期刊
NANOSCALE
卷 3, 期 3, 页码 907-910出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c0nr00666a
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资金
- Australian Research Council [DP0988351]
- National Health and Medical Research Council [513700]
- Sir Harry Secombe Trust [841]
RADA16 self-assembling peptide nanofiber scaffolds (SAPNSs) have been shown to have positive effects on neural regeneration following injury to the central nervous system in vivo, but mechanisms are unclear. Here we show that RADA16 SAPNSs form scaffolds of increasing fiber density with increasing peptide concentration which in turn has a concentration-dependent effect on neurons and astrocytes in mixed retinal cultures. Importantly, we report that the final nanoscale fiber architecture is an important factor to consider in designing scaffolds to promote regeneration in the central nervous system.
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