Article
Biotechnology & Applied Microbiology
Kevin P. Cross, David M. DeMarini
Summary: According to an analysis conducted as part of the International Workshop on Genotoxicity Testing, Salmonella frameshift strain TA98 and base-substitution strain TA100 together with or without S9 can detect the majority of mutagens recommended by OECD TG471. The combination of the two strains provides a comprehensive screening for mutagens of various chemical classes.
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS
(2023)
Article
Construction & Building Technology
Po-Wen Chen, Tai-Chen Kuo, Zhen-Shu Liu, Hung-Fu Lu
Summary: A bacterial reverse mutation assay was developed and improved in this study to evaluate the mutagenicity of indoor air quality using direct gas exposure module. Findings suggest that gaseous HCHO exposure displayed weak but direct, time-dependent, and dose-dependent mutagenic activities, while 50 ppm toluene exposure also showed similar characteristics.
Article
Biology
Nazish Khan, Ibrar Khan, Sadiq Azam, Farhan Ahmad, Hamid Ali Khan, Asma Shah, Midrar Ullah
Summary: The extracts of Pinus wallichiana, Daphne oleoides and Bidens chinensis did not exhibit mutagenic activity against the Salmonella strains tested, and showed moderate cytotoxicity in brine shrimps lethality bioassay.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Environmental Sciences
Justyna Rybak, Magdalena Wrobel, Renata Krzyzynska, Wioletta Rogula-Kozlowska, Tomasz Olszowski
Summary: This study investigated the levels of polycyclic aromatic hydrocarbons (PAHs) in urban road dust samples from Lower and Upper Silesia regions in Poland, as well as their possible sources and potential risks. The results showed high levels of PAHs in the collected dust samples, many of which exhibited mutagenic effects and potential carcinogenic risks. This suggests that urban road dust may have adverse health effects on humans.
ENVIRONMENTAL POLLUTION
(2022)
Article
Plant Sciences
Francisco Laerte Lopes da Silva, Amanda Souza Scotti, Ana Leticia Hilario Garcia, Maria Luiza Brodt Lemes, Ivana Grivicich, Gabriela Mendonca dos Reis, Johnny Ferraz Dias, Fernanda Briao Menezes Boaretto, Jaqueline Nascimento Picada, Juliana da Silva, Alexandre de Barros Falcao Ferraz
Summary: The present study aimed to determine the chemical composition, cytotoxic, genotoxic, mutagenic potential, and antioxidant activity of an aqueous extract of Aloysia gratissima leaves. Results showed that the extract contained terpenoids, flavonoids, and phenolic acids, and exhibited cytotoxic activities against various cancer cells, as well as DNA damage and mutations. Therefore, caution should be exercised when using this plant preparation, despite its pharmacological potential.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Chemistry, Medicinal
Zeliha Aydogan, Fatma Zilifdar Foto, Egemen Foto, Ozlem Temiz-Arpaci, Nuran Diril
Summary: This study investigated the genotoxic potential of benzoxazole derivatives with broad antimicrobial and potent antitumor effects by conducting the Ames test. The results showed that these compounds did not exhibit mutagenic activity.
PHARMACEUTICAL CHEMISTRY JOURNAL
(2022)
Article
Food Science & Technology
Julen Sanz-Serrano, Ariane Vettorazzi, Damian Muruzabal, Amaya Azqueta, Adela Lopez de Cerain
Summary: This article provides a complete in vitro genotoxicity assessment of three nutrients widely used in the European market, demonstrating that they did not show genotoxicity in any of the conditions tested. This study contributes to the limited evidence available and complements EFSA recommendations for in vitro genotoxicity testing of nutrients.
Article
Construction & Building Technology
Po-Wen Chen, Hung-Fu Lu, Zhen-Shu Liu
Summary: This study evaluated the mutagenicity of real polluted air samples using an improved Ames module, and found that the module can be applied to directly detect the mutagenic activities of these samples.
Article
Toxicology
Naima Chamlal, Djamel Eddine Benouareth, Messaouda Khallef, Sophie Simar-Mentieres, Fabrice Nesslany
Summary: This study evaluated the mutagenicity and genotoxicity of industrially processed meat products sold in popular supermarkets in Algeria. The results showed that all extracts analyzed did not induce mutagenic activity, but one extract did cause a significant increase in the number of micronucleated cells. This highlights the importance of genetic damage detection in reducing exposure to harmful contaminants and the need for further research on genotoxic effects of processed meat globally.
TOXICOLOGY IN VITRO
(2021)
Article
Environmental Sciences
Marina Tenorio Botelho, Gabriely Groto Militao, Markus Brinkmann, Gisela de Aragao Umbuzeiro
Summary: This study found that 6PPD-quinone has moderate mutagenicity in the marine amphipod Parhyale hawaiensis and weak mutagenicity in bacteria.
ENVIRONMENTAL AND MOLECULAR MUTAGENESIS
(2023)
Article
Environmental Sciences
Julia Brendt, Sarah E. Crawford, Mirna Velki, Hongxia Xiao, Beat Thalmann, Henner Hollert, Andreas Schiwy
Summary: Metabolic activation systems derived from rat liver showed significant variability and shortcomings, prompting a comparison with a biotechnological alternative, ewoS9R, which demonstrated promising results in mutagenicity assays compared to traditional rat-derived systems. Further research is needed to fully assess the potential of ewoS9R as a replacement.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Environmental Sciences
Gisela A. Umbuzeiro, Daniel A. Morales, Francine Vacchi, Anjaina F. Albuquerque, Malgorzata Szymczyk, Xinyi Sui, Nelson Vinueza, Harold S. Freeman
Summary: This study proposes a strategy for generating high-quality mutagenicity data for dyes using a minimal amount of sample, and evaluated 15 dyes from different chemical classes. The microplate agar protocol successfully identified the mutagenicity of six dyes, providing additional information for the dye mutagenicity database in the literature.
ENVIRONMENTAL AND MOLECULAR MUTAGENESIS
(2021)
Article
Environmental Sciences
Vanessa Silva Granadeiro Garcia, Lenita de Freitas Tallarico, Jorge Marcos Rosa, Celso Fumio Suzuki, Deborah Arnsdorff Roubicek, Eliana Nakano, Sueli Ivone Borrely
Summary: Textile dyeing generates colored effluents with hazardous chemicals, impacting aquatic organisms. This study evaluated the ecotoxicological effects of textile effluents and dye on Vibrio fischeri bacteria, Daphnia similis crustacean, and Biomphalaria glabrata snail. The results indicated significant impacts on different aquatic organisms, highlighting the importance of environmental protection for aquatic ecosystems.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Multidisciplinary Sciences
Siti Nurazwa Zainol, Anis Fadhlina, Sri Vijaya Rentala, Manjula Yalaka, Leela Krishna Vatsavai, Renuka Pillai, Hassan Fahmi Ismail, Fadzilah Adibah Abdul Majid
Summary: This study analyzed the mutagenicity of Synacinn (TM) by evaluating point mutations in five tester strains of Salmonella typhimurium, conducted in two Phases with different experimental methods and formulations. The genetic integrity of tester strains was confirmed before use, and all data acceptability criteria were met, confirming the validity of the test.
Article
Plant Sciences
Okunola Adenrele Alabi
Summary: Concern on the toxicity of final wastewater generated by the petroleum refining industry has increased due to potential health threats. This study found that petroleum refinery wastewater is mutagenic and genotoxic, posing risks to the environment. The substances responsible for this toxicity were identified as organic compounds and heavy metals present in the wastewater.
Article
Environmental Sciences
Helina dos Santos Nascimento, Bruno do Amaral Crispim, Felipe Mendes Merey, Fabio Kummrow, Ricardo Augusto dos Passos, Claudia Andrea Lima Cardoso, Diego Lomonaco, Kelly Mari Pires de Oliveira, Fabiana Gomes da Silva Dantas, Eduardo Jose de Arruda, Alexeia Barufatti
Summary: The use of traditional insecticides for mosquito control is still necessary, but environmentally friendly alternatives are needed due to their negative impacts and increasing mosquito resistance. Research has shown that partially neutralized tCNSL derivatives have larvicidal activity against Aedes aegypti, making them a potential solution for controlling the spread of these mosquitoes.
WASTE AND BIOMASS VALORIZATION
(2022)
Article
Agriculture, Multidisciplinary
Jinze Dou, Polina Ilina, Jarl Hemming, Kiia Malinen, Heidi Makkyla, Natalia Oliveira de Farias, Paivi Tammela, Gisela de Aragao Umbuzeiro, Riikka Raisanen, Tapani Vuorinen
Summary: This paper studied water extracts from the bark of 15 willow hybrids and species as potential antimicrobial additives. The composition of the extracts varied greatly depending on the hybrid or species and the harvesting season. Some chemical compounds showed high antibacterial activity against Staphylococcus aureus, but clear correlation between the antibacterial effect and the chemical composition was not established.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Environmental Sciences
Thatiely N. Magalhaes de Paula, Josiane A. Souza Vendemiatti, Natalia Gabriele Camparotto, Bruna Toledo, Adria Caloto Oliveira, Tauany F. Neves, Gisela A. Umbuzeiro, Patricia Prediger
Summary: Graphene oxide (GO) production has increased and its presence in the environment is inevitable. This study investigates the interaction between GO and four organic water contaminants, and their effects on toxicity. GO reduces the toxicity of some compounds while increasing the toxicity of others. The properties of the organic toxicants can influence the stability of GO suspensions and modulate their toxicity.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Pharmacology & Pharmacy
Natali Bosque Rodrigues, Dimitrius Leonardo Pitol, Fellipe Augusto Tocchini de Figueiredo, Ana Claudia Tenfen das Chagas Lima, Theodore Burdick Henry, Joao Paulo Mardegan Issa, Gisela de Aragao Umbuzeiro, Bruno Fiorelini Pereira
Summary: Eutrophication and cyanobacteria proliferation can lead to harmful algal blooms and increased toxicity in freshwater bodies. The toxic metabolite microcystin can affect the liver and muscle morphology of Astyanax altiparanae, even at sublethal concentrations.
Article
Environmental Sciences
Werner Brack, Damia Barcelo Culleres, Alistair B. A. Boxall, Helene Budzinski, Sara Castiglioni, Adrian Covaci, Valeria Dulio, Beate I. Escher, Peter Fantke, Faith Kandie, Despo Fatta-Kassinos, Felix J. Hernandez, Klara Hilscherova, Juliane Hollender, Henner Hollert, Annika Jahnke, Barbara Kasprzyk-Hordern, Stuart J. Khan, Andreas Kortenkamp, Klaus Kuemmerer, Brice Lalonde, Marja H. Lamoree, Yves Levi, Pablo Antonio Lara Martin, Cassiana C. Montagner, Christian Mougin, Titus Msagati, Joerg Oehlmann, Leo Posthuma, Malcolm Reid, Martin Reinhard, Susan D. Richardson, Pawel Rostkowski, Emma Schymanski, Flurina Schneider, Jaroslav Slobodnik, Yasuyuki Shibata, Shane Allen Snyder, Fernando Fabriz Sodre, Ivana Teodorovic, Kevin V. Thomas, Gisela A. Umbuzeiro, Pham Hung Viet, Karina Gin Yew-Hoong, Xiaowei Zhang, Ettore Zuccato
Summary: A suggestion to establish an international science-policy body has been made to address the severe threats of chemical pollution crisis. Immediate action is crucial and should be informed by reliable scientific knowledge and data. Challenges for such a body include global knowledge production, coverage of all hazardous chemicals, a one-health perspective, and solution-oriented assessments based on systems thinking.
ENVIRONMENTAL SCIENCES EUROPE
(2022)
Article
Environmental Sciences
Lucilene Finoto Viana, Fabio Kummrow, Claudia Andrea Lima Cardoso, Nathalya Alice de Lima, Bruno do Amaral Crispim, Alexeia Barufatti, Alexandro Cezar Florentino
Summary: High concentrations of metals have been found in the Araguari River lower section, posing potential risks to human consumption through bioaccumulation in fish. Some fish species showed concentrations of lead and cadmium exceeding the Brazilian limits, indicating health risks. The consumption of all fish species, particularly detritivorous ones, presents risks when considering the mixture of metals. The study highlights the importance of establishing an environmental monitoring program and educating the local population about safe fish consumption and preparation.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Environmental Sciences
Robson Rolland Monticelli Barizon, Fabio Kummrow, Anjaina Fernandes de Albuquerque, Marcia Regina Assalin, Maria Aparecida Rosa, Debora Renata Cassoli de Souza Dutra, Ricardo Antonio Almeida Pazianotto
Summary: The environmental risks of pesticides in surface waters of a significant agricultural basin in Brazil were estimated through two approaches. The majority of individual pesticides posed no risk to aquatic organisms, but pesticide mixtures presented risks to aquatic life.
Article
Environmental Sciences
Lucilene Finoto Viana, Bruno do Amaral Crispim, Fabio Kummrow, Valter Aragao do Nascimento, Elaine Silva de Padua Melo, Nathalya Alice de Lima, Alexeia Barufatti
Summary: The Aquidauana River in Brazil, one of the most important rivers in the Pantanal region, has been contaminated by nearby anthropogenic activities, which poses a threat to native fish species. A study was conducted to determine the concentrations of various inorganic elements in water, sediment, muscle, and liver tissue samples from the river. The results showed that the water samples exceeded the Brazilian legislation for several elements and presented risks to aquatic biota. In addition, the muscle tissue of certain fish species contained concentrations of Cd and Pb that exceeded the standards for human consumption. The study concluded that the contamination of the Aquidauana River negatively impacts native fish species and poses risks to biodiversity in the Pantanal region.
ENVIRONMENTAL POLLUTION
(2022)
Article
Environmental Sciences
Gustavo Chiang, Gisela Umbuzeiro, Fabiana Lo Nostro
Summary: National and international collaboration and the incorporation of perspectives from outside academia are essential for a paradigm shift in science and a sustainable future. The articles in this special series highlight the latest research and environmental policies in Latin America, focusing on the protection of water, soil, and human health from various pollutants. The knowledge built with the participation of communities helps promote a transdisciplinary understanding of environmental issues.
INTEGRATED ENVIRONMENTAL ASSESSMENT AND MANAGEMENT
(2023)
Article
Environmental Sciences
Lucilene Finoto Viana, Fabio Kummrow, Nathalya Alice de Lima, Bruno do Amaral Crispim, Alexeia Barufatti, Alexandro Cezar Florentino
Summary: The Araguari River, an important waterway in Brazil's Amapa state, is ecologically significant for the conservation of Amazonian fish biodiversity. Previous studies have shown contamination of water and fish by metals, causing genotoxic damage in Danio rerio. This study confirms that native fish species in the lower section of the Araguari River also exhibit genotoxic damage, indicating the presence of genotoxic pollutants in these waters.
BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY
(2023)
Article
Marine & Freshwater Biology
Amanda dos Santos, Marina Tenorio Botelho, Willian Reina Joviano, Vicente Gomes, Jose Roberto Machado Cunha da Silva, Gisela de Aragao Umbuzeiro
Summary: This study characterized the hemolymph cells of the amphipod Parhyale hawaiensis and investigated their phagocytic activity. Three cell types containing lipids were identified, with different proportions and sizes in males and females. The findings contribute to the understanding of hemocytes in P. hawaiensis and their potential use in ecotoxicological studies.
INVERTEBRATE BIOLOGY
(2023)
Article
Limnology
Lucilene Finoto Viana, Debora Cristina Damasceno de Souza, Edmilda Batista da Silva, Fabio Kummrow, Claudia Andrea Lima Cardoso, Nathalya Alice de Lima, Bruno do Amaral Crispim, Alexeia Barufatti, Alexandro Cezar Florentino
Summary: This study investigated the bioaccumulation of metals and resulting nuclear alterations in the Amazonian Pufferfish. It was found that in areas near urban centers, these fish may be exposed to residues containing metal mixtures, leading to genetic alterations. The concentration of metals in different tissues and organs followed the order: liver > skin > gonads > musculature > bones.
Editorial Material
Environmental Sciences
Eduardo Alvesde Almeida, Rosade Fatima Lopes de Freitas, Gisela Aragao Umbuzeiro, Julian Blasco
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Chemistry, Applied
Gabriel Rampazzo Magalhaes, Gabriely Fernanda Groto Militao, Natalia Oliveira de Farias, Anjaina Fernandes de Albuquerque, Marina Tenorio Botelho, Riikka Raisanen, Harold S. Freeman, Gisela de Aragao Umbuzeiro
Summary: Traditional textile dyeing processes require large amounts of water and energy, and produce harmful wastewater. Dyeing in supercritical carbon dioxide (sc-CO2) media has the potential to provide a waterless and energy-saving alternative. This study aims to develop non-mutagenic derivatives of emodin, a natural anthraquinone, for textile dyeing using sc-CO2. Molecular modelling studies showed that introducing acryloyl groups can reduce the mutagenicity of emodin. However, experimental results indicated that the new derivatives still exhibited mutagenicity both in vitro and in vivo.
COLORATION TECHNOLOGY
(2023)
Article
Environmental Sciences
Marina Tenorio Botelho, Gabriely Groto Militao, Markus Brinkmann, Gisela de Aragao Umbuzeiro
Summary: This study found that 6PPD-quinone has moderate mutagenicity in the marine amphipod Parhyale hawaiensis and weak mutagenicity in bacteria.
ENVIRONMENTAL AND MOLECULAR MUTAGENESIS
(2023)