期刊
NANO LETTERS
卷 13, 期 7, 页码 3243-3247出版社
AMER CHEMICAL SOC
DOI: 10.1021/nl401354f
关键词
Plasmonics; nano-optics; sensing; optical dark-field spectroscopy; gold nanorod; multiplexed detection
类别
资金
- ERG [259640]
- graduate school of excellence Materials Science in Mainz
Efficient and cost-effective multiplexed detection schemes for proteins in small liquid samples would bring drastic advances to fields like disease detection or water quality monitoring. We present a novel multiplexed sensor with randomly deposited aptamer functionalized gold nanorods. The spectral position of plasmon resonances of individual nanorods, monitored by dark-field spectroscopy, respond specifically to different proteins. We demonstrate nanomolar sensitivity, sensor recycling, and the potential to upscale to hundreds or thousands of targets.
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