Review
Biotechnology & Applied Microbiology
Laura Locatelli, Sara Castiglioni, Jeanette A. M. Maier
Summary: This review article discusses the effects of space environment on the human vasculature and the adaptive responses activated in such conditions. The study suggests that oxidative stress and mitochondrial dysfunction might be mediators of vascular alterations in space. Understanding the cellular and molecular mechanisms involved in these adaptive processes could provide insights for designing proper countermeasures for space exploration.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Pharmacology & Pharmacy
Tong Li, Baofu Wang, Hao Ding, Shiqi Chen, Weiting Cheng, Yang Li, Xiaoxiao Wu, Lei Wang, Yangyang Jiang, Ziwen Lu, Yu Teng, Sha Su, Xiaowan Han, Mingjing Zhao
Summary: Atherosclerosis (AS)-related diseases are the leading cause of death in clinical patients. Vascular smooth muscle cells (VSMCs) play a crucial role in AS, and intercellular communication through extracellular vesicles (EVs) is important in the pathophysiology of AS.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Cell Biology
Yu-Xia Zhang, Ri-Ning Tang, Li-Ting Wang, Bi-Cheng Liu
Summary: Chronic kidney disease (CKD) is a significant health issue globally, with vascular calcification (VC) playing a major role in the cardiovascular morbidity and high mortality of CKD. Intercellular crosstalk between ECs and SMCs is crucial in the development of VC associated with CKD.
CELL PROLIFERATION
(2021)
Article
Biochemistry & Molecular Biology
Ningning Sun, Beyongsam Chu, Dong-Hyun Choi, Leejin Lim, Heesang Song
Summary: Abnormal communication between endothelial cells (ECs) and vascular smooth muscle cells (VSMCs) promotes vascular diseases. ETS variant transcription factor 2 (ETV2) plays a role in pathological angiogenesis, but its role in the communication between ECs and VSMCs is unknown. CXCL5 induced by ETV2 in ECs promotes VSMC migration through MMP upregulation and the activation of Akt and p38/c-Jun.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Pharmacology & Pharmacy
Gabriel Hoi-Huen Chan, Enoch Chan, Carsten Tsun-Ka Kwok, George Pak-Heng Leung, Simon Ming-Yuen Lee, Sai-Wang Seto
Summary: Ageing is a risk factor for degenerative diseases, including cardiovascular diseases. The tumor suppressor gene p53 may play a regulatory role in vascular remodeling, atherosclerosis, and pulmonary hypertension. Further studies are needed to fully understand the effects of p53 in cardiovascular function and its therapeutic potential.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Nerea Mendez-Barbero, Carmen Gutierrez-Munoz, Luis Miguel Blanco-Colio
Summary: Pathological vascular wall remodeling refers to the changes in structure and function of the vessel wall in response to injury, potentially leading to cardiovascular disease. Communication between endothelial cells and vascular smooth muscle cells is crucial for vasculature development and vessel homeostasis, with aberrant communication associated with various disease states including vascular wall remodeling. Different mechanisms such as paracrine regulations and direct contact play a role in this interplay.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Pharmacology & Pharmacy
Jody Tori O. Cabrera, Ayako Makino
Summary: Cell death and the clearance of apoptotic cells are regulated by signaling molecules. Abnormal clearance of apoptotic cells is associated with various health complications and diseases. During this process, phagocytic cells and/or apoptotic cells release signals to promote engulfment of apoptotic cells. In addition to macrophages and dendritic cells, other cell types such as endothelial cells and fibroblasts can also engulf apoptotic cells, although at a slower rate. This review focuses on the macrophage efferocytosis of vascular cells and its relation to cardiovascular disease, emphasizing the importance of efferocytosis-related molecules in maintaining vascular homeostasis.
PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Biochemistry & Molecular Biology
Mojtaba Parvizi, Zachary C. Ryan, Sanam Ebtehaj, Bonnie K. Arendt, Ian R. Lanza
Summary: Research has shown that senescent preadipocytes can induce an inflammatory phenotype, decrease cell viability, disrupt proliferation and migration, affecting the occurrence of vascular diseases by triggering phenotypic and functional changes in key cellular components of blood vessels.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2021)
Article
Biophysics
Sheng-wen Zhou, Jing Wang, Sheng-yu Chen, Ke-feng Ren, You-xiang Wang, Jian Ji
Summary: Changes in cellular microenvironment stiffness play a crucial role in pathological processes of blood vessels. This study constructed hydrogel substrates with physiological stiffness and found that an increase in stiffness within the physiological range significantly enhanced cell adhesion and proliferation behaviors.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Review
Developmental Biology
Arndt F. Siekmann
Summary: This review discusses the functions of vascular mural cells in blood vessel formation and diameter regulation, as well as their interactions with endothelial cells. It also introduces the signaling pathways controlling mural cell development and highlights distinguishing features of mural cells located on different types of blood vessels. Therapeutic strategies involving mural cells to improve tissue ischemia and vascular efficiency in various diseases are explored.
Article
Biochemistry & Molecular Biology
Misato Ueda, Yasuki Hirayama, Haruo Ogawa, Tadashi Nomura, Hiroto Terashi, Shunsuke Sakakibara
Summary: This study aimed to investigate the vasodilatory effects and cytotoxicity of various vasodilators used as antispasmodic agents during microsurgical anastomosis. The results showed that lidocaine, papaverine, and nitroglycerin had vasodilatory effects but also exhibited cytotoxicity, while phentolamine and olprinone showed antispasmodic effects without cytotoxicity. The concentrations of the vasodilators required for vasodilation were lower than the reported clinical concentrations.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Pharmacology & Pharmacy
Shigang Lin, Ruoran Lin, Hongkun Zhang, Qingbo Xu, Yangyan He
Summary: This review focuses on the functional changes of peripheral arterial cells and the mechanisms of PAD pathogenesis. It summarizes the progress of current clinical treatment and potential therapeutic methods for PAD, and provides insights for future perspectives.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Cardiac & Cardiovascular Systems
Mandy O. J. Grootaert, Martin R. Bennett
Summary: Vascular smooth muscle cells play a key role in atherosclerosis by forming a protective fibrous cap and exhibiting various phenotypes that can affect plaque formation and stability. They are a larger proportion of atherosclerotic plaques than previously thought and their plasticity is regulated by various mechanisms.
CARDIOVASCULAR RESEARCH
(2021)
Review
Cell Biology
Somasundaram Raghavan, Masuma Akter Brishti, M. Dennis Leo
Summary: Rab GTPases, a family of widely expressed proteins, play important roles in cellular functions and have been found to be crucial for normal cell function in the vasculature, particularly in endothelial and smooth muscle cells.
Article
Hematology
Sebastian F. Mause, Elisabeth Ritzel, Annika Deck, Felix Vogt, Elisa A. Liehn
Summary: EPCs stimulate proliferation and migration of SMCs and increase their neointimal accumulation following vascular injury. Furthermore, EPCs context-dependently modify the SMC phenotype with protection from the transformative effect of cholesterol when a direct cell-cell contact is established.
THROMBOSIS AND HAEMOSTASIS
(2022)
