Article
Biophysics
M. R. Poorna, R. Jayakumar, Jyh-Ping Chen, Ullas Mony
Summary: Induced pluripotent stem cells (iPSCs) have great potential in regenerative medicine, and improving culture methods, such as using hydrogels as substrates, can support iPSC adhesion, proliferation, and differentiation. Using hydrogels may help generate large numbers of clinical-grade cells for potential clinical applications.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Biochemistry & Molecular Biology
Muhammad Umar Aslam Khan, Saiful Izwan Abd Razak, Sarish Rehman, Anwarul Hasan, Saima Qureshi, Goran M. Stojanovic
Summary: Bone tissue engineering is an advanced approach for treating bone fractures and defects. In this study, polymeric nano-composite scaffolds with different characteristics were prepared and characterized. The scaffolds exhibited different pore morphology and mechanical behavior, and promoted bone mineralization and cell proliferation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Review
Chemistry, Multidisciplinary
Sarah M. Hull, Lucia G. Brunel, Sarah C. Heilshorn
Summary: Using gel-phase materials as bioinks offers advantages in providing cell protection and biological signals. Challenges remain in terms of cell compatibility and biological functionality of bioink materials.
ADVANCED MATERIALS
(2022)
Article
Dentistry, Oral Surgery & Medicine
D. G. Soares, E. A. F. Bordini, E. S. Bronze-Uhle, F. B. Cassiano, I. S. P. Silva, M. O. Gallinari, H. R. Matheus, J. M. Almeida, L. T. A. Cintra, J. Hebling, C. A. de Souza Costa
Summary: This study evaluated the bioactive potential of a simvastatin (SV)-releasing chitosan-calcium-hydroxide (CH-Ca) scaffold for dentin regeneration. Results showed that the CH-Ca scaffold combined with SV could promote odontoblastic differentiation of dental pulp cells (DPCs) in vitro and in vivo, inducing overexpression of odontoblastic markers and intense mineralization. The scaffold also had a chemoattractant effect on DPCs and enhanced mineralized matrix deposition, showing promise for regenerative dentistry applications.
JOURNAL OF DENTAL RESEARCH
(2021)
Article
Chemistry, Multidisciplinary
Koichiro Hayashi, Toshiki Yanagisawa, Ryo Kishida, Kunio Ishikawa
Summary: This study investigates the effects of scaffold shape on tissue generation. The results show that even tiny protuberances on the scaffold surface can affect the percentage of interscaffold space, thereby exerting dominant effects on osteogenesis.
Article
Chemistry, Physical
Ramon Rial, Natalia Hassan, Zhen Liu, Juan M. Ruso
Summary: The study successfully produced hydrogel microparticles with different morphologies and compositions by combining experimental and computational methods, incorporating drug-doped Hydroxyapatite in their inner matrix. The use of a microfluidic system to obtain crosslinked HMPs with homogeneous sizes and morphologies, as well as the adsorption kinetics and desorption profiles of the chosen drug models, were key aspects of the research. The development of these hydrogel microparticles with improved functionalities is crucial for innovative and sustainable solutions in regenerative medicine.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Review
Engineering, Biomedical
Kamil Elkhoury, Margaretha Morsink, Laura Sanchez-Gonzalez, Cyril Kahn, Ali Tamayol, Elmira Arab-Tehrany
Summary: Natural hydrogels are highlighted as promising biomaterials in tissue engineering applications due to their biocompatibility and biodegradability. Innovative biofabrication techniques, such as textile techniques and 3D bioprinting, play a significant role in developing advanced scaffolds for tissue engineering. This review also discusses the emerging applications of biofabricated natural hydrogels in cardiac, neural, and bone tissue engineering.
BIOACTIVE MATERIALS
(2021)
Review
Engineering, Biomedical
Chaojie Yu, Fanglian Yao, Junjie Li
Summary: Recently, injectable conducting polymer-based hydrogels have gained attention in tissue engineering due to their controlled conductivity and minimally invasive procedures. Functional CPs play a crucial role in designing these hydrogels and have potential applications in neurological treatment, myocardial repair, and skeletal muscle regeneration.
ACTA BIOMATERIALIA
(2022)
Review
Biotechnology & Applied Microbiology
Fatemeh Dadkhah Tehrani, Arezoo Firouzeh, Iman Shabani, Azadeh Shabani
Summary: The amniotic membrane, as the innermost layer of the fetal placenta, has unique properties that make it valuable in regenerative medicine applications. Beyond sterilization and preservation, additional modifications are being explored to enhance its properties and durability, presenting a new area of study in its applications.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Review
Pharmacology & Pharmacy
Zhen Wang, Yichuan Wang, Jiaqi Yan, Keshi Zhang, Feng Lin, Lei Xiang, Lianfu Deng, Zhenpeng Guan, Wenguo Cui, Hongbo Zhang
Summary: Bone regenerative engineering encompasses scaffold design and applications based on electrospinning and 3D bioprinting technologies, aiming to achieve bone tissue regeneration. Electrospun nanofibrous scaffolds and 3D bioprinted scaffolds play crucial roles in bone regeneration, with promising prospects for future development.
ADVANCED DRUG DELIVERY REVIEWS
(2021)
Review
Chemistry, Medicinal
Kavitha Ganesan Nathan, Krishnamurithy Genasan, Tunku Kamarul
Summary: Tissue engineering and regenerative medicine (TERM) offers hope for innovative therapies and relies on various strategies. The development of a scaffold, specifically the Polyvinyl alcohol-chitosan (PVA-CS) scaffold, has shown promise in supporting cell growth and tissue regeneration. It can be tailored to fit different tissues and organs and can be combined with other materials and technologies to enhance its regenerative capabilities. This review summarizes the potential role and functions of PVA-CS in TERM applications.
Article
Green & Sustainable Science & Technology
Mano Govindharaj, Noura Sayed Al Hashemi, Soja Saghar Soman, Sanjairaj Vijayavenkataraman
Summary: This study successfully identified an environmentally destructive tunicate species and proposed sustainable utilization of tunicate tunics as wound-dressing materials, decellularized extracellular matrix (dECM) scaffolds, and bioinks. The tunics showed excellent biocompatibility and tensile modulus. The findings of this work contribute to the preservation of marine ecosystems and the reduction of costs associated with tunicate management.
JOURNAL OF CLEANER PRODUCTION
(2022)
Review
Chemistry, Multidisciplinary
Hyeongtaek Park, Seoyeon Kim, Soojin Kim, Minbae Kim, Yoonjoo Kang, Sivashanmugam Amirthalingam, Subeen Lee, Nathaniel S. Hwang, Kisuk Yang, Hwan D. Kim
Summary: MXene has gained significant attention as a new type of two-dimensional material. It has shown potential applications in catalysts, sensors, energy conversion, and electrochemical storage capacitors. MXene also exhibits biological properties, such as reactive oxygen species induction, photothermal conversion, and antibacterial activity. This review explores MXene synthesis methods, discusses its biological characteristics, and investigates its utilization in tissue engineering.
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
(2023)
Review
Pharmacology & Pharmacy
Mohammad Samiei, Marziyeh Fathi, Jaleh Barar, Nazanin Fathi, Nazanin Amiryaghoubi, Yadollah Omidi
Summary: Regenerative medicine is a promising and rapidly growing field that aims to develop new functional tissues to treat defective cells/tissues and achieve precision medicine. To achieve optimal clinical outcomes, efficient and safe delivery of cell-based medicines to damaged areas is essential.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Danni Gong, Fei Yu, Meng Zhou, Wei Dong, Dan Yan, Siyi Zhang, Yan Yan, Huijing Wang, Yao Tan, Ying Chen, Bei Feng, Wei Fu, Yao Fu, Yang Lu
Summary: dcECM hydrogels derived from porcine ears through enzymatic digestion show good biocompatibility for delivering chondrocytes and forming subcutaneous cartilage in vivo. The structural and gelation kinetics of the hydrogels vary with ECM concentrations, with 10 mg/ml hydrogels supporting adhesion and proliferation of chondrocytes in vitro. In vivo, 10 mg/ml dcECM hydrogel grafts exhibit similar qualities to native cartilage, indicating their potential for tissue engineering applications in ear cartilage regeneration.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Materials Science, Multidisciplinary
Yon Jin Chuah, Yingnan Wu, Mei Ling Shirlynn Cheong, Yan Qing Chia, Ching Ann Tee, Hwan Tak Hee, Chenjie Xu, Yuejun Kang, Dong-An Wang
Summary: The study demonstrated the potential of utilizing coiled hydrogel microfibers to create an engineered tissue model that mimics the structure of native annulus fibrosus (AF) for investigating mesenchymal stem cells (MSCs) in AF tissue engineering. Ascorbic acid (AA)-induced MSCs exhibited increased AF-associated biomarkers and encouraged collagen accumulation in the engineered AF tissue model, suggesting their potential as a cell source for AF tissue engineering.
JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
(2021)
Review
Cell & Tissue Engineering
Min Jin, Junli Shi, Wenzhen Zhu, Hang Yao, Dong-An Wang
Summary: Polysaccharides are considered promising biomaterials for tissue engineering due to their significant bioactivities, natural abundance, immunoactivity, and chemical modifiability. They have unique biological properties compared to synthetic materials and have garnered attention in academia and industry. By modifying functional groups on the surface of polysaccharide molecules, remarkable mechanical properties and tunable tissue response can be achieved.
TISSUE ENGINEERING PART B-REVIEWS
(2021)
Review
Materials Science, Biomaterials
Zuoxiang Dong, Xinyue Meng, Wei Yang, Jinfeng Zhang, Peng Sun, Huawei Zhang, Xing Fang, Dong-An Wang, Changjiang Fan
Summary: Gelatin-based microspheres (GMSs) have attractive features such as biocompatibility, biodegradability, and ease of manipulation. In recent years, they have been used as sustained delivery vehicles of drugs, cell carriers, and 3D scaffold components in tissue engineering, showing promising potentials.
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2021)
Review
Engineering, Biomedical
Chao Tao, Dong-An Wang
Summary: Advances in tissue engineering have moved beyond reconstructing individual tissues or organs and are now focusing on engineering systemic factors like immune objects and functions. Engineered immune tissues and organs show promise in restoring immune system dysfunctions and aplasia, while also aiming to evade immune-mediated inflammatory responses and rejection elicited by engineered implants.
ADVANCED HEALTHCARE MATERIALS
(2021)
Review
Engineering, Biomedical
Kang Sun, Chao Tao, Dong-An Wang
Summary: Tissue engineered cartilaginous constructs have made significant advances in the past decades as a treatment for osteoarthritis. Scaffold-free constructs, which involve only cells and cell-derived matrix, have several advantages over scaffold-based constructs in terms of relying on cells to produce matrix, avoiding interference with cell signaling and introducing no exogenous impurities.
BIOMEDICAL MATERIALS
(2022)
Review
Materials Science, Biomaterials
Bangheng Liu, Chao Tao, Zhonglian Wu, Hang Yao, Dong-An Wang
Summary: This article reviews three main resource categories involved in haematopoietic stem cell niche engineering: the construction of bionic cell culture environments using cytokines, nurse cells or extracellular matrix; the application of microscale technologies to mimic the properties of natural stem cell niches; and the use of biomaterials to construct three-dimensional extracellular matrix-like culture environments.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
Article
Engineering, Biomedical
Peiyan Wang, Xinyue Meng, Runze Wang, Wei Yang, Lanting Yang, Jianxun Wang, Dong-An Wang, Changjiang Fan
Summary: This study explores the use of chemically cross-linked gelatin microsphere aggregates (C-GMSs) scaffolds for vascularized bone reconstruction. The scaffolds enhance focal adhesion, proliferation, and function of functional cells by optimizing cell-material interfaces. In vitro and in vivo experiments confirm the efficacy of C-GMSs scaffolds in inducing angiogenesis and osteogenesis, as well as promoting integration with host bone.
ADVANCED HEALTHCARE MATERIALS
(2022)
Article
Engineering, Biomedical
Guoqing Wang, Xinyue Meng, Peiyan Wang, Xinping Wang, Gaoli Liu, Dong-An Wang, Changjiang Fan
Summary: A new robust hemostatic bioadhesive has been developed, which can rapidly and strongly gel on wet tissues, achieving rapid hemostasis and promoting wound healing.
Article
Engineering, Biomedical
Min Jin, Chao Tao, Xu Hu, Bangheng Liu, Cheng Ma, Zhonglian Wu, Hang Yao, Dong-An Wang
Summary: Due to safety concerns and poor underwater adhesion, current bioadhesives are not suitable for in vivo physiological environments and diverse medical uses. In this study, a novel bioadhesive, PcC, is developed based on electrostatic and hydrophobic interactions, using catechin as an adhesion provider. PcC demonstrates superior underwater adhesion on cartilage in mechanical tests and shows potential in various medical applications such as closing surgical incisions and reducing seroma formation.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Engineering, Biomedical
Hang Yao, Ming Wu, Liwei Lin, Zhonglian Wu, Minjun Bae, Sumin Park, Shuli Wang, Wang Zhang, Jiefeng Gao, Dongan Wang, Yuanzhe Piao
Summary: The wound healing process is often hindered by bacterial infections, leading to impaired healing. The use of adhesive hydrogels with natural antibacterial agents as wound dressings has been recognized as an effective treatment. This review summarizes studies on ingredients, preparation methods, antibacterial mechanisms, and internal factors of adhesive hydrogels, providing insights and prospects for their biomedical applications and clinical research.
MATERIALS TODAY BIO
(2022)
Article
Engineering, Biomedical
Bangheng Liu, Min Jin, Dong-An Wang
Summary: A porous alginate hydrogel-based 3D culture system is effective in maintaining the phenotype and renewability of hematopoietic stem cells (HSCs). It outperforms traditional suspension or non-porous alginate hydrogel culture in terms of HSC expansion efficiency.
ACTA BIOMATERIALIA
(2023)
Editorial Material
Engineering, Biomedical
Kang Sun, Bangheng Liu, Dong-An Wang
Summary: Traditional joint replacement surgery carries risks of trauma and revision, while medication may cause undesirable side effects. Medical research has focused on minimally invasive tissue-engineered scaffolds for cartilage repair. Challenges include cell seeding, scaffold construction, mechanical properties, and regulating the transplant environment. This issue explores cartilage repair development, cutting-edge discoveries, manufacturing technologies, and current technological queries in regenerative medicine.
BIOMEDICAL MATERIALS
(2023)
Article
Cell & Tissue Engineering
Zhen Zhang, Yulei Mu, Huiqun Zhou, Hang Yao, Dong-An Wang
Summary: This review focuses on the advances in cartilage tissue engineering, particularly in preclinical trials and clinical applications, prospects, and challenges. Articular cartilage defects significantly impact the global population's quality of life. Despite various strategies for repair, the therapeutic effects remain suboptimal. However, with the development of cartilage tissue engineering, scientists have made progress in therapeutic cells, biomaterial-based scaffolds, and biological factors, providing new possibilities for better cartilage lesion treatment.
TISSUE ENGINEERING PART B-REVIEWS
(2023)
Article
Engineering, Biomedical
Meng Ma, Jun Gu, Dong-An Wang, Siwei Bi, Ruiqi Liu, Xiaosheng Zhang, Jing Yang, Yi Zhang
Summary: In this paper, various 3D printing technologies commonly used in the biomedical field are briefly introduced, with a focus on their application in aging research and aging care. The aging-related health conditions of the nervous system, musculoskeletal system, cardiovascular system, and digestive system are closely examined in relation to the application of 3D printing, including the creation of in vitro models and implants, production of drugs and drug delivery systems, and fabrication of rehabilitation and assistive medical devices. The opportunities, challenges, and prospects of 3D printing in the field of aging are discussed.
INTERNATIONAL JOURNAL OF BIOPRINTING
(2023)
Article
Chemistry, Multidisciplinary
Min Jin, Bangheng Liu, Zhen Zhang, Yulei Mu, Liang Ma, Hang Yao, Dong-An Wang
Summary: This study develops a nano-scaled micellar composite composed of catechin-functionalized cationic lipopolymer and serum albumin, which improves the bioavailability of catechins by enhancing intracellular delivery. The nano-micellar complexes exhibit anti-tumor properties and the potential for lung disease treatment. The combination of cationic liposomes with catechins creates a tissue-targeted and biologically active delivery system.
ADVANCED MATERIALS
(2023)
