Article
Chemistry, Multidisciplinary
Abolghasem Abbasi Kajani, Laleh Rafiee, Shaghayegh Haghjooy Javanmard, Nasim Dana, Setareh Jandaghian
Summary: In this study, a new and efficient theranostic nanoplatform was developed for targeted cancer therapy and fluorescence imaging using a green approach, without the use of any anticancer chemotherapeutic drugs.
Article
Nanoscience & Nanotechnology
Xiaojuan Zhang, Pengfei Wei, Zhao Wang, Yuan Zhao, Wenke Xiao, Yong Bian, Dong Liang, Qing Lin, Wenli Song, Wei Jiang, Huan Wang
Summary: This study presents a synthesis of a diagnosis and therapy integration nanocarrier for magnetic resonance imaging-guided breast cancer-targeted chemotherapy. The nanocarrier, Fe3O4/P(NIPAM-AA-MAPEG) nanogels (MNLs), was prepared using in situ loading of doxorubicin (DOX) by miniemulsion polymerization. The MNLs showed excellent stability in a physiological environment and could be disrupted in an acidic environment to release the loaded drug. The dual-targeted pH-responsive nanogels demonstrated enhanced therapeutic effects and potential advantages in magnetic resonance imaging (MRI) for breast cancer diagnosis.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Biotechnology & Applied Microbiology
Lingdan Kong, Jingyi Zhu, Hongxing Su, Lingzhou Zhao, Yi Lu, Meilin Zhu, Wenjie Sun
Summary: In this study, we report a new I-131-labeling functional platform for targeted SPECT imaging and radiotherapy of breast adenocarcinoma. The platform consists of PEI-based nanogels modified with targeted agent PBA and labeled with radionuclide I-131. The results show that the labeled nanogels can specifically target breast cancer cells for tumor imaging and radiotherapy.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Shuyao Liu, Zhuoling Zhong, Chuanwei Zhang, Yanqu Zhou, Chunmei Fu, Xiaoping Xu
Summary: Iron-doped orange emissive carbon dots (ICDs) were synthesized using the hydrothermal method and coupled with Trf and glucose oxidase (GOD) to achieve multifunctional enzymolysis of glucose, decomposition of H2O2, and release of ROS in gliomas for efficient targeted killing effect.
NANOSCALE ADVANCES
(2022)
Article
Nanoscience & Nanotechnology
Yu Dang, Ning Gao, Hong Niu, Ya Guan, Zhaobo Fan, Jianjun Guan
Summary: The development of ischemia-targeting poly(N-isopropylacrylamide)-based nanogels specifically delivers an MMP-2 inhibitor CTTHWGFTLC (CTT) into ischemic limbs to regulate MMP-2 bioactivity. These nanogels are sensitive to the pH of ischemic tissues, enabling them to aggregate in the injured area. The released CTT from the nanogels preserves collagen in the muscle, promotes its regeneration, and stimulates angiogenesis, ultimately leading to increased blood flow and vessel density in the ischemic limbs treated with the nanogels.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Biophysics
Wenxian Zhang, Guangyao Dang, Jian Dong, Yanyan Li, Peng Jiao, Mingfeng Yang, Xianwen Zou, Yutao Cao, Haiwei Ji, Lifeng Dong
Summary: The development of a nanoplatform based on graphitic carbon nitride quantum dots allows for simultaneous imaging and chemo-photodynamic combination therapy, demonstrating good physiological stability and anti-tumor efficiency.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Review
Pharmacology & Pharmacy
Abiodun Ayo, Pirjo Laakkonen
Summary: The article discusses a new treatment strategy utilizing tumor-targeting peptides to deliver drugs, as well as the structure-function relationship data of different tumor-targeting peptides. The importance of improving peptide activity and conjugation strategies is also highlighted.
Article
Biochemistry & Molecular Biology
Ankur Sood, Varun Arora, Sadhana Kumari, Ankita Sarkar, S. Senthil Kumaran, Shubhra Chaturvedi, Tapan K. Jain, Garima Agrawal
Summary: This study reports the fabrication of multifunctional nanoparticles with a gold shell over an iron oxide core, combining magnetic properties and surface plasmon resonance. The nanoparticles, coated with thiolated pectin, show potential for drug delivery and MR imaging applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Pharmacology & Pharmacy
Wioletta Liwinska, Ewelina Waleka-Bagiel, Zbigniew Stojek, Marcin Karbarz, Ewelina Zabost
Summary: Enzyme-responsive polymeric-based nanostructures show potential as targeted drug delivery carriers, but their major risks are the fast disassembling of short-lived structures and limited accessibility of the enzyme to internal moieties. A modified environmentally responsive and enzymatically cleavable nanogel carrier was developed, which allowed independent shrinking of different parts of the network and targeted interaction with cellular receptors. Tunable nanogels efficiently stored and triggered the release of doxorubicin and mitoxantrone, with enhanced enzymatic degradation by introducing more hyaluronidase enzyme.
Article
Chemistry, Multidisciplinary
Xiangru Feng, Weiguo Xu, Xiaoru Xu, Gao Li, Jianxun Ding, Xuesi Chen
Summary: The physicochemical characteristics of nanoparticles play a crucial role in determining their drug delivery performance, and altering the amino acid composition can adjust the drug release profile and antitumor efficacy of nanogels.
SCIENCE CHINA-CHEMISTRY
(2021)
Article
Oncology
Ganji Seeta Rama Raju, Begum Dariya, Sathish Kumar Mungamuri, Gayathri Chalikonda, Sung-Min Kang, Ishaq N. Khan, Pinninti Santosh Sushma, Ganji Purnachandra Nagaraju, Eluri Pavitra, Young-Kyu Han
Summary: Cancer is a deadly disease with limitations in traditional therapies. Nanotechnology, as an emerging science, provides more effective cancer treatments by overcoming biomedical and biophysical barriers.
SEMINARS IN CANCER BIOLOGY
(2021)
Review
Polymer Science
Brielle Stawicki, Tyler Schacher, Hyunah Cho
Summary: Chemotherapy and radiation are mainstays in cancer treatment globally, but some therapies have limited specificity and cause harsh side effects in patients. Nanogels, as a unique drug delivery system, show promise in the treatment of brain cancer, despite complications such as handling and chemical stability. Ongoing development of nanogels offers a patient-centered approach for managing brain cancer.
Article
Chemistry, Multidisciplinary
Tianbao Chen, Jie Xu, Lijuan Zhu, Deyue Yan
Summary: Researchers developed a targeted nanodrug delivery system using the cationic amphiphilic chemodrug mitoxantrone (Mito), which interacts with Bcl-2 ASO through electrostatic interaction and self-assembles into nanoparticles (NP[Bcl-2/Mito]). NP[Bcl-2/Mito] protects the ASO from degradation during delivery and combines gene- and chemotherapies to improve the anticancer effect. Cancer cell membranes (CCMs) derived from homologous tumors were used to camouflage NP[Bcl-2/Mito] (NP[Bcl-2/Mito]@CCM) for immune escape and tumor targeting. Both in vitro and in vivo assessments demonstrate the excellent performance of NP[Bcl-2/Mito]@CCM for drug-resistant breast tumor therapy.
Article
Biotechnology & Applied Microbiology
Jun-Yong Wu, Yong-Jiang Li, Jiemin Wang, Xiong-Bin Hu, Si Huang, Shilin Luo, Da-Xiong Xiang
Summary: The multifunctional DTX@Ang-EM significantly inhibit the growth of orthotopic GBM with reduced side effects of chemotherapy, providing a new strategy for targeted brain drug delivery and GBM therapy.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Article
Nanoscience & Nanotechnology
Elizabeth Campbell, Md Tanvir Hasan, Roberto Gonzalez-Rodriguez, Tate Truly, Bong Han Lee, Kayla N. Green, Giridhar Akkaraju, Anton V. Naumov
Summary: This study developed a new multifunctional biocompatible anticancer nanoformulation that provides targeted image-guided cancer therapy, demonstrating capabilities in treatment, imaging, and specific targeting of cancer cells.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2021)
Article
Chemistry, Multidisciplinary
Laetitia Bardet, Herve Roussel, Stefano Saroglia, Masoud Akbari, David Munoz-Rojas, Carmen Jimenez, Aurore Denneulin, Daniel Bellet
Summary: The thermal instability of silver nanowires leads to increased electrical resistance in AgNW networks. Understanding the relationship between structural and electrical properties of AgNW networks is crucial for their integration as transparent electrodes in flexible optoelectronics. In situ X-ray diffraction measurements were used to study the crystallographic evolution of Ag-specific Bragg peaks during thermal ramping, revealing differences in thermal and structural transitions between bare and SnO2-coated AgNW networks.
Article
Chemistry, Multidisciplinary
Nathalia Cancino-Fuentes, Arnau Manasanch, Joana Covelo, Alex Suarez-Perez, Enrique Fernandez, Stratis Matsoukis, Christoph Guger, Xavi Illa, Anton Guimera-Brunet, Maria V. Sanchez-Vives
Summary: This study provides a comprehensive characterization of graphene-based solution-gated field-effect transistors (gSGFETs) for brain recordings, highlighting their potential clinical applications.
Article
Chemistry, Multidisciplinary
Sikandar Aftab, Hailiang Liu, Dhanasekaran Vikraman, Sajjad Hussain, Jungwon Kang, Abdullah A. Al-Kahtani
Summary: This study examines the effects of hybrid nanoparticles made of NiO@rGO and NiO@CNT on the active layers of polymer solar cells and X-ray photodetectors. The findings show that these hybrid nanoparticles can enhance the charge carrier capacities and exciton dissociation properties of the active layers. Among the tested configurations, the NiO@CNT device demonstrates superior performance in converting sunlight into electricity, and achieves the best sensitivity for X-ray detection.
Article
Chemistry, Multidisciplinary
Hyo Jung Shin, Seung Gyu Choi, Fengrui Qu, Min-Hee Yi, Choong-Hyun Lee, Sang Ryong Kim, Hyeong-Geug Kim, Jaewon Beom, Yoonyoung Yi, Do Kyung Kim, Eun-Hye Joe, Hee-Jung Song, Yonghyun Kim, Dong Woon Kim
Summary: This study investigates the role of SOX9 in reactive astrocytes following ischemic brain damage using a PLGA nanoparticle plasmid delivery system. The results demonstrate that PLGA nanoparticles can reduce ischemia-induced neurological deficits and infarct volume, providing a potential opportunity for stroke treatment.
Article
Chemistry, Multidisciplinary
Anurag Chaudhury, Koushik Debnath, Nikhil R. Jana, Jaydeep K. Basu
Summary: The study investigates the interaction between nanoparticles and cell membranes, and identifies key parameters, including charge, crowding, and membrane fluidity, that determine the adsorbed concentration and unbinding transition of nanoparticles.
Article
Chemistry, Multidisciplinary
Sina Sadeghi, Fazel Bateni, Taekhoon Kim, Dae Yong Son, Jeffrey A. Bennett, Negin Orouji, Venkat S. Punati, Christine Stark, Teagan D. Cerra, Rami Awad, Fernando Delgado-Licona, Jinge Xu, Nikolai Mukhin, Hannah Dickerson, Kristofer G. Reyes, Milad Abolhasani
Summary: In this study, an autonomous approach for the development of lead-free metal halide perovskite nanocrystals is presented, which integrates a modular microfluidic platform with machine learning-assisted synthesis modeling. This approach enables rapid and optimized synthesis of copper-based lead-free nanocrystals.
Article
Chemistry, Multidisciplinary
Zahir Abbas, Nissar Hussain, Surender Kumar, Shaikh M. Mobin
Summary: The rational construction of free-standing and flexible electrodes for electrochemical energy storage devices is an emerging research focus. In this study, a redox-active metal-organic framework (MOF) was prepared on carbon nanofibers using an in situ approach, resulting in a flexible electrode with high redox-active behavior and unique properties such as high flexibility and lightweight. The prepared electrode showed excellent cyclic retention and rate capability in supercapacitor applications. Additionally, it could be used as a freestanding electrode in flexible devices at different bending angles.
Article
Chemistry, Multidisciplinary
Lishan Zhang, Xiaoting Zhang, Hui Ran, Ze Chen, Yicheng Ye, Jiamiao Jiang, Ziwei Hu, Miral Azechi, Fei Peng, Hao Tian, Zhili Xu, Yingfeng Tu
Summary: Photodynamic therapy (PDT) is a promising local treatment modality in cancer therapy, but its therapeutic efficacy is restricted by ineffective delivery of photosensitizers and tumor hypoxia. In this study, a phototactic Chlorella-based near-infrared (NIR) driven green affording-oxygen microrobot system was developed for enhanced PDT. The system exhibited desirable phototaxis and continuous oxygen generation, leading to the inhibition of tumor growth in mice. This study demonstrates the potential of using a light-driven green affording-oxygen microrobot to enhance photodynamic therapy.
Article
Chemistry, Multidisciplinary
Yujin Li, Jing Xu, Xinqi Luo, Futing Wang, Zhong Dong, Ke-Jing Huang, Chengjie Hu, Mengyi Hou, Ren Cai
Summary: In this study, hollow heterostructured materials were constructed using an innovative template-engaged method as cathodes for zinc-ion batteries. The materials exhibited fast Zn2+ transport channels, improved electrical conductivity, and controlled volume expansion during cycling. The designed structure allowed for an admirable reversible capacity and high coulombic efficiency.
Article
Chemistry, Multidisciplinary
Paritosh Mahato, Shashi Shekhar, Rahul Yadav, Saptarshi Mukherjee
Summary: This study comprehensively elucidates the role of the core and electrostatic surface of metal nanoclusters in catalytic reduction reactions. The electrostatic surface dramatically modulates the reactivity of metal nanoclusters.
Article
Chemistry, Multidisciplinary
Pei Liu, Mengdi Liang, Zhengwei Liu, Haiyu Long, Han Cheng, Jiahe Su, Zhongbiao Tan, Xuewen He, Min Sun, Xiangqian Li, Shuai He
Summary: This study demonstrates a simple and environmentally-friendly method for the synthesis of zinc oxide nanozymes (ZnO NZs) using wasted hop extract (WHE). The WHE-ZnO NZs exhibit exceptional peroxidase-like activity and serve as effective catalysts for the oxidation of 3,3,5,5-tetramethylbenzidine (TMB) in the presence of hydrogen peroxide (H2O2). In addition, a straightforward colorimetric technique for detecting both H2O2 and glucose was developed using the WHE-ZnO NZs as peroxidase-like catalysts.
Article
Chemistry, Multidisciplinary
Hyunkyu Oh, Young Jun Lee, Eun Ji Kim, Jinseok Park, Hee-Eun Kim, Hyunsoo Lee, Hyunjoo Lee, Bumjoon J. Kim
Summary: Mesoporous carbon particles have unique structural properties that make them suitable as support materials for catalytic applications. This study investigates the impact of channel nanostructures on the catalytic activity of porous carbon particles (PCPs) by fabricating PCPs with controlled channel exposure on the carbon surface. The results show that PCPs with highly open channel nanostructures exhibit significantly higher catalytic activity compared to those with closed channel nanostructures.
Article
Chemistry, Multidisciplinary
Yunjie Lu, Zhaohui Li, Zewei Li, Shihao Zhou, Ning Zhang, Jianming Zhang, Lu Zong
Summary: A tough, long-lasting adhesive and highly conductive nanocomposite hydrogel (PACPH) was fabricated via the synergy of interfacial entanglement and adhesion group densification. PACPH possesses excellent mechanical properties, interfacial adhesion strength, and conductivity, making it a promising material for long-term monitoring of human activities and electrocardiogram signals.
Article
Chemistry, Multidisciplinary
Zichao Wei, Audrey Vandergriff, Chung-Hao Liu, Maham Liaqat, Mu-Ping Nieh, Yu Lei, Jie He
Summary: We have developed a simple method to prepare polymer-grafted plasmonic metal nanoparticles with pH-responsive surface-enhanced Raman scattering. By using pH-responsive polymers as ligands, the aggregation of nanoparticles can be controlled, leading to enhanced SERS. The pH-responsive polymer-grafted nanoparticles show high reproducibility and sensitivity in solution, providing a novel approach for SERS without the need for sample pre-concentration.
Article
Chemistry, Multidisciplinary
Melis Ozge Alas Colak, Ahmet Gungor, Merve Buldu Akturk, Emre Erdem, Rukan Genc
Summary: This research investigates the effect of functionalizing carbon dots with hydroxyl polymers on their performance as electrode materials in a supercapacitor. The results show that the functionalized carbon dots exhibit excellent electrochemical performance and improved stability.