Article
Nanoscience & Nanotechnology
Junshi Li, Yundong Ma, Dong Huang, Zhongyan Wang, Zhitong Zhang, Yingjie Ren, Mengyue Hong, Yufeng Chen, Tingyu Li, Xiaoyi Shi, Lu Cao, Jiayan Zhang, Bingli Jiao, Junhua Liu, Hongqiang Sun, Zhihong Li
Summary: The researchers have developed a flexible MNA electrode that can fit a curved body surface, penetrate the skin without fracture, and be mass-produced with a simplified process. The electrode is compatible with wearable wireless systems and has a short preparation time, improving the comfort and convenience of electrophysiological recording.
NANO-MICRO LETTERS
(2022)
Article
Engineering, Biomedical
Yanjun Li, Jingbo Yang, Ying Zheng, Rui Ye, Bin Liu, Yong Huang, Wei Zhou, Lelun Jiang
Summary: The study introduced a novel iontophoresis-driven porous MA patch (IDPMAP) and a portable iontophoresis-driven device for active transdermal delivery of charged liquid drugs. IDPMAP showed robust drug delivery ability with more advanced controllability and efficiency compared to pristine MA or iontophoresis, offering a platform technique for effective drug delivery in an active-controlled manner.
ACTA BIOMATERIALIA
(2021)
Article
Engineering, Biomedical
Renxin Wang, Jianxin Bai, Xiaohang Zhu, Zhaodong Li, Lixia Cheng, Guojun Zhang, Wendong Zhang
Summary: Traditional wet electrodes with conductive gel effectively reduce electrode-skin interface impedance in the short term. However, their flexibility and stability cannot meet the long-term monitoring requirements of wearable devices. A flexible microneedle array electrode (FMAE) based on a PDMS substrate is developed, which penetrates the skin's stratum corneum and obtains reliable bioelectrical signals. The FMAE has smaller, more stable impedance and can provide durable and reliable signals for long-term ECG monitoring.
BIOMEDICAL MICRODEVICES
(2022)
Article
Multidisciplinary Sciences
Ester Caffarel-Salvador, Soyoung Kim, Vance Soares, Ryan Yu Tian, Sarah R. Stern, Daniel Minahan, Raissa Yona, Xiaoya Lu, Fauziah R. Zakaria, Joy Collins, Jacob Wainer, Jessica Wong, Rebecca McManus, Siddartha Tamang, Shane McDonnell, Keiko Ishida, Alison Hayward, Xiewen Liu, Frantisek Hubalek, Johannes Fels, Andreas Vegge, Morten Revsgaard Frederiksen, Ulrik Rahbek, Tadayuki Yoshitake, James Fujimoto, Niclas Roxhed, Robert Langer, Giovanni Traverso
Summary: A highly drug-loaded microneedle patch was developed for rapid delivery of human insulin and growth hormone to the buccal cavity of swine, with the hard palate identified as the preferred application site. This study suggests that microneedle patches could increase medication adherence and provide painless delivery for pediatric and elderly populations.
Article
Engineering, Biomedical
Yingying Wang, Lelun Jiang, Lei Ren, Pingao Huang, Mei Yu, Lan Tian, Xiangxin Li, Jun Xie, Peng Fang, Guanglin Li
Summary: The use of microneedle electrode array improves the quality of electrophysiological signal recordings on human body surface with lower interface impedance and more stable signal recording characteristics. It enables high-quality electromyography and electrocardiography recordings, without causing discomfort. Microneedles penetrate through the corneum and reach the epidermis to fix electrodes on the body surface for high-quality signal recording, especially during body movements.
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
(2021)
Article
Nanoscience & Nanotechnology
Ying Zheng, Rui Ye, Xia Gong, Jingbo Yang, Bin Liu, Yunsheng Xu, Gang Nie, Xi Xie, Lelun Jiang
Summary: COVID-19 poses a serious threat to public health, and a wearable iontophoresis-driven microneedle (MN) patch is developed for active and efficient transdermal vaccine delivery. The patch consists of polyacrylamide/chitosan hydrogels with excellent properties, and the delivery efficiency is greatly improved by the synergistic effect of MN puncture and iontophoresis. In vitro and in vivo studies demonstrate controlled delivery of ovalbumin and a stronger immune response compared to traditional intramuscular injection, with minimal biosafety concerns. This low-cost and user-friendly delivery system has great potential for vaccine self-administration at home.
MICROSYSTEMS & NANOENGINEERING
(2023)
Article
Materials Science, Multidisciplinary
Lida Pan, Wangqing Wu, Junjie Liu, Xuepeng Li
Summary: This paper proposes an efficient and rapid method for the fabrication of polypropylene (PP) microneedle arrays using ultrasonic plasticization microinjection molding (UPMIM) technology. The research demonstrates that UPMIM can achieve a replication rate of up to 98.6%, resulting in precise PP microneedle arrays with excellent mechanical and penetration properties.
ACS APPLIED POLYMER MATERIALS
(2023)
Article
Nanoscience & Nanotechnology
Yue Hou, Zhaoyu Li, Ziyu Wang, Hongyu Yu
Summary: In long-term health monitoring, a flexible MAE on a Miura-ori structured substrate demonstrates superior accuracy and long-term stability in bio-signal recordings such as ECG and EMG. The device shows enhanced performance in device reliability and air ventilation through two-directional in-plane bendability and air-circulating channels, indicating great potential in health monitoring applications.
MICROSYSTEMS & NANOENGINEERING
(2021)
Article
Materials Science, Biomaterials
Xinfang Li, Qinan Xu, Jing Wang, Peng Zhang, Youxiang Wang, Jian Ji
Summary: By utilizing ultrasonic spraying technology, a gene-coated microneedle patch was successfully fabricated, demonstrating significant anti-tumor efficacy and potential as a transdermal gene/drug delivery platform.
JOURNAL OF MATERIALS CHEMISTRY B
(2021)
Article
Engineering, Biomedical
Wenting Shu, Helen Heimark, Nicky Bertollo, Desmond J. Tobin, Eoin D. O'Cearbhaill, Aisling Ni Annaidh
Summary: This study develops a finite element model for simulating microneedle insertion and penetration into human skin, emphasizing the importance of accurate computational modeling in understanding the mechanics of microneedle insertion. The study reveals the effects of skin pretension and microneedle array geometry on microneedle penetration efficiency.
ACTA BIOMATERIALIA
(2021)
Article
Multidisciplinary Sciences
Wonryung Lee, Seung-Hwan Jeong, Young-Woo Lim, Hyunhwan Lee, Joohyuk Kang, Hyunjae Lee, Injun Lee, Hyung-Seop Han, Shingo Kobayashi, Masaru Tanaka, Byeong-Soo Bae
Summary: The study developed a microneedle sensor on a hybrid substrate based on high Young's modulus epoxy siloxane and low Young's modulus polydimethylsiloxane, successfully achieving a microneedle sensor array on a flexible substrate. Mechanical durability was assessed through insertion into pig skin 1000 times, and the utility of flexible microneedle pH sensors in monitoring pH distribution in a disease model was demonstrated.
Article
Chemistry, Analytical
Mahmood Razzaghi, Mohsen Akbari
Summary: Microneedle arrays (MNAs) are emerging devices used for drug delivery and diagnostics through the skin. 3D printing-based fabrication methods offer advantages such as faster and more precise fabrication, but the penetration capability into the skin needs improvement.
Review
Biochemical Research Methods
Junxia Wang, Ziyi Lu, Ruisi Cai, Hanqi Zheng, Jicheng Yu, Yuqi Zhang, Zhen Gu
Summary: This paper presents an overview of state-of-the-art microneedle-based detection and sensing systems. Firstly, the designs of microneedle devices based on extraction mechanisms are summarized, including different geometries and materials of microneedles. Secondly, the targets of equipment-assisted microneedle detections are discussed, revealing the current performance and potential scenarios of these microneedles. Thirdly, the trend towards highly integrated sensors is elaborated by emphasizing the sensing principles (colorimetric, fluorometric and electronic manner). Finally, the key challenges and future development perspectives are discussed.
Article
Chemistry, Analytical
Ming-Nan Chien, Shih-Hao Fan, Chi-Huang Huang, Chien-Chen Wu, Jung-Tung Huang
Summary: In this study, a low-cost continuous lactate monitoring system (CLMS) is developed based on a percutaneous microneedle array that uses a three-electrode lactate sensor. The CLMS can provide real-time monitoring of lactate levels during exercise and assess the feasibility of evaluating exercise performance and training intensity.
Article
Materials Science, Multidisciplinary
Farzaneh Sabbagh, Pathikrit Saha, Beom Soo Kim
Summary: This study assessed the release rate of catechin in a poly(vinyl alcohol) (PVA) microneedle patch when combined with different constituents. The CMC-based microneedle patch showed the highest catechin release and swelling ratio.
ACS APPLIED POLYMER MATERIALS
(2023)
Article
Engineering, Electrical & Electronic
Kehao Feng, Zhenghua Zhang, Guohua Bai, Xiuyuan Fan, Rongzhi Zhao, Xuefeng Zhang
Summary: This paper proposes a new method to accurately evaluate the high-frequency power loss of soft magnetic materials. Through a two-step calibration, the system is able to compensate for the phase angle discrepancy between the exciting current and induced voltage, enabling a higher power loss measurement frequency.
SENSORS AND ACTUATORS A-PHYSICAL
(2024)
Article
Engineering, Electrical & Electronic
Mingfang Kang, Tong Liu, Hongmei Sun, Lin Li, Keliang Wang
Summary: In this study, the absorption performance of ambient nitrogenous toxic gases on a monolayer of blue phosphorus phase germanium selenide (GeSe) was investigated using density-functional theory calculations. The results showed that GeSe monolayer exhibits higher sensitivity and selectivity for the hazardous gas NO.
SENSORS AND ACTUATORS A-PHYSICAL
(2024)
Article
Engineering, Electrical & Electronic
Yaqiong Niu, Zhicheng Zou, Longsheng Cheng, Chaofeng Ye
Summary: This paper proposes a novel method to stabilize the laser diode output using a close-loop control with two feedbacks. The proposed method performs better for long-time operations.
SENSORS AND ACTUATORS A-PHYSICAL
(2024)
Article
Engineering, Electrical & Electronic
Jiajie Li, Ying Liu, Zhen Chai, Qian Cao, Renjie Li, Yueyang Zhai
Summary: This study proposed an efficient and high-quality beam-splitting method based on a diffractive optical element, enabling multichannel SERF atomic magnetometers to achieve ultra-high consistency and sensitivity. It has significant applications in array biomagnetic measurement systems.
SENSORS AND ACTUATORS A-PHYSICAL
(2024)
Article
Engineering, Electrical & Electronic
E. Oliveira, C. Doering, H. Fouckhardt
Summary: With the development of Lab on a chip technology, fluid management using dispersed droplets has become an important approach. Electrowetting on dielectric (EWOD) is one method for droplet actuation, but it requires prior definition of droplet positions. Optoelectrowetting (OEW) goes further by allowing changes in electrical parameters through impinging light spots, without the need for predefined droplet positions. This study re-evaluates the key parameters of OEW and explores their effects on droplet actuation using numerical optimization methods.
SENSORS AND ACTUATORS A-PHYSICAL
(2024)
Article
Engineering, Electrical & Electronic
Haipeng Wang, Zhiguo Wang, Gancheng Zhu, Shuai Zhang
Summary: A novel capacitive proximity skin was developed to improve the performance of robotics in handling liquid-filled containers. This skin features a flexible structure that can adapt to different grippers and seamlessly integrate with Robot Operating System. Experimental results demonstrated that this proximity skin achieved data-lossless detection and contactless measurement of liquid level, making it suitable for grasping operations.
SENSORS AND ACTUATORS A-PHYSICAL
(2024)
Article
Engineering, Electrical & Electronic
Tsenguun Byambadorj, Xiangyu Zhao, Yutao Qin, Yogesh B. Gianchandani
Summary: In this research, a monolithically microfabricated Knudsen pump (KP) without suspended membranes was presented. These pumps offer improved mechanical robustness, wider process window, and simplified microfabrication process compared to previous designs. The experimental results matched the modeling results well, indicating the potential for monolithic integration onto complex lab-on-a-chip systems.
SENSORS AND ACTUATORS A-PHYSICAL
(2024)
Article
Engineering, Electrical & Electronic
Hamed Karami, Saeed Karami Chemeh, Vahid Azizi, Hooman Sharifnasab, Jose Ramos, Mohammed Kamruzzaman
Summary: Aroma is a significant quality trait for pharmaceutical plants and their products, indicating the quality of the raw material. An electronic nose is an efficient approach for identifying and evaluating the aroma of essential oils. In this study, tarragon was dried at different temperatures and air velocities, and the purity of tarragon essential oil was evaluated using an electronic nose. Multivariate data analysis and artificial neural networks modeling were employed to quantify and classify the obtained essential oils.
SENSORS AND ACTUATORS A-PHYSICAL
(2024)
Article
Engineering, Electrical & Electronic
Xiaoyang Duan, Dan Xu, Wenjun Jia, Ran Li, Bohao Sun, Ruitian Yan, Wenjie Zhao
Summary: Flower-like WO3/WS2 heterojunction materials constructed via a low-temperature in-situ oxidation method exhibit significant improvements in the detection of NO2 gas in gas sensors, along with good selectivity and reproducibility.
SENSORS AND ACTUATORS A-PHYSICAL
(2024)
Article
Engineering, Electrical & Electronic
Peng Yu, Mengyang Zhang, Manqi You, Yuxi Gao, Landong Xiao, Yan Peng, Jingxia Lai, Zhouzhao Shi, Siwei Luo, Gencai Guo, Gang Guo
Summary: Recent studies have shown that two-dimensional Janus transition metal dichalcogenides (TMDs) have great potential for applications in gas sensors. By conducting first principles calculations, this study explores the potential application of Pd-doped monolayer HfSeS as gas sensor materials for detecting CO, CO2, NH3, and NO. The results demonstrate the good thermodynamical stability and reversible adsorption of these molecules on both pristine and Pd-doped HfSeS, with Pd-doped HfSeS showing higher sensitivity towards NO due to its metallic behavior upon NO adsorption.
SENSORS AND ACTUATORS A-PHYSICAL
(2024)
Article
Engineering, Electrical & Electronic
Jinlan Yang, Linjiao Li, Jun Huang, Quan Zhang, Hiba Affane
Summary: This study proposes a method for large-scale aggregation of micro-particles by creating a vortex region using low-frequency oscillation. Experimental results show that this method can achieve a large aggregation area and has the advantages of low cost and low power consumption.
SENSORS AND ACTUATORS A-PHYSICAL
(2024)
Article
Engineering, Electrical & Electronic
Jitendra Singh, Saurabh Kumar Gupta, Vinita
Summary: In this investigation, a Surface Acoustic Wave (SAW) formalin gas sensor was explored for low-level formalin gas sensing applications. The sensor showed stable response and high sensitivity to formalin gas concentration, making it a reliable and useful sensor for room temperature operations.
SENSORS AND ACTUATORS A-PHYSICAL
(2024)
Article
Engineering, Electrical & Electronic
Junyao Wang, Yahao Liu, Huan Liu, Qi Hou, Jianxin Xu, Hongxu Pan, Jingran Quan, Yansong Chen, Hanbo Yang, Lixiang Li
Summary: A flexible electrode with a serpentine-shaped tetra-chiral structure was designed to improve the mechanical properties and prevent mechanical fracture of flexible electrodes. The research demonstrated that this structure reduced the maximum tensile stress by 87.19% compared to the existing tetra-chiral structure. The flexible electrode remained conductive even at a strain of 70% and showed resistance values of 5 ohm and 4.4 ohm at a bending angle of 180 degrees and after 1000 fold cycles. Furthermore, the flexible electrodes showed great potential in biological signal monitoring, particularly in collecting ECG and pulse signals.
SENSORS AND ACTUATORS A-PHYSICAL
(2024)
Article
Engineering, Electrical & Electronic
Taihao Chen, Yong Fang, Mengru Zhu, Zhiwei Zhao, Wei Lei, Zhuoya Zhu, Helong Jiang
Summary: Flexible dual-spectral carbon nanodots/flexible n-silicon heterojunction photodetectors with high responsivity and detectivity are reported. These detectors show photo response in UV illumination and only in forward bias under visible illumination. The photocurrent of the device remains high even under bending strain.
SENSORS AND ACTUATORS A-PHYSICAL
(2024)
Article
Engineering, Electrical & Electronic
M. S. Sikandar Bathusha, Israr Ud Din, Rehan Umer, Kamran A. Khan
Summary: Graphene-based nanomaterials are used as embedded sensors to monitor fracture behavior in composite structures. This study investigates the in-situ crack propagation and fracture behavior in a glass fiber reinforced polymer composite using embedded reduced graphene oxide coated fabrics and highly conductive graphene nanoplatelet paper.
SENSORS AND ACTUATORS A-PHYSICAL
(2024)