Article
Nanoscience & Nanotechnology
Sayantan Ghosh, Muhammad Bilal Khan, Phanish Chava, Kenji Watanabe, Takashi Taniguchi, Slawomir Prucnal, Rene Huebner, Thomas Mikolajick, Artur Erbe, Yordan M. Georgiev
Summary: This work introduces the concept of a mixed-dimensional reconfigurable field effect transistor (RFET) by combining a one-dimensional silicon nanowire with a two-dimensional hexagonal boron nitride (hBN) gate dielectric. The hBN encapsulation improves the device's electrical parameters, reducing hysteresis and increasing the on-off ratio. RFETs have great potential in reducing device count and power consumption, and the concept of mixed-dimensional RFET could further enhance their functionality.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Engineering, Electrical & Electronic
Luca Capua, Yann Sprunger, H. Elettro, F. Risch, A. Grammoustianou, R. Midahuen, T. Ernst, S. Barraud, R. Gill, A. M. Ionescu
Summary: We present a CMOS-compatible double gate and label-free C-reactive protein (CRP) sensor based on silicon on insulator (SOI) silicon nanowires arrays. By exploiting a reference subtracted detection method and a super-Nernstian internal amplification provided by the double gate structure, we overcome the Debye screening of charged CRP proteins in solutions. The demonstrated internal amplification enables the pH response of the sensor, making it an excellent candidate for continuous monitoring of inflammation biomarkers in serum or interstitial fluid.
IEEE TRANSACTIONS ON ELECTRON DEVICES
(2022)
Review
Chemistry, Multidisciplinary
Yutong Niu, Fuzhong Li, Wuxi Zhao, Wei Cheng
Summary: This article reviews the methods for processing nanowires into three-dimensional monolithic aerogels and their applications in various emerging fields. The benefits and drawbacks of different preparation methods, as well as the application of nanowire aerogels in thermal management, energy storage and conversion, catalysis, sensors, and solar steam generation are discussed. The potential for improving the performance of nanowire-based aerogels through engineering their compositions and structures is also explored, along with future development perspectives.
Article
Chemistry, Analytical
Tingxian Li, Lina Tang, Kun Li, Binzhu Liu, Meng -Meng Xiao, Nian Liu, Wei Ni, Yutao Li, Zhiyong Zhang, Guo-Jun Zhang
Summary: To achieve fast and sensitive detection of proteins, researchers have developed a polymer-sorted high-purity semiconducting carbon nanotubes (CNTs) films-based field-effect transistor (FET) biosensor for ultrasensitive and label-free detection of MUC1, a transmembrane protein highly expressed in breast cancer exosomes. The modified CNT FET was capable of sensitively and selectively detecting exosomal MUC1 as low as 0.34 fg/mL, and it could differentiate breast cancer patients from healthy individuals by comparing the expression level of exosomal MUC1. This novel CNT FET biosensor holds great potential for early diagnosis of cancer.
ANALYTICA CHIMICA ACTA
(2023)
Review
Biochemistry & Molecular Biology
Ana Paula Correa Argondizzo, Dilson Silva, Sotiris Missailidis
Summary: Arbovirus infections are a global public health issue, with recent epidemics showing their importance in Brazil and worldwide. Aptamer approaches offer the possibility of differential diagnosis between arboviruses and potential treatment options. This review provides background on arboviruses and a comprehensive understanding of their role, as well as a review of diagnostic and therapeutic approaches using aptamers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Multidisciplinary
Xuan Wang, Yehua Tang, Wanping Wang, Hao Zhao, Yanling Song, Chaoyang Kang, Kefan Wang
Summary: In this study, Bi2Se3 film was deposited onto silicon nanowires using vacuum evaporation method to create a bulk heterojunction, resulting in a self-powered photodetector with a wide detection range and fast response speed. This silicon-based photodetector shows promise for near- and mid-infrared applications, making it a potential candidate for future optoelectronic devices.
Review
Chemistry, Analytical
Foad Ghasemi, Abdollah Salimi
Summary: Two-dimensional (2d) materials are widely used in various fields due to their unique physical and chemical properties. In the field of biomedical diagnostics, field-effect transistor biosensors (bio-FETs) based on 2d nanomaterials show great potential. These bio-FETs not only enhance the bioassay process but also offer label-free, low-cost, real-time, highly sensitive, and selective detection of biomolecules. This review comprehensively focuses on different types of 2d-based bio-FETs, including Apta, DNA (Geno), Immuno, and enzymatic biosensors, and discusses their configurations, detection mechanisms, and potential applications in point-of-care (PoC) testing in biomedical samples.
MICROCHEMICAL JOURNAL
(2023)
Review
Biotechnology & Applied Microbiology
Xiujuan Yin, Zhenqiang He, Weiying Ge, Zhenhua Zhao
Summary: Cancer is a major cause of human death worldwide. Traditional cancer treatments have limitations, such as recurrence, poor efficacy, and side effects. Targeted therapy using aptamer-functionalized nanomaterials (AFNs) has become a hot topic, due to the high stability, affinity, and selectivity of aptamers. AFNs have shown promising applications in targeted therapy for various types of tumors.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Spectroscopy
Xuhua Zhao, Xiaochun Dai, Suya Zhao, Xiaohua Cui, Tao Gong, Zhiling Song, Hongmin Meng, Xiaobing Zhang, Baofeng Yu
Summary: Aptamers, as short single-stranded RNA or DNA molecules that can recognize targets with high affinity and specificity, have unique advantages such as easy chemical synthesis, high stability, low molecular weight, and lack of immunogenicity. Utilizing aptamers in fluorescent sensors provides exciting opportunities for sensitive detection and quantification of analytes, particularly in the field of cancer biomarker detection.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2021)
Article
Engineering, Electrical & Electronic
V. P. Popov, F. V. Tikhonenko, V. A. Antonov, A. A. Zarubanov, A. V. Gluhov, A. A. Tatarintsev, A. V. Miakonkikh, K. V. Rudenko
Summary: This study fabricated parallel nanowire (PNW) SOI transistors with a high-k HfO2/Al2O3 10 nm gate oxide using silicon plasma etching and ALD of dielectric stack. Pseudo-MOSFET and split-CV methods were employed to investigate the sensitivity and stability of the devices in electrolyte liquids.
SOLID-STATE ELECTRONICS
(2022)
Article
Chemistry, Analytical
Zixuen Gan, Muhamad Aidilfitri Mohamad Roslan, Mohd Yunus Abd Shukor, Murni Halim, Nur Adeela Yasid, Jaafar Abdullah, Ina Salwany Md Yasin, Helmi Wasoh
Summary: Aptamers are synthetic single-stranded nucleic acids generated through the SELEX technology with high affinity and specificity. While progress has been made in aptamer design and applications, only a few have achieved widespread commercial and clinical acceptance. Finding more effective ways to acquire high-affinity aptamers remains a challenge.
Review
Biotechnology & Applied Microbiology
Lubin Liu, Zeyu Han, Fei An, Xuening Gong, Chenguang Zhao, Weiping Zheng, Li Mei, Qihui Zhou
Summary: Sepsis is a serious and growing global problem, with early detection of pathogens and biomarkers being crucial in selecting appropriate antibiotics. Aptamer-based biosensors are emerging as a reasonable strategy for sepsis diagnosis due to their accessibility, rapidity, and stability.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Article
Biophysics
Qingqing Huang, Fang Luo, Cuiying Lin, Jian Wang, Bin Qiu, Zhenyu Lin
Summary: Ru-PEI-L-lys was immobilized on ZIF-8 to form Ru-PEI-L-lys-ZIF-8, which was then mixed with PtNPs to enhance the ECL response. The combination of selective aptamer and RecJf exonuclease in the system resulted in a highly sensitive ECL biosensor for thrombin detection, with a linear response range from 1 fM to 10 pM and a detection limit of 0.02 aM. This work presents a new strategy for designing stable ECL indicators and developing sensitive ECL sensors for biological analysis.
BIOSENSORS & BIOELECTRONICS
(2021)
Article
Chemistry, Multidisciplinary
Hongyuan Zhang, Zhi Zheng, Zhicheng Zhang, Liang Hai, Haiyang Li, Shenghong Liu, Xiaoding Lou, Tianyou Zhai, Fan Xia
Summary: A gate-voltage-modulated strategy was proposed to enhance the detection performance of telomerase. The mechanism for the improved detection performance was comprehensively investigated by modulating the electrostatic interaction between a single-stranded DNA probe and electrons of the In2O3 channel. This gate-voltage modulation could potentially be utilized as a universal strategy for high-performance FET biosensors.
CHEMICAL COMMUNICATIONS
(2023)
Article
Biotechnology & Applied Microbiology
Si Yang, Chenxi Li, Hongyan Zhan, Rong Liu, Wenliang Chen, Xiaoli Wang, Kexin Xu
Summary: In this study, a label-free fluorescent biosensor for the detection of tetracycline (TET) was developed using specific aptamer-templated silver nanoclusters (AgNCs). The binding of TET to the aptamer led to a conformational change, resulting in the transformation of AgNCs into larger silver nanoparticles (AgNPs) and a decrease in fluorescence. The proposed biosensor exhibited high sensitivity and selectivity for TET detection in milk, with a limit of detection of 11.46 ng/mL and a linear range of 20 ng/mL-10 g/mL. These findings demonstrate the potential of the biosensor for quantitative determination of TET in food samples and expand the application of DNA-AgNCs in related fields.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Article
Engineering, Biomedical
Minsoo Cho, Seulgi Han, Hyemin Kim, Ki Su Kim, Sei Kwang Hahn
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
(2018)
Article
Nanoscience & Nanotechnology
Hyunsik Choi, Geon-Hui Lee, Ki Su Kim, Sei Kwang Hahn
ACS APPLIED MATERIALS & INTERFACES
(2018)
Article
Chemistry, Multidisciplinary
Donghyun Lee, Songeun Beack, Jounghyun Yoo, Su-Kyoung Kim, Changho Lee, Woosung Kwon, Sei Kwang Hahn, Chulhong Kim
ADVANCED FUNCTIONAL MATERIALS
(2018)
Review
Chemistry, Multidisciplinary
Hyemin Kim, Songeun Beack, Seulgi Han, Myeonghwan Shin, Taehyung Lee, Yoonsang Park, Ki Su Kim, Ali K. Yetisen, Seok Hyun Yun, Woosung Kwon, Sei Kwang Hahn
ADVANCED MATERIALS
(2018)
Article
Chemistry, Multidisciplinary
Seong Uk Yu, Hwiwon Lee, Woo Jong Cho, Chulhyun Kim, Moon Cheol Kang, Hyun-Joon Shin, Namdong Kim, Sei Kwang Hahn, Kwang S. Kim
Article
Nanoscience & Nanotechnology
Jounghyun Yoo, Seulgi Han, Wonchan Park, Taehyung Lee, Yoonsang Park, Heemin Chang, Sei Kwang Hahn, Woosung Kwon
ACS APPLIED MATERIALS & INTERFACES
(2018)
Article
Engineering, Biomedical
Myeong-Hwan Shin, Eun-Yeong Park, Seulgi Han, Ho Sang Jung, Do Hee Keum, Geon-Hui Lee, Taeyeon Kim, Chulhong Kim, Ki Su Kim, Seok Hyun Yun, Sei Kwang Hahn
ADVANCED HEALTHCARE MATERIALS
(2019)
Article
Materials Science, Biomaterials
Ho Sang Jung, Hyun Ho Kim, Myeong Hwan Shin, Seongjong Kim, Ki Su Kim, Kilwon Cho, Sei Kwang Hahn
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2019)
Article
Biochemistry & Molecular Biology
Hyemin Kim, Myeonghwan Shin, Seulgi Han, Woosung Kwon, Sei Kwang Hahn
Article
Chemistry, Multidisciplinary
Hyemin Kim, Yoonsang Park, Molly M. Stevens, Woosung Kwon, Sei Kwang Hahn
JOURNAL OF CONTROLLED RELEASE
(2019)
Article
Biochemistry & Molecular Biology
Hyunsik Choi, Wonseok Choi, Jeesu Kim, Won Ho Kong, Ki Su Kim, Chulhong Kim, Sei Kwang Hahn
Article
Chemistry, Multidisciplinary
Yun Seop Kim, Dong Kyung Sung, Hyemin Kim, Won Ho Kong, Young Eun Kim, Sei Kwang Hahn
JOURNAL OF CONTROLLED RELEASE
(2019)
Article
Materials Science, Biomaterials
Hyemin Kim, Keum-Yong Seong, Jung Ho Lee, Wonchan Park, Seung Yun Yang, Sei Kwang Hahn
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2019)
Article
Optics
Heemin Chang, Jounghyun Yoo, Hyemin Kim, Wonchan Park, Sei Kwang Hahn, Woosung Kwon
JOURNAL OF LUMINESCENCE
(2019)
Article
Chemistry, Multidisciplinary
Jonghwan Mun, Jee Won Mok, Sanghoon Jeong, Seonghwi Cho, Choun-Ki Joo, Sei Kwang Hahn