Article
Nanoscience & Nanotechnology
Sendibitiyosi Gandidzanwa, Natasha Beukes, Sinelizwi Joseph, Arno Janse Van Vuuren, Philani Mashazi, Jonathan Britton, Gareth Kilian, Saartjie Roux, Tebello Nyokong, Michael E. Lee, Carminita L. Frost, Zenixole R. Tshentu
Summary: Folate receptor-targeted therapy shows promise in breast cancer treatment. Folate-conjugated palladium-based nanoparticles with non-toxic concentrations were utilized to specifically target breast cancer cells with overexpressed folate receptors. The nanoparticles were found to selectively accumulate in cancer cells relative to normal cells, as demonstrated by qualitative and quantitative analysis using transmission electron microscopy and inductively coupled plasma-optical emission spectroscopy. These findings support the potential use of folate-conjugated palladium nanoparticles in targeting breast cancer cells for radiopharmaceutical applications.
Article
Chemistry, Medicinal
Yuan Zhao, Yuan-Yuan Guan, Fang Zhao, Tong Yu, Shao-Jie Zhang, Yi-Zhe Zhang, Ying-Chao Duan, Xiao-Li Zhou
Summary: The polycomb repressive complex 2 (PRC2) is an important epigenetic gene silencer, and its abnormal activity is closely related to tumor development and progression. Inhibitors targeting PRC2 have made progress, but limitations and drug resistance exist. Therefore, novel targeted therapy strategies for PRC2 have become a research focus.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Chemistry, Medicinal
Ziqian Wang, Ting Song, Zongwei Guo, Laura B. Uwituze, Yafei Guo, Hong Zhang, Hang Wang, Xiaodong Zhang, Hao Pan, Tong Ji, Fangkui Yin, Sheng Zhou, Jian Dai, Zhichao Zhang
Summary: The novel Hsp70 inhibitor S1g-6 disrupts Hsp70-Bim protein-protein interactions and selectively antagonizes Hsp70 ATPase activity, leading to selective apoptosis induction in certain cancer cell lines. This represents a new class of antitumor candidates targeting cancer-related Hsp70-Bim interactions.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Pharmacology & Pharmacy
Xiaoyan Xu, Tianhao Zhou, Xudong Wei, Xuelian Jiang, Jiyan Cao
Summary: Although surgery-based comprehensive therapy is becoming the main approach to treat laryngeal cancer, recurrence, metastasis, radiotherapy resistance, and chemotherapy tolerance are still the main causes of death in patients. Targeted inhibition of laryngeal cancer stem cells has been considered as the consensus to cure laryngeal cancer. In this study, we developed cRGD peptide-modified chitosan-polyethylene glycol slow-release nanoparticles containing Bmi-1RNAi siRNA oligo and paclitaxel, which showed significant suppression of cell proliferation and migration and induction of apoptosis in laryngeal cancer cells in vitro and inhibited tumor growth significantly in a mouse model with laryngeal cancer.
Review
Immunology
Jia Mai, Limei Wu, Ling Yang, Ting Sun, Xiaojuan Liu, Rutie Yin, Yongmei Jiang, Jinke Li, Qintong Li
Summary: Epithelial ovarian cancer is a deadly gynecological cancer, and targeting the folate receptor alpha has shown promise in its treatment. Various modalities, including antibody-drug conjugates, monoclonal antibodies, and small molecules, have been explored to exploit this target for effective therapy.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Takatsugu Kosugi, Masahito Ohue
Summary: The study developed a quantitative estimation index QEPPI specifically for early screening of compounds targeting protein-protein interactions, which showed better performance compared to the commonly used method QED.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Engineering, Biomedical
Zheng Wang, Minhua Ye, Dehua Ma, Jianfei Shen, Fang Fang
Summary: A novel type of theranostic radioactive agents, Lu-177-labeled nanomaterials conjugated to macromolecules have been studied for targeted radiotherapy and receptor detection in lung carcinoma cells. The fabricated sample showed remarkable radiochemical composition purity and beneficial photo-physical characteristics for bio-imaging, making it a potential nuclear and optical imaging agent for lung cancer. Combining with folate-bombesin might provide a specific target for radiation therapy.
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
(2022)
Article
Chemistry, Applied
Vikas, Matte Kasi Viswanadh, Abhishesh Kumar Mehata, Vishal Sharma, Vishnu Priya, Neelima Varshney, Sanjeev Kumar Mahto, Madaswamy S. Muthu
Summary: By successfully conjugating folate and cetuximab to chitosan nanoparticles, the cytotoxicity against A-549 cells was enhanced, and the relative bioavailability of DXL in rats was improved.
CARBOHYDRATE POLYMERS
(2021)
Article
Polymer Science
Malihe Pooresmaeil, Hassan Namazi
Summary: A novel photoluminescent glycodendrimer was fabricated by growing polyamidoamine dendrimer on a zirconium-based nano metal-organic framework, followed by functionalization with D-galactose. This system showed promising drug loading and controlled release capabilities, enhanced biocompatibility, and targeted hepatic cancer treatment efficacy. The multifunctional UiO-66-NH2-PAMAM-Gal could be a valuable candidate for bioimaging and targeted tumor therapy.
EUROPEAN POLYMER JOURNAL
(2021)
Article
Multidisciplinary Sciences
David Hargreaves, Rodrigo J. Carbajo, Michael S. Bodnarchuk, Kevin Embrey, Philip B. Rawlins, Martin Packer, Sebastien L. Degorce, Alexander W. Hird, Jeffrey W. Johannes, Elisabetta Chiarparin, Markus Schade
Summary: Researchers report the crystal structure of Mcl-1 and its interactions with clinical inhibitors AMG-176, AZD5991 and S64315. They found that highly rigid inhibitors, preorganized in their bioactive conformation, can induce pocket deepening. This work provides a roadmap for targeting the largely untapped PPI class more successfully.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Pharmacology & Pharmacy
Bo Li, Tingfei Tan, Weiwei Chu, Ying Zhang, Yuanzi Ye, Shanshan Wang, Yan Qin, Jihui Tang, Xi Cao
Summary: Breast cancer is a common and dangerous disease, and multi-drug chemotherapy can effectively treat it. In this study, lipid nanoemulsions were developed to deliver PTX and DHA for the treatment of breast cancer. The results showed that the nanoemulsions had a sustained drug release and exhibited high cytotoxicity, effectively inhibiting tumor growth and prolonging survival time.
Article
Instruments & Instrumentation
Francesca Moret, Claudia Conte, Diletta Esposito, Giovanni Dal Poggetto, Concetta Avitabile, Francesca Ungaro, Natascia TIso, Alessandra Romanelli, Paola Laurienzo, Elena Reddi, Fabiana Quaglia
Summary: This study proposes a biodegradable nanoplatform that combines anti-angiogenic activity and targeting of cancer cells to enhance the anticancer effect of docetaxel (DTX). The nanoparticles (NPs) developed in this study showed good size, stability, and the ability to effectively deliver DTX. In various in vitro and in vivo experiments, the NPs exhibited promising therapeutic outcomes and reduced systemic toxicity. Overall, this research emphasizes the importance of nanotechnology in cancer treatment.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2022)
Article
Oncology
Siyuan Peng, Junhong Cai, Shan Bao
Summary: The study investigated the effect of CMBs carrying PTX and C-erbB-2 knockout plasmid on endometrial cancer cells, revealing that C-erbB-2 knockout inhibits proliferation, migration, and invasion of HEC-1A cells. Loading PTX and plasmid simultaneously may be a novel combination therapy with great potential. C-erbB-2 may regulate cell proliferation by downregulating expression of P21 and P27 in HEC-1A cells.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Multidisciplinary Sciences
Seray Sahsuvar, Rabia Guner, Ozgul Gok, Ozge Can
Summary: Cervical cancer has become one of the most common cancers among women worldwide. Traditional cancer treatments often result in side effects, so there is a need for new drug delivery systems to improve therapy. In this study, targeted Melittin conjugates were designed for cervical cancer and tested in vitro, showing effective anticancer activity as well as antioxidant and antibacterial effects.
SCIENTIFIC REPORTS
(2023)
Article
Engineering, Biomedical
Zafar Khan, Abdulsalam Alhalmi, Neha Tyagi, Wasi Uzzaman Khan, Afsana Sheikh, Mohammed A. S. Abourehab, Kanchan Kohli, Prashant Kesharwani
Summary: Non-targeted cancer therapy poses a high risk to patients and a more effective treatment option is needed. This study developed folate-engineered microbeads to target breast cancer cells, which showed high antioxidant activity and significant inhibitory effect on cancer cells. Compared to non-targeted therapy, this targeted approach demonstrated improved uptake and is suitable for oral treatment of breast carcinoma.
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
(2023)
Article
Chemistry, Physical
Sivaram Nallamolu, Vijaya Ratna Jayanti, Mallikarjun Chitneni, Liew Yun Khoon, Shikha Sood, Yassine Riadi, Prashant Kesharwani
Summary: The study successfully synthesized a highly solubilized and biocompatible formulation of RES, using SMEDDS technology to overcome issues related to poor water solubility and low bioavailability.
JOURNAL OF DISPERSION SCIENCE AND TECHNOLOGY
(2022)
Review
Environmental Sciences
Sima Singh, Arshid Numan, Dinesh Sharma, Rahul Shukla, Amit Alexander, Gaurav Kumar Jain, Farhan Jalees Ahmad, Prashant Kesharwani
Summary: The outbreak of the COVID-19 pandemic in 2019 and 2020 has led to a new era of communicable infectious diseases, with the emergence of Hantavirus infection posing a new public health emergency. Hantavirus, a zoonotic pathogen, causes two major clinical manifestations - HFRS and HCPS. Despite the lack of effective treatments or vaccines, public awareness and precautionary measures can help reduce the spread of the virus.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL HEALTH RESEARCH
(2022)
Review
Instruments & Instrumentation
Akanksha R. Singh, Prasanna Kumar Desu, Ramya Krishna Nakkala, Vanitha Kondi, Sushma Devi, Mohammad Sarwar Alam, Hinna Hamid, Rajani B. Athawale, Prashant Kesharwani
Summary: Nanotechnology has opened up new possibilities in the field of nutraceuticals and food industries, offering enhanced properties and applications for nanomaterials. The small size and unique properties of nanomaterials have led to advancements in bioavailability, solubility, stability, and targeted drug delivery in the development of nano-based nutraceuticals, highlighting the potential benefits and future prospects in improving treatment strategies and quality of life in the health sectors.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2022)
Article
Biophysics
Sharvari Thakare, Aazam Shaikh, Dhananjay Bodas, Virendra Gajbhiye
Summary: Conventional immunoassays such as ELISA and FLISA have been replaced by more efficient methods like electrochemical immunosensors. Nanotechnology has seen the utilization of dendrimers in immunoassays, enhancing sensitivity and applications of these sensors in clinical disease diagnosis. The review highlights recent progress in using dendrimers for immunoassays and analyzing biomarkers.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Chemistry, Multidisciplinary
Aazam Shaikh, Prashant Kesharwani, Virendra Gajbhiye
Summary: Dendrimers have a wide range of applications in biomedical fields, including cargo delivery, nucleic acid delivery, and macromolecule delivery. They can also be used to crosslink synthetic and natural polymeric scaffolds and mimic the extracellular matrix. Dendrimers play a crucial role in regulating cell behavior and delivering bioactive molecules, and have shown significant results in stem cell survival, osteogenesis, and repair.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Chemistry, Physical
Namita A. More, Nitin L. Jadhao, Rohan J. Meshram, Prajakta Tambe, Rajesh A. Salve, Jagjivan K. Sabane, Sanskruti N. Sawant, Virendra Gajbhiye, Jayant M. Gajbhiye
Summary: Novel morpholine and its sulfonamide derivatives were designed and synthesized in this study, which demonstrated significant anti-tumor activity against breast cancer cells and a favorable safety profile.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Review
Health Care Sciences & Services
Maha Ali Alghamdi, Antonino N. Fallica, Nicola Virzi, Prashant Kesharwani, Valeria Pittala, Khaled Greish
Summary: Personalized medicine and nanomedicine are both new concepts in medical practice. Personalized medicine aims to customize therapeutic management based on a patient's personal attributes, while nanomedicine applies nanotechnology advances in medicine for diagnosis and treatment. The integration of these two fields can provide more effective treatment options tailored to individual patients.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Aliesha Moudgil, Rajesh Salve, Virendra Gajbhiye, Bhushan P. Chaudhari
Summary: The global burden of cancer is increasing, with breast cancer surpassing other cancers worldwide. This review focuses on the potential of liposomes in superseding conventional therapeutic regimens for breast cancer management. Active targeting using receptors overexpressed on breast cancer cells and passive targeting with drug combinations have been studied over the past decade. The results show that actively targeted liposomal formulations exhibit superior efficacy compared to non-targeted counterparts, highlighting the dominion of liposomal formulations in breast cancer treatment.
CHEMISTRY AND PHYSICS OF LIPIDS
(2023)
Article
Biochemistry & Molecular Biology
Pramod Kumar, Rajesh Salve, Kishore M. Paknikar, Virendra Gajbhiye
Summary: In this study, a multifunctional nanocarrier based on mesoporous silica nanoparticles was developed for co-delivery against drug-resistant triple-negative breast cancer cells. The results showed that the co-delivery of doxorubicin and siRNA using this nanocarrier exhibited significant cytotoxic efficacy and had the potential to overcome drug resistance in breast cancer cells.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Pharmacology & Pharmacy
Prajakta Tambe, Rajesh Salve, Prakash Choudhary, Pramod Kumar, Sachin Jadhav, Kishore M. Paknikar, Virendra Gajbhiye
Summary: The targeted delivery of small interfering RNA (siRNA) using multi-layered dendrimer nanostructures has shown to effectively silence the MCL-1 gene in LHRH receptor overexpressing breast and prostate cancer cells. This leads to apoptosis and tumor regression in both in vitro and in vivo experiments. The study suggests that this approach could be a promising therapy for LHRH overexpressing cancers.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Chemistry, Medicinal
Rajesh Salve, Pramod Kumar, Bhushan P. Chaudhari, Virendra Gajbhiye
Summary: Ovarian cancer is a deadly cancer in female patients. The current treatments for ovarian cancer are limited and inefficient. To address this, we synthesized silica nanoparticles with sulfide derivatives and modified them with polyethylene glycol and mucin-1 aptamer for targeted delivery of paclitaxel to ovarian cancer cells. The results showed that the targeted nanoparticles had significant antitumor effects on ovarian cancer cells.
JOURNAL OF PHARMACEUTICAL SCIENCES
(2023)
Article
Biotechnology & Applied Microbiology
Leila Fotooh Abadi, Pramod Kumar, Kishore Paknikar, Virendra Gajbhiye, Smita Kulkarni
Summary: The study explores the application of nanomedicine in the treatment of HIV/AIDS. A combination of gold nanoparticles and Tenofovir was successfully synthesized and showed multifunctional activity against HIV1 and HIV1 protease. The findings highlight the prospects of developing AuNP-TNF as a novel next-generation platform to treat HIV/AIDS.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Review
Medicine, General & Internal
Tannaz Jamialahmadi, Mitra Abbasifard, Zeljko Reiner, Prashant Kesharwani, Amirhossein Sahebkar
Summary: This meta-analysis found that bariatric surgery significantly decreases MCP-1 concentration, but there was no association between the changes in BMI and absolute difference in MCP-1 levels before and after the surgery. However, a linear relationship between the changes in MCP-1 and length of follow-up was proven.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Engineering, Multidisciplinary
Prashant Kesharwani, Mahak Fatima, Vanshikha Singh, Afsana Sheikh, Waleed H. Almalki, Virendra Gajbhiye, Amirhossein Sahebkar
Summary: This study developed a new hydrogel formulation for treating onychomycosis. The sustained release of drugs from the hydrogel showed promising activity, making it an effective method of drug delivery.
Review
Engineering, Biomedical
Amir R. Afshari, Mehdi Sanati, Prashant Kesharwani, Amirhossein Sahebkar
Summary: Standard cancer chemotherapeutics often lose effectiveness and produce adverse effects due to resistance mechanisms. Curcumin, when combined with traditional chemotherapeutics, has been found to enhance cancer treatment effectiveness and reduce resistance. However, limited bioavailability requires co-delivery strategies for Cur and conventional pharmaceuticals in clinical settings.
JOURNAL OF FUNCTIONAL BIOMATERIALS
(2023)
Article
Nanoscience & Nanotechnology
Daniela Rubanova, Svitlana Skoroplyas, Alena Libanska, Eva Randarova, Josef Bryja, Michaela Chorvatova, Tomas Etrych, Lukas Kubala
Summary: This study explored the use of nanocarriers to deliver dexamethasone for treating rheumatoid arthritis. The results showed that this method increased the accumulation of dexamethasone in the arthritic area, had a dose-dependent healing effect, and reduced the accumulation of the RA mediator RANKL. This study provides a feasible strategy for improving rheumatoid arthritis therapy.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2024)
Article
Nanoscience & Nanotechnology
Thanpisit Lomphithak, Apiwit Sae-Fung, Simone Sprio, Anna Tampieri, Siriporn Jitkaew, Bengt Fadeel
Summary: In this study, iron-doped hydroxyapatite (FeHA) was evaluated as a potential nanomedicine approach for treating PDAC. The results showed that FeHA, in combination with a sublethal dose of the GPX4 inhibitor RSL3, could trigger ferroptosis in KRAS mutant PANC-1 cells while sparing normal human cells. The induction of ferroptosis by FeHA plus RSL3 was found to be dependent on the metalloreductase STEAP3 in PDAC cells.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2024)
Review
Nanoscience & Nanotechnology
Marco Felipe Salas-Orozco, Ana Cecilia Lorenzo-Leal, Idania de Alba Montero, Nuria Patino Marin, Miguel Angel Casillas Santana, Horacio Bach
Summary: The emergence of antibiotic-resistant bacteria in severe infections is a growing concern, particularly in hospital environments. Metal-based nanomaterials have shown potential as an alternative to combat these bacteria, but there is a risk of bacterial resistance and environmental accumulation.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2024)
