Article
Materials Science, Multidisciplinary
Tun Naw Sut, Bo Kyeong Yoon, Won-Yong Jeon, Joshua A. Jackman, Nam-Joon Cho
Summary: Supported lipid bilayer (SLB) coatings, versatile cell-membrane-mimicking biointerfaces, have been expanded for medical and biotechnology applications, facilitating various studies and applications like biosensors, diagnostics, and antifouling surfaces.
APPLIED MATERIALS TODAY
(2021)
Article
Engineering, Electrical & Electronic
Jun Long Han, Hong Hu, Qing Yun Huang, Yu Lin Lei
Summary: In this study, an acoustofluidic platform based on standing surface acoustic waves (SSAWs) was established to analyze the influence of droplet contact angle on particle separation. Experimental results demonstrated the importance of reducing the contact angle for achieving better particle separation efficiency.
SENSORS AND ACTUATORS A-PHYSICAL
(2021)
Article
Engineering, Electrical & Electronic
Cheng Bai, Wen Zhou, Shifeng Yu, Tengfei Zheng, Chaohui Wang
Summary: Microfluidic mixing is an important issue in lab-on-a-chip systems and has various biomedical applications. Acoustic wave-based active micromixers have recently been used to increase mixing efficiency. However, these micromixers also generate additional heat. In this study, a thermal control unit was integrated into a surface acoustic wave (SAW)-assisted micromixer to effectively control the temperature in temperature-sensitive biomedical research.
SENSORS AND ACTUATORS A-PHYSICAL
(2022)
Article
Materials Science, Multidisciplinary
Konstantinos Kallitsis, Anna-Maria Pappa, Zixuan Lu, Alberto Alvarez-Fernandez, Ioanna Charalambous, Sina Schack, Walther C. Traberg, Quentin Thiburce, Karan Bali, Graham Christie, Stefan Guldin, Susan Daniel, Alberto Salleo, Roisin M. Owens
Summary: This study presents a versatile method to modify the surface chemistry of conducting polymers, aiming to bridge the chemical gap between bioelectronic devices and biological systems. The surface of poly(3,4-ethylenedioxythiophene) polystyrene sulfonate (PEDOT:PSS) is modified to enhance the formation of cell-derived supported lipid bilayers (SLBs). The functionalized devices show improved electronic output and demonstrate the potential of this approach in membrane-on-a-chip systems.
MACROMOLECULAR MATERIALS AND ENGINEERING
(2023)
Article
Engineering, Electrical & Electronic
Guojun Liu, Wanghao Shen, Yan Li, Hong Zhao, Xinbo Li, Conghui Wang, Fang He
Summary: This paper proposes a continuous separation method for multiple particles with the same volume but different densities based on a microfluidic chip. By using standing surface acoustic waves and hydrodynamic separation technology, continuous and effective separation of particles can be achieved. Experimental results show that this method can efficiently separate particles with different densities, with potential applications in biological research, disease diagnosis, and clinical practice.
SENSORS AND ACTUATORS A-PHYSICAL
(2022)
Article
Biochemical Research Methods
Naiqing Zhang, Juan P. Zuniga-Hertz, Elizabeth Yan Zhang, Tilvawala Gopesh, Mckenzie J. Fannon, Jiaying Wang, Yue Wen, Hemal H. Patel, James Friend
Summary: This study introduces a novel omnidirectional spiral surface acoustic wave (OSSAW) design for efficient separation of particles in microliter droplets, successfully extracting separated particles for the first time. The technology shows potential for whole blood separation and point-of-care diagnostics.
Article
Nanoscience & Nanotechnology
Guilherme B. Berselli, Aurelien Gimenez, Alexandra O'Connor, Tia E. Keyes
Summary: A biomolecular photoactive device based on light-activated proton pump bR reconstituted into highly fluidic microcavity-supported lipid bilayers (MSLBs) has been developed, demonstrating efficient photoelectrical properties. The optimal conditions for a self-sustaining photoelectrical switch were determined, showing significant increase in transient current for lipid bilayers containing approximately 0.3 mol % bR with a measured photo-current of 250 nA/cm(2).
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Physical
Gustavo A. Vasquez-Montoya, Tadej Emersic, Noe Atzin, Antonio Tavera-Vazquez, Ali Mozaffari, Rui Zhang, Orlando Guzman, Alexey Snezhko, Paul F. Nealey, Juan J. de Pablo
Summary: The optical properties of liquid crystals are typically controlled by electric fields. In this study, we investigate the effects of microfluidic flows and acoustic fields on the molecular orientation and optical response of nematic liquid crystals. We identify several previously unknown structures and explain them through calculations and simulations. These findings hold promise for the development of new systems combining sound, flow, and confinement.
Article
Physics, Applied
Derek A. Bas, Roman Verba, Piyush J. Shah, Serhiy Leontsev, Alexei Matyushov, Michael J. Newburger, Nian X. Sun, Vasyl Tyberkevich, Andrei Slavin, Michael R. Page
Summary: This study demonstrates the observation of the phase nonreciprocity of hybridized surface acoustic waves and spin waves in a magnetoelastic heterostructure, offering potential applications in acoustic isolators and circulators.
PHYSICAL REVIEW APPLIED
(2022)
Article
Biology
Valeria Zoni, Rasha Khaddaj, Pablo Campomanes, Abdou Rachid Thiam, Roger Schneiter, Stefano Vanni
Summary: The interactions between lipid acyl-chains play a key role in regulating the storage of neutral lipids in lipid droplets, affecting their distribution in cells. Different types of acyl-chains have distinct effects on lipid droplet formation and lipid storage.
Article
Chemistry, Physical
N. S. Satpathi, K. N. Nampoothiri, A. K. Sen
Summary: This study investigates the effects of surface wettability, droplet size, impact velocity, and SAW power on the dynamics of droplet impact. The interplay between capillary and viscous forces, inertia forces, and SAW-induced bulk acoustic streaming is found to be the underlying mechanism. The findings provide a deeper understanding of droplet impact on a surface exposed to SAW.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Article
Chemistry, Analytical
Lukas G. Schnitzler, Kathrin Baumgartner, Anna Kolb, Benedikt Braun, Christoph Westerhausen
Summary: This study investigates the acetylcholinesterase (AChE) activity and its non-classical roles. The activity is found to be unaffected by density fluctuations in lipid bilayers, while the presence of small unilamellar vesicles leads to an increase in activity. The increase in activity is proportional to the available membrane area per enzyme.
Article
Multidisciplinary Sciences
Mattia Morandi, Monika Kluzek, Jean Wolff, Andre Schroder, Fabrice Thalmann, Carlos M. Marques
Summary: Research has shown that the growth of plastic waste in the natural environment poses a credible and systemic threat to eukaryotic cells, affecting the mechanical properties and thermodynamics of membrane transitions. However, the fundamental mechanisms of interaction between oligomers and polymers with cell components remain unclear.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Biochemical Research Methods
Siddhartha Banerjee, Yuri L. Lyubchenko
Summary: The article discusses the preparation of smooth, stable, and structurally homogeneous lipid bilayers without trapped vesicles, for probing the time-dependent early stages of aggregation of monomeric amyloid proteins. This methodology development allows for monitoring amyloid protein aggregation at low protein concentrations, and for studying the specific role of different lipids in aggregation kinetics and disease development mechanisms.
Article
Chemistry, Analytical
Karutha Pandian Divya, Shanmuganathan Keerthana, Chinnuswamy Viswanathan, Nagamony Ponpandian
Summary: This paper reports a biomimetic bilayer lipid membrane supported MXene based biosensor for electrochemical hybridization detection of the most prevalent and potential breast cancer biomarker BRCA1. A 2D MXene nanosheet-anchored gold nanoparticle-decorated biomimetic bilayer lipid membrane (AuNP@BLM) biosensor is used for the attachment of thiolated single-stranded DNA (HS-ssDNA) targeting hybridization detection. The synergistic combination of MXene and AuNP@BLM has proven to efficiently improve the detection signal to several folds.
Article
Chemistry, Multidisciplinary
Philip Boehm, Alexandros Koutsioubas, Jean-Francois Moulin, Joachim O. Raedler, Erich Sackmann, Bert Nickel
Article
Chemistry, Multidisciplinary
David Volbers, Valentin K. Stierle, Konstantin J. Ditzel, Julian Aschauer, Joachim O. Raedler, Madeleine Opitz, Philipp Paulitschke
Article
Biochemistry & Molecular Biology
Stefanie Kiderlen, Christoph Polzer, Joachim O. Raedler, Denitsa Docheva, Hauke Clausen-Schaumann, Stefanie Sudhop
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2019)
Article
Physics, Multidisciplinary
David B. Brueckner, Alexandra Fink, Christoph Schreiber, Peter J. F. Roettgermann, Joachim O. Raedler, Chase P. Broedersz
Correction
Physics, Multidisciplinary
David B. Bruckner, Alexandra Fink, Christoph Schreiber, Peter J. F. Rottgermann, Joachim O. Radler, Chase P. Broedersz
Article
Biochemical Research Methods
Christoph Polzer, Stefan Ness, Mojtaba Mohseni, Thomas Kellerer, Markus Hilleringmann, Joachim Raedler, Thomas Hellerer
BIOMEDICAL OPTICS EXPRESS
(2019)
Article
Multidisciplinary Sciences
Fang Zhou, Sophia A. Schaffer, Christoph Schreiber, Felix J. Segerer, Andriy Goychuk, Erwin Frey, Joachim O. Raedler
Article
Multidisciplinary Sciences
Christoph Schreiber, Behnam Amiri, Johannes C. J. Heyn, Joachim O. Raedler, Martin Falcke
Summary: The study explored the motion of cells under different Fibronectin densities and revealed the regulatory roles of adhesion and velocity in cell velocity, as well as the relationship between leading-edge and rear adhesion structures. The findings provide a quantitative mechanistic understanding of the adhesion-velocity relation and cell response to changes in adhesion, integrating various factors such as force-dependent polymerization, retrograde flow, positive feedback, and spring-like front-rear interaction.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Multidisciplinary Sciences
David B. Brueckner, Nicolas Arlt, Alexandra Fink, Pierre Ronceray, Joachim O. Raedler, Chase P. Broedersz
Summary: The study found that the interactions between noncancerous cells are mainly described by repulsion and friction interactions, while cancerous cells exhibit attraction and antifriction interactions. These interaction behaviors were validated in experiments and may provide a unifying theoretical description for diverse cellular interaction behaviors of different cell types.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Instruments & Instrumentation
Tamara Ehm, Julian Philipp, Martin Barkey, Martina Ober, Achim Theo Brinkop, David Simml, Miriam von Westphalen, Bert Nickel, Roy Beck, Joachim O. Raedler
Summary: This paper presents a 3D-printed X-ray chamber that allows for in situ exchange of buffer and in situ optical transmission spectroscopy. The chamber is capable of measuring reversible structural changes in samples under different conditions and enables the study of responsive materials through combined microfluidic exchange and optical spectroscopy.
JOURNAL OF SYNCHROTRON RADIATION
(2022)
Article
Chemistry, Physical
Miriam Grava, Mohd Ibrahim, Akhil Sudarsan, Julio Pusterla, Julian Philipp, Joachim O. Raedler, Nadine Schwierz, Emanuel Schneck
Summary: The protonation degree and lipid packing of ionizable lipids play crucial roles in the performance of lipid-based nanoparticles, and a combination of molecular dynamics simulations and experimental measurements can provide valuable insights for further predictive modeling.
JOURNAL OF CHEMICAL PHYSICS
(2023)
Article
Biochemical Research Methods
Stefan Stoeberl, Miriam Balles, Thomas Kellerer, Joachim O. O. Raedler
Summary: Researchers introduced RGD-functionalized hydrogel structures with pressurized clefts for evaluating invasive migration of cells. Equally spaced blocks of PEG-NB hydrogels were formed using UV-photolithography, which swelled and closed the interjacent gaps, enabling the study of cancer cell transmigration through these clefts. This approach provides soft 3D-microstructures mimicking invasion conditions in the extracellular matrix.
Article
Physics, Fluids & Plasmas
Bernhard G. Mitterwallner, Christoph Schreiber, Jan O. Daldrop, Joachim O. Raedler, Roland R. Netz
Article
Biology
Alexandra Murschhauser, Peter J. F. Roettgermann, Daniel Woschee, Martina F. Ober, Yan Yan, Kenneth A. Dawson, Joachim O. Raedler
COMMUNICATIONS BIOLOGY
(2019)
Correction
Mathematical & Computational Biology
Fabian Froehlich, Anita Reiser, Laura Fink, Daniel Woschee, Thomas Ligon, Fabian Joachim Theis, Joachim Oskar Raedler, Jan Hasenauer
NPJ SYSTEMS BIOLOGY AND APPLICATIONS
(2019)