Review
Biotechnology & Applied Microbiology
Yi Zhang, Zheng Li, Ying Huang, Yong Xu, Bingwen Zou
Summary: This study reviews the use of nanotechnology and curcumin in treating digestive cancers. Nanomedicine offers a solution to the issues hindering the clinical application of curcumin, such as poor solubility and bioavailability. The development of nanoformulations of curcumin, such as nanoparticles and liposomes, has shown promise in improving its efficacy in treating digestive cancers. The study serves as a valuable reference for future research in this therapeutic approach.
Article
Infectious Diseases
Maja Urosevic, Ljubisa Nikolic, Ivana Gajic, Vesna Nikolic, Ana Dinic, Vojkan Miljkovic
Summary: Curcumin is a natural polyphenol with significant pharmacological effects. However, its poor bioavailability in humans has led to the development of various formulations. This paper provides an overview of recent research on the biological and pharmaceutical aspects of curcumin, including sample preparation, analytical methods, and formulation techniques.
Article
Pharmacology & Pharmacy
Leila Farhoudi, Prashant Kesharwani, Muhammed Majeed, Thomas P. Johnston, Amirhossein Sahebkar
Summary: Natural compounds, such as curcumin, have potential benefits in cancer therapy, but their low bioavailability limits their application. Nanotechnology-based drug delivery systems have shown promise in improving the delivery and efficacy of curcumin.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Chemistry, Applied
Norhidayu Zainuddin, Ishak Ahmad, Mohd Hanif Zulfakar, Hanieh Kargarzadeh, Suria Ramli
Summary: The study demonstrates that CTAB-NCC-based microemulsions can be used as a controlled-release topical system for delivering curcumin, leading to enhanced penetration rate and accumulation in the skin without cytotoxic effects on cells.
CARBOHYDRATE POLYMERS
(2021)
Review
Food Science & Technology
Wing-Fu Lai, Dahong Zhang, Obireddy Sreekanth Reddy, Wing-Tak Wong
Summary: Turmeric contains a pigment called curcumin, which has health benefits such as neuroprotection, chemoprevention, and antioxidation. However, its poor solubility and low bioavailability limit its effectiveness.
FOOD REVIEWS INTERNATIONAL
(2023)
Review
Pharmacology & Pharmacy
Glory Kah, Rahul Chandran, Heidi Abrahamse
Summary: Cancer remains a major global health concern, and the need for better treatment options is evident. Curcumin, a natural compound derived from turmeric, has shown promise as an anticancer agent and a photosensitizer in cancer photodynamic therapy. However, its poor bioavailability and pharmacokinetics have limited its clinical utility. This review examines the properties, bioavailability, and safety of curcumin, focusing on its role in cancer therapy and PDT, as well as recent advancements in improving its bioavailability using nanoformulations and delivery systems.
Article
Biochemistry & Molecular Biology
Dawid Lazewski, Malgorzata Kucinska, Edward Potapskiy, Joanna Kuzminska, Lukasz Popenda, Artur Tezyk, Tomasz Goslinski, Marcin Wierzchowski, Marek Murias
Summary: This study has successfully developed a series of curcumin derivatives through modifications. The results showed that one derivative with PEG chains and a BF2 moiety exhibited higher cytotoxicity against bladder cancer cells and stronger anticancer effects under hypoxic conditions. However, PEGylation did not improve cellular uptake, and the lack of serum proteins limited intracellular uptake. The regulation of cell cycle and stress-related proteins may be involved in the anticancer mechanism. In conclusion, PEGylated curcumin derivatives are more effective anti-bladder cancer drugs than the parent compound, and derivative 5 deserves further investigation to elucidate its anticancer mechanism under hypoxic conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Anne Boyina Sravani, K. Mangala Shenoy, Baby Chandrika, B. Harish Kumar, Suvarna G. Kini, K. Sreedhara Ranganatha Pai, Shaila A. Lewis
Summary: The complex of curcumin with sulfobutyl ether-beta-cyclodextrin (SBE beta CD) demonstrates superior antimicrobial activity, making it a promising alternative for the treatment of urinary tract infections (UTIs) caused by Gram-negative bacteria E. coli.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Multidisciplinary Sciences
Alya Elzoheiry, Esraa Ayad, Nahed Omar, Kadry Elbakry, Ayman Hyder
Summary: Liver fibrosis can be inhibited by curcumin through direct binding to fibrosis-mediating proteins. Nano-formulation of curcumin using green silver nanoparticles coated with chitosan can enhance its efficacy as a drug for targeting liver fibrosis.
SCIENTIFIC REPORTS
(2022)
Review
Biochemistry & Molecular Biology
Bwalya Angel Witika, Pedzisai Anotida Makoni, Scott Kaba Matafwali, Larry Lawrence Mweetwa, Ginnethon Chaamba Shandele, Roderick Bryan Walker
Summary: This review highlights the biological and pharmacological properties of curcumin (CUR), as well as the therapeutic effects and encapsulation techniques of nano-encapsulated CUR. The research emphasizes the enhanced biological and pharmacological properties of nano-encapsulated CUR, showing its significant improvement in cancer therapy and other medicinal benefits. Future studies should focus on investigating the effects of encapsulated CUR nanoparticles in different models of human pathology.
Article
Chemistry, Multidisciplinary
Guldjan Yakub, Nevena E. Manolova, Iliya B. Rashkov, Nadya Markova, Reneta Toshkova, Ani Georgieva, Rosica Mincheva, Antoniya Toncheva, Jean -Marie Raquez, Philippe Dubois
Summary: The synthesis of polymer prodrug structures based on natural compounds has shown promise in cancer prevention and detection. In this study, pegylated curcumin derivatives were successfully prepared and showed cytotoxic and antibacterial activity.
Article
Chemistry, Applied
Qihong Zhang, Hui Wang, Zongmiao Feng, Zhaohui Lu, Chen Su, Yunchun Zhao, Jingbo Yu, Alexandr Dushkin, Weike Su
Summary: This study successfully prepared a SD-CUR carrier with enhanced solubility and permeability, demonstrating superior pharmacological activity in hyperlipidemia rats, providing new approaches and directions for the prevention and treatment of hyperlipidemia.
FOOD HYDROCOLLOIDS
(2021)
Article
Food Science & Technology
Longwei Jiang, Ning Xia, Fenghui Wang, Cancan Xie, Rong Ye, Hongjie Tang, Huajiang Zhang, Yingzhu Liu
Summary: This study successfully synthesized curcumin/beta-cyclodextrin inclusion complex nanoparticles using flexible and efficient nanoprecipitation method. The encapsulation efficiency reached over 70% at a ratio of 1:2 or 1:1, and the particle size was around 200 nm. The results from various characterization techniques confirmed the construction of nanoparticles and their stability. Encapsulation of curcumin improved its bioavailability, and the nanoparticles exhibited excellent physicochemical stability. Nanoprecipitation shows promise in synthesizing CD-based nanoparticles with enhanced stability and bioavailability.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Anna Sykula, Agnieszka Bodzioch, Adriana Nowak, Waldemar Maniukiewicz, Sylwia Scieszka, Lidia Piekarska-Radzik, Elzbieta Klewicka, Damian Batory, Elzbieta Lodyga-Chruscinska
Summary: The encapsulation of insoluble compounds using cyclodextrin can improve their solubility and activity. This study investigated the effects of cyclodextrin encapsulation on hesperetin's derivatives and evaluated their antioxidant, cytotoxic, and antibacterial activities. The results showed that cyclodextrin significantly improved the solubility of the compounds, but the pure compounds exhibited higher antioxidant activity.
Review
Medicine, Research & Experimental
Tianqi Ming, Qiu Tao, Shun Tang, Hui Zhao, Han Yang, Maolun Liu, Shan Ren, Haibo Xu
Summary: Cancer is still increasing globally and requires intense study on its pathogenic mechanism and effective therapy. Epigenetics, studying heritable changes in gene expression, plays a crucial role in the initiation and progression of various malignancies. Curcumin, a plant-derived polyphenolic compound with strong bioactivity, has potential value in cancer treatment. This review summarizes recent advances in the efficacy of curcumin on cancer and its epigenetic regulation, as well as discusses methods to improve the bioavailability of curcumin.
BIOMEDICINE & PHARMACOTHERAPY
(2022)