期刊
NANOSCALE
卷 10, 期 34, 页码 16284-16292出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8nr02462f
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资金
- Deutsche Forschungsgemeinschaft (DFG) [SFB 749, SFB 1032]
- Excellence Clusters Nanosystems Initiative Munich (NIM)
- Center for Integrated Protein Science Munich (CIPSM)
- Center for Nano Science (CeNS)
Nanoparticle-based biomedicine has received enormous attention for theranostic applications, as these systems are expected to overcome several drawbacks of conventional therapy. Herein, effective and controlled drug delivery systems with on-demand release abilities and biocompatible properties are used as a versatile and powerful class of nanocarriers. We report the synthesis of a novel biocompatible and multifunctional material, entirely consisting of covalently crosslinked organic molecules. Specifically, -cyclodextrin (CD) precursors were crosslinked with rigid organic linker molecules to obtain small (approximate to 150 nm), thermally stable and highly water-dispersible nanoparticles with an accessible pore system containing -CD rings. The nanoparticles can be covalently labeled with dye molecules to allow effective tracking in in vitro cell experiments. Rapid sugar-mediated cell-uptake kinetics were observed with HeLa cells, revealing exceptional particle uptake within only 30 minutes. Additionally, the particles could be loaded with different cargo molecules showing pH-responsive release behavior. Successful nuclei staining with Hoechst 33342 dye and effective cell killing with doxorubicin cargo molecules were demonstrated in live-cell experiments, respectively. This novel nanocarrier concept provides a promising platform for the development of controllable and highly biocompatible theranostic systems.
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