Review
Chemistry, Multidisciplinary
Rossella Canese, Federica Vurro, Pasquina Marzola
Summary: Iron oxide nanoparticles can be used as MRI contrast agents, with applications in liver-specific contrast agents and diagnostic agents in cancer immunotherapy. In addition to diagnostic purposes, these nanoparticles may also have therapeutic effects. Furthermore, iron oxide nanoparticles have innovative applications in drug delivery and imaging techniques for tumors.
Article
Biochemistry & Molecular Biology
Mihaela Balas, Daniela Predoi, Carmen Burtea, Anca Dinischiotu
Summary: Iron oxide nanoparticles coated with dextran were characterized and their effects on pancreatic cancer cells were investigated. The nanoparticles showed significant negative contrast in MRI and dose-dependent cellular iron uptake and toxicity levels. At low doses, these nanoparticles could serve as safe platforms for drug delivery, as well as antitumoral and imaging agents in pancreatic cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Ivan Zelepukin, Alexey Yaremenko, Ilya N. Ivanov, Mikhail Yuryev, Vladimir R. Cherkasov, Sergey M. Deyev, Petr Nikitin, Maxim P. Nikitin
Summary: Safe application of nanoparticles in medicine requires a full understanding of their pharmacokinetics and degradation in the organism. In this study, a magnetic spectral approach was used for in vivo monitoring of magnetic particle degradation, revealing the significant influence of parameters such as dose, size, surface coating, and internal architecture on the degradation process. These findings provide deeper insights into particle degradation in vivo, potentially facilitating the rational design of nano- and microparticles with predictable long-term fate in vivo.
Article
Environmental Sciences
Beata Dabrowska-Bouta, Grzegorz Sulkowski, Jolanta Orzelska-Gorka, Lidia Struzynska, Ewa Kedzierska, Grazyna Biala
Summary: The study revealed significant deposition of silver nanoparticles in the brains of exposed rats, resulting in transcriptional changes in the cellular components of the neurovascular unit that may lead to blood-brain barrier disintegration. Ultrastructural analysis showed enhanced permeability of cerebral microvessels, causing perivascular edema.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Chemistry, Multidisciplinary
Assaf Zinger, Sirena Soriano, Gherardo Baudo, Enrica De Rosa, Francesca Taraballi, Sonia Villapol
Summary: The study developed leukocyte-based biomimetic nanoparticles for direct treatment of traumatic brain injury, achieving selective targeting of the damaged brain and accumulation in peripheral organs. The therapeutic approach showed potential efficacy in reducing brain damage.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Review
Biochemistry & Molecular Biology
Buddolla Anantha Lakshmi, Young-Joon Kim
Summary: Nanotechnology plays a crucial role in the treatment and diagnosis of glioblastoma. The multifunctional nanomaterials with specific features such as real-time tracking, in-depth tissue penetration, and drug-loading capacity offer effective theranostics for glioblastoma.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemical Research Methods
Boao Xia, Charles Sebesta, Sangsin Lee, Vishnu Nair, Xuan Zhao, Samantha Coffler, Jacob T. Robinson, Jerzy O. Szablowski
Summary: The 'biohybrid' approach combines synthetic materials, genetically encoded proteins or cells, and optical, acoustic, and magnetic energy sources to improve interfacing with the nervous system and achieve enhanced spatial, temporal, cell-type, and molecular precision.
CURRENT OPINION IN BIOTECHNOLOGY
(2021)
Review
Chemistry, Multidisciplinary
Guanyou Lin, Miqin Zhang
Summary: The potential of theranostic nanoparticles in tumor treatment is widely recognized due to their ability to integrate multifaceted functionalities into a single nanosystem. These nanoparticles typically consist of an inorganic core for imaging and therapeutic functions, bioinert coatings for improved biocompatibility, controlled drug-loading-release modules, and targeting ligands for specific cell uptake. The design and assembly of these functionalities require sophisticated molecular design and precise execution. Ligand chemistry plays a decisive role in translating theoretical designs into functionalized theranostic nanoparticles. This Account reviews the properties and utilities of capping ligands, drug-loading ligands, and targeting ligands in theranostic nanoparticles.
ACCOUNTS OF CHEMICAL RESEARCH
(2023)
Article
Computer Science, Interdisciplinary Applications
Apostolos A. Gkountas, Nickolas D. Polychronopoulos, George N. Sofiadis, Evangelos G. Karvelas, Leonidas A. Spyrou, Ioannis E. Sarris
Summary: This study numerically investigates the delivery of magnetic nanoparticles through the blood-brain barrier, showing that an external magnetic field can significantly enhance drug delivery to the central nervous system. Factors such as the size of MNPs, external magnetic field, and blood flow affect the permeability of the barrier.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2021)
Article
Chemistry, Multidisciplinary
Boyan Li, Xin Chen, Wei Qiu, Rongrong Zhao, Jiazhi Duan, Shouji Zhang, Ziwen Pan, Shulin Zhao, Qindong Guo, Yanhua Qi, Wenhan Wang, Lin Deng, Shilei Ni, Yuanhua Sang, Hao Xue, Hong Liu, Gang Li
Summary: A novel composite therapeutic platform combining magnetic nanoparticles and engineered exosomes is proposed for GBM treatment, aiming to improve the penetration through the blood-brain barrier and enhance tumor targeting ability for effective ferroptosis therapy.
Article
Biochemistry & Molecular Biology
R. Shiji, Manu M. Joseph, Anitha Sen, K. Raveendran Pillai, Bs Unnikrishnan, T. T. Sreelekha
Summary: This study modified superparamagnetic iron oxide nanoparticles (SPIONs) using an eco-friendly substance extracted from pomegranate fruit peel, which resulted in tumor-targeted accumulation and improved biocompatibility. By attaching an anticancer drug to the modified nanoparticles, the drug could be selectively released in tumor cells, leading to improved tumor reduction and survival benefits. The modified nanoparticles also exhibited remarkable contrast in magnetic resonance imaging (MRI) for targeted tumor therapy.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Chemistry, Physical
Nidhi Aggarwal, Samraggi Choudhury, Sonika Chibh, Jiban Jyoti Panda
Summary: The review highlights the benefits of combining therapeutic and diagnostic agents in the field of theranostics for managing chronic illnesses and neurodegenerative disorders, emphasizing the challenges in treating neurodegenerative diseases and the potential applications of nanotechnology integrated theranostics. DNA/RNA-aptamer conjugated nanotheranostics are being extensively researched for their role in improving prognosis and therapy for neurodegenerative disorders.
COLLOID AND INTERFACE SCIENCE COMMUNICATIONS
(2022)
Article
Materials Science, Biomaterials
Yaser Rehman, Zhenxiang Cheng, Xiaolin Wang, Xu-Feng Huang, Konstantin Konstantinov
Summary: In this study, size- and shape-controlled two-dimensional superparamagnetic maghemite quantum flakes (MQFs) were synthesized via a simple hydrothermal method for biological applications. These MQFs exhibited superparamagnetic behavior with high saturation magnetization and low coercivity, and showed selective toxicity towards different cell lines based on ROS scavenging/generation and cellular uptake mechanisms. Furthermore, the MQFs demonstrated potential for cancer therapy through ROS generation by hyperthermia in a selective microenvironment, highlighting their theranostic capabilities.
JOURNAL OF MATERIALS CHEMISTRY B
(2021)
Article
Nanoscience & Nanotechnology
Manju Sharma, Virendra Tiwari, Swati Chaturvedi, Muhammad Wahajuddin, Shubha Shukla, Jiban Jyoti Panda
Summary: This study developed self-fluorescent nanoparticles as a therapeutic system for Alzheimer's disease (AD), showing the ability to inhibit and disrupt the amyloid fibrils associated with AD. These nanoparticles were nontoxic to neural cells and protected neurons from cytotoxicity. Animal model experiments demonstrated that the nanoparticles improved memory in AD model rats. Overall, the nanoparticles showed promising potential as nanotheranostic agents for AD therapy.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Review
Pharmacology & Pharmacy
Poonam Parashar, Neelu Singh, Alka, Priyanka Maurya, Shubhini A. Saraf
Summary: Nanoparticles as nanocarriers have great potential in theranostics for early disease diagnosis and treatment. However, the toxicity and size-dependent properties of nanoparticles need to be carefully evaluated to ensure their safe use.
CURRENT PHARMACEUTICAL DESIGN
(2022)
Article
Pathology
Thomas R. Pisanic, Shiho Asaka, Shiou-Fu Lin, Ting-Tai Yen, Hanru Sun, Ash Bahadirli-Talbott, Tza-Huei Wang, Kathleen H. Burns, Tian-Li Wang, Ie-Ming Shih
AMERICAN JOURNAL OF PATHOLOGY
(2019)
Article
Oncology
Thomas R. Pisanic, Yeh Wang, Hanru Sun, Michael Considine, Lihong Li, Tza-Huei Wang, Tian-Li Wang, Ie-Ming Shih
CLINICAL CANCER RESEARCH
(2020)
Article
Oncology
Brendan F. Miller, Thomas R. Pisanic, Gennady Margolin, Hanna M. Petrykowska, Pornpat Athamanolap, Alexander Goncearenco, Akosua Osei-Tutu, Christina M. Annunziata, Tza-Huei Wang, Laura Elnitski
CLINICAL EPIGENETICS
(2020)
Article
Chemistry, Analytical
Joon Soo Park, Thomas Pisanic, Ye Zhang, Tza-Huei Wang
Summary: LiNC PCR is a novel strategy for achieving high-dimensional multiplexing in PCR assays, utilizing a simple ligation reaction and target-specific multicolor fluorescence signals for identifying amplified targets.
ANALYTICAL CHEMISTRY
(2021)
Article
Cell Biology
Huihui Fan, Huda Atiya, Yeh Wang, Thomas R. Pisanic, Tza-Huei Wang, Ie-Ming Shih, Kelly K. Foy, Leonard Frisbie, Ronald J. Buckanovich, Alison A. Chomiak, Rochelle L. Tiedemann, Scott B. Rothbart, Chelsea Chandler, Hui Shen, Lan G. Coffman
Article
Medicine, Research & Experimental
Marina Baretti, Enusha Karunasena, Marianna Zahurak, Rosalind Walker, Yang Zhao, Thomas R. Pisanic, Tza-Huei Wang, Tim F. Greten, Austin G. Duffy, Elske Gootjes, Gerrit Meijer, Henk M. W. Verheul, Nita Ahuja, James G. Herman, Nilofer S. Azad
Summary: A Phase 2 trial of gemcitabine and docetaxel in patients with CHFR-methylated, MSI-high CRC did not show tumor responses according to RECIST criteria. The median progression-free survival was 1.79 months, and the median overall survival was 15.67 months. Despite the negative results, this study demonstrates the potential of using epigenetic biomarkers as inclusion criteria for optimizing combinatorial strategies in personalized medicine.
CTS-CLINICAL AND TRANSLATIONAL SCIENCE
(2021)
Article
Biophysics
Pengfei Zhang, Liben Chen, Jiumei Hu, Alexander Y. Trick, Fan-En Chen, Kuangwen Hsieh, Yang Zhao, Branch Coleman, Kate Kruczynski, Thomas R. Pisanic, Christopher D. Heaney, William A. Clarke, Tza-Huei Wang
Summary: The study introduces a rapid and sensitive magnetofluidic immuno-PCR platform for point-of-care serological testing of COVID-19, which achieved high sensitivity and specificity in clinical sample evaluation.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Oncology
Lihong Li, Maria Facadio Antero, Ming Zhang, Tiffany Chu, Tamer Seckin, Ayse Ayhan, Thomas Pisanic, Tian-Li Wang, Leslie Cope, James Segars, Ie-Ming Shih
Summary: The study suggests that the epithelium and stroma of adenomyosis and peritoneal endometriosis may both develop monoclonally from the same progenitor cells. Despite a patient-specific methylation landscape, adenomyosis epithelium and stroma can be distinguished epigenetically from normal endometrium.
JOURNAL OF PATHOLOGY
(2021)
Review
Oncology
Juliane M. Liberto, Sheng-Yin Chen, Ie-Ming Shih, Tza-Huei Wang, Tian-Li Wang, Thomas R. Pisanic
Summary: Ovarian high-grade serous carcinoma (HGSC) has a high mortality rate due to delays in diagnosis and a lack of sensitive and specific biomarkers for early-stage detection. This review provides an overview of the current landscape of ovarian cancer diagnostics and focuses on emerging methodologies for non-invasive detection of HGSC, particularly in high-risk populations.
Meeting Abstract
Oncology
Sachio Nomura, Toshiyuki Kobayashi, Kiichi Sugimoto, Masami Arai, Thomas R. Pisanic, Hirotaka Momose, Kazuhiro Sakamoto, Okio Hino
Meeting Abstract
Oncology
Leonard Frisbie, HuiHui Fan, Thomas Pisanic, Hui Shen, Lan Coffman
CLINICAL CANCER RESEARCH
(2020)
Meeting Abstract
Medicine, Research & Experimental
Shiho Asaka, Thomas Pisanic, Jeff Wang, Kathleen Burns, Tian-Li Wang, Ie-Ming Shih
LABORATORY INVESTIGATION
(2019)
Meeting Abstract
Pathology
Shiho Asaka, Thomas Pisanic, Jeff Wang, Kathleen Burns, Tian-Li Wang, le-Ming Shih
Correction
Oncology
M. J. Overman, L. Adam, K. Raghav, J. Wang, B. Kee, D. Fogelman, C. Eng, E. Vilar, R. Shroff, A. Dasari, R. Wolff, J. Morris, E. Karunasena, T. R. Pisanic, N. Azad, S. Kopetz
ANNALS OF ONCOLOGY
(2019)
Article
Biochemical Research Methods
Christine M. O'Keefe, Daniel Giammanco, Sixuan Li, Thomas R. Pisanic, Tza-Huei Jeff Wang
Article
Nanoscience & Nanotechnology
Daniela Rubanova, Svitlana Skoroplyas, Alena Libanska, Eva Randarova, Josef Bryja, Michaela Chorvatova, Tomas Etrych, Lukas Kubala
Summary: This study explored the use of nanocarriers to deliver dexamethasone for treating rheumatoid arthritis. The results showed that this method increased the accumulation of dexamethasone in the arthritic area, had a dose-dependent healing effect, and reduced the accumulation of the RA mediator RANKL. This study provides a feasible strategy for improving rheumatoid arthritis therapy.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2024)
Article
Nanoscience & Nanotechnology
Thanpisit Lomphithak, Apiwit Sae-Fung, Simone Sprio, Anna Tampieri, Siriporn Jitkaew, Bengt Fadeel
Summary: In this study, iron-doped hydroxyapatite (FeHA) was evaluated as a potential nanomedicine approach for treating PDAC. The results showed that FeHA, in combination with a sublethal dose of the GPX4 inhibitor RSL3, could trigger ferroptosis in KRAS mutant PANC-1 cells while sparing normal human cells. The induction of ferroptosis by FeHA plus RSL3 was found to be dependent on the metalloreductase STEAP3 in PDAC cells.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2024)
Review
Nanoscience & Nanotechnology
Marco Felipe Salas-Orozco, Ana Cecilia Lorenzo-Leal, Idania de Alba Montero, Nuria Patino Marin, Miguel Angel Casillas Santana, Horacio Bach
Summary: The emergence of antibiotic-resistant bacteria in severe infections is a growing concern, particularly in hospital environments. Metal-based nanomaterials have shown potential as an alternative to combat these bacteria, but there is a risk of bacterial resistance and environmental accumulation.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2024)