Article
Chemistry, Multidisciplinary
Yaqi Wang, Ling Ding, Hui Yu, Feng Liang
Summary: Sensitive spectrophotometric and electrochemical methods have been developed for the detection of metformin (MET) based on the host-guest molecular recognition capability of cucurbit[6]uril (CB[6]) modified on the gold surface. Both methods exhibit good concentration sensitivity to MET in different concentration ranges, providing a powerful tool for its detection.
CHINESE CHEMICAL LETTERS
(2022)
Article
Engineering, Electrical & Electronic
Doaa Sulaiman, Alwan M. Alwan, Walid K. Hamoudi
Summary: Bimetallic alloys nanoparticles were synthesized and combined with Si nano-pillars substrates to prepare SERS sensors, showing excellent recognition of ultra-low concentrations of chlorpyrifos solutions, with the highest enhancement factor obtained in Au-Pd sensors.
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
(2021)
Review
Chemistry, Multidisciplinary
Gour Mohan Das, Stefano Manago, Maria Mangini, Anna Chiara De Luca
Summary: Surface-enhanced Raman spectroscopy (SERS) is a powerful tool for biosensing applications due to its high sensitivity and multiplex detection capabilities. This review outlines the key aspects of SERS in the biomedical field, including mechanisms, substrates and fabrication methods, performance characterization factors, and applications.
Article
Chemistry, Physical
Shengyuan Yao, Yan Lv, Qing Wang, Jinhui Yang, Hongmei Li, Ningning Gao, Furu Zhong, Jihong Fu, Jun Tang, Tao Wang, Dianzeng Jia
Summary: As a new 2D carbon allotrope, graphdiyne (GDY) with its unique electronic space arrangement structure has the characteristics of uniform pores and large specific surface area. A novel gold nanoparticles (Au NPs)/GDY/carbon cloth (CC) SERS substrate was fabricated using GDY nanowall as support. The substrate showed good sensitivity in detecting organic dyes.
APPLIED SURFACE SCIENCE
(2023)
Article
Biochemical Research Methods
Stefano Fornasaro, Alessandro Esposito, Fiorella Florian, Alberto Pallavicini, Luigina De Leo, Tarcisio Not, Cristina Lagatolla, Marica Mezzarobba, Alessia Di Silvestre, Valter Sergo, Alois Bonifacio
Summary: Significant differences were found in the faecal samples of celiac patients and those on a gluten-free diet using SERS spectroscopy and 16S rRNA sequencing analysis. Although there were no significant differences in bacterial composition, the relative intensity of xanthine and hypoxanthine in the SERS spectra of patients on a gluten-free diet was significantly increased.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Physical
Jinling Gao, Wei Zhan, Yuhan Xiao, Xingrui Zhu, Wei Gao, Hong Yin
Summary: In this study, the surface plasmonic coupling between gold nanoparticles and ultrathin boron nitride nanosheets was demonstrated, leading to a significant enhancement of the Raman signal. By varying the size of the nanoparticles, the Raman signal of the nanosheets was improved from 1.7 to 71. The mechanism behind this enhancement was explored through the electromagnetic field coupling strength and charge transfer at the interfaces.
JOURNAL OF CHEMICAL PHYSICS
(2023)
Article
Multidisciplinary Sciences
Bao-xin Yan, Yan-ying Zhu, Yong Wei, Huan Pei
Summary: This paper calculated and analyzed the SERS characteristics of Au and Au@Al2O3 nanoparticle dimers using finite element method, finding that the electric field enhancement factor of Au@Al2O3 dimer is significantly greater than that of Au dimer and reaches its peak at an aluminum oxide shell thickness of 1 nm.
SCIENTIFIC REPORTS
(2021)
Article
Chemistry, Multidisciplinary
Zachary J. Woessner, George R. Lewis, Sandra L. A. Bueno, Emilie Ringe, Sara E. Skrabalak
Summary: This study investigates the asymmetric passivation of plasmonic nanoparticles and its effect on the deposition of new material, revealing that at low metal precursor concentrations, new material only grows on the exposed seed portions, while at high concentrations, nanobowl-like structures are formed. The optoelectronic properties of these nanobowls were probed using surface-enhanced Raman spectroscopy (SERS).
Article
Biophysics
Hao Wang, Bianbian Zhao, Yufei Ye, Xiaoyu Qi, Yuting Zhang, Xiaole Xia, Xiaoli Wang, Nandi Zhou
Summary: In this study, a fluorescence and surface-enhanced Raman scattering dual-mode aptasensor was developed for sensitive and rapid detection of Ochratoxin A (OTA). The aptasensor demonstrated low detection limits in both FL and SERS modes, as well as high specificity and good interferent resistance. It showed great potential for OTA detection in coffee and wine samples.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Chemistry, Physical
Danilo Oliveira de Souza, Jean-Sebastien Girardon, David J. Hoffmann, Elise Berrier
Summary: The time evolution of SERS in a drop-coated coffee-ring pattern of citrate-capped gold colloids under low laser power was studied. Although no spectral changes caused by plasmon-induced reaction were detected, a long-term transient spectral profile with additional lines was observed. By using extreme deviation and cross-correlation statistics, a deep qualitative and quantitative analysis of SERS intensity variation was performed, providing insights on the behavior of citrate-capping layers of gold nanoparticles upon laser illumination. The cross-correlation analysis allowed the tracking of individual events representing the evolution of citrate coordination on the gold surface driven by photo-activation, leading to the detection of very low levels of dicarboxy-acetone (DCA) in the system.
Article
Chemistry, Analytical
Antoine Dowek, Florent Voisin, Laetitia Le, Celine Tan, J. M. Mallet, Florent Carn, Eric Caudron
Summary: This study focuses on the improvement and control of SERS analysis by optimizing the aggregation/self-assembly of AuNPs using quaternized chitosan. The results show that the use of polyelectrolyte chains can stabilize neutral AuNPs aggregates, leading to significant enhancement of Raman signal. The stable and sensitive measurements of epinephrine at low concentrations were achieved, and the signal remained stable in complex media such as isotonic sodium chloride and glucose.
Article
Chemistry, Analytical
Peng Zhao, Jingyi Sun, Shijun Zhao, Yanan Song, Feng Gao, Hongbin Wang, Qingbin Ni, Ying Wang, Baoliang Sun
Summary: This method utilizes gold nanostars for immunoassay, enabling detection of the subarachnoid hemorrhage biomarker GFAP with very low detection limits and performance equivalent to that of conventional ELISA.
Article
Nanoscience & Nanotechnology
Jayakumar Pillanagrovi, Shourya Dutta-Gupta
Summary: This study presents a strategy to assemble gold nanoparticles in resonant gold nanoapertures for coupling-mediated near-field enhancement. The assembled AuNP-NA substrates showed improved SERS potential compared to bare NA templates, and numerical simulations indicated the importance of coupling between plasmonic modes for this enhancement.
Article
Chemistry, Physical
N. P. Kovalets, E. P. Kozhina, I. V. Razumovskaya, S. A. Bedin, A. A. Piryazev, Yu. V. Grigoriev, A. V. Naumov
Summary: This study investigates the hyperenhancement effect of Raman scattering (RS) appearing on microcracks of metal deposition (silver and gold) on uniaxially stretched polymer track-etched membranes. The deformation of membranes with high surface density and small pore diameter leads to the development of many microcracks in the metal coating. The efficiency of surface enhancement RS (SERS) is investigated using malachite green as an example, and the ability to recognize extremely low concentrations of the substance is demonstrated. The study finds that the SERS signal increases with the deformation of the samples and shows even greater enhancement after unloading and relaxation. Tensile strain experiments and changes in electrical conductivity confirm the hypothesis that SERS appears on microcrack edges with a relatively small distance between their boundaries. SERS technique is proposed for analyzing the formation of micro- and nanocracks on metal coatings.
JOURNAL OF CHEMICAL PHYSICS
(2022)
Article
Materials Science, Multidisciplinary
L. F. Gomez-Caballero, J. L. Pichardo-Molina, G. Basurto-Islas
Summary: This study reports the use of a dialysis method for simple preparation of a flexible substrate for Surface-Enhanced Raman Spectroscopy (SERS). The flexible SERS substrate showed good performance and can be used for bending surfaces in sample preparation and analysis.
Article
Nanoscience & Nanotechnology
Javier Redolat, Maria Camarena-Perez, Amadeu Griol, Miroslavna Kovylina, Angelos Xomalis, Jeremy J. Baumberg, Alejandro Martinez, Elena Pinilla-Cienfuegos
Summary: Controlled integration of metallic nanoparticles onto photonic nanostructures enables the realization of complex devices for extreme light confinement and enhanced light-matter interaction. A methodology for precise transfer and positioning of individual nanoparticles onto different photonic nanostructures is presented, using soft lithography printing. Raman spectroscopy confirms enhanced light-matter interactions in the resulting nanophotonic devices.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Optics
Tomoko Takahashi, Zonghua Liu, Thangavel Thevar, Nicholas Burns, Dhugal Lindsay, John Watson, Sumeet Mahajan, Sato Yukioka, Shuhei Tanaka, Yukiko Nagai, Balair Thornton
Summary: Researchers have developed a method that combines morphological and chemical information to accurately identify different particle types using optical measurement techniques that don't require sample preparation. By using a combined holographic imaging and Raman spectroscopy setup, they collected data from six different types of marine particles suspended in a large volume of seawater. Unsupervised feature learning was performed on the images and spectral data, and the learned features were combined to achieve better clustering results compared to using only image or spectral features. This method can be used for long-term monitoring of ocean particles without the need for sample collection, and it can be applied to different types of sensor measurements without significant modifications.
Article
Chemistry, Multidisciplinary
Xujun Qiu, Julian Brueckel, Christoph Zippel, Martin Nieger, Frank Biedermann, Stefan Braese
Summary: In this article, a multifunctionalisable aryl azide, tris(4-azidophenyl)methanol, is reported. It can be used as a protecting group for thiols in peptoid synthesis and can be cleaved under mild reaction conditions via a Staudinger reduction. Additionally, the easily accessible aryl azide can be functionalised through copper-catalysed cycloaddition reactions, offering more possibilities for materials chemistry applications.
Article
Chemistry, Multidisciplinary
Raphael P. B. Jacquat, Georg Krainer, Quentin A. E. Peter, Ali Nawaz Babar, Oliver Vanderpoorten, Catherine K. Xu, Timothy J. Welsh, Clemens F. Kaminski, Ulrich F. Keyser, Jeremy J. Baumberg, Tuomas P. J. Knowles
Summary: This paper presents an approach called nanocavity diffusional sizing (NDS) that relies on nanocavity confinement to measure the size of nanoscale particles and single biomolecules in solution. It uses particle residence times within nanofluidic cavities to determine their hydrodynamic radii. Experimental results show that the residence times scale linearly with the sizes of nanoscale colloids, protein aggregates, and single DNA oligonucleotides. NDS offers a new optofluidic approach for rapid and quantitative sizing of nanoscale particles with potential applications in nanobiotechnology, biophysics, and clinical diagnostics.
Article
Chemistry, Physical
Alex Poppe, Jack Griffiths, Shu Hu, Jeremy J. Baumberg, Margarita Osadchy, Stuart Gibson, Bart de Nijs
Summary: Atomic-scale features play crucial roles in metal-molecule interactions and have significant implications in various applications. However, studying these interactions is challenging due to the small size and transient nature of atomic-scale structures. In this study, we combine single-molecule surface-enhanced Raman spectroscopy with machine learning to extract spectra of perturbed molecules and investigate the formation dynamics of adatoms on metal surfaces. This approach provides unique insights into atomic-scale processes and helps us understand how metallic protrusions form and interact with nearby molecules. Our technique opens new possibilities for controlling metal-molecule interactions at an atomic level and contributes to rational heterogeneous catalyst design.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2023)
Article
Chemistry, Multidisciplinary
Pierre Picchetti, Stefano Volpi, Marianna Rossetti, Michael D. Dore, Tuan Trinh, Frank Biedermann, Martina Neri, Alessandro Bertucci, Alessandro Porchetta, Roberto Corradini, Hanadi Sleiman, Luisa De Cola
Summary: The development of smart nanoparticles with responsive features has expanded the applications of NP-based drugs, vaccines, and diagnostic tools. By combining nucleic acid interactions and sol-gel chemistry, researchers have successfully incorporated synthetic nucleic acids into organosilica nanoparticles, enabling them to respond to various biological, physical, and chemical inputs.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Multidisciplinary
Sara Rocchetti, Alexander Ohmann, Rohit Chikkaraddy, Gyeongwon Kang, Ulrich F. Keyser, Jeremy J. Baumberg
Summary: Developing highly enhanced plasmonic nanocavities allows direct observation of light-matter interactions at the nanoscale. With DNA origami, precise nanopositioning of single-quantum emitters in ultranarrow plasmonic gaps enables detailed study of their modified light emission. By developing nanoparticle-on-mirror constructs with DNA nanostructures as reliable and customizable spacers for nanoparticle binding, it is revealed that the traditional understanding of Purcell-enhanced molecular dye emission is misleading, and the enhanced dipolar dye polarizability greatly amplifies optical forces acting on the facet Au atoms, causing their rapid destabilization. Different dyes exhibit emission spectra dominated by inelastic (Raman) scattering rather than fluorescence, challenging the conventional theories in the field of quantum optics using plasmonics.
Article
Optics
Rohit Chikkaraddy, Rakesh Arul, Lukas A. Jakob, Jeremy J. Baumberg
Summary: This study proposes a method for detecting molecular vibrations in the mid-infrared range at room temperature. By assembling molecules into a plasmonic nanocavity resonant at both mid-infrared and visible wavelengths, and optically pumping them below the electronic absorption band, successful conversion of mid-infrared light and observation of enhanced visible luminescence were achieved.
Article
Chemistry, Multidisciplinary
Aoife Gregg, Michael De Volder, Jeremy J. Baumberg
Summary: Light-responsive microactuators composed of carbon nanotube and hydrogel composites exhibit efficient radiative heating capture and fast response time. The kinetics of these microactuators are limited by polymer diffusion. Additionally, these actuators have potential applications as microswimmers.
Article
Chemistry, Multidisciplinary
Marika Niihori, Tamas Foeldes, Charlie A. Readman, Rakesh Arul, David-Benjamin Grys, Bart de Nijs, Edina Rosta, Jeremy J. Baumberg
Summary: This study demonstrates the sensing of neurotransmitters at nm concentrations using self-assembled monolayers of plasmonic Au nanoparticles. By integrating Fe(III) sensitizers into nanogaps, enhanced surface-enhanced Raman spectroscopy is achieved for dopamine sensing. The transparent glass substrates allow for repeated sensing in different analytes.
Article
Chemistry, Multidisciplinary
David-Benjamin Grys, Marika Niihori, Rakesh Arul, Sarah May Sibug-Torres, Elle W. Wyatt, Bart de Nijs, Jeremy J. Baumberg
Summary: We demonstrate reliable creation of multiple layers of Au nanoparticles in random close-packed arrays with sub-nm gaps as a sensitive surface-enhanced Raman scattering substrate. The nanogaps can be precisely controlled below 1 nm by removing and replacing the original molecules with scaffolding ligands using oxygen plasma etching. The resulting high-performance fluidic sensing cells allow cyclic cleaning and reusing of the films for various analytes.
Article
Optics
Angelos Xomalis, Jeremy J. Baumberg
Summary: In this article, a multichannel lock-in vibrational spectroscopy method is reported, which utilizes acousto-optic modulators to convert nanosecond periodic temporal perturbations into spatially distinct spectra. By projecting the perturbed and reference spectra onto different locations of the spectrometer image, they can be simultaneously resolved. This multichannel time-resolved technique is applied to detect molecular frequency upconversion in plasmonic nanocavities through perturbed Raman scattering at different wavelengths. The phase-sensitive detection scheme can be applied to any spectroscopy within the visible and near-infrared wavelength ranges.
Article
Nanoscience & Nanotechnology
Wei-Hsin Chen, Wenting Wang, Qianqi Lin, David-Benjamin Grys, Marika Niihori, Junyang Huang, Shu Hu, Bart de Nijs, Oren A. Scherman, Jeremy J. Baumberg
Summary: A liquid-based surface-enhanced Raman spectroscopy assay, called PSALM, has been developed for the selective detection of neurotransmitters (NTs) in urine with a detection limit below the physiological range. This assay involves quick and simple mix-and-measure protocols with nanoparticles (NPs), where Fe-III bridges NTs and gold NPs in sensing hotspots. The optimized PSALM allows long-term monitoring of NT variation in urine, enabling the development of NTs as predictive or correlative biomarkers for clinical diagnosis.
ACS NANOSCIENCE AU
(2023)
Article
Biochemistry & Molecular Biology
Yanxi Liu, Changming Hu, Julian A. Serna, Frank Biedermann, Pavel A. Levkin
Summary: Label-free fluorescence-based chemosensing offers simplicity and high sensitivity for intracellular monitoring of molecules. However, conventional indicator displacement assays (IDAs) have limitations. In this study, a covalently coupled CB7-NBD conjugate was used to overcome these limitations and demonstrated to respond to various target analytes in complex live cell systems.
RSC CHEMICAL BIOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Laura M. Grimm, Jeffry Setiadi, Boryslav Tkachenko, Peter R. Schreiner, Michael K. Gilson, Frank Biedermann
Summary: The thermodynamic parameters of host-guest binding can be used to describe, understand, and predict molecular recognition events in aqueous systems. This study focuses on the contributions of water to binding by studying binding thermodynamics for a series of host-guest systems. It is found that the enthalpic driving forces for binding increase at higher temperatures, and heat capacity changes appear to be a general feature of host-guest complex formation in water.
