Article
Microbiology
Vivian Fichman, Fernando Almeida-Silva, Dayvison Francis Saraiva Freitas, Rosely Maria Zancope-Oliveira, Maria Clara Gutierrez-Galhardo, Rodrigo Almeida-Paes
Summary: This study aimed to evaluate the antifungal susceptibility of Sporothrix brasiliensis strains isolated from patients with severe sporotrichosis treated with amphotericin B and correlate with clinical outcomes. The study found no association between antifungal resistance and unfavorable clinical outcomes, indicating that clinical factors play a bigger role in patient outcomes than antifungal resistance.
Article
Microbiology
Ting-Shu Wu, Jung-Fu Lin, Chun-Wen Cheng, Po-Yen Huang, Jeng-How Yang
Summary: The relationship between antifungal susceptibility and treatment outcomes in patients with cryptococcus meningitis (CM) is not well understood. This study aimed to determine the antifungal susceptibility of cerebrospinal fluid (CSF) isolates using YEASTONE colorimetric broth microdilution and identify risk factors for mortality. The results showed high rates of resistance to fluconazole and flucytosine, while voriconazole had the lowest resistance rate. Factors such as concurrent cryptococcemia, Glasgow coma scale (GCS) score, and CSF cryptococcus burden were independent predictors of poor prognosis.
Article
Microbiology
Kevin Brunet, Cheikh A. B. Diop, Alexia Chauzy, Noemie Prebonnaud, Sandrine Marchand, Blandine Rammaert, Frederic Tewes
Summary: This study evaluated the effect of the combination of amphotericin B (AmB) and various non-ionic surfactants on the activity of AmB against Mucorales, the toxicity on eukaryotic cells, and the modification of AmB aggregation states. The results showed that PEG15HS increased the efficacy of AmB against Mucorales without increasing its toxicity.
Article
Polymer Science
Daniela Ailincai, Irina Rosca
Summary: This study investigates the preparation of hydrogels and formulations for the treatment of Candida infections using piperonyl-imino-chitosan derivatives and Amphotericin B drug. The hydrogels were obtained through a reaction of chitosan with piperonal monoaldehyde, while the formulations were obtained through in situ hydrogelation of chitosan with piperonal in the presence of Amphotericin B. Structural characterization revealed the formation of imine units, and supramolecular characterization showed hydrophilic/hydrophobic segregation. The systems exhibited biodegradability, high swelling ability, sustained release of the drug, and promising antifungal activity against Candida strains.
Review
Multidisciplinary Sciences
Daniel C. de Moraes
Summary: Invasive Candida infections are becoming increasingly resistant to available antifungal agents, highlighting the need for alternative therapies. Amphotericin B (AMB) is the gold standard treatment, but its clinical use is limited due to toxicity. Combining AMB with other substances may reduce toxicity and enhance antifungal activity, particularly those targeting the plasma membrane. This mini-review summarizes compounds that have shown synergistic effects with AMB and highlights the potential of these combination therapies for treating Candida infections.
ANAIS DA ACADEMIA BRASILEIRA DE CIENCIAS
(2023)
Article
Microbiology
A. Espinel-Ingroff, M. Sasso, J. Turnidge, M. Arendrup, F. Botterel, N. Bourgeois, B. Bouteille, E. Canton, S. Cassaing, E. Dannaoui, M. Dehais, L. Delhaes, D. Dupont, A. Fekkar, J. Fuller, G. Garcia-Effron, J. Garcia, G. M. Gonzalez, N. P. Govender, H. Guegan, J. Guinea, S. Houze, C. Lass-Florl, T. Pelaez, A. Forastiero, M. Lackner, R. Magobo
Summary: Susceptibility testing for antifungal drugs is crucial in the clinical setting, relying on categorical endpoints and epidemiological cutoff values for different species. Collaborative efforts have led to the development of Etest sensitivity values for various Candida and Aspergillus species, aiding in clinical laboratory testing.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Article
Microbiology
Roya Vahedi-Shahandashti, Anna-Maria Dietl, Ulrike Binder, Markus Nagl, Reinhard Wuerzner, Cornelia Lass-Floerl
Summary: This study found that Aspergillus terreus isolates defined as susceptible to amphotericin B (AMB) therapy based on minimum inhibitory concentration (MIC) may comprise tolerant phenotypes, explaining the poor outcomes of AMB treatment.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Article
Biochemistry & Molecular Biology
Zahra Zareshahrabadi, Mohammad Khorram, Keyvan Pakshir, Ali-Mohammad Tamaddon, Mahboobeh Jafari, Hasti Nouraei, Niloofar Torabi Ardekani, Neda Amirzadeh, Cambyz Irajie, Alireza Barzegar, Aida Iraji, Kamiar Zomorodian
Summary: This study aimed to develop a novel and cost-effective IONPs@CS-AmB formulation to enhance AmB delivery performance and reduce drug dosage and adverse effects. The results showed that IONPs@CS-AmB exhibited significant antifungal activity and had higher biocompatibility compared to plain AmB and fungizone.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Microbiology
Marion Blaize, Anne-Cecile Normand, Sebastien Imbert, Abdullah M. S. Al-Hatmi, Erja Chryssanthou, Sophie Cassaing, Christine Schuttler, Lilia Hasseine, Caroline Mahinc, Damien Costa, Christine Bonnal, Stephane Ranque, Marc Sautour, Elisa Rubio, Laurence Delhaes, Arnaud Riat, Boualem Sendid, Lise Kristensen, Marcel Brandenberger, Dirk Stubbe, Sophie Brun, Renaud Piarroux, Arnaud Fekkar
Summary: The susceptibility of 182 Fusarium species isolates to five antifungal drugs was determined using the EUCAST method, showing variable results depending on the species. Comparison with the gradient concentration strip method revealed essential agreement values for voriconazole, posaconazole, isavuconazole, and amphotericin B of 17%, 91%, 83%, and 70%, respectively.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Review
Medicine, General & Internal
Marek Szalinski, Aleksandra Zgryzniak, Izabela Rubisz, Malgorzata Gajdzis, Radoslaw Kaczmarek, Joanna Przezdziecka-Dolyk
Summary: The management of Fusarium keratitis is challenging due to delays in the onset of symptoms from an injury and difficulties in differentiating fungal from bacterial infections. Therapeutic options are limited, including antifungals, antiseptics, and surgical interventions.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Microbiology
Wissal Chebil, Najoua Haouas, Elja Eskes, Paul Vandecruys, Sameh Belgacem, Hichem Belhadj Ali, Hamouda Babba, Patrick Van Dijck
Summary: Malassezia yeasts, as emerging pathogens associated with dermatological and systemic infections, show different in vitro antifungal susceptibility profiles in pityriasis versicolor lesions and healthy controls, highlighting the importance of accurately evaluating their susceptibility for guiding specific and effective treatment regimens.
Article
Medicine, General & Internal
George R. Thompson III, Alex Soriano, Oliver A. Cornely, Bart Jan Kullberg, Marin Kollef, Jose Vazquez, Patrick M. Honore, Matteo Bassetti, John Pullman, Methee Chayakulkeeree, Ivan Poromanski, Cecilia Dignani, Anita F. Das, Taylor Sandison, Peter G. Pappas
Summary: This study compared the efficacy and safety of intravenous rezafungin with intravenous caspofungin in the treatment of candidaemia and invasive candidiasis. The results showed that rezafungin was non-inferior to caspofungin in terms of efficacy and safety.
Review
Microbiology
Nancy N. Vuong, Danielle Hammond, Dimitrios P. Kontoyiannis
Summary: The role of inhaled antifungals for prophylaxis and treatment of invasive fungal pneumonias in certain high-risk groups has not been clearly defined. Recent literature suggests that inhaled liposomal amphotericin B could be an alternative prophylactic option for neutropenic populations at high risk for invasive fungal pneumonia, where systemic triazoles are not tolerated. Inhaled amphotericin B is commonly used for prophylaxis in lung transplant recipients and shows promise in preventing fungal pneumonias secondary to viral pneumonias, influenza, and SARS CoV-2. Limited data are available for the adjunct treatment of inhaled amphotericin, but its utility is feasible.
Article
Immunology
Amrita Kar, Adithyan Jayaraman, Mamilla R. Charan Raja, Sujatha Srinivasan, Joy Debnath, Santanu Kar Mahapatra
Summary: The combination of eugenol oleate and amphotericin B demonstrates synergistic effects in experimental visceral leishmaniasis, reducing the toxicity of amphotericin B and significantly decreasing parasite burden.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Agronomy
Weronika Kursa, Agnieszka Jamiolkowska, Jakub Wyrostek, Radoslaw Kowalski
Summary: The study evaluated the antifungal effects of leaf extracts from yarrow, tansy, sage, and wormwood on major cereal pathogens of the Fusarium genus. Sage and tansy extracts showed strong inhibitory effects on fungal growth, while yarrow and wormwood extracts had weaker fungistatic effects and even stimulated growth in some cases. The results indicate potential for the development of biopreparations to protect plants against fusariosis.
Article
Infectious Diseases
Karine B. Schlemmer, Francielli P. K. de Jesus, Erico S. Loreto, Julia B. Farias, Sydney H. Alves, Laerte Ferreiro, Janio M. Santurio
Article
Infectious Diseases
Josias R. Stefanello, Fernanda B. Piasentin, Juliana S. M. Tondolo, Erico S. Loreto, Valeria Dutra, Sydney H. Alves, Janio M. Santurio
Article
Mycology
E. S. Loreto, J. S. M. Tondolo, F. P. K. de Jesus, A. M. Engelmann, C. M. de Andrade, J. M. Santurio, R. A. Zanette, G. D. Kommers, T. M. Silva, S. H. Alves
JOURNAL DE MYCOLOGIE MEDICALE
(2020)
Article
Dermatology
Carla Weiblen, Lizandra Jaqueline Robe, Maria Isabel de Azevedo, Lara Baccarin Ianiski, Paula Cristina Stibbe, Tatiana Correa Ribeiro, Regis Adriel Zanette, Daniela Isabel Brayer Pereira, Janio Morais Santurio, Sonia de Avila Botton
Article
Microbiology
Carine E. P. Zimmermann, Francielli P. K. Jesus, Karine B. Schlemmer, Erico S. Loreto, Juliana S. M. Tondolo, David Driemeier, Sydney H. Alves, Laerte Ferreiro, Janio M. Santurio
VETERINARY MICROBIOLOGY
(2020)
Article
Microbiology
Caitlin E. Older, Marcia de Oliveira Sampaio Gomes, Aline Rodrigues Hoffmann, Mariel Dalmedico Policano, Camila Aparecida Cruz dos Reis, Adriano Bonfim Carregaro, Carlos Eduardo Ambrosio, Valeria Maria Lara Carregaro
Article
Chemistry, Applied
Tarcieli Pozzebon Venturini, Luana Rossato, Francieli Chassot, Maria Isabel De Azevedo, Abdullah M. S. Al-Hatmi, Janio Morais Santurio, Sydney Hartz Alves
Summary: Fusarium spp. can cause a wide range of opportunistic infections, and new therapeutic options should be considered. The study found that carvacrol and thymol have potent antifungal activity when combined with caspofungin, amphotericin B, or voriconazole.
JOURNAL OF ESSENTIAL OIL RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Estevan Sonego Zimmermann, Luana Mota Ferreira, Laura Bedin Denardi, Marcel Henrique Marcondes Sari, Veronica Ferrari Cervi, Cristina Wayne Nogueira, Sydney Hartz Alves, Leticia Cruz
Summary: This study evaluated the in vitro antifungal action of a diphenyl diselenide-loaded poly(e-caprolactone) nanocapsules suspension and its in vivo efficacy in an animal model of vulvovaginal candidiasis. Results showed that the nano-based formulation had superior pharmacological action compared to the hydrogel containing non-encapsulated diphenyl diselenide, indicating it as a promising approach against vulvovaginal candidiasis.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Review
Agronomy
Lara Baccarin Ianiski, Fernando de Souza Rodrigues, Paula Cristina Stibbe, Carla Weiblen, Daniela Isabel Brayer Pereira, Janio Morais Santurio, Cristiane de Bona da Silva, Luis Antonio Sangioni, Fernanda Silveira Flores Vogel, Mateus Matiuzzi da Costa, Valeria Dutra, Luciano Nakazato, Sonia de Avila Botton
Summary: This article primarily discusses the applicability of nanotechnology in veterinary medicine and its research in Brazil. The use of nanotechnology in veterinary medicine is still limited, but it has potential in disease treatment and diagnosis. Therefore, research and investment in nanotechnology are expected to promote its development in Brazil.
Article
Infectious Diseases
Luana Rossato, Tarcieli P. Venturini, Maria Isabel de Azevedo, Janio M. Santurio, Sydney H. Alves
Summary: This study evaluated the in vitro activity of tacrolimus and cyclosporine in combination with amphotericin B and fluconazole against C. neoformans, and found that these drug combinations showed synergistic effects against certain isolates, potentially offering novel therapeutic strategies for this opportunistic mycosis.
ENFERMEDADES INFECCIOSAS Y MICROBIOLOGIA CLINICA
(2022)
Article
Biotechnology & Applied Microbiology
P. C. Stibbe, L. B. Ianiski, C. Weiblen, A. F. Maciel, M. L. Machado, T. L. da Silveira, F. A. A. Soares, J. M. Santurio, M. P. Soares, D. I. B. Pereira, L. A. Sangioni, S. de Avila Botton
Summary: The objective of this study was to evaluate the inhibitory effects and toxicity of agricultural fungicides mefenoxam and pyraclostrobin against Pythium insidiosum. The results showed that both compounds had inhibitory effects on the pathogenic oomycete without causing toxicity in vitro and in vivo models. Further studies on pharmacokinetics, toxicity, and pharmacological interactions are necessary for evaluating their potential use in the clinical management of pythiosis.
LETTERS IN APPLIED MICROBIOLOGY
(2022)
Review
Agronomy
Lara Baccarin Ianiski, Aline Fontanella Maciel, Caroline Quintana Braga, Carla Weiblen, Daniela Isabel Brayer Pereira, Luis Antonio Sangioni, Janio Morais Santurio, Luciana Potter, Sonia de Avila Botton
Summary: This study evaluated the use of nanotechnology in the treatment of Pythium insidiosum infections and found that nanotechnology can be a promising alternative for developing antimicrobial compounds with anti-P. insidiosum activity.
Article
Cell Biology
Alessandra de Oliveira Pinheiro, Valeria M. Lara, Aline F. Souza, Juliana B. Casals, Fabiana F. Bressan, Paulo Fantinato Neto, Vanessa C. Oliveira, Daniele S. Martins, Carlos E. Ambrosio
STEM CELLS AND CLONING-ADVANCES AND APPLICATIONS
(2020)
Article
Pharmacology & Pharmacy
V. C. N. Deuschla, R. D. Cruz, V. C. Flores, L. B. Denardi, R. A. N. Deuschle, G. G. Rossi, S. H. Alves, M. M. A. Campos, C. Viena
INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2019)
Article
Agriculture, Dairy & Animal Science
Kelly Cristine Santos Roballo, Aline Fernanda Souza, Valeria Maria Lara, Alessandra Oliveira Pinheiro, Ingrid da Silva Gomes, Rafael Garcia Karam, Daniele dos Santos Martins, Luciana Cristina Machado, Carlos Eduardo Ambrosio
ANIMAL REPRODUCTION
(2019)
