Article
Chemistry, Multidisciplinary
Youssif Merhi, Pablo F. Betancur, Teresa S. Ripolles, Charlotte Suetta, Morten R. Brage-Andersen, Sofie K. Hansen, Anders Frydenlund, Jens Vinge Nygaard, Peter H. Mikkelsen, Pablo P. Boix, Shweta Agarwala
Summary: Muscle atrophy is a common problem caused by immobilization and critical illness, leading to rehabilitation difficulties and increased mortality. This study presents a solution for preserving muscle mass through the use of a customized biocompatible neuromuscular electrical stimulation (NMES) device. The integration of dry and biocompatible electrodes into a compressive stocking textile was demonstrated, resulting in extended usage without skin irritation. Electrochemical analysis showed improved performance of the printed electrodes compared to commercial ones, and promising results were obtained in a hospital setting for muscle atrophy evaluation.
Article
Engineering, Electrical & Electronic
Dapeng Yang, Qi Huang, Zainan Jiang, Li Jianga
Summary: This paper establishes a mathematical model to minimize ES-induced interference in EMG signal, and proposes a new concentric electrode configuration for biphasic transcutaneous electrical nerve stimulation (TENS).
IEEE SENSORS JOURNAL
(2021)
Review
Biology
Thanh-Nhan Doan, Wen-Chao Ho, Liang-Hui Wang, Fei-Chun Chang, Trang Thi Quynh Tran, Li-Wei Chou
Summary: This systematic review and meta-analysis found that the combination of transcutaneous neuromuscular electrical stimulation (TNMES) and conventional swallowing therapies (CSTs) is more effective than CSTs alone for patients with post-stroke dysphagia (PSD). Horizontal electrode placement targeting suprahyoid muscles or both suprahyoid and thyrohyoid muscles provides significant improvement in swallowing function. Individualized electrode placement based on dysphagia evaluation yields the largest effect size.
Article
Chemistry, Multidisciplinary
Ezzoubair Bendadesse, Anatolii V. Morozov, Artem M. Abakumov, Hubert Perrot, Jean-Marie Tarascon, Ozlem Sel
Summary: In this study, an advanced ac-electrogravimetry method combined with classical electrochemical quartz crystal microbalance (EQCM) was used to investigate the effect of solvent/salt combinations on the structure of the electrical double layer (EDL) formed at the electrolyte/electrode interface (EEI) of LixMoO3. The results provided solid experimental evidence of the direct relationship between the solvation of ions and solvent polarity. This elegant and powerful method can be adopted to improve the engineering of interfaces in electrochemical energy storage devices.
Article
Engineering, Biomedical
Tyler Johnson, Dawn Taylor
Summary: This study investigates how modulating cocontraction of antagonist muscles during functional electrical stimulation (FES) can impact reaching performance and energy usage. The results suggest that dynamically modulating limb stiffness can significantly improve energy usage and movement performance. Therefore, brain-controlled FES becomes a more viable option for restoration of reaching after paralysis.
JOURNAL OF NEURAL ENGINEERING
(2021)
Review
Chemistry, Multidisciplinary
Lei Zhao, Yuan Li, Meimei Yu, Yuanyou Peng, Fen Ran
Summary: The electrolyte-wettability of electrode materials in liquid electrolytes is crucial for electrochemical energy storage and conversion systems relying on interface electrochemical processes. Many electrode materials do not have satisfactory electrolyte-wettability, leading to potential issues in electrochemical reactions. This review comprehensively evaluates the effect of electrolyte-wettability on the performance of electrode materials in various electrochemical systems and discusses challenges and future directions for improving electrolyte-wettability.
Review
Materials Science, Multidisciplinary
Na-Yeong Kim, Ilgyu Kim, Behnoosh Bornamehr, Volker Presser, Hiroyuki Ueda, Ho-Jin Lee, Jun Young Cheong, Ji-Won Jung
Summary: A suitable interface between the electrode and electrolyte is crucial for stable electrochemical performance in Li-ion batteries. Recent research has focused on nanoengineering approaches to build a stable electrode-electrolyte interface, and this review presents and summarizes some of these advances. It also assesses the impact of each approach and explores future perspectives on their feasibility and practicality. Overall, this review provides valuable insights for the development of a nanoengineered interphase design, which is essential for high-performance, thermally stable Li-ion batteries.
ENERGY & ENVIRONMENTAL MATERIALS
(2023)
Article
Multidisciplinary Sciences
Emanuel Gunnarsson, Kristian Rodby, Fernando Seoane
Summary: Electro-stimulation has been used successfully for years to alleviate spasticity, pain, and increase mobility. The Mollii-suit by Inerventions utilizes dry conductive rubber electrodes, eliminating the need for frequent replacement. However, fitting the garment on the body is cumbersome. This paper presents the possibility of using knitted dry electrodes instead, which have lower skin friction and can easily be fitted to the body. Through validating the performance of the garment using electrical parameters, it is concluded that knitting techniques can produce a seamlessly integrated garment with beneficial manufacturing and comfort perspectives.
SCIENTIFIC REPORTS
(2023)
Article
Engineering, Biomedical
Ashwati Krishnan, Mats Forssell, Zhanhong Du, X. Tracy Cui, Gary K. Fedder, Shawn K. Kelly
Summary: The study focuses on using residual voltage (RV) from biphasic electrical stimulation pulse to identify degradation at the electrode-tissue interface. The research demonstrates that monitoring RV growth can be an effective method for assessing electrode health. The significance lies in the ability to detect and address faulty electrodes in a timely manner, ensuring optimal long-term operation of multi-electrode arrays.
JOURNAL OF NEURAL ENGINEERING
(2021)
Article
Engineering, Biomedical
Silviu Agotici, Kei Masani, Paul B. Yoo
Summary: The study aimed to better understand the neural activation induced by SDSS in the human lower leg. It was found that SDSS electrically activated multiple sub-populations of motor neurons within the TA muscle, providing insight into the mechanism of action for reducing muscle fatigue during NMES.
IEEE TRANSACTIONS ON NEURAL SYSTEMS AND REHABILITATION ENGINEERING
(2021)
Review
Materials Science, Textiles
Luisa Euler, Li Guo, Nils-Krister Persson
Summary: Electrical stimulation is beneficial for treating nerve and muscle injuries as well as pain, and textile electrodes offer advantages such as flexibility and re-usability. This review assesses research on textile electrode constructions, compares production methods and designs, proposes methods for evaluating stimulation discomfort, and discusses issues related to user compliance. Suggestions for future work focus on investigating the impacts of textile-based electrode parameters on comfort, convenience, and ease of use.
TEXTILE RESEARCH JOURNAL
(2022)
Review
Chemistry, Multidisciplinary
Le Li, Shaofeng Jia, Zhiyi Cheng, Changming Zhang
Summary: Aqueous zinc-ion batteries (ZIBs) are promising next-generation energy storage devices due to their abundant resources, affordability, ecological friendliness, and safety. The solid-electrolyte interface (SEI) formed in ZIBs through electrolyte/electrode interactions plays a significant role in battery performance. This review provides an overview of the impact of SEIs on ZIB performance and proposes an SEI design strategy based on its formation mechanism, type, and characteristics. Furthermore, future investigations on SEIs in ZIBs are expected to enhance our understanding, improve ZIB performance, and promote widespread implementation.
Article
Multidisciplinary Sciences
Marshall A. Trout, Abigail T. Harrison, Mark R. Brinton, Jacob A. George
Summary: Most neural stimulators lack the compliance voltage required for transcutaneous stimulation, whereas few high compliance voltage stimulators are bulky and not portable. To overcome this, a portable, programmable, multichannel, noninvasive neural stimulator has been designed and validated, capable of generating custom bipolar waveforms at +/-150V with high temporal resolution. The stimulator has been tested on a benchtop and a healthy population, proving its effectiveness for sensory and motor stimulation. This development and validation offer an important advancement in the accessibility and use of neural stimulation for education and research.
SCIENTIFIC REPORTS
(2023)
Article
Chemistry, Multidisciplinary
Yingmeng Zhang, Lingxuan Zeng, Zaohui Ding, Wei Wu, Libo Deng, Lei Yao
Summary: In this study, a dual-salt localized high-concentration electrolyte (LHCE) has been optimized to modify the unstable interfacial layers in high-voltage lithium metal batteries (LMBs). The modified interfacial layers on both cathode and anode sides stabilize the high-voltage cathode and high-active Li-metal anode.
CHEMICAL COMMUNICATIONS
(2023)
Review
Neurosciences
Richard G. Carson, Alison R. Buick
Summary: Neuromuscular electrical stimulation (NMES) has proven to be useful in motor rehabilitation following brain injury, promoting sustained adaptations within central motor pathways and ultimately increasing functional capacity. Understanding the mechanisms of adaptation can inform neurorehabilitation practice and provide a means of studying CNS plasticity at a systems level in humans. The fundamental aspects of NMES, along with adjuvant techniques, play a crucial role in enhancing therapeutic potential.
JOURNAL OF PHYSIOLOGY-LONDON
(2021)
Article
Nanoscience & Nanotechnology
Yang Zhao, Mei Yu, Jing Sun, Shenglong Zhang, Qingsong Li, Lijun Teng, Qiong Tian, Ruijie Xie, Guanglin Li, Linhua Liu, Zhiyuan Liu
Summary: Stretchable thin-film conductors are essential in advanced flexible and stretchable electronics, but stability is also crucial. This study investigates the electrical failure mechanism of stretchable conductors, identifying a special failure mode attributed to coupling effects between local thermal strains and dynamic resistance changes. The findings provide insights for designing stable stretchable bioelectrodes and circuits.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Multidisciplinary
Ming Zhu, Shaobo Ji, Yifei Luo, Feilong Zhang, Zhihua Liu, Changxian Wang, Zhisheng Lv, Ying Jiang, Ming Wang, Zequn Cui, Guanglin Li, Longtao Jiang, Zhiyuan Liu, Xiaodong Chen
Summary: Researchers have developed a solderless stretchable interconnection technology using mechanically interlocking microbridges, enabling the assembly of individual stretchable devices onto soft patternable circuits to achieve multifunctional all-stretchable platforms, exhibiting excellent stretchability up to 35%.
ADVANCED MATERIALS
(2022)
Article
Engineering, Biomedical
Wan-Hua Lin, Dingchang Zheng, Guanglin Li, Hui Zhou, Fei Chen
Summary: In this study, an algorithm for reliably detecting the peak of the pulse wave was proposed, and it was used to improve the accuracy of cardiovascular health analysis. The proposed forward peak detection method showed smaller estimation error compared to other characteristic points in estimating heart rate and heart rate variability. Furthermore, the augmentation index extracted from the forward peak was significantly correlated with age.
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
(2022)
Article
Engineering, Biomedical
Hui Wang, Pingao Huang, Tinghan Xu, Guanglin Li, Yong Hu
Summary: This paper presents a novel approach for myoelectric control by designing a fabric myoelectric armband to reduce electrode shifts. A fully unsupervised adaptive method called hybrid serial classifier (HSC) is proposed to eliminate the need for retraining. The performance of the approach is investigated using a dataset of forearm motion and compared with other algorithms, showing higher classification accuracy.
IEEE TRANSACTIONS ON NEURAL SYSTEMS AND REHABILITATION ENGINEERING
(2022)
Review
Chemistry, Multidisciplinary
Hang Zhao, Rui Su, Lijun Teng, Qiong Tian, Fei Han, Hanfei Li, Zhengshuai Cao, Ruijie Xie, Guanglin Li, Xijian Liu, Zhiyuan Liu
Summary: In recent years, the rapid development of flexible and wearable devices has brought new opportunities for real-time health management. Monitoring of chemical factors has become increasingly important, aiding in disease screening, diagnosis, and treatment. Researchers are now focusing on developing wearable devices capable of monitoring chemical factors for a more comprehensive understanding of human health.
Article
Engineering, Biomedical
Yazan Ali Jarrah, Mojisola Grace Asoghon, Oluwarotimi Williams Samuel, Xin Wang, Mingxing Zhu, Ejay Nsugbe, Shixiong Chen, Guanglin Li
Summary: This study investigated the capability of optimized filtering techniques in improving the quality of EMG signals for prosthetic control. The results showed that the Wiener filter achieved significant improvement in accuracy, indicating its potential in enhancing EMG-based control strategies.
BIOMEDICAL SIGNAL PROCESSING AND CONTROL
(2022)
Article
Engineering, Environmental
Ying Yin, Wei Tang, Xiaoyue Ma, Lin Tang, Yu Zhang, Meng Yang, Fangfang Hu, Guanglin Li, Yazhou Wang
Summary: This study presents an effective approach for treating malignant glioma based on neutrophil-macrophage hybrid membrane coating nanotechnology. The biomimetic nanoparticle can overcome the blood-brain barrier and target glioma, showing high therapeutic efficacy.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Engineering, Biomedical
Wei Wang, Naifu Jiang, Lijun Teng, Minghong Sui, ChunZhen Li, Lin Wang, Guanglin Li
Summary: This study utilized HD-EMG to explore the neuromuscular synergy of back muscle activities in AIS patients. The results showed that muscle synergy groups could explain a large portion of muscle activities in both AIS patients and healthy subjects. In AIS patients, there were increased muscle activations on the convex side during flexion/extension and reduced muscle activations and inhomogeneous distribution during lateral bending and axial rotation.
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
(2022)
Article
Chemistry, Physical
Shan Liang, Yechao Han, Wanglinhan Zhang, Tianyan Zhong, Hongye Guan, Yafeng Song, Yan Zhang, Lili Xing, Xinyu Xue, Guanglin Li, Yang Zhan
Summary: A new self-powered wearable system that can monitor body vital signs, transmit neural stimulating signals into the brain, and enhance sports endurance performance has been developed. This system works without external electricity power and is powered by the body itself, showcasing a novel strategy for wearable brain-machine-interface systems in sports and health monitoring.
Article
Neurosciences
Yi Cao, Chongyang Sun, Jianyu Huang, Peng Sun, Lulu Wang, Shuyu He, Jianxiang Liao, Zhonghua Lu, Yi Lu, Cheng Zhong
Summary: Temporal lobe epilepsy impairs risk assessment, and this can be attributed to the imbalance of glutamatergic and GABAergic neurons. Neuronal loss and reorganization also contribute to the impairment of risk assessment. Understanding these mechanisms could lead to improved treatment strategies for epilepsy patients.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Article
Cell Biology
Cheng Zhong, Lulu Wang, Yi Cao, Chongyang Sun, Jianyu Huang, Xufang Wang, Suwan Pan, Shuyu He, Kang Huang, Zhonghua Lu, Fuqiang Xu, Yi Lu, Liping Wang
Summary: An appropriate balance between explorative and defensive behavior is crucial for the survival and reproduction of prey animals in risky environments. In this study, using a semi-naturalistic predator threat test (PTT), researchers found that the activity of dorsal CA3 glutamatergic neurons in mice is suppressed during predatory threat and risk exploration, but activated during contextual exploration. Furthermore, optogenetic excitation of these neurons leads to increased risk exploration. The activation of a specific circuit involving the dorsal CA3, dorsal lateral septal, and dorsomedial hypothalamic areas promotes the switch from defense to risk exploration and suppresses the heightened arousal caused by threats.
Article
Engineering, Biomedical
Mengying Yan, Lulu Wang, Yiyong Wu, Liping Wang, Yi Lu
Summary: Biomimetic brain structures and artificial neural networks have provided a simplified strategy for investigating the complex characteristics of neural networks. Three-dimensional cell culture methods can mimic cell-cell interactions and help understand the function of neurons and neuronal networks. However, the fabrication of 3D scaffolds similar to the natural extracellular matrix has been a challenge. In this study, we developed a simplified and low-cost strategy to fabricate highly porous and cytocompatible hydrogel scaffolds for constructing 3D neural networks.
ACTA BIOMATERIALIA
(2023)
Article
Chemistry, Multidisciplinary
Jiajun Zhang, Lulu Wang, Yu Xue, Iek Man Lei, Xingmei Chen, Pei Zhang, Chengcheng Cai, Xiangyu Liang, Yi Lu, Ji Liu
Summary: Coating conventional metallic electrodes with conducting polymers enables the bioelectrodes to have desirable characteristics for bioelectronics. However, the fragile interface between the conducting polymer and the electrode limits their utility and reliability. In this study, a reliable strategy for seamlessly connecting conventional electrodes with conducting hydrogel coatings is established, which improves the long-term robustness of the interface. Through in vivo implantation in mouse models, stable electrophysiological recording is achieved with a robust conducting hydrogel-electrode interface. This design strategy addresses technical challenges in bioelectrode engineering and opens up new avenues for diagnostic brain-machine interfaces.
ADVANCED MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Hanfei Li, Fei Han, Lulu Wang, Laixin Huang, Oluwarotimi Williams Samuel, Hang Zhao, Ruijie Xie, Ping Wang, Qiong Tian, Qingsong Li, Yang Zhao, Mei Yu, Jing Sun, Ruofan Yang, Xiaomeng Zhou, Fei Li, Guanglin Li, Yi Lu, Peizhi Guo, Zhiyuan Liu
Summary: A hybrid strategy is reported to prepare ultra-narrow multi-channel stretchable microelectrodes without using photolithography or laser-assisting etching. A 10 μm x 10 μm monitoring window is fabricated with enhanced interfacial impedance by the special rough surface. The stretchable microelectrodes can detect electrophysiological signals of single cells in vitro and collect electrophysiological signals more precisely in vivo.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Nanoscience & Nanotechnology
Mengying Yan, Lulu Wang, Yiyong Wu, Xin Liao, Cheng Zhong, Liping Wang, Yi Lu
Summary: Implantable neural microelectrodes serve as a communication bridge between organisms and devices. By combining with optogenetics, they provide a precise method for studying brain functions. In this study, ICPN films are developed to improve the performance of neural microelectrodes, showing enhanced biocompatibility and recording quality. In vivo experiments demonstrate the effectiveness and advantages of ICPN-modified neural implants.
ACS APPLIED MATERIALS & INTERFACES
(2023)
