Smart siRNA delivery systems based on polymeric nanoassemblies and nanoparticles

Rational Design of Targeted Cancer Therapeutics through the Multiconjugation of Folate and Cleavable siRNA to RAFT-Synthesized (HPMA-s-APMA) Copolymers†

(2010) Adam W. York et al.   BIOMACROMOLECULES

Stimuli-responsive smart nanogels for cancer diagnostics and therapy

(2010) Motoi Oishi et al.   Nanomedicine

Chitosan-based formulations for delivery of DNA and siRNA

(2009) Shirui Mao et al.   ADVANCED DRUG DELIVERY REVIEWS

Biodegradable Dextran Nanogels for RNA Interference: Focusing on Endosomal Escape and Intracellular siRNA Delivery

(2009) Koen Raemdonck et al.   ADVANCED FUNCTIONAL MATERIALS

Acid-Responsive Linear Polyethylenimine for Efficient, Specific, and Biocompatible siRNA Delivery

(2009) Min Suk Shim et al.   BIOCONJUGATE CHEMISTRY

Hydrophobically Modified Oligoethylenimines as Highly Efficient Transfection Agents for siRNA Delivery

(2009) Alexander Philipp et al.   BIOCONJUGATE CHEMISTRY

Peptide-Functionalized Nanogels for Targeted siRNA Delivery

(2009) William H. Blackburn et al.   BIOCONJUGATE CHEMISTRY

Enhanced Cytoplasmic Delivery of siRNA Using a Stabilized Polyion Complex Based on PEGylated Nanogels with a Cross-Linked Polyamine Structure

(2009) Atsushi Tamura et al.   BIOMACROMOLECULES

Cytosolic Delivery Mediated via Electrostatic Surface Binding of Protein, Virus, or siRNA Cargos to pH-Responsive Core−Shell Gel Particles

(2009) Yuhua Hu et al.   BIOMACROMOLECULES

Cycloamylose-based Biomaterial: Nanogel of Cholesterol-bearing Cationic Cycloamylose for siRNA Delivery

(2009) Sayaka Toita et al.   CHEMISTRY LETTERS

Stability of siRNA polyplexes from poly(ethylenimine) and poly(ethylenimine)-g-poly(ethylene glycol) under in vivo conditions: Effects on pharmacokinetics and biodistribution measured by Fluorescence Fluctuation Spectroscopy and Single Photon Emission Computed Tomography (SPECT) imaging

(2009) Olivia M. Merkel et al.   JOURNAL OF CONTROLLED RELEASE

Surface-engineered targeted PPI dendrimer for efficient intracellular and intratumoral siRNA delivery

(2009) Oleh Taratula et al.   JOURNAL OF CONTROLLED RELEASE

Synthesis of dendritic carbohydrate end-functional polymers via RAFT: Versatile multi-functional precursors for bioconjugations

(2009) Jiangtao Xu et al.   JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY

A Highly Efficient siRNA Carrier of PBLG Modified Hyperbranched PEI

(2009) Jie Chen et al.   MACROMOLECULAR BIOSCIENCE

In vivo siRNA delivery with dendritic poly(l-lysine) for the treatment of hypercholesterolemia

(2009) Kazuto Watanabe et al.   Molecular BioSystems

Synthesis and Biological Evaluation of a Bioresponsive and Endosomolytic siRNA−Polymer Conjugate

(2009) Martin Meyer et al.   MOLECULAR PHARMACEUTICS

The First Targeted Delivery of siRNA in Humans via a Self-Assembling, Cyclodextrin Polymer-Based Nanoparticle: From Concept to Clinic

(2009) Mark E. Davis   MOLECULAR PHARMACEUTICS

The Effect of Chemical Modification and Nanoparticle Formulation on Stability and Biodistribution of siRNA in Mice

(2009) Shan Gao et al.   MOLECULAR THERAPY

Knocking down barriers: advances in siRNA delivery

(2009) Kathryn A. Whitehead et al.   NATURE REVIEWS DRUG DISCOVERY

In vivo pharmacokinetics, tissue distribution and underlying mechanisms of various PEI(–PEG)/siRNA complexes

(2009) Anastasia Malek et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Simple Modifications of Branched PEI Lead to Highly Efficient siRNA Carriers with Low Toxicity

(2008) Arkadi Zintchenko et al.   BIOCONJUGATE CHEMISTRY

siRNA Conjugate Delivery Systems

(2008) Ji Hoon Jeong et al.   BIOCONJUGATE CHEMISTRY

Monomolecular Assembly of siRNA and Poly(ethylene glycol)−Peptide Copolymers

(2008) Jason DeRouchey et al.   BIOMACROMOLECULES

Environment-Responsive Block Copolymer Micelles with a Disulfide Cross-Linked Core for Enhanced siRNA Delivery

(2008) Satoru Matsumoto et al.   BIOMACROMOLECULES

Poly(β-amino ester) as a carrier for si/shRNA delivery in lung cancer cells

(2008) Dhananjay Jere et al.   BIOMATERIALS

Biodegradable amphiphilic poly(ethylene oxide)-block-polyesters with grafted polyamines as supramolecular nanocarriers for efficient siRNA delivery

(2008) Xiao-Bing Xiong et al.   BIOMATERIALS

Reversible siRNA–polymer conjugates by RAFT polymerization

(2008) Karina L. Heredia et al.   CHEMICAL COMMUNICATIONS

Mechanistic investigation of poly(ethylene imine)-based siRNA delivery: Disulfide bonds boost intracellular release of the cargo

(2008) Miriam Breunig et al.   JOURNAL OF CONTROLLED RELEASE

Local and systemic delivery of VEGF siRNA using polyelectrolyte complex micelles for effective treatment of cancer

(2008) Sun Hwa Kim et al.   JOURNAL OF CONTROLLED RELEASE

Breathing Life into Polycations:  Functionalization with pH-Responsive Endosomolytic Peptides and Polyethylene Glycol Enables siRNA Delivery

(2008) Martin Meyer et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

VEGF siRNA Delivery System Using Arginine-Grafted Bioreducible Poly(disulfide amine)

(2008) Sun Hwa Kim et al.   MOLECULAR PHARMACEUTICS

Nanoparticle therapeutics: an emerging treatment modality for cancer

(2008) Mark E. Davis et al.   NATURE REVIEWS DRUG DISCOVERY

Induction of Apoptosis in Murine Neuroblastoma by Systemic Delivery of Transferrin-Shielded siRNA Polyplexes for Downregulation of Ran

(2008) Nicole Tietze et al.   OLIGONUCLEOTIDES

Efficient siRNA Delivery with Non-viral Polymeric Vehicles

(2008) Won Jong Kim et al.   PHARMACEUTICAL RESEARCH

Impact of tumor-specific targeting and dosing schedule on tumor growth inhibition after intravenous administration of siRNA-containing nanoparticles

(2007) Derek W. Bartlett et al.   BIOTECHNOLOGY AND BIOENGINEERING