Article
Chemistry, Analytical
A. S. Tsagkaris, D. Migliorelli, L. Uttl, D. Filippini, J. Pulkrabova, J. Hajslova
Summary: In this study, a microfluidic paper-based analytical device (μPAD) was developed to rapidly screen for the toxic chlorpyrifos metabolite, chlorpyrifos-oxon, in human serum. The μPAD demonstrated rapid results within 10 minutes, cost efficiency, and a low detection capability, making it potentially applicable for point-of-need use. Additionally, the μPAD was compared to well-established methods such as an in-house BChE microplate assay and liquid chromatography tandem mass spectrometry.
Article
Biophysics
Yongfeng Zhu, Xia Tong, Qisheng Wei, Guihan Cai, Yuanxin Cao, Chaoying Tong, Shuyun Shi, Fang Wang
Summary: A novel platform for multiplex enzyme detection was developed based on 3D origami microfluidic paper-based device, allowing simultaneous detection of two enzymes' activities without pretreatment procedures. The platform exhibited excellent selectivity, good precision, favorable linear range, and high accuracy, successfully detecting alkaline phosphatase and butyrylcholinesterase in human serum samples.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Materials Science, Multidisciplinary
Ricardo Brito-Pereira, Clarisse Ribeiro, Pedro Costa, Vitor Correia, Vanessa F. Cardoso, Senentxu Lanceros-Mendez
Summary: The study proposes multifunctional hydrophobic composites with conductive graphene nanoplatelets (GNPs) integrated into the wax matrix to achieve a dual role of barrier and heater. With post-thermal curing, wax prints with mechanical stability and adequate impregnation can achieve controlled temperatures ranging from room temperature to approximately 107 degrees Celsius in just 10 seconds. This technology has great potential to meet the increasing demand for versatile and effective microfluidic paper-based analytical devices (mu PADs).
ADVANCED MATERIALS TECHNOLOGIES
(2023)
Article
Chemistry, Analytical
Raquel Catalan-Carrio, Tugce Akyazi, Lourdes Basabe-Desmonts, Fernando Benito-Lopez
Summary: The main challenge for the expansion and mass production of microfluidic paper-based analytical devices lies in the lack of fluid flow control due to uncontrolled fabrication protocols. The key to addressing this issue is to generate uniform and reliable microfluidic channels and optimize the fabrication process. Wax printing is the most common method, which requires analysis and optimization of parameters such as device shape, wax barrier width, and internal area.
Article
Chemistry, Analytical
Joule E. Esene, Mawla Boaks, Anna Bickham, Gregory P. Nordin, Adam T. Woolley
Summary: A 3D printed microfluidic system for microchip electrophoresis (mu CE) of preterm birth (PTB)-related peptides and proteins has been developed. The system allowed for control of fluid flow in device microchannels during sample injection, resulting in optimized separation efficiency and resolution. This system holds promise for PTB risk assessment.
Article
Biochemical Research Methods
Sera Ohta, Ryuya Hiraoka, Yuki Hiruta, Daniel Citterio
Summary: This article introduces a traffic light-like microfluidic paper-based analytical device that allows intuitive semi-quantitative analysis without the need for calibration or subjective interpretation. The device displays assay results as traffic light colors and has been designed to eliminate the risk of misinterpretation. The device relies on sample flow modulation through paperfluidic channels to achieve the desired readout. The platform has been successfully demonstrated for glucose quantification in artificial urine as a proof-of-concept.
Article
Chemistry, Analytical
Silvia Dortez, Agustin G. Crevillen, Alberto Escarpa
Summary: In this study, a colorimetric microfluidic paper-based analytical device combined with a smartphone readout was developed for the determination of serum iron levels. The method showed a good linear correlation, low detection limit, and high accuracy and inter-device reproducibility. Moreover, the method offered advantages such as affordability, portability, ease of use, sensitivity, and specificity, making it suitable for point-of-care testing.
Article
Materials Science, Multidisciplinary
Henry Ordutowski, Cesar Parra-Cabrera, Clement Achille, Ruben Dochy, Francesco Dal Dosso, Jeroen Lammertyn, Rob Ameloot, Dragana Spasic
Summary: Although efficient diagnostic testing often relies on centralized laboratories, rapid diagnostics at the point-of-care (POC) are increasingly investigated to provide an affordable and easy-to-use alternative that requires minimal external equipment. 3D printing is a promising technology to enable the single-step fabrication of POC diagnostic devices. In this study, the researchers aimed to improve the time-to-result and detection limit of the 3D-printed microfluidic device used for enzyme-linked immunosorbent assay (ELISA) by designing a second-generation device and optimizing the IgE ELISA.
APPLIED MATERIALS TODAY
(2023)
Article
Chemistry, Analytical
Maliwan Amatatongchai, Suphatsorn Thimoonnee, Kanpitcha Somnet, Sanoe Chairam, Purim Jarujamrus, Duangjai Nacapricha, Peter A. Lieberzeit
Summary: A novel Origami 3D-mu PAD was developed for colorimetric carbaryl detection using mesoporous silica-platinum nanoparticles coated with a molecularly imprinted polymer (PtNPs@MIP). The use of MIP on the PtNPs surface increased selective area and imprinting sites, leading to improved sensitivity and selectivity. The 3D-mu PAD design integrated efficient sample delivery and partition/separation paths to achieve improved detection performance.
Article
Materials Science, Characterization & Testing
F. A. Doronin, Yu Rudyak, G. O. Rytikov, A. G. Evdokimov, V. G. Nazarov
Summary: The paper demonstrates that by modifying the surface structure of PET substrates through multi-gas-phase treatment, the adhesion and wetting properties of PLA filament are significantly improved, enabling the production of planar microfluidic devices on them. Experimental results confirm significant changes in the chemical composition and nanorelief of PET substrates' surfaces, affecting the adhesion and wetting properties of the filament and enhancing the functional characteristics of the microfluidic devices.
Article
Chemistry, Analytical
Janosch Hauser, Matilda Dale, Olof Beck, Jochen M. Schwenk, Claudia Fredolini, Goeran Stemme, Niclas Roxhed
Summary: Patient-centric sampling strategies involving self sampling and centralized laboratory readout are becoming widely adopted. A capillary-driven microfluidic device is presented here for performing biomarker capturing during sample collection, enabling biohazard-free shipment and utilization of advanced laboratory analytics. The device demonstrates multiplexing capability and applicability to patient-centric workflows using various blood biomarkers. The quantification of a biomarker panel offers new possibilities for e-doctor and e-health applications.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Clement Achille, Cesar Parra-Cabrera, Ruben Dochy, Henry Ordutowski, Agnese Piovesan, Pieter Piron, Lore Van Looy, Shashwat Kushwaha, Dominiek Reynaerts, Pieter Verboven, Bart Nicolai, Jeroen Lammertyn, Dragana Spasic, Rob Ameloot
Summary: Rapid diagnostic testing at the site of the patient is essential when a fully equipped laboratory is not accessible. 3D-printed microfluidic devices offer a scalable route to low-cost diagnostics and eliminate the need for assembly of discrete components. The seamless transition between digital data and physical objects allows for rapid design iterations and opens up perspectives on distributed manufacturing.
ADVANCED MATERIALS
(2021)
Article
Chemistry, Analytical
Xueyan Liu, Rongsheng Gao, Lu Han, Chengyou Kan, Jianhong Xu
Summary: In this study, an economical and effective sensing system for Hg2+ quantitation was developed using a smartphone as a processing platform. The system integrated coumarin-modified paper as a probe and demonstrated high sensitivity and selectivity for Hg2+ detection. The smartphone-based system showed great potential for on-site and portable monitoring of Hg2+ in environmental water.
Article
Chemistry, Analytical
Farshad Ardakani, Zahra Shojaeifard, Bahram Hemmateenejad
Summary: We present a three-dimensional origami paper-based analytical device (3D-muPAD) for ABO and Rh blood type detection using a three-dimensional origami microfluidic technology. By counting the number of paper layers through which blood moves in antibody channels, the blood type can be accurately determined. This device offers higher accuracy and efficiency compared to traditional methods.
MICROCHEMICAL JOURNAL
(2022)
Article
Spectroscopy
A. Lakshmi Devi, P. E. Resmi, Aarathi Pradeep, P. V. Suneesh, Bipin G. Nair, T. G. Satheesh Babu
Summary: A paper-based colourimetric assay has been developed for Point-of-Care Testing (PoCT) of bilirubin. The method utilizes a green-coloured copper-bilirubin complex formed from a blue-coloured tetraamminecopper(II) sulphate complex. The assay demonstrated high selectivity for bilirubin, even in the presence of other biomarkers.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2023)
Article
Nanoscience & Nanotechnology
Soogeun Kim, Tae Gi Kim, Soo Hyun Lee, Wansun Kim, Ayoung Bang, Sang Woong Moon, Jeongyoon Song, Jae-Ho Shin, Jae Su Yu, Samjin Choi
ACS APPLIED MATERIALS & INTERFACES
(2020)
Article
Dentistry, Oral Surgery & Medicine
Ki-Ho Park, Se Jik Han, Samjin Choi, Kyung Sook Kim, Steven Park, Jae Hyun Park
JOURNAL OF CLINICAL PEDIATRIC DENTISTRY
(2020)
Article
Spectroscopy
Soogeun Kim, Young Jin Kim, Ayoung Bang, Wansun Kim, Samjin Choi, Hee Joo Lee
Summary: The study investigated the impact of Raman excitation wavelengths on the surface-enhanced Raman spectroscopy (SERS) for the identification of nontuberculous mycobacteria (NTM). By comparing SERS spectra with three commonly used excitation wavelengths, it was found that NTM species could be distinguished with statistical differences. Utilizing principal components-linear discriminant analysis and leave-one-out cross validation, the study achieved identification accuracies for six NTM species using aromatic amino acid biomarkers at different excitation wavelengths.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2021)
Article
Chemistry, Analytical
Soogeun Kim, Jin-Ho Joo, Wansun Kim, Ayoung Bang, Hyung Woo Choi, Sang Woong Moon, Samjin Choi
Summary: A high-performance portable Raman scattering-based sensing platform has been developed for the detection of individual toxic chemicals and simultaneous determination of toxic mixtures with significantly low detection limits for methylene blue and malachite green, as well as good performance in determining individual toxic chemicals in complex aquatic mixtures.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Chemistry, Physical
Hyun-Jung Kim, Ji-Hyun Jang, Sang Uk Woo, Kyoung-Kyu Choi, Sun-Young Kim, Jack L. Ferracane, Jung-Hwan Lee, Dongseok Choi, Samjin Choi, Soogeun Kim, Ayoung Bang, Duck-Su Kim
Summary: The study found that the novel BAG-containing dentin adhesive has the potential to reduce the permeability of demineralized dentin and promote dentin remineralization.
Article
Optics
Ji Hyeon Choi, Munsik Choi, Tien Son Ho, Soogeun Kim, Samjin Choi, Seung Ho Choi, Kyung Min Byun
Summary: A flexible SERS sensor template with nanogap-rich gold nanoislands was fabricated using a silk fibroin film, which showed good detection performance and investigated the effect of surface roughness of the silk substrate on sensor performance.
Article
Biophysics
Wansun Kim, Soogeun Kim, Jisang Han, Tae Gi Kim, Ayoung Bang, Hyung Woo Choi, Gyeong Eun Min, Jae-Ho Shin, Sang Woong Moon, Samjin Choi
Summary: We introduce a label-free surface-enhanced Raman scattering (SERS) biosensing platform that can identify the efficacy of the Oxford-AstraZeneca (AZD1222) vaccine in vaccinated individuals using non-invasive tear samples. The tears of people who receive the AZD1222 vaccine may be similar to those of adenovirus epidemic keratoconjunctivitis patients, as the vaccine is derived from a replication-deficient ChAdOx1 vector of chimpanzee adenovirus. By analyzing the signals from antibodies or immunoglobulin G by-product, we confirmed the potential of three markers for estimating the vaccination status.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Chemistry, Physical
Ji-Hyun Jang, Hyun-Jung Kim, Joo-Young Choi, Hae-Won Kim, Samjin Choi, Soogeun Kim, Ayoung Bang, Duck-Su Kim
Summary: The objective of this study was to evaluate the effect of novel bioactive glass (BAG)-containing desensitizers on dentin permeability. The results showed that desensitizers containing BAG significantly reduced dentin fluid flow rates after two weeks of storage in simulated body fluid. Raman spectroscopy analysis also revealed the formation of hydroxyapatite precipitates on the dentin surface after desensitizer treatment.
Article
Chemistry, Multidisciplinary
Hyerin Lee, Wansun Kim, Min-Young Song, Dong-Ho Kim, Ho Sang Jung, Weon Kim, Samjin Choi
Summary: Rapid and precise diagnosis of acute myocardial infarction (AMI) is crucial for preventing patient death. A nanotechnology-based one-stop immuno-SERS detection platform is reported for the simultaneous detection of multiple cardiac indicators, allowing for rapid screening and tracing of AMI events.
Article
Chemistry, Analytical
Soogeun Kim, Wansun Kim, Ayoung Bang, Jeong-Yoon Song, Jae-Ho Shin, Samjin Choi
Summary: This study introduces a label-free, simple, and high-efficiency breast cancer detection platform with multimodal biomarker analytic algorithms, demonstrating the potential for real-time diagnosis of breast cancer during surgery.
ANALYTICAL METHODS
(2021)
Proceedings Paper
Medical Laboratory Technology
Ayoung Bang, Hyung Woo Choi, Soogeun Kim, Samjin Choi
BIOMEDICAL VIBRATIONAL SPECTROSCOPY 2020: ADVANCES IN RESEARCH AND INDUSTRY
(2020)
Proceedings Paper
Materials Science, Multidisciplinary
Soogeun Kim, Ayoung Bang, Samjin Choi
NANOENGINEERING: FABRICATION, PROPERTIES, OPTICS, THIN FILMS, AND DEVICES XVI
(2019)
Article
Chemistry, Analytical
Soogeun Kim, Seung Ho Lee, Young Jin Kim, Hee Joo Lee, Samjin Choi
ANALYTICAL METHODS
(2019)
Article
Ophthalmology
Junkyu Chung, In Ki Park, Samjin Choi, Jae-Ho Shin
JOURNAL OF THE KOREAN OPHTHALMOLOGICAL SOCIETY
(2019)
Article
Dentistry, Oral Surgery & Medicine
Kyung Sook Kim, Se Jik Han, Tae-Hee Lee, Tae-Joon Park, Samjin Choi, Yoon-Goo Kang, Ki-Ho Park
KOREAN JOURNAL OF ORTHODONTICS
(2019)
Article
Chemistry, Analytical
Mengmeng Guo, Na Luo, Yueling Bai, Zhenggang Xue, Qingmin Hu, Jiaqiang Xu
Summary: A porous heterostructure WO3-C/In2O3 was designed and prepared for a miniature H2 sensor, which showed higher response value, lower operating temperature, fast response-recovery speed, and low limit of detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Feng Hu, Hui Hu, Yuting Li, Xiaohui Wang, Xiaowen Shi
Summary: Arsenic contamination in water bodies is a significant health risk. This study developed a chitosan-catechol modified electrode for rapid and accurate detection of trace amounts of arsenic. The modified electrode demonstrated good detection capability and resistance to ionic interference, making it suitable for in situ detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Yantao Zhang, Qian Liu, Tao Tian, Chunhua Xu, Pengli Yang, Lianju Ma, Yi Hou, Hui Zhou, Yongjun Gan
Summary: In this study, a lysosome-targeting buffering fluorogenic probe (Lyso-BFP) was designed and synthesized, demonstrating excellent photostability, pH specificity, and responsiveness to lysosomal acidification in living cells. The performance of Lyso-BFP in pH sensing was attributed to the inhibition of the photo-induced electron transfer process. Lyso-BFP allowed for wash-free imaging and long-term real-time monitoring of lysosome pH changes based on its off-on fluorescence behavior and buffer strategy.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Wei Cai, Wenbo Sun, Jiayue Wang, Xiaokui Huo, Xudong Cao, Xiangge Tian, Xiaochi Ma, Lei Feng
Summary: In this study, a near-infrared fluorescent probe HCBG was developed for imaging of alpha-GLC. HCBG exhibited excellent selectivity and sensitivity towards alpha-GLC in complex bio-samples, and showed good cell permeability for in situ real-time imaging. Through the high-throughput screening system established by HCBG, a natural alpha-GLC inhibitor was successfully isolated and identified. This study provides a novel fluorescence visualization tool for discovering and exploring the biological functions of diabetes-related gut microbiota, and a high-throughput screening approach for alpha-GLC inhibitor.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Trey W. Pittman, Xi Zhang, Chamindie Punyadeera, Charles S. Henry
Summary: Heart failure is a growing epidemic and a significant clinical and public health problem. Researchers have developed a portable and affordable diagnostic device for heart failure that can be used at the point-of-care, providing a valid alternative to current diagnostics approaches.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Anders O. Tjell, Barbara Jud, Roland Schaller-Ammann, Torsten Mayr
Summary: An optical hydrogen peroxide sensor based on catalytic degradation and the detection of produced oxygen is presented. The sensor offers higher resolution and better sensitivity at lower H2O2 concentrations. By removing O2 from the sample solution, a more sensitive O2 sensor can be used for measurement. The sensor has been successfully applied in a flow-through cell to measure H2O2 concentration in different flow rates.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Seong Jae Kim, Ji-hun Jeong, Gaabhin Ryu, Yoon Sick Eom, Sanha Kim
Summary: Surface-enhanced Raman spectroscopy (SERS) is a high-sensitivity, label-free detection method with various analytical applications. Researchers have developed a hydrophobic SERS substrate based on engineered carbon nanotube arrays (CNT-SERS) and studied the role of structural design at both micro and nanoscales. The substrate demonstrated controlled self-enrichment capability and enhanced sensitivity, with a significant increase in the SERS signal. The study also proposed a theoretical model and a concentration strategy inspired by plants for analyte deposition on microarrays.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Dan Zhao, Renjun Jiang, Xiaoqiang Liu, Subbiah Alwarappan
Summary: In this study, a novel ternary composite material was constructed by assembling cerium vanadate nanorods on reduced graphene oxide-microcrystalline cellulose nanosheets, and it was used for real-time monitoring of the concentration of superoxide anions in vivo. The ternary composite showed excellent conductivity, large surface area, and abundant active sites, leading to a wider linear range, high sensitivity, low detection limit, and fast response time for superoxide anion detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Tengfei Wang, Liwen Wang, Guang Wu, Dating Tian
Summary: In this study, a covalent organic framework material TaTp-COF with porous and uniform spheres was successfully prepared via hydrothermal reaction, and it was found to significantly enhance the aggregation-induced emission (AIE) of berberine. The unique emission properties of berberine on TaTp-COF were studied and utilized for the sensitive detection of berberine.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Lin Li, Yilei Ding, Lei Xu, Shuoran Chen, Guoliang Dai, Pengju Han, Lixin Lu, Changqing Ye, Yanlin Song
Summary: In this study, a novel TTI based on a ratiometric fluorescent nanosensor is designed, which has the advantages of high accuracy and low cost. Experimental and theoretical investigations confirm its pH responsiveness and demonstrate its good sensitivity and reliability. By monitoring the total volatile basic nitrogen, this TTI can accurately predict food spoilage and can be adaptively modified for different types of food. The TTI based on this nanosensor enables visual monitoring of food quality.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Fangju Chen, Xueting Wang, Wei Chen, Chenwen Shao, Yong Qian
Summary: Lung cancer is the second most common malignant tumor worldwide. Drug resistance in lung cancer leads to treatment failure and recurrence in majority of patients. This study developed a fluorescent prodrug that can be activated in cancer cells to release drugs, and its signal can be tracked by imaging. It shows a unique autophagy-driven ferroptosis effect, indicating its potential for targeting drug-resistant cancer cells.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Weichao Li, Qiming Yuan, Zhangcheng Xia, Xiaoxue Ma, Lifang He, Ling Jin, Xiangfeng Chu, Kui Zhang
Summary: This study developed a high-performance gas sensor for formaldehyde detection by modifying ZnSnO3 with ZnO QDs and SnO2 QDs. The modified sensor showed improved sensing response and lower working temperature. The presence of ZnO QDs formed rich heterojunctions, increased surface area, and provided oxygen deficiency for formaldehyde sensing reaction, thus enhancing the sensor performance. This research provides an alternative method to enhance the sensing properties of MOS by QDs modification.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Joung-Il Moon, Eun Jung Choi, Younju Joung, Jin-Woo Oh, Sang-Woo Joo, Jaebum Choo
Summary: A novel nanoplasmonic substrate was developed for biomedical applications, which showed strong hot spots for detecting biomarkers at low concentrations. The substrate, called AuNPs@M13, was made by immobilizing 60 nm gold nanoparticles onto the surface of an M13 bacteriophage scaffold. It demonstrated higher sensitivity and lower limit of detection compared to commercially available assays.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Ning Li, Ya Zhang, Ying Xu, Xiaofang Liu, Jian Chen, Mei Yang, Changjun Hou, Danqun Huo
Summary: The molecular subtype of breast cancer guides treatment and drug selection. Invasive tests can promote cancer cell metastasis, so the development of high-performance, low-cost diagnostic tools for cancer prognosis is crucial. Liquid biopsy techniques enable noninvasive, real-time, dynamic, multicomponent, quantitative, and long-term observations at the cellular, genetic, and molecular levels. A Cu-Zr metal-organic framework (MOF) nanoenzyme with monatomic Cu attachment has been synthesized and proven to have high catalytic performance. The sensor constructed using this nanoenzyme shows potential for accurate classification of breast cancer serum samples.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Jeongmin Kim, Hyemin Kim, Seunghyun Park, Hyeonaug Hong, Yong Jae Kim, Jiyong Lee, Jaeho Kim, Seung-Woo Cho, Wonhyoung Ryu
Summary: This study presents a method to fabricate independently functioning microneedle (MN) electrodes with narrow intervals for high precision electrochemical sensing. The optimized mixture of photocurable polymer and single-wall carbon nanotubes was used to mold single composite MNs, which were then attached to pre-patterned electrodes. Plasma etching and electropolymerization were performed to enhance the electrochemical activity, and Prussian blue and glucose oxidase were electrodeposited on the MNs for glucose detection. The MN electrodes showed good sensitivity and linearity, and the feasibility of glucose detection was demonstrated in an in vivo mouse study.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
