Review
Biotechnology & Applied Microbiology
Alexander Malogolovkin, Alexander D. Egorov, Alexander Karabelsky, Roman A. Ivanov, Vladislav V. Verkhusha
Summary: Optogenetics, a technique that enables precise control of gene and cell activity using light, offers new possibilities for cancer treatment. By activating immune response, inhibiting tumor growth, and modulating cell signaling using specific wavelengths of light, optogenetics has the potential to revolutionize cancer therapy.
BIOTECHNOLOGY ADVANCES
(2022)
Review
Pharmacology & Pharmacy
Neetu Singh, Sixiang Shi, Shreya Goel
Summary: This review discusses the application of ultrasmall silica nanoparticles (USNs) in biomedical research, with a focus on their potential in diagnostics, therapy, and drug delivery. The review summarizes synthetic strategies for USNs, including control over size and surface chemistry, functionalization, and pharmacokinetic and toxicological profiles. Additionally, the review highlights challenges in the translation of inorganic nanotechnology and proposes potential solutions and future opportunities for accelerating the widespread adoption of USN technology in biomedical research.
ADVANCED DRUG DELIVERY REVIEWS
(2023)
Review
Oncology
Felix T. Kurz, Heinz -Peter Schlemmer
Summary: This review aims to present recent advancements in translational cancer imaging research, specifically focusing on novel, recently established, or soon to be established cross-sectional imaging techniques such as computed tomography (CT), magnetic resonance imaging (MRI), and positron-emission tomography (PET), as well as computational investigations based on machine-learning techniques.
CANCER BIOLOGY & MEDICINE
(2022)
Review
Immunology
Yinxi Zhou, Jinghua Xia, Shuonan Xu, Tao She, Yanning Zhang, Ying Sun, Miaomiao Wen, Tao Jiang, Yanlu Xiong, Jie Lei
Summary: The development and growth of tumors pose a significant and ongoing threat to human life globally. Despite the remarkable progress achieved by advanced therapeutic strategies such as immune checkpoint therapy and CAR-T in treating solid and hematological malignancies, the malignant initiation and progression of cancer remains controversial and requires further research. Experimental animal models not only have great advantages in simulating tumor occurrence, development, and malignant transformation mechanisms, but also can be used to evaluate the therapeutic effects of diverse clinical interventions, gradually becoming indispensable in cancer research. This paper reviews recent research progress in mouse and rat models, focusing on spontaneous, induced, transgenic, and transplantable tumor models, aiming to provide guidance for future studies on malignant mechanisms and tumor prevention.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Chemistry, Multidisciplinary
Rosalia Moreddu
Summary: Bioelectricity plays a critical role in regulating cellular function and communication, and has potential uses in cancer diagnosis, prognosis, and treatment. Cancer cells exhibit abnormal electrical properties compared to healthy cells, and nanotechnology holds promise for understanding and exploiting these differences.
Review
Oncology
Peng Jiang, Sanju Sinha, Kenneth Aldape, Sridhar Hannenhalli, Cenk Sahinalp, Eytan Ruppin
Summary: Historically, cancer research has focused on a few essential pathways and genes, but recent advances in high-throughput technologies have led to the rapid accumulation of large-scale cancer omics data. The analysis of this "big data" requires significant computational resources and has the potential to bring new insights to cancer research. The combination of big data, bioinformatics, and artificial intelligence has already made notable advances in our understanding of cancer biology and translational research. Future progress will require collaboration among data scientists, clinicians, biologists, and policymakers.
NATURE REVIEWS CANCER
(2022)
Article
Polymer Science
Pedro Francisco, Mariana Neves Amaral, Afonso Neves, Tania Ferreira-Goncalves, Ana S. Viana, Jose Catarino, Pedro Faisca, Sandra Simoes, Joao Perdigao, Adilia J. Charmier, M. Manuela Gaspar, Catarina Pinto Reis
Summary: This study focuses on the production and characterization of AgNPs loaded in a Pluronic((R)) F127 hydrogel, as well as assessing its antimicrobial and wound-healing potential. The results showed that hydrogel-loaded AgNPs is potentially an important resource in the treatment of skin burns due to their proven efficacy by topical administration.
Review
Oncology
Michael W. Lee, Mihailo Miljanic, Todd Triplett, Craig Ramirez, Kyaw L. Aung, S. Gail Eckhardt, Anna Capasso
Summary: Recent advancements in pre-clinical screening tools have led to a new era in drug development, with more accurate prediction of clinical effects and adverse events for candidate therapeutic agents. However, careful evaluation is necessary to determine the individual merits of these translational research tools to provide appropriate information for clinical researchers to conduct pre-clinical screening in an accelerated and rational manner.
CANCER AND METASTASIS REVIEWS
(2021)
Review
Biochemistry & Molecular Biology
Therese Seidlitz, Daniel E. Stange
Summary: Organoid technology allows for the generation of patient-derived models to better understand cancer biology, guide treatment selection, and study biological pathways contributing to tumor development and disease progression.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2021)
Review
Public, Environmental & Occupational Health
Paul A. Schulte, Rebecca J. Guerin, Thomas R. Cunningham, Laura Hodson, Vladimir Murashov, Borsika Adrienn Rabin
Summary: Translational science focuses on applying scientific knowledge from the lab to the field and back again. In the field of occupational safety and health, translational science plays a crucial role in protecting workers by translating research findings into effective interventions. For the field of nanotechnology, translational research is essential for understanding and mitigating the risks associated with occupational exposure to nanomaterials. Stakeholder engagement and the dissemination of information are key in the translational research process to ensure the effectiveness and sustainability of interventions to protect workers.
FRONTIERS IN PUBLIC HEALTH
(2022)
Editorial Material
Physics, Multidisciplinary
Leonida A. Gizzi, Maria Grazia Andreassi
Summary: Laser accelerators have not been able to meet the requirements for dose control and stability in biomedical applications, but an experiment has now achieved translational research with proton beams at ultrahigh dose rate.
Review
Oncology
Peng Ge, Yalan Luo, Haiyang Chen, Jiayue Liu, Haoya Guo, Caiming Xu, Jialin Qu, Guixin Zhang, Hailong Chen
Summary: Pancreatic cancer is one of the most common malignant tumors in the digestive tract globally, and significant progress has been made in research on its diagnosis and treatment. However, the current situation is still unsatisfactory, and there is an urgent need for academia to integrate basic research and clinical data.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Patrizio di Micco, Albert A. Antolin, Costas Mitsopoulos, Eloy Villasclaras-Fernandez, Domenico Sanfelice, Daniela Dolciami, Pradeep Ramagiri, Ioan L. Mica, Joseph E. Tym, Philip W. Gingrich, Huabin Hu, Paul Workman, Bissan Al-Lazikani
Summary: canSAR is the largest public cancer drug discovery and translational research knowledgebase, integrating billions of experimental measurements from various fields and applying unique machine learning algorithms for drug discovery.
NUCLEIC ACIDS RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Costas Mitsopoulos, Patrizio Di Micco, Eloy Villasclaras Fernandez, Daniela Dolciami, Esty Holt, Ioan L. Mica, Elizabeth A. Coker, Joseph E. Tym, James Campbell, Ka Hing Che, Bugra Ozer, Christos Kannas, Albert A. Antolin, Paul Workman, Bissan Al-Lazikani
Summary: canSAR is a comprehensive knowledgebase for oncology, integrating multidisciplinary data and providing AI-informed target assessment for drug discovery. The new implementation of the system, canSARblack, offers new functionality to assist in translation hypothesis generation and experimental design.
NUCLEIC ACIDS RESEARCH
(2021)
Review
Immunology
Erica L. Katz, John E. Harris
Summary: Vitiligo is a skin disease characterized by white spots, and significant progress has been made in understanding its pathogenesis over the past 30 years through perseverance, collaboration, and open-minded discussion. Researchers have explored various possible mechanisms through innervation, microvascular anomalies, oxidative stress, defects in melanocyte adhesion, autoimmunity, somatic mosaicism, and genetics, with animal models and improved patient sample collection methods playing important roles in translational studies.
FRONTIERS IN IMMUNOLOGY
(2021)
