Cytogenetic evaluation for genotoxicity of Bisphenol-A in bone marrow cells of Swiss albino mice

Bisphenol-A (BP-A) is a xenobiotic estrogenic compound used in a wide range of consumer products. BP-A was tested for its genotoxicity by employing three cytogenetic assays. viz., chromosomal aberration test. micronucleus assay and test for c-mitotic effects in Swiss albino mice. Studies were carried out for three doses. 10, 50 and 100 mg/kg in single oral exposure and 10 mg/kg in repeated oral exposure for 5 days). It is evident from the present investigation that although BP-A failed to induce conventional chromosomal aberrations and micronuclei, its genotoxic potential was manifested in the form of achromatic lesion and c-mitotic effects in the bone marrow cells. It can also be speculated from the results that the threshold concentration of BP-A required for the formation of MN is much higher than that for the induction of c-mitotic effects. (C) 2009 Elsevier B.V. All rights reserved.