Article
Medicine, Research & Experimental
Mengqi Yu, Hardeep S. Oberoi, Hitesh S. Purohit, Craig A. Fowler, Devalina Law
Summary: Amorphous solid dispersions (ASDs) are a formulation approach that enhances the bioavailability of poorly water-soluble molecules in oral drug products. Directly delivering drug-rich amorphous nanoparticles can reduce polymer quantities without sacrificing bioavailability. This study demonstrates the importance of understanding the impact of stabilizing agents on nanoparticle behavior and redispersion in designing high-drug-load amorphous formulations for poorly water-soluble compounds.
MOLECULAR PHARMACEUTICS
(2023)
Article
Chemistry, Multidisciplinary
Jocelyn C. Ayala-Fuentes, Maryam Soleimani, Jonathan Javier Magana, Jose Mario Gonzalez-Meljem, Rocio Alejandra Chavez-Santoscoy
Summary: Researchers developed a novel hybrid inulin-soy protein nanoparticle formulation loaded with (-)-epicatechin and quercetin to enhance their bioavailability. The nanoparticles exhibited desired size and charge, and demonstrated excellent performance in terms of release and digestion. Additionally, the nanoparticles exhibited inhibitory effects on Caco-2 cells, highlighting their potential in improving the bioavailability of bioactive compounds.
Article
Chemistry, Applied
Yilun Weng, Supun Ranaweera, Da Zou, Anna P. Cameron, Xiaojing Chen, Hao Song, Chun-Xia Zhao
Summary: Enzymes are essential for industries, but their sensitivity to high temperatures can be problematic. Encapsulation with alginate microparticles has been shown to improve enzyme thermal stability, but other factors like enzyme loading and bioavailability also need to be considered. This study optimized the efficiency of enzyme encapsulation and achieved high enzyme loading and thermal stability, with excellent bioavailability demonstrated in an animal trial.
FOOD HYDROCOLLOIDS
(2023)
Article
Materials Science, Paper & Wood
Melika Sharahi, Ahmad Hivechi, S. Hajir Bahrami, Nahid Hemmatinejad, Peiman B. Milan
Summary: This study produced nanoparticles from walnut shells and co-electrospun them with polycaprolactone and gelatin to create nanofibers with excellent mechanical properties. The nanofiber scaffolds showed excellent viability, growth, and proliferation of adipose-derived mesenchymal stem cells.
Article
Engineering, Chemical
Seyede Elaheh Ghafouri, Seyed Rasoul Mousavi, Maliheh Khakestani, Shahla Mozaffari, Narges Ajami, Hossein Ali Khonakdar
Summary: This study investigates the release of levetiracetam using poly(lactic acid), poly(epsilon-caprolactone), and their blend electrospun nanofibers as novel systems. Scanning electron microscopy confirms the smooth and beads-free morphology of the samples. With increasing levetiracetam content, the average diameters of the nanofibers also increase. FTIR spectroscopy is used for structural confirmation and observation of functional groups. X-ray diffraction reveals a decrease in crystallinity and different drug release kinetics are evaluated using various models.
POLYMER ENGINEERING AND SCIENCE
(2022)
Article
Food Science & Technology
Anubhav Pratap-Singh, Alejandro Leiva
Summary: This study examines the spray-drying microencapsulation of iron and zinc simultaneously as a strategy to combat nutrient deficiency. The microcapsules showed higher resistance to intestinal conditions, quickly releasing iron and zinc in stomach and intestinal digestion. The Higuchi mathematical model best fit the release of iron and zinc, suggesting a transport phenomenon governed by diffusion through the coating material.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2021)
Article
Chemistry, Medicinal
Bilge Bicak, Serda Kecel-Gunduz, Yasemin Budama-Kilinc, Burak Ozdemir
Summary: This study presents the development of YKT tripeptide-based nanodrugs. YKT-loaded PCL nanoparticles were synthesized and characterized, and molecular dynamics simulations were conducted to investigate the interactions between YKT and growth factors and hormone receptors. The ADME profile of YKT was also determined.
ARCHIV DER PHARMAZIE
(2022)
Review
Agronomy
Meisam Zargar, Maryam Bayat, Francess Sia Saquee, Simbo Diakite, Nakhaev M. Ramzanovich, Khasukhadzhiev A. S. Akhmadovich
Summary: The number of effective herbicides available to farmers is decreasing due to increasing herbicide resistance. It is important to address weed management challenges by investigating the potential of newly introduced materials, such as biocompatible polymer-based nanoparticles.
Article
Materials Science, Multidisciplinary
Thannaphat Jenvoraphot, Boontharika Thapsukhon, Donraporn Daranarong, Robert Molloy, Chayarop Supanchart, Suttichai Krisanaprakornkit, Paul D. Topham, Brian Tighe, Anisa Mahomed, Winita Punyodom
Summary: In this research, a periodontal membrane with nanoporous structure and tetracycline drug loading was designed and fabricated to improve periodontal regeneration and anti-inflammatory effect.
ACS APPLIED POLYMER MATERIALS
(2022)
Article
Pharmacology & Pharmacy
Jaehyeok Lee, Chul Haeng Lee, Jong-Geon Lee, So Yeon Jeon, Min-Koo Choi, Im-Sook Song
Summary: A pH-modified extended-release formulation of Ursodeoxycholate (UDCA) was developed, which improved the solubility and dissolution profile of UDCA. This formulation increased the oral bioavailability of UDCA in rats by 251%.
Article
Materials Science, Characterization & Testing
Lidong Feng, Sheng Xiang, Yanlong Liu, Xinchao Bian, Gao Li, Xuesi Chen
Summary: An analytical method using gas chromatography with an internal standard was developed to quantitatively determine residual monomers in PLCL, which showed high precision with RSD less than 5.6% and 4.3% for LA and CL measurements, respectively. The recovery rate of standard addition for LA and CL in PLCL was between 96.5%-101.5% and 98.4%-104.2%, with RSD not exceeding 2.0%, indicating the method was sufficiently accurate.
Article
Pharmacology & Pharmacy
Ekta Singh, Riyaz Ali M. Osmani, Rinti Banerjee, Amr Selim Abu Lila, Afrasim Moin, Khaled Almansour, Hany H. Arab, Hadil Faris Alotaibi, El-Sayed Khafagy
Summary: This study developed leflunomide-loaded nanoparticles as a local drug delivery system for the treatment of rheumatoid arthritis. The nanoparticles showed sustained drug release in simulated synovial fluid and demonstrated efficacy in reducing inflammation and immune responses without notable toxicity in animal models. These findings suggest that intra-articularly administered leflunomide nanoparticles could be a potential alternative to systemic drugs for the treatment of rheumatoid arthritis.
Article
Engineering, Chemical
Keziban Huner
Summary: Conductive polymers (P3ANA and PEDOT:PSS) were mixed with biocompatible and biodegradable PCL to prepare electrospun nanofibers. The nanofibers containing 10% P3ANA showed the highest antioxidant activity and were non-toxic to cells. The nanofiber with the highest amount of P3ANA also had a higher anodic current value than other P3ANA nanofibers.
POLYMER ENGINEERING AND SCIENCE
(2023)
Article
Materials Science, Textiles
Rezvan Mohamadinooripoor, Soheila Kashanian, Kobra Omidfar
Summary: Electrospun composite mats of PCL/PEE were used to fabricate PCL-PEE sutures with desirable mechanical and antibacterial properties. The sutures showed promising characteristics including sustained drug release, high tensile strength, antifungal effects, and accelerated wound healing.
FIBERS AND POLYMERS
(2023)
Article
Polymer Science
Victoria J. Barber, Meredith A. Borden, Jill W. Alty, Ly D. Tran, Hilmar Koerner, Luke A. Baldwin, Erik J. Alexanian, Frank A. Leibfarth
Summary: There is an increasing demand for degradable polymers in sustainable plastics and medical implants. To improve their usability, it is necessary to have a better understanding of degradation factors and develop new tools for modulation. In this study, poly(caprolactone) was modified through C-H xanthylation, resulting in changes in material properties and slower degradation. The interplay between molecular and materials characteristics was found to impact the degradation rate.
Article
Chemistry, Physical
Prakram Singh Chauhan, Inbal Abutbul Ionita, Hen Moshe Halamish, Alejandro Sosnik, Dganit Danino
Summary: The use of antiretroviral (ARV) cocktail therapy has revolutionized the treatment of HIV and shows promise for other infectious diseases. This study demonstrates a new encapsulation technology platform for oral delivery of fixed dose combinations, enhancing their physicochemical stability and release profiles.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2021)
Review
Biotechnology & Applied Microbiology
Areen Ashkar, Alejandro Sosnik, Maya Davidovich-Pinhas
Summary: Oral administration is a popular route for drug delivery, but it faces challenges due to the involvement of the gastro-intestinal system and drug bioavailability. Researchers have developed strategies to improve drug solubility and permeability in the intestine by using lipid-based systems. This review provides an overview of different structured edible lipid-based oral delivery systems and emphasizes their contribution to drug delivery performance.
BIOTECHNOLOGY ADVANCES
(2022)
Article
Chemistry, Multidisciplinary
Guillem Pascual-Pasto, Helena Castillo-Ecija, Nora Unceta, Rosario Aschero, Claudia Resa-Pares, Alberto Gomez-Caballero, Monica Vila-Ubach, Oscar Munoz-Aznar, Mariona Sunol, Victor Burgueno, Soledad Gomez-Gonzalez, Alejandro Sosnik, Manuel Ibarra, Paula Schaiquevich, Enrique de Alava, Oscar M. Tirado, Jaume Mora, Angel M. Carcaboso
Summary: Secreted protein acidic and rich in cysteine (SPARC) promotes the accumulation of nanoparticle albumin-bound (nab)paclitaxel in pediatric sarcomas through its high affinity to albumin.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Chemistry, Multidisciplinary
Ella Peled, Alejandro Sosnik
Summary: The study shows that drug-free nanoparticles are capable of inducing polarization of macrophages to an M2-like phenotype and accelerating wound healing. Additionally, in vitro experiments demonstrate that M2 polarization increases fibroblast migration significantly.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Pharmacology & Pharmacy
Alejandro Sosnik, Ronya Ben Shabo, Hen Moshe Halamish
Summary: This study developed mixed polymeric micelles made of chitosan and poly(vinyl alcohol) for encapsulating the anti-inflammatory cannabinoid CBD, demonstrating their potential for ocular drug delivery.
Article
Chemistry, Multidisciplinary
A. Pariente, E. Peled, I Zlotver, A. Sosnik
Summary: Sonodynamic therapy is an effective localized anticancer therapy that generates reactive oxygen species to kill cancer cells, showing potential for application in cancer treatment.
MATERIALS TODAY CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
R. A. Jimenez, D. Millan, A. Sosnik, M. R. Fontanilla
Summary: Microgels can absorb and retain a large amount of solvents, especially water, and the release kinetics of active molecules from microgels is easier to control than from hydrogels. In this study, cytocompatible collagen I microgels were produced by emulsification-gelation, and the effect of collagen I concentration and homogenization method on the properties of microgels was evaluated.
MATERIALS TODAY CHEMISTRY
(2022)
Article
Engineering, Biomedical
Daniela Dobrynin, Iryna Polishchuk, Lotan Portal, Ivan Zlotver, Alejandro Sosnik, Boaz Pokroy
Summary: The Delta and Omicron variants of SARS-CoV-2 exhibit higher adsorption capacities compared to the original strain, indicating a correlation between adsorption capacity and transmissibility. Additionally, the S1 subunit shows strongest adsorption ability at physiological pH 7.4.
MATERIALS TODAY BIO
(2022)
Article
Chemistry, Multidisciplinary
Jiri Trousil, Nils-Jorgen K. Dal, Federico Fenaroli, Inbar Schlachet, Pavia Kubickova, Olga Janouskova, Ewa Pavlova, Misa Skoric, Katerina Trejbalova, Oto Pavlis, Alejandro Sosnik
Summary: Encapsulating levofloxacin in amphiphilic polymeric nanoparticles enhances antibacterial efficacy, with potential for targeting intracellular infections.
Review
Pharmacology & Pharmacy
Rania Awad, Avi Avital, Alejandro Sosnik
Summary: Neurodegenerative diseases and neurodevelopmental disorders are challenging to treat due to the blood-brain barrier. The nose-to-brain pathway offers a promising solution, especially for intranasally administered nanoparticle drugs. Polymeric nanocarriers have shown great potential in improving drug bioavailability in the brain. This review provides an overview of the challenges faced and the contribution of intranasal nano-drug delivery systems in treating CNS conditions.
ACTA PHARMACEUTICA SINICA B
(2023)
Article
Chemistry, Physical
Hen Moshe Halamish, Ivan Zlotver, Alejandro Sosnik
Summary: In this study, self-assembled multi-micellar colloidal systems of an amphiphilic poly(vinyl alcohol)-g-poly(methyl methacrylate) copolymer surface-modified with boric acid were designed for the active targeting of solid tumors that overexpress sialic acid. The results showed that surface boration increased the permeability and uptake of the nanoparticles, and in vivo experiments confirmed a significant increase in intertumoral accumulation of the modified nanocarriers.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2022)
Article
Chemistry, Multidisciplinary
Ivan Zlotver, Alejandro Sosnik
Summary: Sonodynamic therapy (SDT) is an effective anti-cancer strategy that utilizes sono-responsive hybrid nanomaterials to generate reactive oxygen species (ROS) upon ultrasound irradiation. This study synthesized and characterized sonodynamic hybrid nanomaterials composed of titanium dioxide and an amphiphilic block copolymer, and investigated their efficiency in vitro and in vivo. The results showed that glucosylated hybrid nanoparticles exhibited significantly higher sonodynamic efficiency compared to unmodified ones. Furthermore, by controlling the nanoparticle size and surface features, the accumulation of nanoparticles in tumors was increased, resulting in prolonged animal survival and significantly reduced tumor volumes in a mouse model of rhabdomyosarcoma.
Article
Materials Science, Biomaterials
Alejandro Sosnik, Ivan Zlotver, Ella Peled
Summary: This study investigates the effect of drug-free self-assembled hydrolyzed galactomannan-poly(methyl methacrylate) nanoparticles on the activation of macrophages. Results show that the nanoparticles are cell compatible, upregulate metallothionein genes, and induce the release of anti-inflammatory cytokines by macrophages. These findings suggest the potential application of hGM-g-PMMA nanoparticles in inflammation therapy.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Article
Nanoscience & Nanotechnology
Alexandra Bukchin, Macarena Sanchez-Navarro, Adam Carrera, Claudia Resa-Pares, Helena Castillo-Ecija, Leire Balaguer-Lluna, Meritxell Teixido, Nagore G. Olaciregui, Ernest Giralt, Angel M. Carcaboso, Alejandro Sosnik
Summary: The study developed modified drug-loaded nanoparticles that can enhance transport across the blood-brain barrier and display anticancer activity in DIPG cells. These nanoparticles are mainly internalized by DIPG cells through clathrin-mediated endocytosis and show strong anticancer efficacy in vivo by killing a substantial amount of DIPG cells.
ACS APPLIED NANO MATERIALS
(2021)
Article
Pharmacology & Pharmacy
Nicole Lecot, Romina Glisoni, Natalia Oddone, Juan Benech, Marcelo Fernandez, Juan Pablo Gambini, Pablo Cabral, Alejandro Sosnik
Summary: This study investigates the potential of glycosylation to enhance the internalization of nanodrug delivery systems in breast cancer cells, showing promising results.
ADVANCED THERAPEUTICS
(2021)
