Article
Multidisciplinary Sciences
Surbhi Gupta, Parveen Kumar, Bhawna Rathi, Vivek Verma, Rakesh Singh Dhanda, Pooja Devi, Manisha Yadav
Summary: Urinary tract infections are common infectious diseases, but treating them is becoming difficult due to antibiotic resistance. This study developed a novel CRISPR gene editing strategy to target bacterial adhesion molecules, reducing pathogenicity.
SCIENTIFIC REPORTS
(2021)
Article
Spectroscopy
Adity Chopra, Anuradha Swami, Rohit Sharma, Neha Devi, Sherry Mittal, Rohit K. Sharma, Nishima Wangoo
Summary: This study presents a fluorescence resonance energy transfer-based assay for the detection of Staphylococcal enterotoxin. The developed method showed high sensitivity and specificity, and was successfully applied for quantification in apple juice.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2023)
Article
Chemistry, Multidisciplinary
Annamaria Panniello, Mariachiara Trapani, Massimiliano Cordaro, Carlo Nazareno Dibenedetto, Raffaele Tommasi, Chiara Ingrosso, Elisabetta Fanizza, Roberto Grisorio, Elisabetta Collini, Angela Agostiano, Maria Lucia Curri, Maria Angela Castriciano, Marinella Striccoli
Summary: Efficient FRET systems were developed by combining colloidal CdSe quantum dots (QDs) donors and BODIPY acceptors. The optimization of the distance between the organic fluorophore and the QDs through careful system engineering led to effective energy transfer in solution and solid state, with efficiencies reaching 76%. Deposition of QDs and dye as single coordinated units in solid state further increased efficiency by reducing the distance between the fluorophores to 2.2 nm, demonstrating the effectiveness of the coupling strategy.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Review
Chemistry, Physical
Akash S. Rasal, Sudesh Yadav, Anil A. Kashale, Ali Altaee, Jia-Yaw Chang
Summary: This review discusses the factors influencing the performance stability of QDSSCs and provides insights into the mechanisms causing degraded performances. It also presents cutting-edge strategies for improving the overall performance stability of QDSSCs.
Article
Multidisciplinary Sciences
Da-Seul Kim, Jun-Kyu Lee, Jun Hyuk Kim, Jaemin Lee, Dong Seon Kim, Sanghyun An, Sung-Bin Park, Tae-Hyung Kim, Jong Seop Rim, Soonchul Lee, Dong Keun Han
Summary: In this study, a PLGA scaffold combined with magnesium hydroxide and bone extracellular matrix was utilized to enhance anti-inflammation, mechanical properties, and osteoconductivity. Additionally, the development of a bioactive nanocomplex containing polydeoxyribonucleotide and bone morphogenetic protein 2 showed synergistic abilities in angiogenesis and bone regeneration, leading to outstanding performance in anti-inflammation, angiogenesis, and osteogenesis for the PME/NC scaffold. Such an advanced PME/NC scaffold suggests an integrated bone graft substitute for bone regeneration.
Article
Biophysics
Ganapathi Bharathi, Fangrui Lin, Liwei Liu, Tymish Y. Ohulchanskyy, Rui Hu, Junle Qu
Summary: Ovarian cancer is a deadly disease threatening women's health, and late diagnosis is a major reason for related deaths. Using HE4 as a biomarker can improve the accuracy of ovarian cancer diagnosis. Developing an all-graphene quantum dot FRET probe allows for ratiometric detection of the HE4 ovarian cancer biomarker.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Medicine, Research & Experimental
Yuang Chen, Yixian Huang, Haozhe Huang, Zhangyi Luo, Ziqian Zhang, Runzi Sun, Zhuoya Wan, Jingjing Sun, Binfeng Lu, Song Li
Summary: This study focuses on nanocomplex-assisted delivery of cancer vaccines, with FTS-PEI showing more effective tumor transfection than other delivery methods and significant presence of transfected cells in lymph nodes. It also demonstrates significant tumor growth inhibition through effective gene delivery to tumors and lymph nodes for neoantigen vaccination.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2021)
Article
Chemistry, Multidisciplinary
Jakub Slawski, Katarzyna Walczewska-Szewc, Joanna Grzyb
Summary: Controlled junctions of proteins and nanomaterials have potential applications in nanobiodevice construction. Crosstalk between sequential monolayers was studied using confocal microscopy and FLIM imaging, revealing the importance of coverage and distance between monolayers. Monte Carlo computation was used to estimate coverage in sequential monolayers. Quantum dots/protein-composed systems showed higher yield than predicted due to protein reorientation on nanoparticle surface. External application of poly-L-lysines modulated resonance energy transfer yield.
APPLIED SCIENCES-BASEL
(2023)
Article
Chemistry, Applied
Xiujin Chen, Guowen Li, Xin Yue, Chifang Peng, Jun Wang
Summary: In this study, a nanocomplex (NCP), AuAgNCs-CD, was prepared by self-assembling gold nanoclusters (AuNCs), silver nanoclusters (AgNCs) and carboxymethyl-β-cyclodextrin (CM-β-CD) using a one-step method. The emission of AuNCs was significantly enhanced. It was observed that FRET occurred between AuAgNCs-CD and rhodamine B (RhB) when they were combined. The presence of carbendazim (CBZ) induced an anti-FRET effect by competing with RhB and binding to AuAgNCs-CD. This phenomenon was utilized to develop a ratiometric fluorescent detection method for CBZ.
Review
Chemistry, Multidisciplinary
Olanrewaju A. Aladesuyi, Thabang C. Lebepe, Rodney Maluleke, Oluwatobi S. Oluwafemi
Summary: Semiconductor nanomaterials, known as quantum dots (QDs), have attracted significant interest for their excellent optical properties and potential biomedical applications. However, the presence of toxic heavy metals in conventional QDs poses a major challenge. Ternary I-III-VI QDs have emerged as viable alternatives with tunable optical properties that emit in the near-infrared region. This review discusses the recent progress in using ternary QDs in applications such as Forster resonance energy transfer (FRET), nanomedicine, optical imaging, biosensing, and multimodal imaging. It also examines the pharmacokinetics, biodistribution, and toxicity concerns of these QDs, as well as the current status, challenges, and future directions in their application.
NANOTECHNOLOGY REVIEWS
(2022)
Article
Biotechnology & Applied Microbiology
Rkia El-Kharrag, Kurt E. Berckmueller, Ravishankar Madhu, Margaret Cui, Gabriela Campoy, Heather M. Mack, Carl B. Wolf, Anai M. Perez, Olivier Humbert, Hans-Peter Kiem, Stefan Radtke
Summary: This study evaluated the feasibility of polymer-based nanoparticles (NPs) for the delivery of mRNA and nucleases to human CD34+ cells. The results showed that NP-mediated gene editing had high efficiency and low toxicity, with a reduced amount of reagents compared to electroporation. Additionally, the use of NPs enhanced the engraftment potential of HSCs in a mouse xenograft model.
Article
Chemistry, Physical
Tingting Cai, Wenjing Zheng, Qing Chang, Ning Li, Jinlong Yang, Shengliang Hu
Summary: This study presents a novel method of tuning visible light conversion to facilitate the release and activation of H2O2 through the integration of CaO2 with biocompatible carbon dots. The incorporation of carbon dots significantly enhances the catalytic performance of H2O2 released from CaO2.
JOURNAL OF MATERIALS CHEMISTRY A
(2022)
Article
Chemistry, Multidisciplinary
Peili Gao, Zinan Chen, Shuming Chen
Summary: This study investigates the degradation mechanism of blue quantum-dot light-emitting diodes (B-QLEDs) and reveals the accumulation of electrons in the quantum-dots (QDs) as the main cause of device degradation. The accumulated electrons induce the detachment of ligands and degrade the hole transport layer (HTL), while surface defects and HTL decomposition also contribute to B-QLEDs' stability.
ADVANCED MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Sijie Xian, Yuanhui Xiang, Dongping Liu, Bowen Fan, Katarina Mitrova, Rachel C. Ollier, Bo Su, Muhammad Ali Alloosh, Jiri Jiracek, Michael Sturek, Mouhamad Alloosh, Matthew J. Webber
Summary: A nanoscale complex combining electrostatic- and dynamic-covalent interactions between a synthetic dendrimer carrier and a modified insulin analogue has been developed, providing an injectable insulin depot with glucose-responsive and long-lasting insulin availability.
ADVANCED MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Ajmeeta Sangtani, Okhil K. Nag, Eunkeu Oh, Michael H. Stewart, James B. Delehanty
Summary: In this study, a quantum dot-chlorin e6 nanobioconjugate system was developed for membrane-localized ROS generation, leading to lipid peroxidation, increased membrane permeability, and inhibition of cellular proliferation. This system represents a promising approach for the further evolution of QD-based PDT systems.
JOURNAL OF NANOPARTICLE RESEARCH
(2021)
Article
Engineering, Biomedical
Yawen Ma, Huimin Lin, Peng Wang, Haocheng Yang, Jie Yu, Hao Tian, Tianyu Li, Shengfang Ge, Yilong Wang, Renbing Jia, Kam W. Leong, Jing Ruan
Summary: MicroRNA-based gene therapy using biocompatible nanocarriers shows promise in treating ocular melanoma by up-regulating tumor suppressor miR-30a-5p and inhibiting malignant phenotypes. The nanocarrier with high miRNA loading and redox-responsive release capabilities enhances the therapeutic effect. Furthermore, it promotes M1 macrophage polarization and activates Fenton reaction, synergistically enhancing anti-tumor immunity. The study demonstrates the potential of this nanocarrier for targeted gene therapy in melanoma and other cancers.
ACTA BIOMATERIALIA
(2023)
Article
Chemistry, Multidisciplinary
Jiaqi Xu, Junchao Xu, Tongfei Shi, Yinlong Zhang, Fangman Chen, Chao Yang, Xinjing Guo, Guangna Liu, Dan Shao, Kam W. Leong, Guangjun Nie
Summary: Microbiota-based therapeutics offer innovative strategies to treat inflammatory bowel diseases (IBDs), but the clinical outcome and bacterial approach need improvement. Inspired by the benefits of probiotics, bioartificial probiotics are designed to restore intestinal microenvironment and shift the gut microbiome to an anti-inflammatory state. The bioartificial probiotic consists of E. coli Nissle 1917-derived membrane (EM) as the surface and biodegradable diselenide-bridged mesoporous silica nanoparticles (SeM) as the core. This work suggests a safe and effective nanomedicine for IBDs therapy.
ADVANCED MATERIALS
(2023)
Article
Engineering, Biomedical
Baoding Huang, Qianfen Wan, Tianyu Li, Lexiang Yu, Wen Du, Carmen Calhoun, Kam W. Leong, Li Qiang
Summary: As a solution to the chronic inflammation and local adiposity caused by obesity, cationic polyamidoamine (PAMAM) treatment has shown promising results in improving metabolic functions and reducing body weight in diet-induced obese (DIO) mice. The treatment involves the use of PAMAM generation 3 (P-G3) scavenger and complexing P-G3 with human serum albumin (HSA) to achieve sustained release. Local injection of HSA-PG3 successfully restricts the distribution of the complex within the targeted adipose tissue and reduces focal adiposity.
Article
Engineering, Biomedical
Xing-Xing Yang, Chi-Hung Yip, Shirui Zhao, Yi-Ping Ho, Barbara Pui Chan
Summary: By chemically modifying collagen and hyaluronic acid and co-precipitating with glycosaminoglycans, a biomimetic nano-material that mimics the composition, ultra-structure, and function of the glycosaminoglycans-rich extracellular matrix in the nucleus pulposus has been fabricated. This nano-material shows superior composition, ultra-structure, and function compared to the native nucleus pulposus. This work is of great importance for the development of intervertebral disc tissue engineering.
Article
Plant Sciences
Wan-Ting Sun, Sy-Chyi Cheng, Ya-Ting Chao, Shu-Yao Lin, Ting-Ting Yang, Yi-Ping Ho, Ming-Che Shih, Swee-Suak Ko
Summary: This study investigated the morphology, cytology, biochemistry, and sucrose transporters in the pollinia of Phalaenopsis orchids. Results showed that the mature pollinia accumulated high levels of sugars, including sucrose, galactinol, myo-inositol, and glucose, which provided nutrients and enhanced pollinia germination and tube growth. The expression of sucrose transporters in the pollinia was associated with pollinia maturation and germination.
JOURNAL OF EXPERIMENTAL BOTANY
(2023)
Article
Chemistry, Multidisciplinary
Pengchao Zhao, Fuyang Qu, Hao Fu, Jianyang Zhao, Jiaxin Guo, Jiankun Xu, Yi-Ping Ho, Michael K. Chan, Liming Bian
Summary: Developing magnetic ultrasoft robots requires materials with excessive deformability, responsive actuation, and rapid adaptability, which are difficult to achieve with current soft polymeric materials. We have developed a magnetically actuatable and water immiscible coacervate liquid robot based on magnetic core-shell nanoparticles. This millimeter-sized liquid robot can remain stable under changing conditions, release loaded cargoes on demand, squeeze through capillary networks within seconds, and achieve intravascular targeting guided by a magnetic field. This coacervate-based liquid robot represents a distinct design strategy for high-performance ultrasoft robots in biomedicine.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Multidisciplinary
Naoto Yoshinaga, Joyce K. Zhou, Cong Xu, Chai Hoon Quek, Yuefei Zhu, Ding Tang, Lin Yung Hung, Sarah A. Najjar, Chin Ying Angela Shiu, Kara Gross Margolis, Yeh-Hsing Lao, Kam W. Leong
Summary: Effective delivery of CRISPR-Cas9 components is crucial and oral delivery has not been explored due to the degradative nature of the gastrointestinal tract. In this study, we developed novel PBA-functionalized CS-PEI polymers for oral CRISPR delivery, which showed effective penetration in the intestinal mucosa and achieved downregulation of the target protein and reduction in cholesterol. This study demonstrates the potential of addressing the needs of gene editing in a patient-compliant manner.
Article
Engineering, Biomedical
Shuai Deng, Xiaoyu Zhao, Yanlun Zhu, Ning Tang, Rongliang Wang, Xuerao Zhang, Fuyang Qu, Yi-Ping Ho, Wayne Yuk-Wai Lee, Jiansu Chen, Mingqiang Li, Yu Tao, Hon Fai Chan
Summary: Liver tissue engineering is advanced through the fabrication of collagen type I microspheres, enabling efficient hepatic differentiation of stem cells and assembly of prevascularized liver tissue. The microspheres exhibit high uniformity and can self-assemble with endothelial cells to form high cell-packing density liver tissue. This technology has potential applications in regenerative medicine, drug screening, and in vitro liver modeling.
Article
Engineering, Biomedical
Ganchimeg Davaa, Jin Young Hong, Jung-Hwan Lee, Min Soo Kim, Jennifer O. Buitrago, Yu-Meng Li, Hae-Hyoung Lee, Dong Wook Han, Kam W. Leong, Jung Keun Hyun, Hae-Won Kim
Summary: Neural stem cells (NSC) have the potential to regenerate injured neural tissues, but suffer from low survival and uncontrolled differentiation. This study demonstrates that mechanically-tuned protein hydrogels can protect and enhance the long-term survival of reprogrammed NSC, alleviate neural inflammation, promote differentiation, and improve locomotor functions in treating injured spinal cord.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Cell Biology
Yunfei Li, Zhixiong Sun, Huixiang Zhu, Yan Sun, David B. Shteyman, Sander Markx, Kam W. Leong, Bin Xu, Bingmei M. Fu
Summary: The integrity of the blood-brain barrier formed by brain microvascular endothelial cells derived from 22q11.2 Deletion Syndrome patients is compromised. The haploinsufficiency of CRKL, a gene within the 22q11.2 DS deletion region, contributes to this deficit. Treatment with imatinib, an FDA-approved drug, restores the compromised blood-brain barrier by increasing the level of active forms of the CRKL protein.
Article
Chemistry, Analytical
Yuanyuan Wei, Tianle Wang, Yuye Wang, Shuwen Zeng, Yi-Ping Ho, Ho-Pui Ho
Summary: In this paper, a simple, rapid, low-cost, biocompatible, and detachable microfluidic chip fabrication method based on Parafilm(R) is reported. The Parafilm(R) acts as both a bonding agent and a functional membrane, allowing the fabrication of 3D structured microfluidic chips within 2 hours with high ultimate tensile stress and high shear stress. The fabricated chips demonstrate better stability, reliability, and high performance for practical actuation devices. Moreover, the Parafilm(R)-based microfluidic devices show excellent biocompatibility and can be used for biochemical applications and point-of-care diagnostics.
Article
Engineering, Biomedical
Hye Sung Kim, Tzu-Chieh Ho, Moshe J. Willner, Michael W. Becker, Hae-Won Kim, Kam W. Leong
Summary: In this study, we propose an ex vivo T cell expansion system that mimics natural antigen-presenting cells for adoptive cell therapy. The system utilizes microfiber scaffolds coated with dendritic cell membrane to replicate the physicochemical properties of dendritic cells, leading to greater expansion and functionality of T cells. This scalable and customizable platform holds promise for future research and application in cell therapy.
BIOACTIVE MATERIALS
(2023)
Article
Engineering, Biomedical
Ho-Ying Wan, Jack Chun Hin Chen, Qinru Xiao, Christy Wingtung Wong, Boguang Yang, Benjamin Cao, Rocky S. S. Tuan, Susan K. K. Nilsson, Yi-Ping Ho, Michael Raghunath, Roger D. D. Kamm, Anna Blocki
Summary: This study introduces a strategy for stabilizing microvascular networks (MVNs) through macromolecular crowding (MMC), which enhances their stability and functionality by promoting the accumulation of cellular junctions and basement membrane components. Applying MMC to MVNs in microfluidic devices provides a reliable and versatile approach to stabilize engineered microvessels under simulated physiological conditions.
BIOMATERIALS RESEARCH
(2023)
Article
Nanoscience & Nanotechnology
Qinru Xiao, Yanping He, Md Habibur Rahman, Guangyao Cheng, Renjie Zhou, Yi-Ping Ho
Summary: Quantitative phase deformability cytometry (QPDC), constructed from a quantitative phase imaging system, improves the analysis of cellular contours and provides accurate characterization of cellular mechanical properties, especially for cells subjected to actin depolymerization. The platform enhances the capabilities of label-free cell characterization for biological and clinical applications.
Article
Chemistry, Multidisciplinary
Yongqiang Xiao, He Fang, Yuefei Zhu, Jie Zhou, Zhanzhan Dai, Hongxia Wang, Zhaofan Xia, Zhaoxu Tu, Kam W. Leong
Summary: This study investigates the effectiveness of cationic hyperbranched polyaminoglycosides derived from tobramycin (HPT) and disulfide-included HPT (ss-HPT) in scavenging cell-free nucleic acids (cfNAs) to mitigate posttrauma inflammation and hypercoagulation. Both polymers demonstrate the ability to suppress inflammation and hypercoagulation by efficiently scavenging cfNAs, and exhibit potent antibacterial effects. Additionally, these polymers exhibit favorable modulatory effects on inflammation and therapeutic outcomes in a mouse model. Notably, ss-HPT shows high accumulation and retention in injured organs of traumatized mice, with a higher biodegradation rate in healthy mice compared to HPT.
Article
Chemistry, Multidisciplinary
Xintong Zhang, Yanhong Liu, Wei Liu, Liqing Chen, Mingji Jin, Zhonggao Gao, Wei Huang
Summary: This study developed a macrophage-hitchhiking gene delivery system for the treatment of rheumatoid arthritis. The system demonstrated excellent targeting ability and nuclear entry ability, leading to efficient transfection of interleukin-10 in macrophages and alleviation of inflammation symptoms. This research provides a novel strategy for gene therapy and gene delivery system design for rheumatoid arthritis and other similar inflammatory diseases.
Article
Chemistry, Multidisciplinary
Richard K. Cross, Dave Spurgeon, Claus Svendsen, Elma Lahive, Simon Little, Frank von der Kammer, Frederic Loosli, Marianne Matzke, Teresa F. Fernandes, Vicki Stone, Willie J. G. M. Peijnenburg, Eric A. J. Bleeker
Summary: Even small changes in physicochemical properties of nanoforms (NFs) can influence their environmental fate and hazard. Testing and characterizing each individual NF will not be feasible due to the large number of new materials being developed. Targeting the most relevant form of the NF for a given exposure is important for efficient risk assessment. In aquatic systems, functional fate processes play a key role in determining the exposure relevant form of NFs. Grouping of NFs and read-across based on functional fate pathways can be justified by considering the shared fate and hazard profile. A new Integrated Approaches to Testing and Assessment (IATA) is presented, focusing on dissolution, dispersion stability, chemical transformations, and the contribution to toxicity from particles and dissolved components. This IATA can be used as a template for future in vivo kinetic assessments.
Article
Chemistry, Multidisciplinary
Minhui Lu, Xiaoxuan Zhang, Lijun Cai, Jingjing Gan, Jinglin Wang, Yu Wang, Yuanjin Zhao
Summary: Researchers have proposed a novel black phosphorus-loaded hydrogel inverse opal microneedle patch that exhibits photothermal responsive capacity and vivid structural color screening for psoriasis treatment. With improved materials, structures, and functions, the microneedle patch enables intelligent drug delivery and enhances drug loading and controllable release.
Article
Chemistry, Multidisciplinary
Qianyun Tang, Dandan Wang, Jinhui Cui, Yiheng Zhang, Junyang Mei, Jing Du, Anyue Xia, Qian Sun, Dan Luo, Baosan Han, Mingzhe Gan, Peifeng Liu
Summary: This study presents a novel microfluidic platform for precise and flexible control of oxygen concentrations in microbial suspension culture. The platform demonstrates unique capabilities for spatiotemporal gas control and detection, allowing for applications in screening, studying, and culturing industrial or niche-specific environmental microbiomes.
Review
Chemistry, Multidisciplinary
Jiaen Wu, Hao Chen, Jiawei Xu, Muhammad Saif Ur Rahman, Shengmei Li, Jie Wang, Shifen Huang, Charles C. Han, Shanshan Xu, Ying Liu
Summary: This review categorizes the potential health risks of microplastic pollution by focusing on the three primary pollution sources. It provides an in-depth analysis of the pharmacokinetics, toxicity potential, and biological mechanism of microplastics in the human body. The review aims to fill knowledge gaps about the toxicity of microplastics on human health and provide ideas for repairing the damage caused by microplastics.
Article
Chemistry, Multidisciplinary
Fanshu Ma, Yi Cao, Jincong Yan, Zhongzhong Lu, Lina Sun, Zahid Hussain, Zheng Wang, Li Wang, Renjun Pei
Summary: This study proposes a simple yet powerful method to create multifunctional hybrid nanovesicles that combine the characteristics of oncolytic viruses and pyroptosis, leading to enhanced tumor targeting and improved immune response. The results demonstrate excellent tumor inhibition efficacy against melanoma and pulmonary metastasis.
Article
Chemistry, Multidisciplinary
Fangmian Wei, Johannes Karges, Siyuan Gao, Lili Wang, Xiting Zhang, Xing-Can Shen, Liangnian Ji, Hui Chao
Summary: This study presents the coordination of Ru(II) polypyridine complexes to graphitic carbon nitride nanosheets for oxygen-self-sufficient two-photon photodynamic immunotherapy. The conjugates were found with strong two-photon absorption and could generate reactive oxygen species (ROS) to induce cell death and inhibit tumor growth through immune system activation.
Article
Chemistry, Multidisciplinary
Weiwei Zheng, Shun-Yu Yao, Haijun Hu, Xiping Chen, Zhefeng Qian, Wenxing Liu, Yang Zhu, Zhengwei Mao, Dong-Sheng Guo, Changyou Gao
Summary: In this study, a hypoxia-responsive self-assembled peptide hydrogel was prepared for ischemic stroke treatment. The hydrogel showed the ability to release drugs and effectively improve motor function, reduce infarct volume, and alleviate inflammation.
Article
Chemistry, Multidisciplinary
Qianqian Qiao, Jinyu Wang, Kai Long, Linwei Li, Jiahao Chen, Yuhao Guo, Ziqiang Xu, Ying Kuang, Tianjiao Ji, Cao Li
Summary: This study developed a catalytic system using titanium-based MXene nanosheets to load enzymes and anticancer drugs. The nanosheets demonstrated catalase-like activity and photothermal capability, enabling enhanced cancer treatment through starvation therapy and alleviation of hypoxia. In vitro and in vivo studies confirmed the effective anticancer capability of this enzyme cascade system.
Article
Chemistry, Multidisciplinary
Shiyang Wu, Yan He, Ruiqi Zhou, Chunlin Chen, Dawei Chen, Haiyang Hu
Summary: In this research, LDHA@MIP-DSD nanoparticles were designed to enhance the effectiveness of immunogenic cell death (ICD) in cancer immunotherapy. LDHA@MIP-DSD improved the accessibility of nanodrugs to cancer cells by surface imprinting LDHA and induced autophagy with SLN. The combination of these two effects resulted in optimal immune stimulation and antitumor efficiency.
Article
Chemistry, Multidisciplinary
Xu Zhang, Kejian Shi, Jiahui Mao, Kerou Mao, Yangrui Jia, Jiakun Zhang, Qingzhen Wang, Ru Bai, Fene Gao, Shihui Liu, Mengyu Guo, Fenglan Qin, Shengmin Li, Chunying Chen, Huige Zhou, Jing Liu, Fulin Chen
Summary: Compared with vein injection, oral administration is a preferred non-invasive and self-help treatment option for cancer therapy. However, the harsh gastrointestinal tract and biological barriers limit the stability and efficiency of oral drug delivery systems. To overcome these challenges, researchers have developed Cyssome, a drug delivery platform that can maintain stability in harsh environments, penetrate biological barriers, and improve drug release and bioavailability.
