Article
Engineering, Biomedical
Feng-Qin Luo, Wei Xu, Jing-Yang Zhang, Rong Liu, Yong-Cong Huang, Chunsheng Xiao, Jin-Zhi Du
Summary: In this study, a nanocomposite hydrogel was developed to improve local drug delivery by enhancing drug retention and penetration in tumor tissues. The results showed that the nanocomposite hydrogel effectively inhibited tumor growth and metastasis.
ACTA BIOMATERIALIA
(2022)
Article
Chemistry, Multidisciplinary
Hongyi Chen, Haolin Song, Yifan Luo, Chufeng Li, Yu Wang, Jie Liu, Feifei Luo, Hongrui Fan, Xuwen Li, Tao Sun, Chen Jiang
Summary: The hyperproliferative tumor stroma of pancreatic ductal adenocarcinoma limits drug permeation and creates an immunosuppressive microenvironment, leading to resistance to chemotherapy and immunotherapy. Traditional nanomedicine mainly focuses on manipulating nanoparticles' properties to penetrate the tumor tissue. Therefore, a versatile drug-polymer conjugate is prepared for the codelivery of chemotherapy drug gemcitabine and FAK inhibitor defactinib. The conjugate can bind with cell membranes reversibly and trigger transcytosis for enhanced tumor penetration and cellular uptake.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Instruments & Instrumentation
Dwi L. Priwitaningrum, Kunal Pednekar, Alexandros V. Gabriel, Aida A. Varela-Moreira, Severine Le Gac, Ivo Vellekoop, Gert Storm, Wim E. Hennink, Jai Prakash
Summary: In this study, the effect of nano-chemotherapeutics on tumor stroma was evaluated using a tumor stroma-mimicking 3D in vitro model. The results showed that polymeric nanoparticles could penetrate the tumor stroma and induce cytotoxicity in tumor cells, but the efficacy was limited in the 3D model. This tumor stroma-mimicking 3D model can serve as an excellent platform for studying the penetration and effects of nanotherapeutics.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2023)
Article
Chemistry, Physical
Yonghua Gong, Jinyang Zhang, Yan Lu, Dong Wan, Jie Pan, Guilei Ma
Summary: To address the challenges of poor drug permeation and immune-cold tumor microenvironment in solid tumors, light-activated nanoparticles were developed for co-delivery of chemotherapy drug, photosensitizer, and angiotensin II receptor blockers. These nanoparticles achieved deep drug penetration and synergistic photo-chemo-immunotherapy. In mouse models, the treatment effectively inhibited tumor growth, down-regulated a-smooth muscle actin expression, induced dendritic cells maturation, and promoted intratumoral infiltration of cytotoxic T lymphocytes. Combination therapy with the nanoparticles and anti-PD-1 monoclonal antibody showed potential for preventing tumor recurrence and metastasis by eliciting memory T cell response.
Article
Chemistry, Multidisciplinary
Rong Liu, Qian Liang, Jia-Qi Luo, Yu-Xuan Li, Xin Zhang, Kelong Fan, Jin-Zhi Du
Summary: In this study, a ferritin-based nanocomposite hydrogel was developed for cancer chemoimmunotherapy. The hydrogel releases intact drug-loaded ferritin nanocage, facilitating tumor penetration and creating an immunostimulatory tumor microenvironment through immunogenic cell death effect. The hydrogel exhibits superior antitumor efficacy in aggressive breast and glioblastoma tumor models.
Article
Chemistry, Multidisciplinary
K. Laxmi Swetha, Milan Paul, Kavya Sree Maravajjala, Soniya Kumbham, Swati Biswas, Aniruddha Roy
Summary: Previous studies have shown that breast cancer cells employ various strategies to resist anticancer drugs, such as docetaxel, through drug-resistance mechanisms like overexpression of P-glycoprotein and cancer stem cells. By inhibiting both P-glycoprotein and cancer stem cells, the combination of docetaxel and disulfiram shows potential in sensitizing drug-resistant breast cancer cells. This study developed a pH-responsive nanoparticle system for the co-delivery of docetaxel and disulfiram, which demonstrated improved drug release, penetration, and cytotoxic efficacy against drug-resistant breast cancer cells in vitro, as well as enhanced tumor drug delivery and anti-tumor efficacy in vivo.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Engineering, Biomedical
Chenghu Wu, Wenjuan He, Yue Chen, Jie Cai, Fanjun Zeng, Zidong Lu, Jilong Wang
Summary: Tumor immunotherapy has the potential to enhance antitumor immune response by utilizing whole tumor antigen-based vaccines generated from tumor cell lysate or irradiated tumor cells. In this study, polydopamine nanoparticles were coated with tumor cell lysate to form PDA@CL. Engineered Salmonella wrapped with PDA@CL (EnS@PDA@CL) was administered intravenously to target the tumor site. The PDA@CL particles facilitated the maturation of dendritic cells, leading to the infiltration of cytotoxic T lymphocytes and triggering antitumor immunity.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Zhihao Zhao, Yupu Feng, Jiajia Xiang, Jing Liu, Ying Piao, Shiqun Shao, Jianbin Tang, Zhuxian Zhou, Youqing Shen
Summary: A type of tertiary amine oxide (TAO)-containing zwitterionic liposomal nanocarriers has been developed to hitchhike red blood cells (RBCs) to tumor blood vessels and enter solid tumors through transcytosis. Two types of TAO liposomes (TAOLs) have been identified that can induce efficient tumor cell transcytosis through rapid macropinocytosis and endoplasmic reticulum/Golgi-involved exocytosis. These zwitterionic TAOLs can hitchhike RBCs to gain long blood circulation and effectively enter and infiltrate the whole tumor through transcytosis. Chemotherapeutic drug-loaded liposomes have shown superior antitumor activity compared to traditional liposomal drugs.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Pharmacology & Pharmacy
Javiana Luengo, Marc Schneider, Anna M. Schneider, Claus-Michael Lehr, Ulrich F. Schaefer
Summary: The study showed that PLGA nanoparticles can enhance the permeation of the anti-inflammatory drug flufenamic acid (FFA) through the skin, with both drug-free and drug-loaded nanoparticles increasing drug permeation. In addition, the pH values of buffered vehicles were found to influence the permeation of FFA.
Article
Chemistry, Multidisciplinary
Guowei Wang, Chao Zhang, Yifan Jiang, Yue Song, Jifan Chen, Yu Sun, Qunying Li, Zhuxian Zhou, Youqing Shen, Pintong Huang
Summary: The study introduces an ultrasonic cavitation-assisted and acid-activatable active transporting liposome, SCGLN, which is capable of overcoming the tight blood vessel walls and exhibiting potent antitumor activity in multiple poorly permeable tumor models.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Luntao Liu, Qingqing Li, Lanlan Chen, Lihong Song, Xueqiang Zhang, Hongqi Huo, Zhixin You, Ying Wu, Zongsheng Wu, Jiamin Ye, Qinrui Fu, Lichao Su, Xuan Zhang, Huanghao Yang, Jibin Song
Summary: In this study, multifunctional photocatalysis-powered nanomotors were developed for synergistically enhanced cancer radiotherapy. The nanomotors showed superior motility and efficient accumulation in tumor due to the catalytic generation of hydrogen. The nanomotors also exhibited a high radiation dose deposition, leading to enhanced therapeutic efficacy.
Article
Pharmacology & Pharmacy
Hen Popilski, Valeria Feinshtein, Sivan Kleiman, Andrea Mattarei, Mariangela Garofalo, Stefano Salmaso, David Stepensky
Summary: The decoration of PEGylated doxorubicin liposomes (PLD) with cell penetration enhancers (CPEs) can increase tumor permeability and enhance anti-cancer effects in vivo, despite lower tumor accumulation. However, this may also lead to higher distribution to non-target organs and tissues. Further studies are needed to assess the mechanisms of CPE-mediated effects on liposome disposition.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Pharmacology & Pharmacy
Guoliang Liu, Min Wang, Hongyu He, Jiannan Li
Summary: This study developed tumor-targeting nanoparticles loaded with doxorubicin for the treatment of colorectal cancer. The nanoparticles utilize a peptide, VATANST (STP), to achieve tumor-targeting effects, have a core-shell structure, and are sensitive to the tumor microenvironment. In vivo experiments in mice demonstrated the nanoparticles' properties as drug delivery systems and their good antitumor effects.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Corentin Gauthier, Julie Mariot, Morgane Daurat, Christine Dhommee, Khaled El Cheikh, Elodie Morere, Geoffrey Depaepe, Magali Gary-Bobo, Alain Morere, Marcel Garcia, Ilaria Basile, Valerie Gouilleux-Gruart, Marie Maynadier
Summary: The grafting of AMFA on therapeutic proteins improves enzyme delivery by increasing cellular uptake via the M6PR receptor. In this study, the impact of AMFA grafting on the cell uptake and recycling of a monoclonal antibody was investigated. AMFA grafting increased drug release in cells and had no effect on antibody recycling mediated by the FcRn receptor. AMFA grafting did not impair the pharmacokinetics and showed high stability.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Chemistry, Multidisciplinary
Yao Wu, Honglei Xie, Yongping Li, Xinyue Bao, Guo-Liang Lu, Jingyuan Wen, Yuan Gao, Yaping Li, Zhiwen Zhang
Summary: The researchers developed a bioinspired lipoprotein system loaded with a glutathione-activated nitric oxide donor (NO-BLP) to improve tumor vasculature normalization and enhance the delivery efficiency of albumin-bound paclitaxel nanoparticles (PAN) in tumors. NO-BLP exhibited superior tumor accumulation and penetration compared to liposomal formulation (NO-Lipo), resulting in significant vascular normalization and a 2.33-fold increase in PAN accumulation. The sequential treatment of NO-BLP with PAN showed an 81.03% inhibition of tumor growth, outperforming monotherapy and the counterpart NO-Lipo plus PAN treatment. Thus, the bioinspired lipoprotein system of NO-BLP provides a promising platform for tumor vessel normalization and efficient intratumor delivery of nanomedicines.
Article
Chemistry, Organic
Weizhun Yang, Jicheng Zhang, Chia-Wei Yang, Sherif Ramadan, Richard Staples, Xuefei Huang
Summary: The formation of a novel 12-membered macrocyclic ketal through long-range participation of a levulinoyl group across a glycosidic linkage in glycosylation reactions indicates that stereodirecting participation is not limited to groups within the glycan ring being activated, thus expanding the scope of remote group participation in glycosylation.
Article
Biochemistry & Molecular Biology
Peng Wang, Jing Zhao, Seyedmehdi Hossaini Nasr, Sarah A. Otieno, Fuming Zhang, Wei Qiang, Robert J. Linhardt, Xuefei Huang
Summary: The highly sulfated HS oligosaccharides show the strongest binding affinity with A beta and can reduce cellular toxicities induced by A beta. Elongating the glycan length significantly enhances A beta affinity. This study provides new insights into HS/A beta interactions.
ACS CHEMICAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Kunli Liu, Xuefei Huang
Summary: Hyaluronan nanoparticles (HA-NPs) have gained increasing interest for targeted imaging and therapy. By utilizing the interaction between HA and CD44, as well as the enhanced permeability and retention (EPR) effect, selective accumulation of HA-NPs at disease sites can be achieved. This review focuses on the synthesis strategies of HA-NPs and their applications in therapy and biomedical imaging.
CARBOHYDRATE RESEARCH
(2022)
Article
Chemistry, Medicinal
Shivangi Chugh, Cheryl Swenson, Vilma Yuzbasiyan-Gurkan, Xuefei Huang
Summary: In this study, a peptide conjugate was constructed using a specific peptide epitope and a mutant bacteriophage carrier, successfully developing a vaccine candidate against bovine leukemia virus. The vaccine candidate generated durable immunity and effectively inhibited viral infection.
ACS INFECTIOUS DISEASES
(2022)
Article
Chemistry, Multidisciplinary
Kedar N. Baryal, Sherif Ramadan, Guowei Su, Changxin Huo, Yuetao Zhao, Jian Liu, Linda C. Hsieh-Wilson, Xuefei Huang
Summary: A divergent approach was used to synthesize a library of HS tetrasaccharides that covered all possible sulfation structures. This library helped identify the structural requirements for HS sequences to bind to fibroblast growth factor-2 and showed weak affinity for platelet factor-4. This could lead to the development of new HS-based therapeutics without the adverse effect of heparin-induced thrombocytopenia.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Biochemistry & Molecular Biology
J. Sebastian Temme, Jennifer A. Crainic, Laura M. Walker, Weizhun Yang, Zibin Tan, Xuefei Huang, Jeffrey C. Gildersleeve
Summary: This study has identified 26 anti-glycan antibodies, most of which bind microbial carbohydrates, and found that these antibodies predominantly originate from IgG+ memory B cells, rather than from naive, early emigrant, or immature B cells.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Article
Biochemical Research Methods
Aniwat Juhong, Bo Li, Cheng-You Yao, Chia-Wei Yang, Dalen W. Agnew, Yu Leo Lei, Xuefei Huang, Wibool Piyawattanametha, Zhen Qiu
Summary: Traditionally, high-performance microscopes are required for high-resolution imaging, but the resulting images are typically large and not easily managed or stored. This study demonstrates custom convolution neural networks (CNNs) for super-resolution image enhancement and characterization of breast cancer histopathological images. The results show improved image quality and segmentation compared to other methods.
BIOMEDICAL OPTICS EXPRESS
(2023)
Article
Chemistry, Multidisciplinary
Mengxia Sun, Chi Zhang, Dexin Sui, Canchai Yang, Dohun Pyeon, Xuefei Huang, Jian Hu
Summary: Phosphatidylinositol phosphate kinases (PIPKs) are enzymes that produce lipid signaling molecules and have become attractive drug targets for various diseases. Researchers have designed and synthesized D-galactosyl lysophospholipids, which can selectively target phosphatidylinositol 4-phosphate 5-kinase. This study also discovered a human PIKfyve inhibitor that enhances the inhibition of Apilimod, an ATP-competitive PIKfyve inhibitor, in clinical trials for SARS-CoV-2 infection and amyotrophic lateral sclerosis. These findings demonstrate the potential of D-galactose-based phosphoinositide mimetics as artificial substrates and inhibitors of PIPKs.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Yanan Gao, Wei Wang, Yunru Yang, Qingyu Zhao, Chendong Yang, Xiaoying Jia, Yang Liu, Minmin Zhou, Weihong Zeng, Xuefei Huang, Sandra Chiu, Tengchuan Jin, Xuanjun Wu
Summary: Researchers have developed functionalized nanoparticles as a universal vaccine design platform for major diseases such as cancer and COVID-19. The nanoparticles induce potent immune responses and provide effective protection against tumors and the SARS-CoV-2 virus.
Article
Nanoscience & Nanotechnology
Chia-Wei Yang, Kunli Liu, Cheng-You Yao, Bo Li, Aniwat Juhong, Zhen Qiu, Xuefei Huang
Summary: Breast cancer is a major cause of cancer-related deaths in women, and there is an urgent need for non-invasive detection and imaging techniques. Multimodality breast cancer imaging, using indocyanine green-conjugated superparamagnetic iron oxide nanoworms, shows promising results in providing more accurate cancer detection and imaging. The nanoworms offer large tumor to normal tissue contrasts in multiple imaging modalities, making them an attractive platform for non-invasive breast cancer diagnosis.
ACS APPLIED NANO MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Lei Wang, Alexander W. Sorum, Bo-Shun Huang, Mallory K. Kern, Guowei Su, Nitin Pawar, Xuefei Huang, Jian Liu, Nicola L. B. Pohl, Linda C. Hsieh-Wilson
Summary: Glycosaminoglycans (GAGs) are complex carbohydrates in biology, and their biological roles and structure-function relationships are not well understood. Synthesizing large collections of structurally diverse GAG oligosaccharides would provide valuable insights and advancements in glycoscience. A new platform for synthesizing heparan sulfate (HS) oligosaccharide libraries displaying comprehensive sulfation patterns was developed, enabling the generation of a complete library of diverse HS oligosaccharides. These structures offer a unique perspective on the sulfation code of GAGs and identify sequences for modulating the activities of important growth factors and chemokines.
Article
Engineering, Electrical & Electronic
Aniwat Juhong, Bo Li, Cheng-You Yao, Chia-Wei Yang, Kunli Liu, Dalen W. Agnew, Yu Leo Lei, Gary D. Luker, Harvey Bumpers, Xuefei Huang, Wibool Piyawattanametha, Zhen Qiu
Summary: Near-infrared (NIR) fluorescence imaging is proven to be useful in medical applications, especially image-guided surgery. We introduce a low-cost and portable NIR fluorescence imaging system that utilizes Nyxel(R) technology to improve quantum efficiency in the NIR range. By conjugating ICG with nanoworm particles (NWs-ICG), our system shows impressive applications in ex vivo tissues and in vivo image-guided surgery for breast tumors.
IEEE PHOTONICS TECHNOLOGY LETTERS
(2023)
Article
Biochemical Research Methods
Aniwat Juhong, Bo Li, Yifan Liu, Cheng-You Yao, Chia-Wei Yang, Dalen W. Agnew, Yu Leo Lei, Gary D. Luker, Harvey Bumpers, Xuefei Huang, Wibool Piyawattanametha, Zhen Qiu
Summary: Multispectral optoacoustic tomography (MSOT) is a useful technique for detailed analysis of biological samples, but it's time-consuming. This study proposes a deep learning model based on hybrid recurrent and convolutional neural networks to generate sequential cross-sectional images for MSOT. By using a larger step size for input images, the proposed model can generate additional high-resolution images, reducing acquisition time by approximately 71%.
JOURNAL OF BIOPHOTONICS
(2023)
Article
Materials Science, Biomaterials
Huiling Dong, Xuefei Huang, Xuanjun Wu
Summary: 9-SH-Sia is coupled to CPT to form a novel CPT prodrug (CPT-ss-Sia) that self-assembles into nanostructures in an aqueous solution. CPT-ss-Sia exhibits enhanced water solubility, GSH-triggered CPT release, and increased E-lactone ring stability, with comparable cancer cell-killing ability to CPT. Intravenous administration of CPT-ss-Sia inhibits tumor growth and reduces lesions without adverse effects on body weight in mice. This is the first report of the 9-SH-Sia conjugate-based prodrug, with broad clinical application prospects.
BIOMATERIALS SCIENCE
(2023)
Article
Chemistry, Organic
Sherif Ramadan, Guowei Su, Kedar Baryal, Linda C. Hsieh-Wilson, Jian Liu, Xuefei Huang
Summary: This study reports an automated machine-aided solid-phase strategy for the assembly of HS disaccharides, which significantly improves the synthesis efficiency. A diverse HS disaccharide library with different sulfation patterns was successfully prepared using this method.
ORGANIC CHEMISTRY FRONTIERS
(2022)
Article
Chemistry, Multidisciplinary
Laetitia Bardet, Herve Roussel, Stefano Saroglia, Masoud Akbari, David Munoz-Rojas, Carmen Jimenez, Aurore Denneulin, Daniel Bellet
Summary: The thermal instability of silver nanowires leads to increased electrical resistance in AgNW networks. Understanding the relationship between structural and electrical properties of AgNW networks is crucial for their integration as transparent electrodes in flexible optoelectronics. In situ X-ray diffraction measurements were used to study the crystallographic evolution of Ag-specific Bragg peaks during thermal ramping, revealing differences in thermal and structural transitions between bare and SnO2-coated AgNW networks.
Article
Chemistry, Multidisciplinary
Nathalia Cancino-Fuentes, Arnau Manasanch, Joana Covelo, Alex Suarez-Perez, Enrique Fernandez, Stratis Matsoukis, Christoph Guger, Xavi Illa, Anton Guimera-Brunet, Maria V. Sanchez-Vives
Summary: This study provides a comprehensive characterization of graphene-based solution-gated field-effect transistors (gSGFETs) for brain recordings, highlighting their potential clinical applications.
Article
Chemistry, Multidisciplinary
Sikandar Aftab, Hailiang Liu, Dhanasekaran Vikraman, Sajjad Hussain, Jungwon Kang, Abdullah A. Al-Kahtani
Summary: This study examines the effects of hybrid nanoparticles made of NiO@rGO and NiO@CNT on the active layers of polymer solar cells and X-ray photodetectors. The findings show that these hybrid nanoparticles can enhance the charge carrier capacities and exciton dissociation properties of the active layers. Among the tested configurations, the NiO@CNT device demonstrates superior performance in converting sunlight into electricity, and achieves the best sensitivity for X-ray detection.
Article
Chemistry, Multidisciplinary
Hyo Jung Shin, Seung Gyu Choi, Fengrui Qu, Min-Hee Yi, Choong-Hyun Lee, Sang Ryong Kim, Hyeong-Geug Kim, Jaewon Beom, Yoonyoung Yi, Do Kyung Kim, Eun-Hye Joe, Hee-Jung Song, Yonghyun Kim, Dong Woon Kim
Summary: This study investigates the role of SOX9 in reactive astrocytes following ischemic brain damage using a PLGA nanoparticle plasmid delivery system. The results demonstrate that PLGA nanoparticles can reduce ischemia-induced neurological deficits and infarct volume, providing a potential opportunity for stroke treatment.
Article
Chemistry, Multidisciplinary
Anurag Chaudhury, Koushik Debnath, Nikhil R. Jana, Jaydeep K. Basu
Summary: The study investigates the interaction between nanoparticles and cell membranes, and identifies key parameters, including charge, crowding, and membrane fluidity, that determine the adsorbed concentration and unbinding transition of nanoparticles.
Article
Chemistry, Multidisciplinary
Sina Sadeghi, Fazel Bateni, Taekhoon Kim, Dae Yong Son, Jeffrey A. Bennett, Negin Orouji, Venkat S. Punati, Christine Stark, Teagan D. Cerra, Rami Awad, Fernando Delgado-Licona, Jinge Xu, Nikolai Mukhin, Hannah Dickerson, Kristofer G. Reyes, Milad Abolhasani
Summary: In this study, an autonomous approach for the development of lead-free metal halide perovskite nanocrystals is presented, which integrates a modular microfluidic platform with machine learning-assisted synthesis modeling. This approach enables rapid and optimized synthesis of copper-based lead-free nanocrystals.
Article
Chemistry, Multidisciplinary
Zahir Abbas, Nissar Hussain, Surender Kumar, Shaikh M. Mobin
Summary: The rational construction of free-standing and flexible electrodes for electrochemical energy storage devices is an emerging research focus. In this study, a redox-active metal-organic framework (MOF) was prepared on carbon nanofibers using an in situ approach, resulting in a flexible electrode with high redox-active behavior and unique properties such as high flexibility and lightweight. The prepared electrode showed excellent cyclic retention and rate capability in supercapacitor applications. Additionally, it could be used as a freestanding electrode in flexible devices at different bending angles.
Article
Chemistry, Multidisciplinary
Lishan Zhang, Xiaoting Zhang, Hui Ran, Ze Chen, Yicheng Ye, Jiamiao Jiang, Ziwei Hu, Miral Azechi, Fei Peng, Hao Tian, Zhili Xu, Yingfeng Tu
Summary: Photodynamic therapy (PDT) is a promising local treatment modality in cancer therapy, but its therapeutic efficacy is restricted by ineffective delivery of photosensitizers and tumor hypoxia. In this study, a phototactic Chlorella-based near-infrared (NIR) driven green affording-oxygen microrobot system was developed for enhanced PDT. The system exhibited desirable phototaxis and continuous oxygen generation, leading to the inhibition of tumor growth in mice. This study demonstrates the potential of using a light-driven green affording-oxygen microrobot to enhance photodynamic therapy.
Article
Chemistry, Multidisciplinary
Yujin Li, Jing Xu, Xinqi Luo, Futing Wang, Zhong Dong, Ke-Jing Huang, Chengjie Hu, Mengyi Hou, Ren Cai
Summary: In this study, hollow heterostructured materials were constructed using an innovative template-engaged method as cathodes for zinc-ion batteries. The materials exhibited fast Zn2+ transport channels, improved electrical conductivity, and controlled volume expansion during cycling. The designed structure allowed for an admirable reversible capacity and high coulombic efficiency.
Article
Chemistry, Multidisciplinary
Paritosh Mahato, Shashi Shekhar, Rahul Yadav, Saptarshi Mukherjee
Summary: This study comprehensively elucidates the role of the core and electrostatic surface of metal nanoclusters in catalytic reduction reactions. The electrostatic surface dramatically modulates the reactivity of metal nanoclusters.
Article
Chemistry, Multidisciplinary
Pei Liu, Mengdi Liang, Zhengwei Liu, Haiyu Long, Han Cheng, Jiahe Su, Zhongbiao Tan, Xuewen He, Min Sun, Xiangqian Li, Shuai He
Summary: This study demonstrates a simple and environmentally-friendly method for the synthesis of zinc oxide nanozymes (ZnO NZs) using wasted hop extract (WHE). The WHE-ZnO NZs exhibit exceptional peroxidase-like activity and serve as effective catalysts for the oxidation of 3,3,5,5-tetramethylbenzidine (TMB) in the presence of hydrogen peroxide (H2O2). In addition, a straightforward colorimetric technique for detecting both H2O2 and glucose was developed using the WHE-ZnO NZs as peroxidase-like catalysts.
Article
Chemistry, Multidisciplinary
Hyunkyu Oh, Young Jun Lee, Eun Ji Kim, Jinseok Park, Hee-Eun Kim, Hyunsoo Lee, Hyunjoo Lee, Bumjoon J. Kim
Summary: Mesoporous carbon particles have unique structural properties that make them suitable as support materials for catalytic applications. This study investigates the impact of channel nanostructures on the catalytic activity of porous carbon particles (PCPs) by fabricating PCPs with controlled channel exposure on the carbon surface. The results show that PCPs with highly open channel nanostructures exhibit significantly higher catalytic activity compared to those with closed channel nanostructures.
Article
Chemistry, Multidisciplinary
Yunjie Lu, Zhaohui Li, Zewei Li, Shihao Zhou, Ning Zhang, Jianming Zhang, Lu Zong
Summary: A tough, long-lasting adhesive and highly conductive nanocomposite hydrogel (PACPH) was fabricated via the synergy of interfacial entanglement and adhesion group densification. PACPH possesses excellent mechanical properties, interfacial adhesion strength, and conductivity, making it a promising material for long-term monitoring of human activities and electrocardiogram signals.
Article
Chemistry, Multidisciplinary
Zichao Wei, Audrey Vandergriff, Chung-Hao Liu, Maham Liaqat, Mu-Ping Nieh, Yu Lei, Jie He
Summary: We have developed a simple method to prepare polymer-grafted plasmonic metal nanoparticles with pH-responsive surface-enhanced Raman scattering. By using pH-responsive polymers as ligands, the aggregation of nanoparticles can be controlled, leading to enhanced SERS. The pH-responsive polymer-grafted nanoparticles show high reproducibility and sensitivity in solution, providing a novel approach for SERS without the need for sample pre-concentration.
Article
Chemistry, Multidisciplinary
Melis Ozge Alas Colak, Ahmet Gungor, Merve Buldu Akturk, Emre Erdem, Rukan Genc
Summary: This research investigates the effect of functionalizing carbon dots with hydroxyl polymers on their performance as electrode materials in a supercapacitor. The results show that the functionalized carbon dots exhibit excellent electrochemical performance and improved stability.