crucial role of PDGFR beta in regulating EMT in breast CSCs, leading to increased physiological and molecular properties in breast cancer cells and CSCs with PDGFR beta overexpression. Mechanistically, PDGFR beta overexpression induces FAK and Src activation, promoting cell migration and invasion. Stable silencing of PDGFR beta disrupts these biological phenomena and could be a potential therapeutic target for treating TNBC patients.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Kanakaraju Manupati, Ragini Yeeravalli, Komal Kaushik, Digvijay Singh, Bhupendra Mehra, Nitin Gangane, Anupama Gupta, Kalyan Goswami, Amitava Das
Summary: Breast cancer stem cells with high CD44 expression play a key role in tumorigenesis by activating PSTAT3, SNAI3, and LPL genes. Inhibiting CD44 or targeting LPL can effectively prevent tumor progression and neoangiogenesis.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2021)
Article
Cell Biology
Digvijay Singh, Rohit K. Deshmukh, Amitava Das
Summary: The study identified the crucial role of SNAI1 in inducing the expression of differentially expressed genes in breast cancer cells, leading to increased migration, invasion, and in vitro tumorigenesis, comparable to TNBC. The activation of breast cancer stem cell (CSC) phenotypes mediated by SNAI1 was perturbed by inhibiting downstream target MMPs, highlighting the importance of MMPs in SNAI1-mediated EMT regulation.
CELLULAR SIGNALLING
(2021)
Article
Biochemistry & Molecular Biology
Surbhi Shivhare, Amitava Das
Summary: This study found that breast cancer cells grown at low seeding density exhibit chemoresistance to doxorubicin or tamoxifen. In addition, the use of ABC transporter inhibitors can enhance the efficacy of chemotherapy drugs.
MOLECULAR BIOLOGY REPORTS
(2023)
Article
Medicine, Research & Experimental
Shilpa Chawla, Amitava Das
Summary: Acute and chronic liver diseases are leading causes of illness and death worldwide. While liver transplantation is a commonly used treatment for liver failure, the scarcity of liver donors has prompted the exploration of alternative approaches, such as cell-based regenerative medicine. Recent advancements in stem cell differentiation and liver tissue engineering have shown promise in generating effective therapies for liver regeneration. The development of bioengineered liver organoids holds great potential in treating liver injuries caused by chronic liver diseases.
CURRENT RESEARCH IN TRANSLATIONAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Surbhi Shivhare, Subholakshmi Choudhury, Digvijay Singh, Amitava Das
Summary: Chemoresistance presents a challenge in treating breast cancer patients. The zinc finger E-box binding homeobox 1 (ZEB1) transcription factor plays a key role in regulating breast cancer stem cells (CSCs) and their chemoresistance. In-silico analysis showed that high ZEB1 expression in breast cancer patients is associated with lower survival rates. Experimental results further demonstrated that overexpression of ZEB1 in breast CSCs correlated with increased drug resistance and decreased apoptosis. Targeting ZEB1 and its downstream effectors may be a potential therapeutic approach for overcoming chemoresistance in breast cancer patients.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2023)
Review
Cell Biology
Sowmya Mekala, Prachi Dugam, Amitava Das
Summary: Hepatic fibrosis is a common pathological change caused by increased synthesis and accumulation of extracellular matrix components. Chronic insult from hepatotoxicants leads to liver cirrhosis and if not treated in time, liver transplantation is the only effective therapy. Moreover, the disease often progresses into hepatic carcinoma. Understanding the novel molecular signaling mechanisms involved in the disease progression would help develop effective therapeutics.
JOURNAL OF CELL COMMUNICATION AND SIGNALING
(2023)
Article
Biotechnology & Applied Microbiology
Mahendra Kumar Sahu, Komal Kaushik, Amitava Das, Harit Jha
BIORESOURCES AND BIOPROCESSING
(2020)
Article
Biotechnology & Applied Microbiology
Sean P. Hopkins, Megan C. Frost
BIOENGINEERING-BASEL
(2020)
