期刊
NANOSCALE
卷 3, 期 9, 页码 3788-3792出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c1nr10518c
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资金
- Academy of Finland [218182, 130900, 115976]
- Finnish Cultural Foundation
We present a method for controlled connection of gold electrodes with dsDNA molecules (locally on a chip) by utilizing polymerase to elongate single-stranded DNA primers attached to the electrodes. Thiol-modified oligonucleotides are directed and immobilized to nanoscale electrodes by means of dielectrophoretic trapping, and extended in a procedure mimicking PCR, finally forming a complete dsDNA molecule bridging the gap between the electrodes. The technique opens up opportunities for building from the bottom-up, for detection and sensing applications, and also for molecular electronics.
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