Article
Chemistry, Analytical
Dan Liu, Haibin Tang, Yupeng Yuan, Chuhong Zhu
Summary: Surface-enhanced Raman scattering (SERS) spectroscopy provides sensitive rapid detection of molecules. A simple and effective method using seed-assisted electrodeposition is developed for fabricating a 3D SERS substrate composed of multilayer Au nanoparticles. The resulting multilayer Au nanoparticles-assembled film shows high SERS sensitivity, good spectral uniformity, and reproducibility, with a low detection limit for rhodamine 6G. Moreover, it is also effective in detecting organic pollutants such as crystal violet and methylene blue.
MICROCHEMICAL JOURNAL
(2023)
Article
Chemistry, Analytical
Yu Li, Jing Yuan, Shengnan Zhan, Jiaqi Hu, Yuqian Guo, Lu Ding, Xiaolin Huang, Yonghua Xiong
Summary: In this study, a DLS-based immunosensor was developed for the high-sensitivity detection of AFP, an important biomarker in the early diagnosis of primary liver cancer. By utilizing a gold in situ growth strategy and the burst release of numerous small-sized AuNPs, the sensor achieved ultrasensitive detection of AFP with a detection limit of 0.36 pg mL(-1). The proposed method was further validated with clinical serum samples and compared with a chemiluminescence immunosensor, demonstrating its potential as a novel bioanalytical platform.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Chemistry, Inorganic & Nuclear
Haiyun Liu, Na Ren, Yi Gao, Tingfan Wu, Boren Sui, Zhen Liu, Bin Chang, Man Huang, Hong Liu
Summary: In this study, a miRNA detection strategy based on the self-assembly of AuNPs induced by the hairpin probe-guided DNAzyme walker enzyme cleavage and walk was established. This strategy utilizes the continuous mechanical motion characteristics of DNAzyme walker to improve reaction efficiency and achieves ultra-sensitive detection using dynamic light scattering technology. It has also been successfully applied to analyze target miRNAs in cancer cell samples.
DALTON TRANSACTIONS
(2023)
Article
Chemistry, Physical
Ada Herrero-Ruiz, Gregorio Carolo, Guillermo Gonzalez-Rubio, Marek Grzelczak, Jan S. Niehaus, Horst Weller, Luis M. Liz-Marzan
Summary: In this study, we demonstrate the use of a purposely devised millifluidic flow reactor for the seeded growth of monodisperse gold nanoparticles. The system offers high process control and batch-to-batch reproducibility, allowing for the synthesis of various gold nanoparticle shapes and dimensions.
JOURNAL OF PHYSICAL CHEMISTRY C
(2023)
Article
Chemistry, Analytical
Antoine Dowek, Florent Voisin, Laetitia Le, Celine Tan, J. M. Mallet, Florent Carn, Eric Caudron
Summary: This study focuses on the improvement and control of SERS analysis by optimizing the aggregation/self-assembly of AuNPs using quaternized chitosan. The results show that the use of polyelectrolyte chains can stabilize neutral AuNPs aggregates, leading to significant enhancement of Raman signal. The stable and sensitive measurements of epinephrine at low concentrations were achieved, and the signal remained stable in complex media such as isotonic sodium chloride and glucose.
Article
Chemistry, Physical
Fengqi Qin, Huan Zhang, Taixing Tan, Jie Wang, Huiling Liu, Cheng Wang
Summary: In this study, a seed-mediated synthesis method for mass production of ultrathin silver nanowires (AgNWs) was reported. The synthesized AgNWs had an average diameter of 17 nm and an aspect ratio of 1000. The method utilized pentatwinned gold dodecahedrons as primitive seeds and Ag nanorods (AgNRs) as secondary seeds. The process eliminated the need for purification and resulted in high purity AgNWs through a simple precipitation process.
CHEMISTRY OF MATERIALS
(2022)
Article
Chemistry, Analytical
Qian Guo, Lu Ding, Yu Li, Sicheng Xiong, Hao Fang, Xiangmin Li, Lijuan Nie, Yonghua Xiong, Xiaolin Huang
Summary: A novel dynamic light scattering (DLS) immunosensing strategy based on COF@AuNP was reported for highly sensitive protein marker detection. The COF@AuNP was designed as a signal amplifier to boost the release of AuNPs, which were then enlarged by gold growth to amplify the DLS signal transduction and improve the sensitivity. The immunosensor exhibited high selectivity, accuracy, reproducibility, and reliability in spiked and actual whole blood samples.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Chemistry, Analytical
Galina V. V. Presnova, Gleb A. A. Zhdanov, Luibov Yu. Filatova, Mariya M. M. Ulyashova, Denis E. E. Presnov, Maya Yu. Rubtsova
Summary: Gold nanoparticles (AuNPs) are used to enhance color intensity for DNA membrane microarrays through seed-mediated growth. The method involves hybridization of biotin-labeled DNA with capture oligonucleotide probes, followed by detection of AuNPs through a streptavidin-AuNP conjugate. The optimized seed-mediated enlargement of AuNPs resulted in larger particles and improved signal/background ratio.
Article
Chemistry, Multidisciplinary
Emma E. Coughlin, Jingtian Hu, Andrew Lee, Teri W. Odom
Summary: This paper demonstrates the light-directed functionalization of anisotropic gold nanoparticles with different thiolated-DNA oligomer sequences, enabling the creation of nanoparticle superstructures with precise control over oligo presentation at the single-particle level.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Review
Chemistry, Multidisciplinary
Meng-Qi He, Yongjian Ai, Wanting Hu, Liandi Guan, Mingyu Ding, Qionglin Liang
Summary: The unprecedented advances in metal nanoparticle synthesis have opened up new possibilities for their broad applications. The precise control of metal nanoparticle morphology relies on seed-mediated growth methods, which are sensitive to various influencing factors. The understanding of how each factor precisely regulates the morphology of metal nanoparticles is important for further developments and applications.
ADVANCED MATERIALS
(2023)
Article
Chemistry, Analytical
Sheida Khajir, Zahra Karimzadeh, Maryam Khoubnasabjafari, Vahid Jouyban-Gharamaleki, Elaheh Rahimpour, Abolghasem Jouyban
Summary: In this study, a RLS technique based on beta-cyclodextrin modified gold nanoparticles was used to determine phenytoin concentration in exhaled breath condensate. The method relies on the formation of a complex between beta-cyclodextrins and phenytoin, resulting in an aggregation-induced Rayleigh light scattering intensity enhancement that is proportional to the phenytoin concentration. The method has a linear relationship with phenytoin concentration in the range of 0.005-0.6 μg/mL and a limit of detection of 0.003 μg/mL.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2023)
Article
Materials Science, Biomaterials
Dong Zhao, Pengli Xiao, Xiushan Dong, Yang Ge, Xing Guo, Jianlong Ji, Yongqiang Cheng, Shengbo Sang
Summary: Recently, a mechanical biosensor based on membrane-mediated magneto-stress-electric coupled sensitization (MSEC-MMB) was developed to improve the sensitivity and practicality of single molecule detection in clinical applications. The MSEC-MMB showed enhanced sensitivity by introducing Fe3O4 nanoparticles and a magnetic field to the traditional stress-electric biosensors, resulting in a LOD of 24 pg mL-1 for HSA. The MSEC-MMB also demonstrated high specificity, selectivity, and stability, making it a promising platform for early nephropathy diagnosis.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Article
Multidisciplinary Sciences
Yan Ye, David Y. H. Pui
Summary: Intentionally intensifying the light scattering of medium molecules allows the detection of suspended nanoparticles under conditions not suitable for conventional optical microscopies or laser particle counters. This method can distinguish between nanoparticles and microparticles, and directly detect suspended nanoparticles much smaller than visible light wavelengths.
SCIENTIFIC REPORTS
(2021)
Article
Engineering, Environmental
Yiseul Yu, Shreyanka Shankar Naik, Yewon Oh, Jayaraman Theerthagiri, Seung Jun Lee, Myong Yong Choi
Summary: A versatile green synthesis technique utilizing pulsed laser irradiation and the sonochemical process was used to produce functionalized gold nanoparticles in the presence of lignin matrixes. The resulting lignin functionalized Au NPs were characterized and showed a selective colorimetric sensing tendency toward Pb2+ ions, indicating their potential as effective sensors for rapid and selective detection of Pb2+ ions in real environmental samples.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Article
Optics
Yu Xu, Huiqing Zhong, Meng Shi, Zhidong Zheng, Shaojing Liu, Qian Shou, Heng Li, Guanjie Yang, Zongbao Li, Xiaobo Xing
Summary: The rapid photothermal self-assembly of Au nanoparticles in water provides a highly sensitive SERS substrate for detecting chemical pollutants. The smart reversible assembly allows for tuning SERS activity, showing promising applications in SERS-based sensors and environmental pollutant detection.
Article
Agriculture, Dairy & Animal Science
Shi Wenying, Lu Chunlian, Li Shang, Song Jiachun, Cao Hongzhan
Summary: This study evaluated the effects of different levels of citric acid on the growth performance, nutrient digestibility, and gastrointestinal pH of weaned piglets. The results showed that adding 1% citric acid improved feed intake and daily gain, as well as the utilization rates of protein, calcium, and phosphorus. Additionally, citric acid effectively reduced the pH of the stomach, duodenum, jejunum, and ileum contents.
INDIAN JOURNAL OF ANIMAL RESEARCH
(2023)
Article
Nanoscience & Nanotechnology
Alexandra Chrysanthou, Hassan Kanso, Wencheng Zhong, Li Shang, Julien E. Gautrot
Summary: Cell culture at liquid-liquid interfaces using supercharged albumins and a co-surfactant is shown to form strong elastic protein nanosheets, which can mediate extracellular matrix protein adsorption and cell adhesion. The mechanical properties of these nanosheets are characterized and compared to other albumins. The impact of the co-surfactant on the assembly is investigated. The potential of supercharged proteins for engineering biointerfaces for stem cell manufacturing is demonstrated.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Multidisciplinary
Ziqi Xu, Tianyi Wang, Yixiao Li, Mengyao Wen, Kangqiang Liang, Chenlong Ruan, Lianbing Zhang, Yumeng Xue, Li Shang
Summary: In this study, supercharged gold nanoclusters were used as a novel interface modulator for infected wound treatment. The researchers found that the supercharged gold nanoclusters can immobilize on bioactive glass nanoparticles and provide excellent antibacterial activity and positive effect on cell proliferation. Moreover, the photoluminescent property of the gold nanoclusters can be used for bioimaging-guided therapy.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Rongbing Li, Xiaoxuan Sun, Yujia Jiang, Ling Liu, Yunhui Li, Dengbin Yu, Jianwei Zhu, Shaojun Dong
Summary: In this study, a colorimetric biosensor based on the rapid color change of E. coli and BQ was introduced for water toxicity evaluation. The biosensor showed a dose-dependent response, with IC20 values for Cu2+ and Hg2+ obtained based on RGB values. It has the potential to quickly detect the toxicity of Cu2+ and Hg2+ in water.
BIOELECTROCHEMISTRY
(2023)
Article
Engineering, Environmental
Wenxing Gao, Qiang Li, Qi- Long Yan, Wencheng Zhong, Xiaomeng Zhou, Li Shang
Summary: The development of reliable sensors for explosive detection is crucial for reducing safety risks and environmental concerns. However, achieving on-site detection of multiple analytes in a simple and efficient way remains highly challenging.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Xiaomeng Zhou, Xinjie Wang, Li Shang
Summary: A novel dual-emissive fluorescence nanoplatform was designed for ATP sensing based on red emissive europium metal-organic framework (Eu-MOF) and blue emissive gold nanoclusters (AuNCs). The presence of ATP caused the decomposition of Eu-MOF, resulting in a decrease in red emission while the blue emission of AuNCs remained unchanged. This emission intensity change enabled the establishment of a ratiometric fluorescent and visual sensor of ATP. A fluorescent paper-based sensor was also fabricated for easy-to-use and visual detection of ATP in serum samples using a smartphone.
CHINESE CHEMICAL LETTERS
(2023)
Article
Chemistry, Physical
Jianguo Zhao, He Zhang, Xiaoxuan Sun, Shuai Hao, Panpan Zhao, Xinyang Zhu, Shaojun Dong
Summary: This paper reports an integrated bio-photoelectrochemical system based on photo-enzyme coupled catalysis for glucose oxidation and hydrogen peroxide production. The proposed system shows excellent performance in terms of maximum power output and efficient H2O2 accumulation, expanding the functional versatility of green energy devices.
JOURNAL OF MATERIALS CHEMISTRY A
(2023)
Article
Chemistry, Physical
Wenfeng Guo, Wenxing Gao, Qiang Li, Shaohua Qu, Lianbing Zhang, Li-Li Tan, Li Shang
Summary: A novel type of MOF nanocomposite with gold nanorods (AuNRs) and gold nanoclusters (AuNCs) was designed to achieve remarkable visible light photocatalytic antibacterial activity. The introduction of AuNRs improved the visible light absorption of ZIF-8, enhancing the production of reactive oxygen species (ROS). Additionally, AuNCs were integrated into the composites to further generate ROS under visible light irradiation. The obtained nanocomposites exhibited strong photo-bactericidal activity against Escherichia coli and Staphylococcus aureus, and could be easily deposited on mask fibers for excellent antibacterial properties compared to commercial masks. This study provides a new plasmon-enhanced approach for enhanced photo-bactericidal activity of MOFs in environmental and biomedical fields.
JOURNAL OF MATERIALS CHEMISTRY A
(2023)
Article
Chemistry, Analytical
Zhixuan Yu, Jiaxin Zhang, Jinxing Chen, Liyi Zhao, Dengbin Yu, Ling Liu, Shaojun Dong
Summary: fi-D-Glucuronidase (GUS) plays a crucial role in clinical treatment assessment and environmental monitoring. However, current GUS detection tools have limitations in terms of pH continuity and diffusion. In this study, a novel GUS recognition tool called ERNathG was developed, which addressed these issues by utilizing pH-matching and endoplasmic reticulum-anchoring strategies. ERNathG enabled continuous and anchored GUS detection without pH adjustment, demonstrating superior properties compared to commonly used commercial molecules.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Physical
Long Pang, Zhiwei Zhao, Xian-Yin Ma, Wen-Bin Cai, Limin Guo, Shaojun Dong, Chuntai Liu, Zhangquan Peng
Summary: Researchers have developed a novel analytical method that combines differential electrochemical mass spectrometry and attenuated total reflection surface enhanced infrared absorption spectroscopy to simultaneously detect deposited and volatile interface species. This technique is particularly suitable for non-aqueous, electrolyte-based energy devices. By applying this method in lithium-ion and lithium-oxygen batteries, they obtained valuable reaction mechanisms. Overall, this coupled and complementary technique provides important insights into the interfacial electrochemistry of energy storage materials and is expected to generate significant interest in the electrochemistry community and beyond.
JOURNAL OF CHEMICAL PHYSICS
(2023)
Article
Chemistry, Analytical
Qiang Li, Xiaomeng Zhou, Li-Li Tan, Li Shang
Summary: Ultrasmall gold nanoclusters (AuNCs) with distinct photoluminescence properties were effectively modulated by encapsulating them into zeolite imidazolate frameworks-8 (ZIF-8), resulting in enhanced near-infrared (NIR) fluorescence intensity. The AuNCs@ZIF-8 composites exhibited an emission maximum at 830 nm, longer than AuNCs without ZIF-8 encapsulation. This strategy was utilized for the detection of acetylcholinesterase (AChE) using a ratiometric fluorescent sensing platform, showing high sensitivity and good specificity in biological samples.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Chemistry, Physical
Panpan Zhao, Xiaoxuan Sun, Shuai Hao, Yuehan Zhang, Jinxing Chen, He Zhang, Shaojun Dong
Summary: In this work, rhodium single-atom nanozymes (Rh SANs) were designed to mimic the function of natural glucose oxidase (GOD) for glucose oxidation. The Rh SANs demonstrated the same biocatalytic mechanism and electrocatalytic path as natural GOD. By coupling a bilirubin oxidase biocathode, a Rh SANs-based glucose/O2 enzymatic biofuel cell (EBFC) was developed with a significantly enhanced power density compared to a natural GOD-based EBFC. This device not only accelerates the development of nanozymes but also paves avenues for powering portable and wearable devices.
ACS ENERGY LETTERS
(2023)
Article
Chemistry, Multidisciplinary
Kangqiang Liang, Yumeng Xue, Bin Zhao, Mengyao Wen, Ziqi Xu, Gleb Sukhorukov, Lianbing Zhang, Li Shang
Summary: By functionalizing MoS2 quantum dots (QDs) with l-/d-penicillamine, we found that d-MoS2 QDs exhibited a positive effect in promoting the growth, proliferation, and migration of human umbilical vein endothelial cells. This distinct phenomenon was largely attributed to the higher internalization efficiency of d-MoS2 QDs than l-MoS2 QDs and chirality-dependent nano-bio interactions. In vivo angiogenic assay demonstrated that the expression level of angiogenic markers in newly-formed skin tissues of the d-MoS2 QDs group was higher than that in the l-MoS2 QDs group, leading to accelerated re-epithelialization and improved skin regeneration.
Article
Chemistry, Multidisciplinary
Wencheng Zhong, Kangqiang Liang, Wenfeng Liu, Li Shang
Summary: In this study, a new design of Forster resonance energy transfer-based dual-color photoswitchable fluorescent nanoparticles (DPF NPs) was reported by using ligand-protected gold nanoclusters (AuNCs). The ultrasmall-sized AuNCs act as the FRET donors and also regulate the properties of spiropyran through ligand-spiropyran interactions. These DPF NPs exhibit high fluorescence on/off ratios for both green and red fluorescence emission, and show good reversibility during cycled photo-stimulation. Cell imaging experiments demonstrated that DPF NPs can specifically accumulate in lipid droplets and enable photoswitchable dual-color imaging in living cells.
Article
Chemistry, Multidisciplinary
Wencheng Zhong, Xiaojian Yan, Shaohua Qu, Li Shang
Summary: A fluorescence photoswitch was successfully fabricated by incorporating a photochromic dye and fluorescent nanoclusters into albumin proteins, demonstrating high switching efficiency, reversible fluorescence response, and good antifatigue performance.
