Article
Materials Science, Biomaterials
Youwei Zhang, Qing Pei, Ying Yue, Zhigang Xie
Summary: In this study, carrier-free self-activated prodrug nanoparticles combining chemotherapy and photodynamic therapy were developed to enhance antitumor efficiency. These nanoparticles can generate reactive oxygen species for photodynamic therapy and trigger on-demand drug release for chemotherapy, showing great potential in advancing cancer treatment.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
Article
Nanoscience & Nanotechnology
Jiaojiao Chen, Yarong Song, Wenqian Yang, Jianhui Guo, Saihui Zhang, Dong Wan, Yonghui Liu, Jie Pan
Summary: In this study, tumor-targeted polymeric micelles were synthesized, and drug release was achieved through extracellular enzyme response and intracellular reduction response, thereby improving the disadvantages of chemotherapy drugs. The experiments demonstrated that this method had good anti-tumor activity in vivo and reduced toxic side effects on normal tissues.
ACS APPLIED NANO MATERIALS
(2023)
Article
Pharmacology & Pharmacy
Amal A. Sultan, Ghada A. Saad, Gamal M. El Maghraby
Summary: This study investigated the use of bilosomes encapsulating absorption enhancers as carriers for enhancing the oral absorption and cytotoxicity of doxorubicin. The bilosomes were found to significantly improve the intestinal absorption and cytotoxicity of doxorubicin against breast cancer cells.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Materials Science, Biomaterials
Chenxian Zhu, Zhongxing Zhang, Yuting Wen, Xia Song, Jingling Zhu, Yifei Yao, Jun Li
Summary: There is a significant global need for effective osteoarthritis (OA) treatment due to limited efficacy of current options. Insufficient drug delivery to the cartilage is a major obstacle. This study demonstrates that positively charged micelles can enhance intra-cartilage drug delivery and retention, making them promising carriers for OA treatment.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Article
Chemistry, Medicinal
Quanling Guo, Lu Zhang, Mengmeng He, Xiaohua Jiang, Jingrui Tian, Qiurong Li, Zhiwei Liu, Longgang Wang, Haotian Sun
Summary: A method utilizing amphipathic and natural antibacterial peptide daptomycin to stabilize doxorubicin and form zwitterionic nanodrug showed promising targeting and anti-tumor effects in experiments, with higher cytotoxicity and tumor inhibition rate than free doxorubicin. The biocompatible daptomycin-based drug delivery system selectively accumulated at tumor sites in vivo through EPR effect, reducing toxicity and achieving excellent tumor inhibition.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Medicine, Research & Experimental
Carolina Henriques Cavalcante, Renata Salgado Fernandes, Juliana de Oliveira Silva, Caroline Mari Ramos Oda, Elaine Amaral Leite, Geovanni Dantas Cassali, Ives Charlie-Silva, Bianca Helena Ventura Fernandes, Lucas Antonio Miranda Ferreira, Andre Luis Branco de Barros
Summary: The developed pH-sensitive micelles encapsulating DOX showed promising results with small diameter, high stability, low toxicity, and significantly better inhibition of tumor growth compared to other forms of DOX.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Pharmacology & Pharmacy
Svetlana V. Kurmaz, Vladislav M. Ignatiev, Nina S. Emel'yanova, Dmitry A. Konev, Vladimir V. Kurmaz, Anastasiya A. Balakina, Alexey A. Terentyev
Summary: In this study, nanosized systems of DOX based on micelle-like particles of amphiphilic thermosensitive copolymers were investigated. The formation of hydrogen bonds between the copolymer units and DOX was confirmed through experimental data and quantum-chemical modeling. The encapsulated DOX showed easier oxidation and somewhat more difficult reduction compared to free DOX in electrochemical studies. The copolymer compositions containing 5 and 15 wt% DOX exhibited active accumulation in cell nuclei without causing visual changes in cell morphology.
Article
Pharmacology & Pharmacy
Su Jeong Song, Joon Sig Choi
Summary: Self-assembled peptide nanostructures are gaining attention as drug delivery systems due to their enhanced biocompatibility and biodegradability compared to polymer-based carriers. In this study, an enzyme-responsive peptide nanoparticle system was introduced, which showed effective controlled release of cargo molecules. The system exhibited good cellular uptake and biocompatibility, and demonstrated superior anticancer effects compared to the control groups.
Review
Pharmacology & Pharmacy
Masomeh Maleki, Asal Golchin, Forough Alemi, Simin Younesi, Zatollah Asemi, Samira Javadi, Payam Ali Khiavi, Jafar Soleinmapour, Bahman Yousefi
Summary: This study systematically reviewed the cytotoxic effects and apoptosis of nanoparticles (NPs) on cellular viability in vitro. It found that 43.47% of synthesized NPs showed no toxicity to osteosarcoma cells, while 39.13% showed time and/or concentration-related cytotoxicity. There was a significant difference in the half-maximal inhibitory concentration (IC50) between drug and drug/NP in all studies, indicating the potential for using NPs as drug delivery systems.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Riham O. Bakr, Ahmed Tawfike, Heba A. El-Gizawy, Nashwa Tawfik, Usama Ramadan Abdelmohsen, Miada F. Abdelwahab, Walaa A. Alshareef, Sahar M. Fayez, Shereen M. S. El-Mancy, Ahlam M. El-Fishawy, Mostafa A. Abdelkawy, Marwa A. A. Fayed
Summary: This study used metabolomics examination and chemical analysis to validate the medicinal activity and anti-Helicobacter effect of different Mentha species, with tentative identification of the active constituents.
Article
Chemistry, Physical
Mehrdad Aghaei, Vahid Erfani-Moghadam, Leila Daneshmandi, Alireza Soltani, Nafiseh Abdolahi, Marco Cordani, Asieh Yahyazadeh, Sahar Moazen Rad, Samaneh Tavassoli, Hanzaleh Balakheyli
Summary: Encapsulating sulfasalazine (SSZ) within a micellar/niosomal formulation enhances its anticancer efficacy by promoting apoptosis in cancer cell lines and improving its bioavailability.
JOURNAL OF MOLECULAR STRUCTURE
(2021)
Article
Chemistry, Multidisciplinary
Wenzhao Han, Fanwei Meng, Hao Gan, Feng Guo, Junfeng Ke, Liping Wang
Summary: ATN-FFPFF-ATN, a new targeted antitumor drug carrier designed in this study, polymerized from phenylalanine dipeptide (FF), ATN-161 peptide, and Pluronic (R) F-127, can smartly unravel in acidic environment to achieve specific drug accumulation, effectively inhibiting cell proliferation.
Article
Chemistry, Multidisciplinary
Won Jung Kim, Eu Hyun Lee, Yong-Jin Kwon, Sang-Kyu Ye, Kyu Oh Kim
Summary: An amphipathic PAA-POSS@DOX drug delivery system that is sensitive to pH changes in the cancer microenvironment has been developed using a nanoparticle based on inorganic polyhedral oligomeric silsesquioxane (POSS). This system has high loading efficiency and can quickly release the drug to the target area, as confirmed by cell death in the MDA-MB-231 breast cancer line.
Article
Biotechnology & Applied Microbiology
Qu Chen, Wenjing Deng, Jingjin He, Li Cheng, Pei-Gen Ren, Yang Xu
Summary: In this study, a self-powered drug delivery system was designed using a friction engine as a current source to stimulate cells to uptake chemotherapy drugs, providing a new opportunity for disease treatment.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jiawen Zhang, Shuo Wang, Honghui Huang, Hongqian Chen, Jinghua Chen, Huijie Zhang
Summary: CpG ODNs have significant promise for immunotherapy, but are limited by quick digestion and low cellular internalization. This study developed a novel vector, NH2-St, using starch as a delivery system for CpG ODNs. NH2-St effectively encapsulated CpG ODNs, protected them from digestion, and enhanced cellular uptake. NH2-St/CpG induced secretion of antitumor cytokines and suppressed tumor cell growth.