期刊
NANOMEDICINE
卷 6, 期 3, 页码 449-458出版社
FUTURE MEDICINE LTD
DOI: 10.2217/NNM.10.134
关键词
brain tumor; glioblastoma multiforme; IL-13; imaging; metallofullerenes; nanoparticle; targeting
资金
- NIH/NCI [R01 CA119371]
- NSF/NIRT [DMR-0507083]
- Center for Innovative Technology, Commonwealth of Virginia
- VCU Department of Anatomy and Neurobiology Microscopy Facility
- NIH-NINDS [5P30NS047463]
Background: Glioblastoma multiforme is the most common and most lethal primary brain tumor in humans, with median survival of approximately 1 year. Owing to the ability of glioma cells to aggressively infiltrate normal brain tissue and survive exposure to current adjuvant therapies, there is a great need for specific targeted nanoplatforms capable of delivering both therapeutic and imaging agents directly to invasive tumor cells. Method: Gadolinium-containing endohedral fullerenes, highly efficient contrast agents for MRI, were functionalized and conjugated with a tumor-specific peptide and assessed for their ability to bind to glioma cells in vitro. Results: We report the successful conjugation of the carboxyl functionalized metallofullerene Gd3N@C-80(OH)(similar to 26)(CH2CH2COOH)(similar to 16) to IL-13 peptides and the successful targeting ability towards brain tumor cells that overexpress the IL-13 receptor (IL-13R alpha 2). Conclusion: These studies demonstrate that IL-13 peptide-conjugated gadolinium metallofullerenes could serve as a platform to deliver imaging and therapeutic agents to tumor cells.
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