Article
Chemistry, Multidisciplinary
Mahdi Hesari, Hui Ma, Zhifeng Ding
Summary: The study reported for the first time single Au-38 nanocluster reaction events of highly efficient electrochemiluminescence (ECL) with tri-n-propylamine radicals as a reductive co-reactant at the surface of an ultramicroelectrode (UME). Statistical analyses of individual reactions confirm stochastic single ones influenced by the applied potential.
Article
Chemistry, Analytical
Rongfang Li, Zhiwei Jing, Guomin Yang, Ruo Yuan, Fang Xin Hu, Shihong Chen
Summary: This study successfully applied nickel single-atom catalysts (Ni SACs) in the graphitic carbon nitride (g-C3N4)-H2O2 electrochemiluminescence (ECL) system and significantly enhanced its cathodic emission. The developed system was also able to detect hepatitis B virus (HBV) DNA with excellent performance.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Yujie Liu, Hongding Zhang, Binxiao Li, Jianwei Liu, Dechen Jiang, Baohong Liu, Neso Sojic
Summary: This study successfully imaged single biomolecules using RuDSNs/AuNPs as ECL nanoemitters, demonstrating the visualization of single protein molecules and single membrane proteins in cells, overcoming the challenges in ultrasensitive ECL analysis and providing valuable information for cellular biology research.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Article
Chemistry, Physical
Brady R. Layman, Jeffrey E. Dick
Summary: Multiphase chemical systems, with their unique environment and properties, require the development of new tools for a detailed understanding. In this study, electrogenerated chemiluminescence (ECL) is used to precisely and comprehensively elucidate phase boundaries in a multiphase system. The results reveal unexpected lack of electronic communication in solvent inclusions, which has implications for energy storage and conversion devices and wearable/implantable sensors.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2023)
Article
Chemistry, Analytical
Yue Zhang, Jia-Hang Li, Xiao-Long Zhang, Hai-Jun Wang, Ruo Yuan, Ya-Qin Chai
Summary: Due to effective tackling of aggregation-caused quenching of traditional ECL emitters, aggregation-induced electrochemiluminescence (AIECL) has emerged as a research hotspot in aqueous detection and sensing. However, existing AIECL emitters still face challenges of low efficiency, poor biocompatibility, and high cost. In this study, aluminum(III)-based organic nanofibrous gels (AOGs) are used as a novel AIECL emitter to construct a rapid and ultrasensitive sensing platform for detecting Flu A virus biomarker DNA (fDNA) with the assistance of a high-speed and hyper-efficient signal magnifier, a rigid triplex DNA walker (T-DNA walker). The proposed AOGs exhibit efficient ECL response, outstanding biocompatibility, and the on-off ECL biosensor shows a low detection limit for target fDNA, providing a useful platform for rapid and sensitive monitoring of biomolecules and expanding potential applications in molecular devices, clinical diagnosis, and sensing analysis.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Analytical
Yuchan Ma, Yu Zhang, Jiaqi Gao, Hui Ouyang, Yong He, Zhifeng Fu
Summary: Ni single-atom catalysts (SACs) were synthesized and functionalized to develop highly sensitive electrochemiluminescent (ECL) probes for biosensors. The functionalized Ni SACs exhibited good aqueous dispersibility and could significantly enhance the ECL signal, making them suitable for various applications in biosensing.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
Huairong Zhang, Yong Liu, Mei Yao, Wenxiu Han, Shusheng Zhang
Summary: Cathodic electrochemiluminesence (ECL) microscopy based on luminol analog L012 utilizes multiwalled carbon nanotubes (MWCNTs) as coreactant accelerators to convert oxygen and H2O2 into reactive oxygen species. The produced ROS oxidizes L012 to emit bright cathodic ECL illumination, enabling the imaging of nanotubes and nucleolin on tumor cells. By modifying MWCNTs with AS1411 aptamers, label-free ECL imaging of nucleolin on plasma membranes was achieved, providing a universal approach in single nanomaterial and single-cell imaging.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Analytical
Ali Firoozbakhtian, Morteza Hosseini, Yiran Guan, Guobao Xu
Summary: Point-of-care testing is crucial in resource-poor areas, and this study presents the development of an integrated MXene-modified SEES device for visual and high-throughput ECL immunoassays. The developed system achieved a remarkable minimum virus detection limit and showed promising potential for efficient point-of-care testing.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Analytical
Fanwei Luo, Fei Chen, Yi Xiong, Zhen Wu, Xiuhua Zhang, Wei Wen, Shengfu Wang
Summary: The integration of magnetic separation and DNA walker amplification has resulted in a robust and sensitive single-particle electrochemical biosensor. This method effectively captures and separates targets from complex samples, avoiding interference and aggregation, leading to cyclic amplification and greatly enhanced detection sensitivity. The ultrasensitive detection of HIV DNA in complex systems demonstrates promising potential for real sample applications and the development of new single-entity biosensors.
ANALYTICAL CHEMISTRY
(2021)
Review
Chemistry, Analytical
Zhichen Zhang, Cheng Ma, Qin Xu, Jun-Jie Zhu
Summary: Electrochemiluminescence microscopy (ECLM) is an emerging visualization tool that allows direct study of the morphological structures and functional characteristics of cells. Compared to other imaging methods, ECLM has advantages such as low optical background, high sensitivity, simple instrumentation, and surface-confined mode.
Article
Chemistry, Multidisciplinary
Hui Zhu, Dechen Jiang, Jun-Jie Zhu
Summary: By mapping the electrocatalytic activity of a single graphene sheet with nanometer resolution using electrochemiluminescence (ECL) microscopy, this study effectively avoids the problem of overlapping ECL emissions from adjacent regions and achieves nanometer spatial resolution for the first time. The varied adsorption of hydrogen peroxide on the graphene surface leads to unsynchronized ECL emission, allowing the ECL intensity of each pixel to reflect the electrocatalytic features of the graphene surface with a resolution of 400 nm.
Article
Chemistry, Multidisciplinary
Jingjing Zhang, Lin Hao, Jie Chao, Lianhui Wang, Shao Su
Summary: In this study, an ECL imaging technique for single cell membrane protein based on Co3O4 nanozyme catalytic enhancement strategy was developed. The highly efficient catalytic performance of Co3O4 nanozymes allows efficient decomposition of H2O2 into reactive oxygen radicals, leading to enhanced reaction with the luminescence reagent L012 and stronger ECL emission. The optimized design of Co3O4 nanozymes coupled with anti-CEA enables specific recognition of overexpressed CEA on the MCF-7 cell membrane, enabling rapid ECL imaging of single cell membrane protein.
CHEMICAL COMMUNICATIONS
(2023)
Article
Chemistry, Analytical
Wenling Gu, Xiaosi Wang, Mengzhen Xi, Xiaoqian Wei, Lei Jiao, Ying Qin, Jiajia Huang, Xiaowen Cui, Lirong Zheng, Liuyong Hu, Chengzhou Zhu
Summary: In this study, iron single-atom catalysts were used as efficient co-reaction accelerators to achieve strong cathodic electrochemiluminescence at an ultralow potential. The catalysts activate H2O2 to produce reactive oxygen species, which directly react with a luminol to generate intense emission.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
Zhen Luo, Weiqing Xu, Zhichao Wu, Lei Jiao, Xin Luo, Mengzhen Xi, Rina Su, Liuyong Hu, Wenling Gu, Chengzhou Zhu
Summary: The Ru(bpy)(3)(2+)-tripropylamine ECL system is widely used in commercial bioanalysis, but the presence of amines in the biological environment causes unwanted anodic interference signals. To overcome this, a cathodic Ru(bpy)(3)(2+) ECL system is proposed, which utilizes the iron-nitrogen-carbon catalyst to activate the ECL signal. This innovative system shows great potential for practical applications, demonstrated by the successful development of an ECL biosensor for detecting alkaline phosphatase activity.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Analytical
Suyu Lin, Suiting Zheng, Hao Wu, Ziheng Zhang, Xinyuan Xie, Peihui Yang, Yu Huang, Fengyu Li
Summary: Electrochemiluminescence (ECL) has high sensitivity and specificity, but the lack of sufficient luminescent reagents limits its use in complex systems or multi-analyte detections. This study enhanced the selectivity and discrimination of ECL detection by using multi-stopband photonic crystals (PCs) to improve assigned ECL. The PC electrode achieved accurate qualitative and quantitative analysis of 10 antibiotics with 100% accuracy and a LOD of 0.44 μM in PBS buffer and human serum. The designed PC luminescence amplifications improved the selectivity of ECL detection for multi-analytes.
ANALYTICAL CHEMISTRY
(2023)
