Article
Engineering, Chemical
Ze-Lin Qiu, Wen-Han Yu, Yu-Jie Shen, Bao-Ku Zhu, Li-Feng Fang
Summary: The use of cationic hyperbranched poly (amido-amine)s as macromonomers for nanofiltration membrane fabrication allows for modulation of outer voids between molecules to enhance permeability and selectivity. The resultant membrane demonstrates ultrahigh retention for molecules with high molecular weights or positive charges, achieving molecular-level selectivity for different types of molecules.
JOURNAL OF MEMBRANE SCIENCE
(2021)
Article
Chemistry, Physical
Shu Yan, Pengfei Jiang, Xinghong Zhang, Yongsheng Guo, Wenjun Fang
Summary: To enhance the extraction efficiency of crude oil emulsions, researchers have designed and synthesized n-hexadecanoyl hyperbranched poly(amido-amine) (CHPAMAM) as an amphiphilic demulsifier with hyperbranched poly(amido-amine) as the core and palmitic acid chains as the shell. Stable oil-in-water emulsions can be completely separated into two phases at low temperature with the presence of highly active CHPAMAM, resulting in a clear phase interface and a thin transition layer. By adding 80 ppm CHPAMAM to simulated emulsions and crude oils from China's oilfields, the oil removal ratios can exceed 99.9% and the water contents in the oil phase can be reduced to less than 0.01%, achieving demulsification equilibrium within 40 min at 30 degrees C. The demulsification process is monitored in real-time using laser scanning confocal microscopy (LSCM). The demulsification mechanism of CHPAMAM is studied through adsorption kinetics experiments and validated by dissipative particle dynamics simulation, demonstrating its ability to disrupt the stabilizing materials and enhance demulsification performance at low temperature.
JOURNAL OF MATERIALS CHEMISTRY A
(2023)
Article
Chemistry, Physical
Xiao-Jun Feng, Yin-Jun Tang, Yin Yang, Gang Wang, Ping Mei, Lu Lai
Summary: The relationship between demulsification performance and the dynamic interfacial activity of polyether demulsifiers is crucial. The study found that the optimal polyether demulsifiers have a specific RSN value and can achieve complete separation with increasing EO content, but overdosing has a negative effect. Additionally, the dehydration efficiency was positively correlated with dynamic interfacial activity, providing insight for effective demulsification and demulsifier screening.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2022)
Article
Engineering, Biomedical
Molly K. Grun, Alexandra Suberi, Kwangsoo Shin, Teresa Lee, Victoria Gomerdinger, Zoe M. Moscato, Alexandra S. Piotrowski-Daspit, W. Mark Saltzman
Summary: The study found that low concentrations of PACE-PEG can improve polyplex stability but also inhibit transfection efficiency. In vivo, the effect of PACE-PEG incorporation on transfection varied by delivery route, and excess PEGylation was detrimental to vehicle function.
Article
Chemistry, Analytical
Cheng Li, Qian-Qi Yang, Tian-Jiao Zhang, Zhao-Zi Lv, Yong Wang, Yu Chen
Summary: The study introduces a hybrid ratiometric fluorescence sensor for efficient and accurate detection of dissolved CO2, which was proven effective for determining the CO2 concentration in real samples. This is the first report of a water-soluble, quantitatively CO2-responsive, ratiometric fluorescence sensor synergizing TPE and Au NCs in the amino-rich hyperbranched skeleton without the participation of any free organic compounds.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Polymer Science
Wasana Nonkrathok, Tatiya Trongsatitkul, Nitinat Suppakarn
Summary: In this study, the shape memory properties of poly(lactic acid) (PLA)/poly(ethylene glycol) (PEG) blends were improved by adding maleic anhydride-grafted poly(lactic acid) (PLA-g-MA) as a compatibilizer. The PLA-g-MA improved interfacial adhesion between phases and promoted chain entanglement, leading to enhanced mechanical properties and shape fixity performance. The compatibilized blend containing 2 wt% PLA-g-MA exhibited the best shape fixity and recovery performance.
Article
Chemistry, Inorganic & Nuclear
Zhi-Rong Feng, Bao-Bo Wang, Hao Dong, Shun-Ping Zhao, Yu-Ping Wu, Qiao Qiao, Xiao-Ming Ren
Summary: In this study, three covalently grafted kaolinites were prepared by forming Al-O-C bonds between the OH groups of propanediol (PD)/butanediol (BD)/glycerol (GL) and the surface of kaolinite. The hybrids showed excellent chemical stability to water and exhibited ferroelectricity at room temperature.
DALTON TRANSACTIONS
(2023)
Article
Chemistry, Multidisciplinary
Ekkachai Martwong, Yvette Tran
Summary: The study reports on the synthesis and temperature-responsive properties of poly(PEGMA) hydrogel thin films. Surface-attached poly(PEGMA) hydrogel films were synthesized using a simple, versatile, and well-controlled thiol-ene click reaction method, with the transition temperature finely tunable by adjusting the number of PEG units. The LCST properties of the hydrogel films are not sensitive to salt, holding promise for applications in biology such as injectable hydrogels, drug delivery systems, microfluidic valves, and flow switches for biotechnologies.
Article
Polymer Science
Wei-Chi Lai, Li-Jie Liu
Summary: Polylactic acid (PLA) bioplastics have garnered attention due to their biomass-derived nature and low toxicity. However, the slow crystallization of PLA limits its commercial applications. This study developed a simple and cost-effective approach using eco-friendly low molecular weight poly(ethylene glycol) (PEG) as a green solvent to enhance the PLA crystallization process.
POLYMERS FOR ADVANCED TECHNOLOGIES
(2022)
Article
Chemistry, Multidisciplinary
Xue Geng, Rongjun Qu, Xiangyu Kong, Shengnan Geng, Ying Zhang, Changmei Sun, Chunnuan Ji
Summary: Dendrimers and hyperbranched dendrimers are commonly used metal ions adsorption materials, with the latter being more economical and suitable for industrial large-scale adsorption. The study found that the optimal pH for Hg(II) removal was 5.0, and the adsorption kinetic curves followed the pseudo-second-order model. Additionally, the maximum adsorption capacity for Hg(II) of HPAMAM-ECH-3 was 3.36 mmol/g at pH 5.0 and 35 degrees C according to the Langmuir model.
FRONTIERS IN CHEMISTRY
(2021)
Article
Materials Science, Multidisciplinary
Yadagiri L. N. K. Mallela, Se Young Jeong, Santosh Kumar, Jae-Suk Lee
Summary: Silica nanoparticles with hyperbranched polyglycidol (hbP) grafts were synthesized and their ionic conductivity was enhanced by end functionalization with a nitrile group. Among the different batches of hbPs, the 6th-batch CN-hbP-SiO2 nanoparticles showed the best ionic conductivity when blended with PEO.
MACROMOLECULAR MATERIALS AND ENGINEERING
(2021)
Article
Biochemistry & Molecular Biology
Gan Lin, Christina Cortez-Jugo, Yi Ju, Quinn A. Besford, Timothy M. Ryan, Shuaijun Pan, Joseph J. Richardson, Frank Caruso
Summary: In this study, a strategy based on the noncovalent coordination between PEG-polyphenolic ligands and transition metal ions was used to synthesize sub-100 nm PEG NPs with tunable size and morphology. The self-assembly of PEG-gallol/metal NPs was driven by metal-phenolic coordination, resulting in a series of metal-stabilized PEG NPs with different sizes and morphologies. The formation of the PEG-gallol/Mn-II NPs was predominantly driven by ionic interactions, leading to high biocompatibility and functionality, suggesting their potential for biomedical applications.
Article
Biochemistry & Molecular Biology
Pawika Towongphaichayonte, Rangrong Yoksan
Summary: This study successfully fabricated polyelectrolyte complexes from mPEG-g-CTS and ALG, which could form fibrous network macrogels or spherical nanoparticles with different physicochemical properties depending on the mPEG chain length and weight ratios. These complexes have potential applications as carriers for functional food additives, drugs, and bioactive compounds.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Polymer Science
Wenju Hu, Haozhi Sun, Lixia Pan, Chaoqun Zhang, Xin Shen, Feng Su, Jie Song
Summary: The encapsulation and release of hydrophobic drugs from PTMC-PEG micelles were studied to enhance drug delivery. By adjusting the hydrophilic/hydrophobic segment length, high drug loading and sustained release were achieved. The PTMC-PEG micelles showed good biocompatibility.
POLYMERS FOR ADVANCED TECHNOLOGIES
(2023)
Article
Polymer Science
Corina Logigan, Christelle Delaite, Crina-Elena Tiron, Cristian Peptu, Marcel Popa, Catalina Anisoara Peptu
Summary: Chitosan hydrogels were prepared by chemical modification and double crosslinking in a water/oil emulsion. The modified chitosan showed better control of dimensional properties and morphology compared to neat chitosan. In addition, the modified hydrogels exhibited pH-dependent behavior and demonstrated excellent capacity for drug loading and release, making them suitable for controlled release applications in biomedicine.
Article
Chemistry, Multidisciplinary
Qin Jiang, Kuang Wang, Xingyu Zhang, Boshu Ouyang, Haixia Liu, Zhiqing Pang, Wuli Yang
Article
Chemistry, Multidisciplinary
Yongbin Cao, Wang Song, Qin Jiang, Ye Xu, Sanjun Cai, Sheng Wang, Wuli Yang
Article
Chemistry, Multidisciplinary
Zhen Mi, Ting Zhou, Weijun Weng, Junjuda Unruangsri, Ke Hu, Wuli Yang, Changchun Wang, Kai A. I. Zhang, Jia Guo
Summary: The study integrates cyclic diquats into a 2D COF platform, promoting consecutive electron transfer in photochemical processes through multi-component cooperation. The resulting materials combine photosensitizing units and ETMs into one system, exhibiting enhanced hydrogen evolution rate and sustained performance.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Engineering, Chemical
Yuanying Zhang, Xuechun Zhang, Yongbin Cao, Jiachun Feng, Wuli Yang
Summary: In this study, acrylonitrile-styrene-acrylate copolymer (ASA) particles were synthesized with different microstructure via emulsion polymerization for toughening poly(styrene-co-acrylonitrile) (SAN) resin. The optimum toughening efficiency was achieved when ASA particles had a complete core-shell structure with a shell composition similar to the SAN matrix. Adjusting the microstructure of the particles, including morphology, composition, and size, improved the notched impact strength of the resin without sacrificing tensile strength. The toughening mechanism was attributed to the crazings and cavitation of particles observed on impact-fractured surfaces.
ADVANCES IN POLYMER TECHNOLOGY
(2021)
Article
Engineering, Biomedical
Haibao Peng, Xingcai Zhang, Peng Yang, Jiaxu Zhao, Wei Zhang, Nianping Feng, Wuli Yang, Jing Tang
Summary: In this study, a metal-organic framework (MOF)-red blood cell (RBC) membrane-camouflaged multi-drug-delivery nanoplatform was designed and fabricated for combined ferroptosis-apoptosis treatment of multidrug-resistant cancer. The nanoplatform, created through a solvothermal synthesis process, demonstrated the ability to deplete glutathione, increase reactive oxidative species oxidative stress, and exhibit remarkable anticancer properties. This research provides a new strategy for overcoming multidrug resistance.
BIOACTIVE MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Shuting Mai, Xianxian Yao, Chenzi Li, Zhiwen Yin, Minghua Zhang, Jian Xu, Zhuofan Diao, Wuli Yang
Summary: In this study, a zwitterionic polymer nanogel was successfully synthesized by one-step reflux precipitation polymerization for doxorubicin (DOX) loading. The nanogels exhibited excellent blood circulation and low immunogenicity due to the introduction of zwitterionic groups. Additionally, the nanogels displayed glutathione-responsive degradation and efficient drug release, thanks to the presence of disulfide bonds.
Article
Chemistry, Physical
Dan Shu, Sicong Tu, Shuting Mai, Jian Xu, Wuli Yang
Summary: This study presents a post-crosslinking strategy to prepare highly crosslinked poly (methyl methacrylate) (PMMA) microspheres by separation of polymerization and crosslinking processes. Silane coupling agents containing double bonds were used as comonomers and hydrolyzed to form Si-O-Si crosslinked structure. The resulting microspheres exhibit high crosslinking degree, uniform particle size distribution, and good thermal stability, making them suitable as light diffusion agents in a polycarbonate matrix.
COLLOID AND POLYMER SCIENCE
(2023)
Article
Nanoscience & Nanotechnology
Jian Xu, Weichu Zhu, Xianxian Yao, Shuting Mai, Chenzi Li, Minghua Zhang, Dan Shu, Wuli Yang
Summary: Conventional chemotherapy is limited by toxicity and therapeutic effects. Gas therapy, particularly hydrogen sulfide (H2S), has been found to inhibit tumor growth. In this study, researchers developed a mesoporous organosilica-based H2S nanogenerator, which could release H2S to suppress tumor growth and release chemotherapy drugs.
ACS APPLIED NANO MATERIALS
(2023)
Article
Pharmacology & Pharmacy
Haixia Liu, Xianxian Yao, Weichu Zhu, Jiaxin Zhang, Shuangping Ma, Daru Lu, Wuli Yang
Summary: Colorectal cancer is a common cause of cancer-related deaths. Researchers have synthesized a new type of nanoparticle that effectively eliminates human colorectal carcinoma cells by triggering ferroptosis. The nanoparticles deliver an antineoplastic agent (SIM) and shRNA to the tumor sites, showing improved targeting ability and cytotoxicity against tumors. This alternative therapy addresses the limitations of chemotherapy and has great clinical potential.
ADVANCED THERAPEUTICS
(2023)
Article
Materials Science, Biomaterials
Weichu Zhu, Jian Xu, Xianxian Yao, Shuting Mai, Dan Shu, Wuli Yang
Summary: A pH-responsive nanoparticle, DOX@ZIF-8@PCBMA, was developed for the delivery of doxorubicin, and decitabine was loaded to create a pyroptosis nanotuner, DOX@ZIF-8@PCBMA-DAC. This nanotuner exhibited prolonged circulation and enhanced tumor accumulation, and the ZIF-8 structure and disulfide-crosslinked PCBMA coating allowed for pH- and glutathione-responsive degradation. The sustained release of DAC and DOX from the nanotuner robustly activated caspase-3, inducing GSDME-dependent pyroptosis and effectively suppressing tumors with minimal side effects.
BIOMATERIALS SCIENCE
(2023)
Article
Engineering, Biomedical
Jiaxin Zhang, Kaicheng Zhou, Jingbo Lin, Xianxian Yao, Dianwen Ju, Xian Zeng, Zhiqing Pang, Wuli Yang
Summary: This study investigated the relationship between chemotherapy resistance and ferroptosis in TNBC, and found that DOX-resistant TNBC cells had higher expression of Gpx4. Inducing ferroptosis by inhibiting Gpx4 expression can reduce TNBC resistance to DOX and enhance the therapeutic effect of chemotherapy. The combination of Fe3O4-PGA-DHA and Fe3O4-PASP-DOX demonstrated stronger cytotoxicity and increased intracellular accumulation of reactive oxygen species and lipid peroxides in TNBC cells. Furthermore, Fe3O4-PGA-DHA + Fe3O4-PASP-DOX triggered ferroptosis by inhibiting the PI3K/AKT/mTOR/GPX4 pathway. The study showed great potential for improving the therapeutic effect of TNBC.
Article
Materials Science, Biomaterials
Jingbo Lin, Jiaxin Zhang, Kuang Wang, Shengdi Guo, Wuli Yang
Summary: Ferroptosis, an alternative form of cell death, holds great promise for non-apoptotic cancer treatment. This study focused on the use of iron-based nanomaterials coated with zwitterionic polymers to enhance the effect of ferroptosis in colon cancer treatment. The results showed good biocompatibility and excellent tumor inhibitory effect in vivo.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
Review
Nanoscience & Nanotechnology
Xianxian Yao, Binru Yang, Jian Xu, Qianjun He, Wuli Yang
Summary: Gas therapy is an emerging cancer treatment method that utilizes nanotechnology for precise and targeted treatment. Combining gas therapy with other treatment methods can enhance the efficacy of cancer therapy. Understanding the mechanism of how gas enhances other therapies is crucial for designing effective cancer treatment strategies.
Article
Nanoscience & Nanotechnology
Haibao Peng, Zhuoyuan Xu, Yongcheng Wang, Nianping Feng, Wuli Yang, Jing Tang
ACS APPLIED BIO MATERIALS
(2020)
Article
Materials Science, Biomaterials
Xingyu Zhang, Jun Chen, Qin Jiang, Xiaoquan Ding, Yunxia Li, Chen Chen, Wuli Yang, Shiyi Chen
JOURNAL OF MATERIALS CHEMISTRY B
(2020)