期刊
NANOSCALE
卷 6, 期 15, 页码 9215-9222出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4nr01097c
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资金
- National Basic Research Program of China (973 Program) [2013CB934400, 2012CB932400]
- Funds for International Cooperation and Exchange of the National Natural Science Foundation of China [61361160412]
- Natural Science Foundation of Jiangsu Province of China [BK20130052, BK20130298]
- Six Talent Peaks Project of Jiangsu Province [2013-XCL-036]
A class of stem-loop DNA-assisted silicon nanowires (SiNWs)-based fluorescent biosensor is presented in this report. Significantly, the sensor enables rapid and sensitive detection of DNA targets with a concentration as low as 1 pM. Moreover, the large planar surface of SiNWs facilitates simultaneous assembly with different DNA strands, which is favorable for multiplexed DNA detection. On the other hand, the SiNWs-based sensor is highly efficacious for detecting heavy metal ions. Mercury ions (Hg2+) of low concentrations (e.g., 5 pM) are readily identified from its mixture with over 10 kinds of interfering metal ions, even in real water samples. Given that SiNWs can be fabricated in a facile, reproducible and low-cost manner, this kind of SiNWs-based high-performance sensor is expected to be a practical analytical tool for a variety of biological and environment-protection applications.
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