Article
Agriculture, Dairy & Animal Science
Dagmar S. Trachsel, Hannah J. Stage, Sebastian Rausch, Susanne Trappe, Katharina Sollig, Gerhard Sponder, Roswitha Merle, Jorg R. Aschenbach, Heidrun Gehlen
Summary: This study explores the potential of adipose tissue-derived stem cells in the differentiation into heart cells in horses. By comparing different isolation methods from various adipose tissue sources, it was found that abdominal adipose tissue is suitable for isolating equine stem cells. However, unlike in other species, equine stem cells showed resistance to the induction of heart cell differentiation.
Article
Biochemistry & Molecular Biology
Parastoo Tambrchi, Amir Hossein Mahdavi, Morteza DaliriJoupari, Leila Soltani
Summary: This study developed a novel synthetic scaffold combining polycaprolactone (PCL) and polylactic acid (PLA) for cardiomyocyte differentiation of adipose-derived mesenchymal stem cells (Ad-MSCs). The scaffold supplemented with both 5-azacytidine and transforming growth factor-beta (TGF-beta) showed the most efficient differentiation of Ad-MSCs into cardiomyocytes.
CELL BIOCHEMISTRY AND FUNCTION
(2022)
Article
Materials Science, Multidisciplinary
Danli Zhu, Wanting Bao, Boxuan Wei, Hao Wei, Jinwu Wang, Guangdong Zhou, Xiansong Wang, Shanyu Guo
Summary: In this study, a strategy for the construction of vascularized tissue-engineered adipose tissue was proposed. By integrating a gas-foamed method (soil) and three-dimensional cell spheroids (seeds), adipose tissue regeneration was achieved. The prepared soil significantly enhanced the vascularization of the regenerated tissue, while optimizing the seed cells promoted adipogenesis. This study provides a solution for the regeneration of vascularized adipose tissue and establishes a general research model for the reconstruction of breast defects.
APPLIED MATERIALS TODAY
(2023)
Article
Biochemistry & Molecular Biology
Alvaro Yogi, Marina Rukhlova, Claudie Charlebois, Ganghong Tian, Danica B. Stanimirovic, Maria J. Moreno
Summary: The study found that VSMCs differentiated from adipose-derived stem cells (ASCs) show potential for populating PET-based vascular scaffolds. By shortening the differentiation period and studying the role of downstream effectors of TGF-beta, the process was stabilized. The non-woven PET structure did not affect ASC differentiation, providing a novel alternative to address issues with long-term patency of vascular grafts.
Article
Nanoscience & Nanotechnology
Natsumi Ueda, Shiho Sawada, Fumiya Yuasa, Karen Kato, Koji Nagahama
Summary: This study reports an injectable covalent stem cell-combining biohybrid material for in vivo tissue engineering, which can achieve controlled differentiation and integration with host tissues. By incorporating specific modified stem cells and alginate polymers in a cross-linking agent, the mechanical properties of the material can be adjusted. Experimental results in a mouse muscle defect model demonstrate that this covalent material treatment can effectively promote tissue regeneration with better outcomes compared to control materials.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Multidisciplinary Sciences
Evdokiia Potolitsyna, Sarah Hazell Pickering, Thomas Germier, Philippe Collas, Nolwenn Briand
Summary: HOTAIR plays important regulatory roles in adipogenesis, influencing protein synthesis pathways and cytoskeleton remodeling, which subsequently impact the lipid storage capacity of mature adipocytes.
SCIENTIFIC REPORTS
(2022)
Review
Materials Science, Multidisciplinary
Miaomiao Zhang, Shixin Xu, Ruoying Wang, Yongan Che, Cuicui Han, Wei Feng, Chengwei Wang, Wen Zhao
Summary: Electrospun nanofiber/hydrogel composites have gained significant attention due to their combination of excellent biochemical properties of hydrogel with the biomimetic nature of electrospun fibers. These composites, with tunable mechanical properties, can mimic the microstructure of extracellular matrix (ECM) and microenvironment of cells, making them advantageous for tissue repair. However, a comprehensive review on their application as tissue engineering scaffolds is lacking. This article systematically reviews the preparation and application of electrospun fiber/hydrogel composites in tissue engineering, providing insights for future research directions.
JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
(2023)
Article
Materials Science, Characterization & Testing
Maria Herrero-Herrero, Sara Alberdi-Torres, Maria Luisa Gonzalez-Fernandez, Guillermo Vilarino-Feltrer, Jose Carlos Rodriguez-Hernandez, Ana Valles-Lluch, Vega Villar-Suarez
Summary: This study evaluated the behavior of adipose tissue-derived mesenchymal stem cells cultured on different biomaterials manufactured by electrospinning. The results showed that cellular response was significantly better on PCL compared to other materials, and PCL/PCL blends did not surpass the characteristics of PCL. Interestingly, ASCs were able to differentiate into chondrocytes without the addition of specific chondrogenic media in all three biomaterials tested.
Article
Biochemistry & Molecular Biology
Priyadharshni Muniyandi, Vivekanandan Palaninathan, Tatsuro Hanajiri, Toru Maekawa
Summary: This study demonstrates that co-delivery of 5' AZA and miR-133a nanoformulation can induce direct reprogramming of cardiac fibroblasts to cardiomyocyte-like cells in-vitro, while also highlighting the influence of miR-133a and 5' AZA as epigenetic regulators in determining cell fate.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Zhengkai Lu, Zhen Jiang, Juan Tang, Chao-Po Lin, Hui Zhang
Summary: Cardiac adipose tissue can modulate cardiovascular functions, but abnormal deposition of adipose tissue can contribute to the development of heart diseases. Accumulation of triglyceride droplets in cardiac cells may lead to cardiomyocyte injury and cardiac hypertrophy.
Review
Polymer Science
Xuan Yan, Haiyan Yao, Jun Luo, Zhihua Li, Junchao Wei
Summary: This review introduces bone-tissue engineering and the use of electrospun nanofibers as scaffolds. The unique characteristics of electrospun nanofibers, such as their similarity with the extracellular matrix, larger surface areas, porosity, and processability, make them ideal candidates for bone-tissue engineering. The review highlights the functionalization of electrospun nanofibers to enhance bone regeneration and addresses the existing deficiencies in promoting osteogenesis.
Article
Multidisciplinary Sciences
Yuki Komatsu, Kiyoshi Aoyama, Mamoru Yoneda, Shogo Ito, Yusuke Sano, Yumeno Kawai, Xixi Cui, Yuichiro Yamada, Nozomi Furukawa, Katsuhide Ikeda, Kohzo Nagata
Summary: The removal of interscapular brown adipose tissue (iBAT) attenuated the exacerbation of cardiac inflammation and fibrosis induced by salt loading in DS/obese rats, but did not affect the development of hypertension. Salt loading led to adipocyte hypertrophy and increased inflammation in white adipose tissue, while the conversion of iBAT to white adipose tissue-like tissue contributed to elevated levels of circulating interleukin-6, exacerbating cardiac pathology.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2021)
Review
Cell Biology
Maria Elena Soto, Israel Perez-Torres, Maria Esther Rubio-Ruiz, Linaloe Manzano-Pech, Veronica Guarner-Lans
Summary: Cardiac cachexia is a condition caused by congestive heart failure, resulting in muscle degradation and increased morbidity. It is characterized by an imbalance between protein synthesis and degradation or intestinal malabsorption. In contrast, fat accumulation in the heart is protective in this condition. This review explores the relationship between heart failure and cardiac cachexia, highlighting the role of cardiac obesity as a protective factor. The review also discusses possible screening methods and various therapeutic approaches, although there is currently no cure for cachexia.
Article
Polymer Science
Miguel A. Jimenez-Beltran, Alan J. Gomez-Calderon, Rafael E. Quintanar-Zuniga, Daniel Santillan-Cortez, Mario A. Tellez-Gonzalez, Juan A. Suarez-Cuenca, Silvia Garcia, Paul Mondragon-Teran
Summary: The extracellular matrix is important for maintaining normal organ function. Tissue engineering and regenerative medicine can produce constructs resembling the native extracellular matrix to support organ restoration. This study found that electrospinning can optimize the structural characteristics of nanofiber scaffolds, making them suitable for integrating and proliferating human endothelial progenitor cells.
Article
Biochemistry & Molecular Biology
Nukhba Akbar, Hira Anum, Syeda Saima Razzaq, Asmat Salim, Shumaila Usman, Kanwal Haneef
Summary: This study aims to examine the synergistic effects of epigenetic modifiers and cardiomyogenic molecules in the cardiac differentiation of BM-MSCs. The results show that the combination of epigenetic modifiers VPA or 5-aza with AA and SA significantly upregulates the expression of cardiac genes and proteins. These findings suggest that the pretreatment strategy of VPA and 5-aza with AA and SA can be used for designing stem cell-based therapeutic strategies for cardiovascular diseases.
MOLECULAR BIOLOGY REPORTS
(2023)
Article
Public, Environmental & Occupational Health
Sara Hanaei, Amirhossein Takian, Reza Majdzadeh, Christopher Ryan Maboloc, Igor Grossmann, Orlando Gomes, Milos Milosevic, Manoj Gupta, Alireza A. Shamshirsaz, Amine Harbi, Amer M. Burhan, Lucina Q. Uddin, Arutha Kulasinghe, Chi-Ming Lam, Seeram Ramakrishna, Abass Alavi, Jan L. Nouwen, Tommaso Dorigo, Michael Schreiber, Ajith Abraham, Natalya Shelkovaya, Wojtek Krysztofiak, Majid Ebrahimi Warkiani, Frank Sellke, Shuji Ogino, Francisco J. Barba, Serge Brand, Clara Vasconcelos, Deepak B. Salunke, Nima Rezaei
Summary: The COVID-19 pandemic has had a significant impact on human life, leading to the postponement, cancellation, or virtualization of activities that require gatherings. While virtual settings offer increased inclusivity and accessibility and reduce carbon emissions, they cannot fully replace in-person scientific events. In-person meetings allow for socialization, collaboration, and idea sharing, providing novel opportunities. A hybrid model that combines in-person and virtual components may be a solution, allowing participants to choose their preferred mode of participation.
DISASTER MEDICINE AND PUBLIC HEALTH PREPAREDNESS
(2022)
Review
Anatomy & Morphology
Sairish Malik, Subramanian Sundarrajan, Tanveer Hussain, Ahsan Nazir, Seeram Ramakrishna
Summary: Research on nanomaterials has led to the exploitation of their potential applications, with electrospinning being particularly noteworthy for its ability to synthesize novel nanostructures. Among these, polymers, especially block copolymers, are extensively studied due to their unique properties and behavior when varying composition ratio and molecular weight, making them suitable for a wide range of applications.
CELLS TISSUES ORGANS
(2022)
Article
Green & Sustainable Science & Technology
Piya Kerdlap, Aloisius Rabata Purnama, Jonathan Sze Choong Low, Daren Zong Loong Tan, Claire Y. Barlow, Seeram Ramakrishna
Summary: The study compares the environmental performance of distributed and centralized sorting and recycling of plastic bottles and takeaway containers in Singapore, finding that distributed scenarios have higher environmental impacts in terms of climate change, water depletion, and terrestrial ecotoxicity by 7-30% compared to centralized scenarios.
JOURNAL OF INDUSTRIAL ECOLOGY
(2022)
Review
Materials Science, Ceramics
Elahe Bahremandi-Toloue, Zahra Mohammadalizadeh, Shayanti Mukherjee, Saeed Karbasi
Summary: Today, the integration of medical and engineering principles in producing biological replacements has become a hot topic. Tissue engineering utilizes the electrospinning method to create scaffolds, with the addition of ceramics to enhance their mechanical properties and biological behavior, as well as induce other effects such as improved hydrophilicity, antibacterial and antioxidant properties.
CERAMICS INTERNATIONAL
(2022)
Review
Biotechnology & Applied Microbiology
Raj Kumar, Keshaw Ram Aadil, Kunal Mondal, Yogendra Kumar Mishra, David Oupicky, Seeram Ramakrishna, Ajeet Kaushik
Summary: Neurodegenerative disorders are prevalent among the aging population, causing memory loss and motor coordination issues, leading to significant socio-economic burdens. Nano-biotechnology-based approaches offer effective and personalized alternatives for managing these diseases.
CRITICAL REVIEWS IN BIOTECHNOLOGY
(2022)
Review
Biotechnology & Applied Microbiology
Pavni Rekhi, Moushmi Goswami, Seeram Ramakrishna, Mousumi Debnath
Summary: Polymers are essential in modern living, but those with a large carbon footprint are increasingly seen as harmful to the environment. Polyhydroxyalkanoate (PHA) is regarded as a potential alternative derived from microbial biopolymer. PHA shows promise for various applications, particularly in the medical sector due to its biodegradability and biocompatibility.
CRITICAL REVIEWS IN BIOTECHNOLOGY
(2022)
Article
Chemistry, Physical
Hossein Sharifi, Behrooz Mosallanejad, Mohammadkhalil Mohammadzad, Seyed Morteza Hosseini-Hosseinabad, Seeram Ramakrishna
Summary: The study found that cycling-induced aging at different C-rates significantly impacts the performance of LiFePO4/graphite full cells, especially at relatively high current rates where the formation of an active lithium ion-impermeable covering layer on the anode surface leads to electrode performance degradation. This degradation is mainly attributed to the instability of the electrode/electrolyte interface and the solid electrolyte interphase (SEI) layer, causing the loss of active lithium ions and ultimately resulting in electrode deactivation.
Article
Polymer Science
Lakshmanan Muthulakshmi, A. Varada Rajulu, Seeram Ramakrishna, Sabu Thomas, Catalin I. Pruncu
Summary: This study utilized proteins to prepare biodegradable films with the addition of plasticizers and cross-linking agents, ultimately forming biocomposite films. These films have good biodegradable properties and can be used for food packaging applications.
JOURNAL OF APPLIED POLYMER SCIENCE
(2022)
Article
Biotechnology & Applied Microbiology
Hadi Rouhani, Fatola Farhadi, Mahsa Akbari Kenari, Seeram Ramakrishna
Summary: By optimizing the temperature range for clay treatment, the study achieved a longer service life for the clay and introduced a new process arrangement that significantly reduced operational costs in industrial production.
JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY
(2022)
Article
Engineering, Biomedical
Shayanti Mukherjee, Smriti Sharma, Vivek Soni, Amruta Joshi, Amit Gaikwad, Jayesh Bellare, Jyoti Kode
Summary: In this study, a composite coating of ceramic apatite-wollastonite (AW) and polymer chitosan was synthesized by electrophoretic deposition on titanium implants. The coated substrates showed significant positive effects on cell proliferation, growth, and mineralization compared to uncoated titanium samples. The coating was non-toxic to cells and enhanced cell adhesion and protein production.
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
(2022)
Article
Nanoscience & Nanotechnology
Heng-Shu Guan, Wei-Zhi Song, Lin-Peng Huang, Zhong Liu, Jun Zhang, Seeram Ramakrishna, Yun-Ze Long
Summary: Biofuel cell is a technology that converts renewable energy into electricity using biological enzymes. Researchers have successfully developed a biofuel cell based on a polyaniline/thermoplastic polyurethane fiber membrane, which can stably output voltage in simulated blood, showing potential applications in implantable devices and blood glucose monitoring.
Article
Chemistry, Multidisciplinary
Jyoti Kode, Jitendra Maharana, Asif Amin Dar, Shayanti Mukherjee, Nikhil Gadewal, Dilep Kumar Sigalapalli, Satyanshu Kumar, Debashis Panda, Soumyajit Ghosh, Supriya Suman Keshry, Prabhudutta Mamidi, Soma Chattopadhyay, Trupti Pradhan, Vaishali Kailaje, Sunil Inamdar, Vidula Gujjarwar
Summary: Recent global health concern has led to the investigation of natural medicinal plant resources as alternative treatments for COVID-19 infection and inflammation. In this study, a phytochemical called 6-shogaol was explored as a potential anti-inflammatory and anti-COVID-19 agent. 6-shogaol was found to efficiently inhibit SARS-CoV2 replication and regulate the expression of inflammasome pathway molecules. Compared to existing drugs, 6-shogaol demonstrated similar efficacy and better safety in terms of physicochemical properties and clinical toxicity. This study provides important insights for the further development of 6-shogaol as a potential therapeutic agent against inflammation and viral infections.
Review
Chemistry, Analytical
Xue Pan, Lu Bai, Chengcheng Pan, Zhicheng Liu, Seeram Ramakrishna
Summary: This review discusses the fabrication methods and applications of SERS substrates based on electrospun nanofibers, and highlights the challenges and prospects.
CRITICAL REVIEWS IN ANALYTICAL CHEMISTRY
(2023)
Review
Engineering, Multidisciplinary
Ashwini Vasudevan, Dinesh M. Tripathi, Subramanian Sundarrajan, Jayarama Reddy Venugopal, Seeram Ramakrishna, Savneet Kaur
Summary: The major goal of liver tissue engineering is to reproduce the phenotype and functions of liver cells. Nanofibrous scaffolds, produced using techniques such as electrospinning, have been widely used due to their resemblance with the native tissue extracellular matrix environment. Synthetic and natural electrospun polymers, as well as liver extracellular matrix, are utilized in the fabrication of these scaffolds, along with novel strategies such as galactosylation and matrix protein incorporation.
Review
Engineering, Biomedical
Masoud Sarraf, Erfan Rezvani Ghomi, Saeid Alipour, Seeram Ramakrishna, Nazatul Liana Sukiman
Summary: Commercially pure titanium and titanium alloys are widely used in biomedical applications due to their excellent mechanical properties, corrosion resistance, biocompatibility, and antibacterial properties. Future research will focus on advanced manufacturing technologies, effects of alloying elements on biocompatibility, and the role of titanium in regenerative and nanomedicine applications.
BIO-DESIGN AND MANUFACTURING
(2022)
