Article
Chemistry, Multidisciplinary
Joshua A. Jackman, Bo Kyeong Yoon, Natalia Mokrzecka, Gurjeet Singh Kohli, Elba R. Valle-Gonzalez, Xinyi Zhu, Martin Pumera, Scott A. Rice, Nam-Joon Cho
Summary: Research shows that graphene oxide (GO) can protect Staphylococcus aureus bacterial cells under starvation conditions, increasing their viability. Transcriptomic profiling reveals that bacterial cells generally shut down metabolic activity in starvation conditions, but cells exposed to GO increase production of specific enzymes involved in the glyoxalase detoxification pathway while repressing autolysis.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Huarong Tan, Yuqi Huang, Shuqing Dong, Zetai Bai, Cheng Chen, Xiunan Wu, Minghao Chao, Hanrong Yan, Shaoshen Wang, Deqin Geng, Fenglei Gao
Summary: This article reports the development of a stimulus-responsive chiral nanomaterial, MSP-U, for the treatment of Alzheimer's disease. MSP-U stimulates neural stem cell differentiation, promotes in situ hydrogen production, and clears beta-amyloid plaques, showing promising potential as a treatment for AD using chiral nanomaterials.
Editorial Material
Biochemistry & Molecular Biology
Wei Pin Teh, He Zhu, Jarrod A. Marto, Sara J. Buhrlage
Summary: Henning et al. (2022) have developed a novel class of agents called bivalent deubiquitinase (DUB)-targeting chimeras (DUBTACs), which can selectively stabilize protein targets. This finding encourages further exploration of targeted protein stabilization as a new paradigm in chemical biology and drug discovery.
Review
Biotechnology & Applied Microbiology
Poonam Banthia, Lokesh Gambhir, Asha Sharma, Dhiraj Daga, Neha Kapoor, Rishabh Chaudhary, Gaurav Sharma
Summary: This review discusses the breakthrough of nanotechnology in targeted drug delivery for breast cancer treatment. Nanomedicines using nanoenabled carriers offer advantages like targeted delivery, stability, biocompatibility, and enhanced efficacy. Various nanoassemblies have revolutionized targeted therapeutic delivery by improving drug solubility, reducing dose and toxicity. However, challenges such as identifying appropriate biomarkers, understanding biological processes, ensuring batch uniformity and nanomaterial toxicity and stability still exist.
Editorial Material
Environmental Sciences
Samuel Pironon, Marybel Soto Gomez
Summary: A study has revealed that extreme heat events pose a risk to sweet potato production, but some heat-tolerant cultivars still have the potential to provide climate resilience.
NATURE CLIMATE CHANGE
(2021)
Editorial Material
Microbiology
Lacey J. Luense, Shelley L. Berger
Summary: RNA expression of endogenous retroviral elements can threaten the genome and cell function, potentially leading to disease. Recent research identifies m(6)A mRNA methylation as a regulatory mechanism to defend cells against these threats.
CELL HOST & MICROBE
(2021)
Editorial Material
Biology
Hannah M. Wesselman, Rebecca A. Wingert
Summary: The ability of adult zebrafish to regenerate damaged nephrons in the kidney relies on close collaboration between renal progenitor cells and renal interstitial cells.
Editorial Material
Biochemistry & Molecular Biology
Thomas E. Mulroney, Tuija Poyry, Anne E. Willis
Summary: A new study has identified genes that protect Caenorhabditis elegans from hypoxic stress, revealing a regulatory interaction between a threonyl-tRNA synthetase and ribosome biogenesis that modulates global translation and hypoxic sensitivity.
Editorial Material
Cell Biology
Michael Karin
Summary: The study reveals that FKBP11, a target of XBP1, is repressed in the liver of obese mice. Its re-expression activates a protective unfolded protein response pathway and restores insulin sensitivity.
Article
Health Care Sciences & Services
Stefano Piero Bernardo Cioffi, Osvaldo Chiara, Luca Del Prete, Alessandro Bonomi, Michele Altomare, Andrea Spota, Roberto Bini, Stefania Cimbanassi
Summary: This study aimed to investigate the impact of a standardised and integrated surgical and critical care step-up approach on the failure-to-rescue rate of complex enteric fistulas (CEF). The results showed that using this approach could improve the cure rate of fistulas and reduce the occurrence of postoperative complications.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Review
Environmental Sciences
Thanh Tam Toan Tran, Mai Nguyen Do, Thi Ngoc Hoa Dang, Quang Huy Tran, Van Thuan Le, Anh Quang Dao, Yasser Vasseghian
Summary: This paper presents recent advances in the use of graphene nanomaterials for biosensors to detect antibiotics, and discusses the emerging issues and potential opportunities in this field. Various electrochemical techniques were employed to determine antibiotic residues in different systems, and it was demonstrated how graphene nanomaterials can be utilized for antibiotic detection.
ENVIRONMENTAL RESEARCH
(2022)
Editorial Material
Microbiology
Eric M. Brown
Summary: Researchers have discovered that the addition of exogenous Bacteroides sphingolipids can reverse lipid accumulation in the liver in a mouse model of hepatic steatosis. They also found a unique microbially produced sphingolipid that can transit to the liver.
CELL HOST & MICROBE
(2022)
Article
Environmental Sciences
Bingxu Cheng, Feiran Chen, Chuanxi Wang, Xiaofei Liu, Le Yue, Xuesong Cao, Zhenyu Wang, Baoshan Xing
Summary: Fluorescent silica ENMs were synthesized to enhance rice growth and resistance to planthoppers, increasing shoot fresh and dry weight, root length, and forming mechanical barriers against the insects. Transcriptome data revealed upregulation of genes related to plant-pathogen interactions, hormone signal transduction, and metabolism pathways, promoting rice seedling growth and resistance.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Computer Science, Information Systems
Yongwei Zhao, Zidong Du, Qi Guo, Zhiwei Xu, Yunji Chen
Summary: Since the early days of computers, the focus has been on universality, with academia considering it a primary principle in the building of computing machines. However, the Curse of universality, as described by L. G. Valiant, states that universal and efficient computers based on logic circuits are impossible. Recent developments, such as the ending of Dennard scaling and Moore's law, have led to the rise of domain-specific architectures (DSAs) like deep learning processors. These DSAs sacrifice universality for optimal efficiency. This paper discusses the concept of quasi-universal architectures and introduces the Recursive-Encapsulated (RENC) architecture as a solution to the Curse, providing maximal universality with optimal efficiency.
SCIENCE CHINA-INFORMATION SCIENCES
(2023)
Review
Engineering, Biomedical
Shuai Zha, Ka-Leung Wong, Angelo H. All
Summary: Intranasal delivery of nanoparticles offers a non-invasive and effective method for delivering therapeutic agents to the brain, bypassing the blood-brain barrier.
ADVANCED HEALTHCARE MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Xintong Zhang, Yanhong Liu, Wei Liu, Liqing Chen, Mingji Jin, Zhonggao Gao, Wei Huang
Summary: This study developed a macrophage-hitchhiking gene delivery system for the treatment of rheumatoid arthritis. The system demonstrated excellent targeting ability and nuclear entry ability, leading to efficient transfection of interleukin-10 in macrophages and alleviation of inflammation symptoms. This research provides a novel strategy for gene therapy and gene delivery system design for rheumatoid arthritis and other similar inflammatory diseases.
Article
Chemistry, Multidisciplinary
Richard K. Cross, Dave Spurgeon, Claus Svendsen, Elma Lahive, Simon Little, Frank von der Kammer, Frederic Loosli, Marianne Matzke, Teresa F. Fernandes, Vicki Stone, Willie J. G. M. Peijnenburg, Eric A. J. Bleeker
Summary: Even small changes in physicochemical properties of nanoforms (NFs) can influence their environmental fate and hazard. Testing and characterizing each individual NF will not be feasible due to the large number of new materials being developed. Targeting the most relevant form of the NF for a given exposure is important for efficient risk assessment. In aquatic systems, functional fate processes play a key role in determining the exposure relevant form of NFs. Grouping of NFs and read-across based on functional fate pathways can be justified by considering the shared fate and hazard profile. A new Integrated Approaches to Testing and Assessment (IATA) is presented, focusing on dissolution, dispersion stability, chemical transformations, and the contribution to toxicity from particles and dissolved components. This IATA can be used as a template for future in vivo kinetic assessments.
Article
Chemistry, Multidisciplinary
Minhui Lu, Xiaoxuan Zhang, Lijun Cai, Jingjing Gan, Jinglin Wang, Yu Wang, Yuanjin Zhao
Summary: Researchers have proposed a novel black phosphorus-loaded hydrogel inverse opal microneedle patch that exhibits photothermal responsive capacity and vivid structural color screening for psoriasis treatment. With improved materials, structures, and functions, the microneedle patch enables intelligent drug delivery and enhances drug loading and controllable release.
Article
Chemistry, Multidisciplinary
Qianyun Tang, Dandan Wang, Jinhui Cui, Yiheng Zhang, Junyang Mei, Jing Du, Anyue Xia, Qian Sun, Dan Luo, Baosan Han, Mingzhe Gan, Peifeng Liu
Summary: This study presents a novel microfluidic platform for precise and flexible control of oxygen concentrations in microbial suspension culture. The platform demonstrates unique capabilities for spatiotemporal gas control and detection, allowing for applications in screening, studying, and culturing industrial or niche-specific environmental microbiomes.
Review
Chemistry, Multidisciplinary
Jiaen Wu, Hao Chen, Jiawei Xu, Muhammad Saif Ur Rahman, Shengmei Li, Jie Wang, Shifen Huang, Charles C. Han, Shanshan Xu, Ying Liu
Summary: This review categorizes the potential health risks of microplastic pollution by focusing on the three primary pollution sources. It provides an in-depth analysis of the pharmacokinetics, toxicity potential, and biological mechanism of microplastics in the human body. The review aims to fill knowledge gaps about the toxicity of microplastics on human health and provide ideas for repairing the damage caused by microplastics.
Article
Chemistry, Multidisciplinary
Fanshu Ma, Yi Cao, Jincong Yan, Zhongzhong Lu, Lina Sun, Zahid Hussain, Zheng Wang, Li Wang, Renjun Pei
Summary: This study proposes a simple yet powerful method to create multifunctional hybrid nanovesicles that combine the characteristics of oncolytic viruses and pyroptosis, leading to enhanced tumor targeting and improved immune response. The results demonstrate excellent tumor inhibition efficacy against melanoma and pulmonary metastasis.
Article
Chemistry, Multidisciplinary
Fangmian Wei, Johannes Karges, Siyuan Gao, Lili Wang, Xiting Zhang, Xing-Can Shen, Liangnian Ji, Hui Chao
Summary: This study presents the coordination of Ru(II) polypyridine complexes to graphitic carbon nitride nanosheets for oxygen-self-sufficient two-photon photodynamic immunotherapy. The conjugates were found with strong two-photon absorption and could generate reactive oxygen species (ROS) to induce cell death and inhibit tumor growth through immune system activation.
Article
Chemistry, Multidisciplinary
Weiwei Zheng, Shun-Yu Yao, Haijun Hu, Xiping Chen, Zhefeng Qian, Wenxing Liu, Yang Zhu, Zhengwei Mao, Dong-Sheng Guo, Changyou Gao
Summary: In this study, a hypoxia-responsive self-assembled peptide hydrogel was prepared for ischemic stroke treatment. The hydrogel showed the ability to release drugs and effectively improve motor function, reduce infarct volume, and alleviate inflammation.
Article
Chemistry, Multidisciplinary
Qianqian Qiao, Jinyu Wang, Kai Long, Linwei Li, Jiahao Chen, Yuhao Guo, Ziqiang Xu, Ying Kuang, Tianjiao Ji, Cao Li
Summary: This study developed a catalytic system using titanium-based MXene nanosheets to load enzymes and anticancer drugs. The nanosheets demonstrated catalase-like activity and photothermal capability, enabling enhanced cancer treatment through starvation therapy and alleviation of hypoxia. In vitro and in vivo studies confirmed the effective anticancer capability of this enzyme cascade system.
Article
Chemistry, Multidisciplinary
Shiyang Wu, Yan He, Ruiqi Zhou, Chunlin Chen, Dawei Chen, Haiyang Hu
Summary: In this research, LDHA@MIP-DSD nanoparticles were designed to enhance the effectiveness of immunogenic cell death (ICD) in cancer immunotherapy. LDHA@MIP-DSD improved the accessibility of nanodrugs to cancer cells by surface imprinting LDHA and induced autophagy with SLN. The combination of these two effects resulted in optimal immune stimulation and antitumor efficiency.
Article
Chemistry, Multidisciplinary
Xu Zhang, Kejian Shi, Jiahui Mao, Kerou Mao, Yangrui Jia, Jiakun Zhang, Qingzhen Wang, Ru Bai, Fene Gao, Shihui Liu, Mengyu Guo, Fenglan Qin, Shengmin Li, Chunying Chen, Huige Zhou, Jing Liu, Fulin Chen
Summary: Compared with vein injection, oral administration is a preferred non-invasive and self-help treatment option for cancer therapy. However, the harsh gastrointestinal tract and biological barriers limit the stability and efficiency of oral drug delivery systems. To overcome these challenges, researchers have developed Cyssome, a drug delivery platform that can maintain stability in harsh environments, penetrate biological barriers, and improve drug release and bioavailability.
