Review
Engineering, Biomedical
Zimeng Zhai, Yiyun Cheng, Jiaxu Hong
Summary: Glaucoma, the leading cause of irreversible blindness worldwide, requires long-term management with drugs, but there is a shortage of effective antiglaucoma drugs due to biological barriers of the human eyes. Nanomedicines have emerged as promising alternatives to conventional ophthalmic formulations, offering improved drug delivery and potential for neuroprotective treatment of damaged nerves in glaucoma.
ACTA BIOMATERIALIA
(2021)
Article
Materials Science, Biomaterials
Arjaree Jobdeedamrong, Man Theerasilp, Norased Nasongkla, Daniel Crespy
Summary: In this study, silica nanocapsules (SiO2NCs) stabilized with a reactive surfactant were synthesized to prevent leaching during dialysis, showing superior stability and biocompatibility compared with SiO2NCs prepared with conventional surfactants. These SiO2NCs can be used in self-healing materials, smart agriculture, and biomedical applications.
BIOMATERIALS SCIENCE
(2021)
Article
Chemistry, Multidisciplinary
Vitale Miceli, Marco Fornasier, Matteo Bulati, Giandomenico Amico, Pier Giulio Conaldi, Anna Casu, Sergio Murgia
Summary: In this study, a new nanotool based on functionalized nanoerythrosomes was developed and tested on cell lines. The results showed that the nanotool had minimal impact on cell proliferation and function, except for inhibitory effects on MSI cell line at the highest concentration. Additionally, the nanotool exhibited diffuse fluorescence in the cytosol of MSI cells.
Review
Biochemistry & Molecular Biology
Elzbieta Pedziwiatr-Werbicka, Katarzyna Horodecka, Dzmitry Shcharbin, Maria Bryszewska
Summary: Nanomedicine is a promising alternative to traditional cancer treatment methods, but it does not completely overcome the limitations of oncology. Nanoparticles used in cancer therapy can serve as drug carriers and offer some advantages, but they do not significantly enhance the effectiveness of chemotherapeutic agents.
CURRENT MEDICINAL CHEMISTRY
(2021)
Article
Nanoscience & Nanotechnology
Fang-Chu Lin, Qilin Yu, Jeffrey Zink
Summary: This self-contained nanocapsule utilizes an esterase and an alternating magnetic field to achieve nonspecific cytotoxic anticancer drug delivery and release. In vivo experiments demonstrated excellent biocompatibility and high tumor-targeting/inhibiting efficiency, with the esterase efficiently cleaving ester bonds for enhanced anticancer efficacy.
ACS APPLIED NANO MATERIALS
(2021)
Article
Chemistry, Physical
Russell J. Wilson, Yue Hui, Andrew K. Whittaker, Chun-Xia Zhao
Summary: A novel biomimetic method for preparing silica nanocapsules loaded with iron oxide nanoparticles is reported in this study, showing excellent stability and drug loading efficiency for drug delivery applications.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2021)
Article
Chemistry, Multidisciplinary
Thao P. Doan-Nguyen, Shuai Jiang, Kaloian Koynov, Katharina Landfester, Daniel Crespy
Summary: The study introduces a novel method to synthesize ultrasmall nanocapsules with a diameter of 6 nm, demonstrating a core-shell structure formed by a sol-gel reaction and Ostwald ripening. Results indicate that the size of the nanocapsules depends on the ripening rate and alkoxysilane conversion rate.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Review
Chemistry, Medicinal
Thayse V. de Oliveira, Renan Stein, Diego F. de Andrade, Ruy C. R. Beck
Summary: This systematic review confirms the efficacy of curcumin-loaded polymeric nanocapsules in inhibiting tumor growth and reducing tumor weight, regardless of the solid tumor model. The analysis on bias risk suggests that nanoparticle encapsulation can enhance the anti-tumor effects of curcumin.
PHYTOTHERAPY RESEARCH
(2022)
Review
Chemistry, Multidisciplinary
Ahmed A. H. Abdellatif, Hamdoon A. Mohammed, Riaz A. Khan, Varsha Singh, Abdellatif Bouazzaoui, Mohammed Yusuf, Naseem Akhtar, Maria Khan, Amal Al-Subaiyel, Salman A. A. Mohammed, Mohsen S. Al-Omar
Summary: This review focuses on the preparation of nano-structured delivery devices from biodegradable and biocompatible natural and synthetic polymers, metals, metal oxides, and other compounds. Various nano-entities such as nanoparticles, liposomes, hydrogels, dendrimers, and carbon-based nano-entities have been produced using different preparative techniques. The review outlines developments in design, structural specifications, preparative strategies, chemo-biological interfacing, and applications of nanomaterials in biomedical fields.
NANOTECHNOLOGY REVIEWS
(2021)
Review
Chemistry, Multidisciplinary
Eman Jaradat, Edward Weaver, Adam Meziane, Dimitrios A. Lamprou
Summary: In conventional drug administration, drug molecules may not effectively reach the pathological site, so nanoparticles (NPs) as drug carriers have potential. NPs have a large surface area and quantum properties. Traditional methods for manufacturing NPs have limitations and new methods need to be investigated.
Review
Nanoscience & Nanotechnology
Ziyuan Li, Yingwen Mu, Cheng Peng, Martin F. Lavin, Hua Shao, Zhongjun Du
Summary: Nanomedicine, a rapidly emerging discipline in biology, medicine, and pharmacology, utilizes silica nanoparticles (SNPs) for drug delivery and biomedical imaging due to their unique properties and biocompatibility. Adverse effects of SNPs in nanomedicine applications are reviewed, along with potential opportunities and challenges for future use.
WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY
(2021)
Review
Pharmacology & Pharmacy
Zoila Gandara, Noelia Rubio, Rafael R. Castillo
Summary: The use of nanoparticles is crucial for the development of nanodevices for clinical applications. Silica-based nanoparticles can be tailored with functional biopolymers, providing advantages such as limitation of interaction, preservation of cargo and particle integrity, reduction of immune response, additional therapeutic effects, and cell targeting. Therefore, engineering advanced functional coatings is important to enhance the biocompatibility of existing biomaterials.
Article
Engineering, Biomedical
Gabriela Arias-Alpizar, Panagiota Papadopoulou, Xabier Rios, Krishna Reddy Pulagam, Mohammad-Amin Moradi, Roy Pattipeiluhu, Jeroen Bussmann, Nico Sommerdijk, Jordi Llop, Alexander Kros, Frederick Campbell
Summary: Plasma lipid transport and metabolism are crucial for cellular function. A lipid nanoparticle formulation composed of two lipids can effectively be recognized and taken up by specific endothelial cell subsets through a lipase-mediated pathway. The liposome-lipase interaction is mediated by a unique liposome morphology. These compositionally simplistic liposomes provide new insights into the design of lipid-based nanoparticles for targeted delivery in vivo.
ADVANCED HEALTHCARE MATERIALS
(2023)
Review
Environmental Sciences
Zaid Ulhassan, Javaid Akhter Bhat, Weijun Zhou, Ahmed M. Senan, Pravej Alam, Parvaiz Ahmad
Summary: Excessive arsenic accumulation in plant tissues can have toxic impacts on growth and human health. Engineered nanoparticles (ENPs) have been found to reduce arsenic accumulation and toxicity, but the mechanisms are not fully understood.
ENVIRONMENTAL POLLUTION
(2022)
Review
Environmental Sciences
Muhammad Riaz, Muhammad Kamran, Muhammad Rizwan, Shafaqat Ali, Aasma Parveen, Zaffar Malik, Xiurong Wang
Summary: Cadmium is a major contaminant in agricultural soils worldwide, with varying abilities among different plant species and genotypes to uptake, transport, detoxify, and accumulate it. Strategies such as selenium and silicon applications have been suggested to decrease Cd toxicity, with mechanisms like vacuolar sequestration, formation of phytochelatins, and cell wall adsorption reported as effective for detoxification. This review discusses past and current literature to better understand Cd toxicity and its mitigation through different feasible and practical approaches.
Review
Energy & Fuels
Brandon Johnston, Hakeem Henry, Nam Kim, Sang Bok Lee
Summary: As lithium-ion batteries reach their limits, magnesium-ion batteries are seen as a promising alternative. Vanadium Oxide (V2O5) is a potential cathode material due to its high capacity, ease of synthesis, and operating voltage. The addition of water to electrolytes can improve magnesium-ion insertion into V2O5, but the challenge lies in leaching water during cycling and protecting the magnesium anode.
FRONTIERS IN ENERGY RESEARCH
(2021)
Article
Chemistry, Applied
Caleb Luvonga, Catherine A. Rimmer, Lee L. Yu, Sang Bok Lee
Summary: The study surveyed total arsenic content and mass fractions of hydrophilic arsenic species in five different marine food types, showing that hydrophilic arsenic species comprise the majority of total arsenic.
JOURNAL OF FOOD COMPOSITION AND ANALYSIS
(2021)
Review
Materials Science, Multidisciplinary
Shoukang Hong, Yang Wang, Nam Kim, Sang Bok Lee
Summary: This review highlights the recent progress of polymer-based all-solid-state lithium-sulfur batteries and discusses the potential of polymer electrolytes in addressing challenges in lithium-sulfur batteries. Possible solutions such as the addition of inorganic fillers and interface modification are introduced, as well as state-of-the-art approaches with performance improvement.
JOURNAL OF MATERIALS SCIENCE
(2021)
Article
Energy & Fuels
Emily Sahadeo, Gary Rubloff, Sang Bok Lee, Chuan-Fu Lin
Summary: This paper discusses the properties of Al2O3 thin films deposited using atomic layer deposition as an artificial solid electrolyte interphase at the Mg anode. Results show that Al2O3 prevents electrolyte degradation due to the reductive nature of Mg, but undesirable properties such as defects and layer breakdown lead to soft-shorting issues. The study suggests that Al2O3 is not ideal for use as a protective layer, as it cannot prevent soft-shorting and instead hinders Mg growth.
FRONTIERS IN ENERGY RESEARCH
(2021)
Article
Nanoscience & Nanotechnology
Sri Harsha Akella, Sarah Taragin, Yang Wang, Hagit Aviv, Alexander C. Kozen, Melina Zysler, Longlong Wang, Daniel Sharon, Sang Bok Lee, Malachi Noked
Summary: Zirconium phosphate (ZrxPOy) and lithium-containing zirconium phosphate (LixZryPOz) coatings as artificial cathode-electrolyte interphases (ACEIs) were synthesized on NMC811 using atomic layer deposition. The LixZryPOz coating with Li ions improved capacity retention and rate performance compared to the uncoated NMC811, while largely suppressing degradative parasitic side reactions.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Inorganic & Nuclear
R. Blake Nuwayhid, Daniela Fontecha, Alexander C. Kozen, Angelique Jarry, Sang Bok Lee, Gary W. Rubloff, Keith E. Gregorczyk
Summary: This paper compares the ALD processes and reaction mechanisms of LiPON, NaPON, and KPON thin-film ion conductors. While NaPON and LiPON share similar reaction mechanisms, KPON shows distinct differences in its film composition and likely undergoes an entirely different reaction mechanism. This comprehensive summary of ALD ion conducting APON films highlights the versatility of ALD chemistries for the development of novel thin film ion-conductors.
DALTON TRANSACTIONS
(2022)
Article
Chemistry, Physical
Yang Wang, Emily Sahadeo, Sang Bok Lee
Summary: In this study, a thin Mg'-conducting elastomeric artificial solid electrolyte interphase (ASEI) layer was formed by electrochemically polymerizing 1,3-dioxolane (DOL) to pretreat Mg metal anodes, which effectively protected the anodes and improved the cycling performance of Mg-Mg symmetric cells at high current density.
ACS APPLIED ENERGY MATERIALS
(2022)
Article
Nanoscience & Nanotechnology
Haotian Wang, Nam Soo Kim, Yueming Song, Paul Albertus, Sang Bok Lee, Gary Rubloff, David Stewart
Summary: This study presents a stress characterization of crystalline Si electrodes using micro-Raman spectroscopy. The phase heterogeneity in the electrodes after initial lithiation was investigated, and a three-phase layer structure was observed. A Raman scan was performed to characterize the stress distribution, which showed that the maximum tensile stress occurred at the interface between different layers. The stress distribution and failure mechanism of the electrodes after delithiation and cycling were also studied.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Electrochemistry
Nam Kim, Marco Casareto, Miles Mowbray, Robert Henry, John Hayden, Gary Rubloff, Sang Bok Lee, Keith E. Gregorczyk
Summary: Wide pore AAOs with ohmic bottom contacts were successfully fabricated on 76 mm Si wafers, and the surface of Al was smoothed using a quiescent electropolishing technique. Standard photolithography was used to define the active area on the Al for anodization, followed by a two-step anodization process to produce wide pore AAOs with pore diameters ranging from 130 +/- 32 nm to 400 +/- 31 nm and an interpore distance of 480 +/- 47 nm. The study also showed that the ordering of the pores depended on the current density rather than the conventional anodization time.
JOURNAL OF THE ELECTROCHEMICAL SOCIETY
(2023)
Article
Nanoscience & Nanotechnology
Haotian Wang, Yueming Song, Victoria Castagna Ferrari, Nam Soo Kim, Sang Bok Lee, Paul Albertus, Gary Rubloff, David Murdock Stewart
Summary: It was found experimentally that patterned Si island electrodes with a thickness of 200 nm and a width less than 7 μm can deform elastically. By comparing the model and experimental data, it was observed that the competition of Li diffusion flux leads to Li diffusion towards the edges below the critical size, while a stress plateau inhibits Li diffusion to the edge above the critical size, resulting in stress relief by cracking. This work is of great significance for in situ characterization of electro-chemo-mechanical coupling in battery electrodes, with suggestions for further improvement.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Physical
Yang Wang, Jeonghyun Ko, Myungsuk Lee, Sam Klueter, Elias Kallon, John Hoerauf, Daniela Fontecha, Cholho Lee, Gary W. W. Rubloff, Sang Bok Lee, Alexander C. C. Kozen
Summary: The family of thio-LISICON solid-state electrolytes (SSEs) is one of the most promising material systems for solid-state batteries. Among them, Li10GeP2S12 (LGPS) is a promising candidate due to its high ionic conductivity. However, LGPS is unstable when in direct contact with both Li metal and conventional cathode materials. In this study, an elastomeric artificial solid electrolyte interphase (ASEI) was used as a protective layer to improve the stability and performance of Li/LGPS/Li symmetric cells.
ACS APPLIED ENERGY MATERIALS
(2023)
Article
Materials Science, Multidisciplinary
Yang Wang, Sam Klueter, Myungsuk Lee, Junnyeong Yun, Binh Hoang, Elias Kallon, Cholho Lee, Chuan-Fu Lin, Gary W. Rubloff, Sang Bok Lee, Alexander C. Kozen
Summary: Li10GeP2S12 (LGPS) is a superionic conductor with high ionic conductivity, making it a promising material for solid-state batteries. However, it reacts chemically and electrochemically with lithium metal, leading to the formation of high impedance interphase layers. Artificial solid electrolyte interphase (ASEI) layers are a potential solution to mitigate this reactivity.
MATERIALS ADVANCES
(2022)
Article
Chemistry, Physical
Victoria C. Ferrari, Nam S. Kim, Sang Bok Lee, Gary W. Rubloff, David M. Stewart
Summary: This study presents a low temperature synthesis method for pre-lithiated cathodes in thin film batteries using a co-sputtering process. The analysis reveals the presence of multiple phases of LixV2O5 in the thin films, which remain unchanged after electrochemical cycling. The co-sputtering process allows for tuning of lithium content and achieves a highly lithiated state. The thin film solid-state battery prototype using the lithiated vanadium oxide as a cathode demonstrates a relatively high coulombic efficiency.
JOURNAL OF MATERIALS CHEMISTRY A
(2022)
Article
Electrochemistry
Yang Wang, Binh Hoang, John Hoerauf, Cholho Lee, Chuan-Fu Lin, Gary W. Rubloff, Sang Bok Lee, Alexander C. Kozen
Summary: LGPS is a superionic conductor that shows potential for solid-state Li metal batteries, with researchers successfully using hot pressing to fabricate pellets with the highest density and ionic conductance. The XPS analysis indicates no chemical degradation of LGPS powder during the hot pressing process.
JOURNAL OF THE ELECTROCHEMICAL SOCIETY
(2021)
Article
Chemistry, Physical
Peng Wang, Yunfeng Li, Luning Wang, Zhiwei Peng, Nam Kim, Hendrik Bluhm, Karen Gaskell, Ping Liu, Sang Bok Lee, Bryan W. Eichhorn, YuHuang Wang
