Article
Nanoscience & Nanotechnology
Ningqin Lin, Liang Wu, Xing Xu, Qiaoyi Wu, Yuzhe Wang, Haicong Shen, Yanling Song, Hongyao Wang, Zhi Zhu, Dezhi Kang, Chaoyong Yang
Summary: Gliomas, the most common primary brain tumors, have poor prognosis and survival rates despite advancements in surgical and radio-chemotherapy technologies. The cell-SELEX technology has been used to develop the S6-1b aptamer, which can distinguish molecular differences between glioma cells and human astrocytes, showing potential for diagnostic and therapeutic applications in malignant gliomas.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Biophysics
Min Wu, Zhuokun Chen, Qihui Xie, Bolin Xiao, Gang Zhou, Gang Chen, Zhuan Bian
Summary: This study introduces a novel fluorescent biosensor for one-step sensitive quantification of salivary exosomes, offering high sensitivity and a low limit of detection.
BIOSENSORS & BIOELECTRONICS
(2021)
Article
Engineering, Biomedical
Bin Wu, Kun Li, Feiyue Sun, Jintong Niu, Rongrong Zhu, Yechang Qian, Shilong Wang
Summary: Visualization technology has become a trend in tumor therapy, with graphene quantum dots showing promise for tumor diagnosis. The combination of sulfur-doped graphene quantum dots with etoposide in layered double hydroxides offers a reliable strategy for precise visualization therapy. The trifunctional LDH@SGQD-VP16 integrated nanoprobes can achieve targeted aggregation, fluorescence visualization, and chemotherapy simultaneously, demonstrating enhanced therapeutic effects in gastric cancer.
ADVANCED HEALTHCARE MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Ju Lu, Shenfei Zong, Zhuyuan Wang, Chen Chen, Yizhi Zhang, Hong Wang, Yiping Cui
Summary: This article introduces a dual-labeled graphene quantum dot-based Forster resonance energy transfer nanoprobe suitable for single-molecule localization microscopy imaging, demonstrating fluorescence intensity fluctuations and excellent blinking behavior under specific excitation conditions, with great potential for super-resolution imaging in cells.
Article
Spectroscopy
Adity Chopra, Anuradha Swami, Rohit Sharma, Neha Devi, Sherry Mittal, Rohit K. Sharma, Nishima Wangoo
Summary: This study presents a fluorescence resonance energy transfer-based assay for the detection of Staphylococcal enterotoxin. The developed method showed high sensitivity and specificity, and was successfully applied for quantification in apple juice.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2023)
Review
Chemistry, Analytical
Dongmin Kim, Seungmin Yoo
Summary: Quantum dots (QDs) are a promising new generation of luminophores with tunable photoluminescence and photochemical stability. The development of aptamer-functionalized QD biosensors has enabled highly sensitive detection of molecules in clinical and environmental settings, with recent advances focusing on optical signal enhancement and quenching strategies. Potential strategies for further expanding the practical applications of biosensors across various scientific and technological fields are also discussed.
Article
Chemistry, Analytical
Tracy Ann Bruce-Tagoe, Michael K. Danquah
Summary: Bioaffinity nanoprobes are biosensors that utilize the specific binding properties of biological molecules for the detection of foodborne pathogens. They provide highly specific and sensitive detection, making them attractive for food safety testing. Their advantages include detecting low levels of pathogens, rapid analysis time, and cost-effectiveness, but limitations include specialized equipment and potential cross-reactivity. Research focuses on optimizing performance and expanding application in the food industry.
Article
Chemistry, Physical
Myeong Geun Cha, Won Ki Son, Yun-Sik Choi, Hyung-Mo Kim, Eunil Hahm, Bong-Hyun Jun, Dae Hong Jeong
Summary: A dual-modal fluorescence-SERS quantum dot embedded silver bumpy nanoparticles were developed for high-throughput multiplex analysis in biological encoding and biomarker imaging. This nanoprobe produced strong SERS and fluorescence signals, and a barcode-based machine learning algorithm was created to identify chemical information. The multiplex detection platform will be extremely useful for analyzing and encoding biological targets.
APPLIED SURFACE SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Kyeong-Min Ham, Minhee Kim, Sungje Bock, Jaehi Kim, Wooyeon Kim, Heung Su Jung, Jaehyun An, Hobeom Song, Jung-Won Kim, Hyung-Mo Kim, Won-Yeop Rho, Sang Hun Lee, Seung-Min Park, Dong-Eun Kim, Bong-Hyun Jun
Summary: A Cd-free quantum dot nanoprobe for bioimaging was fabricated by embedding multiple indium phosphide/zinc sulfide quantum dots onto silica templates and coating them with a silica shell. The resulting nanoparticles exhibited excellent optical properties and hydrophilicity, and showed prominent fluorescence signals in tumors, demonstrating their potential for bioimaging applications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Engineering, Biomedical
Xiao-He Ren, Di Han, Xiao-Yan He, Tao Guo, Xue-Si Chen, Xuan Pang, Si-Xue Cheng
Summary: A multiple targeting delivery vector has been developed to exert therapeutic actions in heterogeneous cancer cells and assess the therapeutic efficacy by detection of cancer biomarkers via liquid biopsy.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Shutian Lu, Catherine R. R. Fowler, Brian Ream, Sheela M. M. Waugh, Theresa M. M. Russell, John C. C. Rohloff, Larry Gold, Jason P. P. Cleveland, Stefan Stoll
Summary: Recent developments in aptamer chemistry have provided new opportunities for protein biosensing tools. This study presents a method that uses immobilized slow off-rate modified aptamers (SOMAmers) labeled with a nitroxide radical to detect protein binding. The rotational mobility of the spin label is changed by protein binding, which is detected using solution-state electron paramagnetic resonance (EPR) spectroscopy.
Review
Nanoscience & Nanotechnology
Arjun Sabu, Te- Liu, Siew Suan Ng, Ruey-An Doong, Yu-Fen Huang, Hsin-Cheng Chiu
Summary: This review discusses the therapeutic strategies and underlying mechanisms of glioma stem cells (GSCs) in the treatment of glioblastoma (GBM). GSCs play a crucial role in tumor propagation, treatment resistance, and tumor recurrence. The review highlights the methods of targeting GSC surface markers, blocking essential signaling pathways of GSCs, and manipulating the tumor microenvironment for GBM treatment. In addition, the application of nanotechnology in GSC-targeted therapy is also discussed.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Engineering, Biomedical
Yinzhou Ma, Shangwen He, Jianyong Huang
Summary: This study describes a new type of hydrogel composed of long single-stranded DNA, which can selectively capture and separate DNA, proteins, and bacteria from solution. This DNA hydrogel has larger distances between crosslinks and a larger specific surface area, allowing for easy diffusion of biomacromolecules. The study expands the application of DNA hydrogels and paves the way for developing novel selective biomaterials.
ACTA BIOMATERIALIA
(2022)
Article
Nanoscience & Nanotechnology
Xuan Zhang, Xing Wei, Xue Men, Cheng-Xin Wu, Jun-Jie Bai, Wei-Tao Li, Ting Yang, Ming-Li Chen, Jian-Hua Wang
Summary: The efficient recognition of circulating tumor cells using a biomimetic sea urchin-like nanoprobe resulted in 100% capture of CTCs and a sorting separation rate of 93.6% at a flow rate of 60 muL min(-1). The dual-aptamer nanoprobe showed improved binding efficiency by more than 200% and 73.8 +/- 5.0% measurement efficiency for single CTCs.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Review
Chemistry, Physical
Akash S. Rasal, Sudesh Yadav, Anil A. Kashale, Ali Altaee, Jia-Yaw Chang
Summary: This review discusses the factors influencing the performance stability of QDSSCs and provides insights into the mechanisms causing degraded performances. It also presents cutting-edge strategies for improving the overall performance stability of QDSSCs.