Article
Chemistry, Analytical
Danting He, Jia Yang, Jiahui Zhang, Chengguo Hu
Summary: A simple filtration method is reported for the fabrication of salt-induced nanoporous gold electrodes (SINPGEs) from gold nanoparticles (AuNPs). This method utilizes sodium chloride (NaCl) to trigger the aggregation, sintering, and deposition of AuNPs on polyvinylidene fluoride (PVDF) membranes, resulting in the scalable fabrication of flexible SINPGEs with high conductivity, good mechanical property, large surface area, and low cost. The nanoporous structure of SINPGEs improves the electrochemical responses of various species, and the passivation effect of chloride ions on the oxidation of hydrogen peroxide can be repressed by electrochemical activation.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Chemistry, Analytical
Je Hyun Bae, Kayeon Kim, Donghoon Han, Taek Dong Chung
Summary: Nanoporous Pt coating enhances the performance of neural electrodes by reducing impedance, improving neural signal recording, and facilitating the efficiency of implanted electronic devices.
Article
Biotechnology & Applied Microbiology
Mohaddeseh Vafaiee, Raheleh Mohammadpour, Manouchehr Vossoughi, Elham Asadian, Mahyar Janahmadi, Pezhman Sasanpour
Summary: Carbon nanotubes coatings have shown promising properties for neural interface applications, with advantages such as low impedance, high stability, durability, and scratch resistance. This makes them suitable for long-term use in neural interfaces.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Young Uk Cho, Ju Young Lee, Ui-Jin Jeong, Sang Hoon Park, Se Lin Lim, Kyung Yeun Kim, Je Wu Jang, Jong Ho Park, Hyun Woo Kim, Hyogeun Shin, Ho Jeong Jeon, Young Mee Jung, Il-Joo Cho, Ki Jun Yu
Summary: Transparent implantable devices combining neural recording and optical modalities have promising applications. The introduction of a PEDOT:PSS electrode array has advantages of being photoelectric artifact-free with superior optical, mechanical, and electrical characteristics. The device can assemble transparent neural interfaces more efficiently through a simple ethylene glycol immersing process.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Lisheng Zhang, Yiyuan Zhang, Xueyan Wang, Duan Zhang
Summary: The study focused on preparing an Au nanoporous array photocatalyst driven by surface plasmons, investigating the redistribution of excited carriers and processes, and introducing sodium borohydride for reverse photocatalysis. The research aims to enable drawing of graphics and achieving information encryption on the micro/nano scale.
Review
Neurosciences
Ieva Vebraite, Yael Hanein
Summary: Electrophysiological investigations provide valuable insights into the organization and function of the retina, with multi-electrode arrays being widely used for high-resolution studies. Challenges and opportunities exist in conducting high-resolution electrophysiological investigations on the intact retina.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Chemistry, Multidisciplinary
James E. Tyrrell, Martyn G. Boutelle, Alasdair J. Campbell
Summary: OECTs have proven to be successful in transducing physiological information and measuring high-frequency signals, with significant improvements in key performance parameters like peak transconductance and response time.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Nanoscience & Nanotechnology
Hyunah Kwon, Hannah-Noa Barad, Alex Ricardo Silva Olaya, Mariana Alarcon-Correa, Kersten Hahn, Gunther Richter, Gunther Wittstock, Peer Fischer
Summary: Plasma treatment of metal nanoparticles formed by physical vapor deposition is a general method to fabricate nanoporous metallic films, which are free of impurities, highly curved ligaments, and nanopores. The films are ultrathin, but robust and well connected, making them highly promising for various applications such as transparent conducting electrodes.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Materials Science, Multidisciplinary
Moxia Li, Yaomengli Xu, Bingwu Liu, Jianfang Liu, Xuguang Sun, Dongmei Deng, Xidong Duan, Jiawen Hu
Summary: This article presents a bottom-up nanowelding strategy for the fabrication of high-purity nanoporous gold (NPG) from gold nanoparticles (NPs). By transferring the layered Au NP film onto a solid substrate and conducting direct current (DC) nanowelding, NPG can be produced at low temperatures within 10 seconds without damaging the spherical structure. This method also allows for the tunability of thickness, ligament size, and pore size by using differently sized Au NPs as starting building blocks, providing great flexibility for creating functional porous nanomaterials.
SCIENCE CHINA-MATERIALS
(2022)
Article
Multidisciplinary Sciences
Tuerkan Bayrak, Amanda Martinez-Reyes, David Daniel Ruiz Arce, Jeffrey Kelling, Enrique C. Samano, Artur Erbe
Summary: A method based on directed molecular self-assembly was introduced to manufacture and electrically characterise C-shape gold nanowires, revealing hopping, thermionic, and tunneling transports indicating weakly coupled metallic segments along the wires.
SCIENTIFIC REPORTS
(2021)
Article
Biochemical Research Methods
Marjon Zamani, Catherine M. M. Klapperich, Ariel L. L. Furst
Summary: Gold electrodes are commonly used as substrates for electrochemical biosensors due to their ease of functionalization with biomolecules. Traditional methods for fabricating gold electrodes are expensive and require specialized equipment, limiting their use in low-resource settings. Alternative fabrication methods, such as screen and inkjet printing, as well as physical fabrication with wire or gold leaf, have been developed to simplify and lower the cost of manufacturing gold electrodes. These methods have successfully functionalized the electrodes with biomolecules, demonstrating their suitability for biosensors. This review highlights recent advances in the fabrication, characterization, and functionalization of next-generation gold electrodes, with a focus on cost and complexity comparisons with traditional cleanroom fabrication. The potential of gold leaf electrodes in low-resource settings is also emphasized, as they offer advantages that make them broadly applicable beyond such settings.
Article
Biophysics
Venkata Suresh Vajrala, Kamil Elkhoury, Sophie Pautot, Christian Bergaud, Ali Maziz
Summary: This paper reports a novel Hollow Ring-like type electrode for sensing and/or stimulating neural activity from three-dimensional neural networks. The ring electrode architecture enables easy access to three-dimensional neural networks with reduced mechanical contact on the biological tissue, and provides improved electrical interface with cells. The hollow ring design shows great potential for developing next-generation microelectrodes for applications in neural interfaces.
BIOSENSORS & BIOELECTRONICS
(2023)
Article
Chemistry, Analytical
Hyun Ju Yang, Donghoon Han, Jinju Kim, Young Heon Kim, Je Hyun Bae
Summary: A constant phase element (CPE) is an electrical circuit component that describes the behavior of a double layer at the electrode and electrolyte interface. Its interpretation becomes more complicated when applied to nanoporous electrodes, due to the morphological effect. The CPE depends on electrolyte concentration and ionic size, with ion depletion and transport affecting capacitance and leading to non-ideality.
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
(2022)
Article
Materials Science, Multidisciplinary
Zhen Qi, Monika M. Biener, Ajay R. Kashi, Sara Hunegnaw, Alvin Leung, Sichao Ma, Ziyang Huo, Kendra P. Kuhl, Juergen Biener
Summary: Integrating ultrathin monolithic nanoporous gold catalyst coatings in a large electrode area electrochemical membrane reactor with gas diffusion electrodes has shown an increase in CO Faraday efficiency with thicker layers. The configuration of a single npAu leaf layer demonstrates an extremely high CO current density, showing potential for commercial applications.
MATERIALS RESEARCH LETTERS
(2021)
Article
Engineering, Electrical & Electronic
Hifza Iqbal, Bushra Parveen, Sama Kiran, Muhammad Imran, Farzana Saddique, Mahmood Ul Hassan, Aamir Razaq
Summary: Metal sulfide-based electrodes have significant importance in energy storage applications due to their unique characteristics. In this study, chromium sulfide and reduced graphene oxide-based electrodes were synthesized and characterized for supercapacitor applications. The results showed that both chromium sulfide and reduced graphene oxide exhibited pseudocapacitive behavior, with high specific capacitance and energy density. The asymmetric system of chromium sulfide and reduced graphene oxide also showed promising performance, making it suitable for high power density in energy storage devices.
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
(2022)
Article
Biotechnology & Applied Microbiology
Ehab O. A. Hafiz, Beyza Bulutoglu, Soheir S. Mansy, Yibin Chen, Hoda Abu-Taleb, Somia A. M. Soliman, Ali A. F. El-Hindawi, Martin L. Yarmush, Basak E. Uygun
Summary: This study demonstrated the successful formation of transplantable hepatic microtissues with functional bile drainage, achieved through the coculturing of rat primary hepatocytes, cholangiocytes, and stromal cells. The hepatocytes maintained viability and functionality within the spheroids for up to 7 days, showing potential for repopulating liver scaffolds for transplantable liver grafts.
BIOTECHNOLOGY AND BIOENGINEERING
(2021)
Article
Critical Care Medicine
Safak Mert, Beyza Bulutoglu, Christopher Chu, Maggie Dylewski, Florence M. Lin, Yong-Ming Yu, Martin L. Yarmush, Robert L. Sheridan, Korkut Uygun
Summary: This study observed significant metabolic and lipid changes in liver and muscle tissues of severe burn injury rats, indicating potential liver-muscle crosstalk during hypermetabolism, where the tissues may exacerbate each other's metabolic pathologies through excessive utilization of certain metabolites.
JOURNAL OF BURN CARE & RESEARCH
(2021)
Article
Dermatology
Mengjie Wu, Andrey Ethan Rubin, Tianhong Dai, Rene Schloss, Osman Berk Usta, Alexander Golberg, Martin Yarmush
Summary: The study optimized PEF parameters to achieve the best disinfection efficacy for Pseudomonas aeruginosa infection in a stable mouse burn wound model. Results showed that PEF treatment reduced bacterial load, decreased inflammatory signs, and modulated inflammatory responses in infected burn wounds, suggesting PEF treatment as a potent candidate for antimicrobial therapy for P. aeruginosa burn infections.
ADVANCES IN WOUND CARE
(2021)
Article
Engineering, Biomedical
Aylin Acun, Ruben Oganesyan, Korkut Uygun, Heidi Yeh, Martin L. Yarmush, Basak E. Uygun
Summary: The extracellular matrix of the liver changes with age, affecting cell function, and donor age should be considered an important factor for bioengineering liver substitutes.
Article
Chemistry, Multidisciplinary
Barath Palanisamy, Noah Goshi, Erkin Seker
Summary: This study demonstrates the use of nanoporous gold thin films for in-plane transport of fluorescein over large distances to establish a constant molecular release. The presence of halides allows for the preferential adsorption onto the gold surface, enabling the in-plane fluorescein transport. The nanoporous film also serves as a size-exclusion matrix for sustained release in biofouling conditions.
Article
Chemistry, Multidisciplinary
Hwan June Kang, Suneel Kumar, Arielle D'Elia, Biraja Dash, Vikas Nanda, Henry C. Hsia, Martin L. Yarmush, Francois Berthiaume
Summary: The combination of AGEs and RAGE triggers pro-inflammatory signals that inhibit the proliferative phase of skin wound healing. A new coacervate system has been developed to reverse AGE-mediated changes, accelerate diabetic wound healing, and provide a potential therapeutic approach.
JOURNAL OF CONTROLLED RELEASE
(2021)
Review
Biotechnology & Applied Microbiology
Anil B. Shrirao, Rene S. Schloss, Zachary Fritz, Mayur V. Shrirao, Robert Rosen, Martin L. Yarmush
Summary: Blood autofluorescence is explored as a label-free approach for detecting cell types and diseases. Despite its high sensitivity, it lacks disease specificity and is affected by various factors such as sample type and preparation.
BIOTECHNOLOGY AND BIOENGINEERING
(2021)
Review
Engineering, Biomedical
Haishui Huang, Xiaoming He, Martin L. Yarmush
Summary: This review summarizes the principles and procedures of the three classical core technologies for preserving live mammalian biospecimens and how their limitations are being addressed through a combination of microfabrication, nanofabrication, materials science, and thermal-fluid engineering. It also examines the classical methods for preservation of mammalian biospecimens and discusses the mechanisms of cryoinjury, as well as how the limitations of these methods are being addressed.
NATURE BIOMEDICAL ENGINEERING
(2021)
Article
Chemistry, Medicinal
Zachary R. Fritz, Rene S. Schloss, Martin L. Yarmush, Lawrence J. Williams
Summary: A novel engineering strategy was presented to improve autoantibody detection by using peptide fragments derived from the parent antigen. The study focused on enhancing binding affinity between peptides and antibodies by designing different flanking regions, leading to significant improvements in binding affinity and limits of detection for certain peptides. The reevaluation of the epitope suggested improved binding energy calculations and experimental data agreement, showcasing the potential of the Hidden Symmetry Model for peptide design and analysis.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2021)
Article
Engineering, Biomedical
Beyza Bulutoglu, Aylin Acun, Sarah L. Deng, Safak Mert, Elise Lupon, Alexandre G. Lellouch, Curtis L. Cetrulo, Basak E. Uygun, Martin L. Yarmush
Summary: Elastin-like peptides (ELPs) are a versatile platform for tissue engineering and drug delivery. In this study, therapeutic molecules are genetically fused to ELPs and applied to wound healing. The results show that the fused molecules retain their bioactivity and the application of these ELP nanoparticles significantly promotes wound closure in diabetic mice.
ADVANCED HEALTHCARE MATERIALS
(2022)
Article
Biochemistry & Molecular Biology
Noah Goshi, Hyehyun Kim, Erkin Seker
Summary: This study demonstrates the screening capabilities of a primary cortical cell tri-culture and emphasizes the significant role of microglia in the neuroinflammatory response to TLR activation in vitro.
Article
Cell Biology
Noah Goshi, Hyehyun Kim, Gregory Girardi, Alexander Gardner, Erkin Seker
Summary: Neuroinflammation is crucial in neurological disorders, and its impact on electrophysiological activity can be studied using in vitro models. This study utilized a tri-culture of rat neurons, astrocytes, and microglia to investigate the effect of microglia on neural function and response to neuroinflammatory stimuli. The results showed that the tri-culture provided a better representation of the in vivo rat cortex and captured electrophysiological manifestations of neuroinflammation. This technology is expected to aid in understanding various brain disease mechanisms.
Article
Chemistry, Analytical
Gregory Girardi, Danielle Zumpano, Noah Goshi, Helen Raybould, Erkin Seker
Summary: The gut-brain axis plays a crucial role in the communication between the gastrointestinal tract and the central nervous system. Vagal afferent neurons (VANs) act as sensors for gut-derived signals and are influenced by effector molecules released by the gut microbiota. This study presents a cell-based sensor, VAN culture, to monitor the influence of gastrointestinal effector molecules on neuronal behavior.
Article
Biochemical Research Methods
Noah Goshi, Gregory Girardi, Felipe da Costa Souza, Alexander Gardner, Pamela J. Lein, Erkin Seker
Summary: The study investigates the impact of microchannel geometry and cell seeding density on the performance of compartmentalized microfluidic neural cell culture platforms. It concludes that microchannel height is the primary determinant of device performance, while other parameters offer additional flexibility for customization. This research provides design rules for engineering microfluidic neural culture platforms and demonstrates their utility in long-term studies.
Proceedings Paper
Engineering, Biomedical
Zubayer Ibne Ferdous, Anlan Yu, Yuan Zeng, Xiaochen Guo, Zhiyuan Yan, Yevgeny Berdichevsky
Summary: Simplified models of neurons are commonly used in computational studies of large networks, with accuracy in reproducing action potential timing being a key performance metric. This article introduces a simple and computationally efficient neuron model that accurately matches spike times and frequency adaptation of cortical pyramidal neurons. The model's accuracy is comparable to a more complex biophysically realistic model, providing an improved spike timing accuracy for use in modeling large neural networks.
2021 43RD ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE & BIOLOGY SOCIETY (EMBC)
(2021)