期刊
NANOMEDICINE
卷 6, 期 8, 页码 1365-1379出版社
FUTURE MEDICINE LTD
DOI: 10.2217/NNM.11.39
关键词
bioavailability; daidzein; intestinal absorption; mixed micelle; oral delivery
资金
- The National Basic Research Program of China [2009CB930304, 2007CB935800]
- National Natural Science Foundation of China [30925041, 30901866]
- Shanghai Nanomedicine Program [1052nm06300]
- National Science & Technology Major Project 'Key New Drug Creation and Manufacturing Program' [2009ZX09501-024, 2009ZX09301-001]
A self-assembled nano-based delivery system was designed and developed to increase the oral bioavailability of poor hydrophilic and lipophilic daidzein. Methods: Daidzein was firstly combined with lecithin to form the daidzein-lecithin complex, then self-assembled into micelles (DLMs) with lecithin and sodium bile. The physiochemical properties and intestinal absorption of DLMs were characterized, and the pharmacokinetic behavior was evaluated in rats. Results: DLMs exhibited nanometer-sized particles. DLMs were mainly distributed in the stomach and proximal intestine after oral administration. The intestinal absorption of DLMs was significantly improved, and DLMs could be absorbed via both endocytosis and passive transport. The AUC(0-t) value of daidzein in rats treated with DLMs was ninefold greater than that of free daidzein suspension. Conclusion: The presented delivery system could provide a new promising strategy for enhancing the oral bioavailability of drugs with poor hydrophilicity and lipophilicity.
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