Article
Chemistry, Multidisciplinary
Yan Zhu, Qianhui Wei, Qingxi Jin, Gangrong Li, Qingzhu Zhang, Han Xiao, Tengfei Li, Feng Wei, Yingchun Luo
Summary: In this paper, a simple mixed-catalyzer layer modified silicon nanowire field-effect transistor biosensor was proposed, which enabled direct detection of glucose with low-charge in high ionic strength solutions. The biosensor showed high sensitivity, strong specificity, and fast real-time response.
Article
Chemistry, Physical
Himanshu Bharadwaj, Naveen Kumar, S. Intekhab Amin, Sunny Anand
Summary: The study simulates a device called Dopingless Vertical Nanowire Tunnel Field Effect Transistor as a biosensor using Charge Plasma for general doping. It explores the sensitivity of the biosensor to different biomolecules and finds that a larger dielectric constant leads to better performance.
Article
Biophysics
Dujuan Li, Huiyi Chen, Kai Fan, Vladimir Labunov, Serguei Lazarouk, Xiaojie Yue, Chaoran Liu, Xun Yang, Linxi Dong, Gaofeng Wang
Summary: The FET biosensor based on uniform high-response silicon nanowire array studied in this research shows significant superiority in real-time, label-free, super-sensitive detection of PIK3CA E542K ctDNA, achieving ultralow detection limit of 10 aM and high selectivity in recognizing complementary target ctDNA. The biosensor also demonstrated potential for clinical applications by successfully detecting target ctDNA in human serum samples.
BIOSENSORS & BIOELECTRONICS
(2021)
Article
Biophysics
Cao-An Vu, Hsin-Ying Lai, Chia-Yu Chang, Hardy Wai-Hong Chan, Wen-Yih Chen
Summary: MicroRNA sensing is crucial for diagnosing diseases, especially cancers, and a novel technique using modified silicon nanowire field-effect transistors (SiNWFETs) with two-component mixed self-assembled monolayers (mSAMs) has been developed for miRNA-21 detection, showing high sensitivity and selectivity. The approach has the potential to revolutionize nucleic acid testing for disease diagnosis.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Review
Chemistry, Analytical
Marcel Tintelott, Vivek Pachauri, Sven Ingebrandt, Xuan Thang Vu
Summary: SiNW-FET sensors have been developed as highly sensitive detectors for a variety of molecules due to their exceptional electrical properties. The bottom-up approach allows for the synthesis of silicon nanowires in a range of diameters, while the top-down approach utilizes advanced lithography techniques to fabricate SiNW out of high-quality SOI wafers. Despite the advancements in fabrication techniques, sensor-to-sensor variation remains a challenge for large-scale production in commercial applications.
Article
Materials Science, Multidisciplinary
Jianqiang Guo, Jingjing Tan, Ning Dou, Thangavel Lakshmipriya, Subash C. B. Gopinath
Summary: Abdominal aortic aneurysm (AAA) is a bulge in the abdominal aorta with potentially fatal consequences. Detection of MMP-9 levels can help identify the condition of AAA, and this research focused on enhancing MMP-9 detection on an IDE sensing system.
APPLIED PHYSICS A-MATERIALS SCIENCE & PROCESSING
(2021)
Article
Chemistry, Analytical
Jiawei Hu, Yinglu Li, Xufang Zhang, Yanrong Wang, Jing Zhang, Jiang Yan, Junjie Li, Zhaohao Zhang, Huaxiang Yin, Qianhui Wei, Qifeng Jiang, Shuhua Wei, Qingzhu Zhang
Summary: A biosensor based on a silicon nanowire field-effect transistor (SiNW FET) was developed for the quantitative detection of Cys-C. By optimizing the sensor's sensitivity and specificity, it achieved a lower limit of detection (LOD) of 0.25 ag/mL and demonstrated a good linear correlation in the concentration range of 1 ag/mL to 10 pg/mL. This holds great potential for early detection and prevention of acute kidney injury.
Article
Nanoscience & Nanotechnology
Hui Zhang, Yawei Qiu, Fumiya Osawa, Meiko Itabashi, Noriyasu Ohshima, Taira Kajisa, Toshiya Sakata, Takashi Izumi, Hayato Sone
Summary: In this study, SiNW biosensors with different widths were designed and fabricated to investigate the critical effect of 10-nm-scaled SiNW width on detection sensitivity. The detection limit and depletion region changes were calculated by detecting various concentrations of anti-ovalbumin immunoglobulin G (IgG). The results showed that the proportion of the depletion region over the entire SiNW channel is the essential reason for high-sensitivity detection. Therefore, this study is crucial for maximizing the sensitivity of SiNW biosensors.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Multidisciplinary
Xiaopan Song, Ting Zhang, Lei Wu, Ruijin Hu, Wentao Qian, Zongguang Liu, Junzhuan Wang, Yi Shi, Jun Xu, Kunji Chen, Linwei Yu
Summary: This research demonstrates a fabrication method for large-area stretchable electronics using silicon nanowire field effect transistors (SiNW-FETs). By utilizing the solid-liquid-solid mechanism, SiNW channels can be precisely grown onto elastomers and transferred onto large-area substrates. The SiNW-FETs exhibit high performance and stability, making them promising for future flexible display and wearable electronic applications.
Article
Chemistry, Multidisciplinary
Siti Fatimah Abd Rahman, Nor Azah Yusof, Mohd Khairuddin Md Arshad, Uda Hashim, Mohammad Nuzaihan Md Nor, Mohd Nizar Hamidon
Summary: A highly sensitive silicon nanowire-based sensor device was developed using electron beam lithography integrated with CMOS technology. The device showed good alignment and linearity for pH sensing, and could also be used for detecting specific ssDNA molecules.
Article
Physics, Applied
Katsuhiko Nishiguchi, Hiroshi Yamaguchi, Akira Fujiwara, Herre S. J. van der Zant, Gary A. Steele
Summary: We have demonstrated charge detection with single-electron resolution at high readout frequency using a silicon field-effect transistor integrated with double resonant circuits. The transistor, with a channel width of 10 nm, can detect a single electron at room temperature. The transistor is connected to resonant circuits composed of coupled inductors and capacitors, providing two resonance frequencies. By driving the transistor with a carrier signal at the lower resonance frequency, a small signal applied to the transistor's gate modulates the resonance condition, resulting in a reflected signal appearing near the higher resonance frequency. This operation allows for charge detection with a single-electron resolution of 3 x 10(-3) e/Hz(0.5) and a readout frequency of 200 MHz at room temperature.
APPLIED PHYSICS LETTERS
(2023)
Article
Materials Science, Multidisciplinary
Qiao Li, Shanyong Chen, Hong Yu, Jinlei Chen, Xingwu Yan, Lu Li, Maowen Xu
Summary: In this study, a tunneling-current junction welding strategy is proposed to preserve the polymer shell material and overcome its conductivity limit, demonstrating effective welding of Ag@PVP nanowire film. The results show that the Ag@PVP film exhibits good stability and high opto-electrical performance, indicating that the polymer shell greatly improves the stability of AgNW without compromising its opto-electrical performance.
JOURNAL OF MATERIALS CHEMISTRY C
(2021)
Article
Chemistry, Analytical
Cao-An Vu, Pin-Hsien Pan, Yuh-Shyong Yang, Hardy Wai-Hong Chan, Yoichi Kumada, Wen-Yih Chen
Summary: By integrating aptamer as a signal amplifier into SiNWFET immunosensors with Fab as the receptors, the detection limit has been significantly improved, especially with Fab/PEG-SiNWFET immunosensors showing enhanced performance to detect IgG levels down to 1 pg/mL, surpassing the capabilities of Wab/PEG-SiNWFET immunosensors.
Article
Chemistry, Multidisciplinary
Sergi Brosel-Oliu, Gemma Rius, Anna Avino, Nako Nakatsuka, Xavi Illa, Elena del Corro, Marta Delga-Fernandez, Eduard Masvidal-Codina, Natalia Rodriguez, Juan Pedro Merino, Alejandro Criado, Maurizio Prato, Raphaela Tkatchenko, Ramon Eritja, Philippe Godignon, Jose Antonio Garrido, Rosa Villa, Anton Guimera, Elisabet Prats-Alfonso
Summary: This article presents a new method for direct biofunctionalization on graphene surfaces for biosensing applications, which is based on single-step immobilization of chemically modified aptamers. The feasibility of this method is validated using arrays of 48 gSGFETs. The study demonstrates that the single-step strategy has higher efficiency and robustness in chemical coupling.
Article
Chemistry, Multidisciplinary
Viraj Bhingardive, Guillaume Le Saux, Avishay Edri, Angel Porgador, Mark Schvartzman
Summary: The cytotoxic activity of natural killer cells is regulated by various chemical and physical cues, with a newly engineered platform based on nanowires revealing how spatial heterogeneity affects NK cell function. The platform demonstrates the tunability of NK cell cytotoxicity, offering insights into their immune function and potential applications in immunotherapy.
Article
Chemistry, Multidisciplinary
Weiwei Cui, Meihang He, Luye Mu, Zuzeng Lin, Yanyan Wang, Wei Pang, Mark Reed, Xuexin Duan
Article
Physics, Applied
Sonya D. Sawtelle, Zachary A. Kobos, Mark A. Reed
APPLIED PHYSICS LETTERS
(2018)
Article
Nanoscience & Nanotechnology
S. D. Sawtelle, Z. A. Kobos, M. A. Reed
Article
Multidisciplinary Sciences
Tian Li, Sylvia Xin Li, Weiqing Kong, Chaoji Chen, Emily Hitz, Chao Jia, Jiaqi Dai, Xin Zhang, Robert Briber, Zuzanna Siwy, Mark Reed, Liangbing Hu
Review
Chemistry, Physical
Samuel Faucher, Narayana Aluru, Martin Z. Bazant, Daniel Blankschtein, Alexandra H. Brozena, John Cumings, J. Pedro de Souza, Menachem Elimelech, Razi Epsztein, John T. Fourkas, Ananth Govind Rajan, Heather J. Kulik, Amir Levy, Arun Majumdar, Charles Martin, Michael McEldrew, Rahul Prasanna Misra, Aleksandr Noy, Tuan Anh Pham, Mark Reed, Eric Schwegler, Zuzanna Siwy, YuHuang Wang, Michael Strano
JOURNAL OF PHYSICAL CHEMISTRY C
(2019)
Article
Chemistry, Multidisciplinary
Sylvia Xin Li, Nam S. Kim, Kim McKelvey, Chanyuan Liu, Henry S. White, Gary W. Rubloff, Sang Bok Lee, Mark A. Reed
Article
Biochemical Research Methods
Shupeng Ning, Shuchang Liu, Yunjie Xiao, Guanyu Zhang, Weiwei Cui, Mark Reed
Summary: A high-throughput acoustofluidic device is presented for separating bacteria from human blood cells efficiently, utilizing a serpentine microfluidic design and standing surface acoustic waves. The device enhances flow rate without compromising separation purity or cell recovery, offering advantages such as low cost, high biocompatibility, label-free separation, and integration potential with on-chip biosensors for clinical point-of-care diagnostics.
Article
Biochemical Research Methods
Pedro A. Duarte, Lukas Menze, Gaser N. Abdelrasoul, Shari Yosinski, Zak Kobos, Riley Stuermer, Mark Reed, Jian Yang, Xiujie S. Li, Jie Chen
Article
Chemistry, Multidisciplinary
Weiwei Cui, Luye Mu, Xuexin Duan, Wei Pang, Mark A. Reed
Article
Materials Science, Multidisciplinary
S. D. Sawtelle, M. A. Reed
Article
Nanoscience & Nanotechnology
Weiwei Zhou, Luye Mu, Jinfeng Li, Mark Reed, Peter J. Burke
Article
Chemistry, Multidisciplinary
Xiaokai Li, Marina Mariano, Lyndsey McMillon-Brown, Jing-Shun Huang, Matthew Y. Sfeir, Mark A. Reed, Yeonwoong Jung, Andre D. Taylor
Article
Chemistry, Analytical
Luye Mu, Ilia A. Droujinine, Jieun Lee, Mathias Wipf, Paschall Davis, Chris Adams, Jennifer Hannant, Mark A. Reed
ANALYTICAL CHEMISTRY
(2017)
Article
Nanoscience & Nanotechnology
Ning Tang, Luye Mu, Hemi Qu, Yanyan Wang, Xuexin Duan, Mark A. Reed
ACS APPLIED MATERIALS & INTERFACES
(2017)
Article
Biophysics
Jieun Lee, Mathias Wipf, Luye Mu, Chris Adams, Jennifer Hannant, Mark A. Reed
BIOSENSORS & BIOELECTRONICS
(2017)