期刊
NANOMEDICINE
卷 9, 期 13, 页码 1971-1989出版社
FUTURE MEDICINE LTD
DOI: 10.2217/NNM.14.139
关键词
colloids; dosimetry; functional toxicity; implant debris; ligand; nanogold; nanomaterial; particle characterization; surfactant
资金
- German Research Foundation [SPP1313, BA3580-10-1, RA898-8-1]
Many studies have evaluated the toxicity of gold nanoparticles, although reliable predictions based on these results are rare. In order to overcome this problem, this article highlights strategies to improve comparability and standardization of nanotoxicological studies. To this end, it is proposed that we should adapt the nanomaterial to the addressed exposure scenario, using ligand-free nanoparticle references in order to differentiate ligand effects from size effects. Furthermore, surface-weighted particle dosing referenced to the biologically relevant parameter (e. g., cell number or organ mass) is proposed as the gold standard. In addition, it is recommended that we should shift the focus of toxicological experiments from 'live-dead' assays to the assessment of cell function, as this strategy allows observation of bioresponses at lower doses that are more relevant for in vivo scenarios.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据