期刊
NANOSCALE
卷 6, 期 24, 页码 14686-14690出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4nr03604b
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资金
- Swedish Research Council for Environment, Agricultural Sciences and Spatial Planning (FORMAS)
- European Commission [310584]
- NIEHS [RO1ES019304]
- Juvenile Diabetes Research Foundation
- Arthritis National Research Foundation
- US Environmental Protection Agency STAR Graduate Fellowship program [FP-91713801]
Single-walled carbon nanotubes (SWCNTs) coated or functionalized with PEG chains of different molecular weight were assessed for their propensity to undergo biodegradation under in vitro conditions using recombinant myeloperoxidase (MPO) or ex vivo using freshly isolated primary human neutrophils. Our findings suggest that under natural conditions, a combined process of 'stripping' (i.e., defunctionalization) and biodegradation of PEG-SWCNTs might occur and that PEG-SWCNTs are a promising - and degradable - nanomedicine vector.
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