4.8 Article

Sealing of Submicrometer Wells by a Shear-Driven Lipid Bilayer

期刊

NANO LETTERS
卷 10, 期 5, 页码 1900-1906

出版社

AMER CHEMICAL SOC
DOI: 10.1021/nl100779k

关键词

Spreading lipid bilayers; black lipid membranes; microfluidics; molecule encapsulation; nanostructures

资金

  1. Swedish Research Council for Engineering Sciences [2005-3140]
  2. Swedish Strategic Research Foundation
  3. Royal Physiographic Society in Lund

向作者/读者索取更多资源

A supported lipid bilayer (SLB) was formed in a microfluidic channel by vesicle fusion. The SLB, formed on a flat part of the surface, was driven by the shear forces of a bulk flow above the SLB to a part of the surface with embedded submicrometer wells. When using a bulk solution with a pH of 9.5 the advancing lipid bilayer sealed the wells, creating free-spanning membranes, whereas at a pH of 8.0 the SLB instead followed the contour of the wells.

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