Article
Microbiology
Aria Jazdarehee, Leilynaz Malekafzali, Jason Lee, Richard Lewis, Ilya Mukovozov
Summary: Onychomycosis is a common fungal infection of the nail that can be transmitted within households through shared surfaces, equipment, and pets. Understanding the specific mechanisms of household transmission and implementing preventive measures is important for reducing the spread of onychomycosis.
Article
Dermatology
Kristoffer Nagy Skaastrup, Karen Marie Thyssen Astvad, Maiken Cavling Arendrup, Gregor Borut Ernst Jemec, Ditte Marie Lindhardt Saunte
Summary: Soaking sock pieces in a QAC-detergent for 24 hours effectively disinfects them from terbinafine-resistant or terbinafine-susceptible isolates of Trichophyton spp. Freezing and steam washing methods did not show any disinfectant properties.
Article
Dermatology
Hiromitsu Noguchi, Tadahiko Matsumoto, Utako Kimura, Masataro Hiruma, Rui Kano, Masahide Kubo, Satoshi Fukushima, Hironobu Ihn
Summary: Fosravuconazole is a novel oral antifungal drug developed in Japan for treating tinea unguium, showing safety and efficacy in elderly patients.
JOURNAL OF DERMATOLOGY
(2021)
Article
Microbiology
Silvia Crotti, Deborah Cruciani, Sara Spina, Vincenzo Piscioneri, Ylenia Natalini, Giovanni Pezzotti, Michela Sabbatucci, Manuela Papini
Summary: This study presents the first clinical description of tinea corporis and onychomycosis caused by T. indotineae. The strain was identified as terbinafine-sensitive through culture and molecular biology techniques, and treatment with oral terbinafine and topical ciclopirox nail solution resulted in remission of the clinical manifestations.
Article
Dermatology
Abdurrahim Yilmaz, Fatih Goktay, Rahmetullah Varol, Gulsum Gencoglan, Huseyin Uvet
Summary: The study introduces a deep neural network structure for automatic fungi detection in grayscale images without dyes, achieving rapid and accurate results. The model outperforms dermatologists in terms of accuracy and specificity.
Article
Microbiology
Felix Marcos-Tejedor, Marta Mota, Maria Jose Iglesias-Sanchez, Raquel Mayordomo, Teresa Goncalves
Summary: Onychomycosis is a common reason for visiting podiatrist clinics, with accurate identification of the infectious agents and complementary tests being crucial for successful treatment. Yeasts (particularly Candida) were found to be the most common etiological agents of onychomycosis, especially in individuals over 65 years old.
Article
Medical Laboratory Technology
Marjan Motamedi, Abdulbaqi Amini, Somayeh Yazdanpanah, Mozhgan Mahmoodi, Hossein Khodadadi, Hamidreza Zalpoor
Summary: This study compared three steel-bullet beating methods for extracting nail DNA and found that method 1 was the most effective in terms of extraction quality, cost effectiveness, and simplicity. Additionally, PCR detection had a higher rate of fungal agent detection in nail samples compared to direct microscopic examination.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2022)
Article
Dermatology
Ilaria Trave, Emanuele Cozzani, Paola Canepa, Simonetta Verdiani, Aurora Parodi
Summary: This study evaluated the applicability of EUROArray dermatomycosis kit in the diagnosis of onychomycosis and found that its combination with microscopy had better sensitivity compared to microscopy, fungal culture, and PCR alone. Moulds were more frequently positive in culture than in PCR, while dermatophytes were the most common pathogens in both culture and PCR.
Article
Dermatology
Hiromitsu Noguchi, Masahide Kubo, Kayo Kashiwada-Nakamura, Katsunari Makino, Jun Aoi, Satoshi Fukushima
Summary: Efinaconazole is effective in treating tinea unguium, and sequential combination therapy shows promise in improving the cure rate for patients with poor responses to terbinafine.
JOURNAL OF DERMATOLOGY
(2021)
Article
Dermatology
Hiromitsu Noguchi, Tadahiko Matsumoto, Yoshihiro Mimura, Masahide Kubo, Sara Higuchi, Kayo Kashiwada-Nakamura, Utako Kimura, Masataro Hiruma, Satoshi Fukushima
Summary: A dermatophyte antigen kit (DQT) was introduced in Japan as a diagnostic tool to identify tinea unguium. A study was conducted from July 2022 to February 2023 to evaluate the accuracy of DQT in confirming fungal elements. The results showed that DQT was beneficial for diagnosing onychomycosis where traditional microscopy methods were insufficient.
JOURNAL OF DERMATOLOGY
(2023)
Review
Dermatology
Danuta Nowicka, Urszula Nawrot
Summary: Fungal infections present a broad spectrum of diseases in humans, with skin infections being a relatively less explored area. Superficial mycoses are a common problem in some communities, such as athlete's foot.
Article
Microbiology
Isabella Pospischil, Charlotte Reinhardt, Olympia Bontems, Karine Salamin, Marina Fratti, Gabriela Blanchard, Yun-Tsan Chang, Helga Wagner, Philipp Hermann, Michel Monod, Wolfram Hoetzenecker, Emmanuella Guenova
Summary: This study highlights the importance of molecular mycology in improving diagnostic yield for onychomycosis, particularly in cases where conventional diagnostics are inconclusive. Molecular methods like PCR and DNA sequencing should be used in conjunction with traditional methods for more accurate and timely fungal identification.
Article
Dermatology
Ryoji Tsuboi, Takashi Mochizuki, Haruo Ito, Shiomi Kawano, Yosuke Suzuki, Wataru Naka, Yasuki Hata, Taizo Hamaguchi, Ryuji Maruyama
Summary: The LFIA kit shows high sensitivity and specificity for diagnosing tinea unguium, serving as a useful supplement to direct KOH microscopy. For definitive diagnosis of suspected cases, appropriate sampling, repeated examinations, and a combination of diagnostic techniques are essential.
JOURNAL OF DERMATOLOGY
(2021)
Article
Public, Environmental & Occupational Health
Laura Trovato, Maria Domina, Maddalena Calvo, Rocco De Pasquale, Guido Scalia, Salvatore Oliveri
Summary: This study evaluated the DermaGenius (DG) multiplex kit for detecting and identifying dermatophytes from nail samples of untreated and treated patients with a clinical suspicion of onychomycosis. The results showed that DG had a high sensitivity and specificity in diagnosing onychomycosis, especially in patients who had undergone antifungal treatments without clinical improvement. The positive results of cultural exams were significantly lower in treated patients compared to untreated patients.
JOURNAL OF INFECTION AND PUBLIC HEALTH
(2022)
Review
Public, Environmental & Occupational Health
Sophie Soyeon Lim, Kihyuk Shin, Je-Ho Mun
Summary: This article provides an overview of the dermoscopic features of cutaneous fungal infections and emphasizes the importance of dermoscopy in improving diagnostic accuracy, reducing unnecessary testing, and enhancing clinical practice.
HEALTH SCIENCE REPORTS
(2022)