Article
Oncology
Ilmo Leivo, Reetta Holmila, Daniele Luce, Torben Steiniche, Michael Dictor, Pirjo Heikkila, Kirsti Husgafvel-Pursiainen, Henrik Wolff
Summary: Wood dust exposure is a known factor for sinonasal intestinal-type adenocarcinoma, with France having a higher occurrence of this cancer type compared to Finland due to different wood usage patterns. This study highlights the importance of source of wood dust in the pathogenesis of sinonasal adenocarcinomas.
Article
Medicine, Research & Experimental
Yiran Zhou, Jiabin Jin, Yuchen Ji, Jiaqiang Zhang, Ningzhen Fu, Mengmin Chen, Jun Wang, Kai Qin, Yu Jiang, Dongfeng Cheng, Xiaxing Deng, Baiyong Shen
Summary: This study revealed the impact of different TP53 mutation subtypes on the clinical characteristics and outcomes of patients with pancreatic ductal adenocarcinoma (PDAC). TP53 missense mutation was associated with poor tumor differentiation and revealed gain-of-function properties in small-sized KRAS transformed PDAC. It was also found that TP53 missense mutation was associated with reduced disease-free survival and overall survival in patients who did not receive chemotherapy, but higher overall survival in patients who received chemotherapy.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Review
Environmental Sciences
Teresa Curiel-Garcia, Cristina Candal-Pedreira, Leonor Varela-Lema, Julia Rey-Brandariz, Beatriz Casal-Accion, Lucia Moure-Rodriguez, Adolfo Figueiras, Alberto Ruano-Ravina, Monica Perez-Rios
Summary: This study aimed to investigate the risk of wood dust-related occupations on the development of small cell lung cancer (SCLC), taking tobacco use into account. The results showed that exposure to wood dust significantly increases the risk of SCLC. Therefore, it is recommended to implement effective control measures to reduce occupational exposure to wood dust in order to prevent SCLC.
JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Flora Doffe, Vincent Carbonnier, Manon Tissier, Bernard Leroy, Isabelle Martins, Johanna S. M. Mattsson, Patrick Micke, Sarka Pavlova, Sarka Pospisilova, Jana Smardova, Andreas C. Joerger, Klas G. Wiman, Guido Kroemer, Thierry Soussi
Summary: Infrequent and rare genetic variants in the human population outnumber common ones significantly. The TP53 coding region shows far more polymorphism than previously thought and presents high ethnic diversity. Analyses of new missense TP53 variants revealed they are benign and do not display loss of function compared to the normal TP53 gene.
CELL DEATH AND DIFFERENTIATION
(2021)
Article
Public, Environmental & Occupational Health
Angelo D'Errico, Jana Zajacova, Anna Cacciatore, Santo Alfonzo, Fabio Beatrice, Fulvio Ricceri, Guido Valente
Summary: The study confirmed the associations of SNEC with wood dust, leather dust, and nickel, while also observing new associations with other hazards, indicating the need for further investigation.
OCCUPATIONAL AND ENVIRONMENTAL MEDICINE
(2021)
Article
Oncology
Ling Cai, Ralph J. DeBerardinis, Guanghua Xiao, John D. Minna, Yang Xie
Summary: This study investigated a tumor mutation database and identified TP53 and RB1 as the most diverse and frequent concurrent mutations. The study found that TP53/RB1 co-mutations are associated with certain cancer types and poor clinical outcomes. Additionally, the study identified drugs that can and cannot be used to treat TP53/RB1 co-mutated cancers.
Article
Immunology
Sophia Keddache, Caroline Laheurte, Laura Boullerot, Lucie Laurent, Jean-Charles Dalphin, Olivier Adotevi, Thibaud Soumagne
Summary: Inflammatory responses in COPD patients secondary to organic dust exposure differ from those in COPD patients due to tobacco smoking. OD-COPD patients exhibit higher levels of type 2 immunity related cytokines, while T-COPD patients have lower levels of IL-13 after flagellin stimulation.
CLINICAL IMMUNOLOGY
(2021)
Article
Environmental Sciences
Amirabbas Mofidi, Emile Tompa, Christina Kalcevich, Christopher McLeod, Martin Lebeau, Chaojie Song, Joanne Kim, Paul A. Demers
Summary: This study estimated the incidence and economic burden of nasopharynx cancers (NPCs) and sinonasal cancers (SNCs) in Canada in 2011, caused by occupational exposure to wood dust. The results emphasized the importance of these occupational cancers, especially in countries with large wood-related industries. The findings provide valuable information for policymakers in making evidence-based decisions about occupational cancer prevention efforts.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Cell Biology
Ziwen Zhang, Ran Hao, Qiusheng Guo, Sheyu Zhang, Xiaojia Wang
Summary: The TP53 mutation is significantly associated with a shorter overall survival in patients with breast cancer, and is an independent predictive factor for overall survival. The TP53-mutant group exhibits higher tumor mutation burden, microsatellite instability, and tumor immune dysfunction and exclusion values for immunotherapy. In addition, TP53 mutation is related to increased ImmuneScore and StromalScore, and promotes the infiltration of Tregs, T helper cells, and M0-type macrophages in the tumor microenvironment.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Public, Environmental & Occupational Health
Hui Wang, Rui Meng, Xuelin Wang, Zhikang Si, Zekun Zhao, Haipeng Lu, Huan Wang, Jiaqi Hu, Yizhan Zheng, Jiaqi Chen, Ziqi Zhao, Hongmin Zhu, Xiaoming Li, Ling Xue, Shengguang Yan, Jian Sun, Yu Su, Jianhui Wu
Summary: Dust exposure and smoking are identified as significant risk factors for COPD incidence among coal mine workers, although there is no discernible interaction between these two causal agents.
Article
Oncology
Alvin Kunyao Guo, Yoko Itahana, Veerabrahma Pratap Seshachalam, Hui Ying Chow, Sujoy Ghosh, Koji Itahana
Summary: This study identified a novel interaction between TP53(R273H) and BCAR1, where BCAR1 translocates from the cytoplasm to the nucleus and binds to TP53(R273H) in a manner dependent on SRC family kinases (SFKs), promoting cancer cell invasion. High BCAR1 expression was associated with a poorer prognosis among patients with mutant TP53, highlighting the potential therapeutic approach of disrupting the TP53(R273H)-BCAR1 binding in TP53(R273H)-harbouring cancer patients.
BRITISH JOURNAL OF CANCER
(2021)
Article
Urology & Nephrology
Kara N. Maxwell, Heather H. Cheng, Jacquelyn Powers, Roman Gulati, Elisa M. Ledet, Casey Morrison, Anh Le, Ryan Hausler, Jill Stopfer, Sophie Hyman, Wendy Kohlmann, Anne Naumer, Jennie Vagher, Samantha E. Greenberg, Lorraine Naylor, Mercy Laurino, Eric Q. Konnick, Brian H. Shirts, Saud H. AlDubayan, Eliezer M. Van Allen, Bastien Nguyen, Joseph Vijai, Wassim Abida, Maria Carlo, Marianne Dubard-Gault, Daniel J. Lee, Luke D. Maese, Diana Mandelker, Bruce Montgomery, Michael J. Morris, Piper Nicolosi, Robert L. Nussbaum, Lauren E. Schwartz, Zsofia Stadler, Judy E. Garber, Kenneth Offit, Joshua D. Schiffman, Peter S. Nelson, Oliver Sartor, Michael F. Walsh, Colin C. Pritchard
Summary: Complementary analysis of prostate cancer incidence in LFS males and gTP53 prevalence in prostate cancer cohorts suggests that gTP53 predisposes to aggressive prostate cancer. Prostate cancer should be considered as part of LFS screening protocols and TP53 should be considered in germline prostate cancer susceptibility testing.
Article
Medicine, General & Internal
Hongyu Qiao, Zhongxiang Ding, Youcai Zhu, Yuguo Wei, Baochen Xiao, Yongzhen Zhao, Qi Feng
Summary: This study investigated the correlation between TP53 gene expression and radiomic features in lung cancer, showing a high level of association between the two. Through model prediction, the type of TP53 gene mutation in lung cancer lesions can be accurately predicted.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2022)
Article
Cell Biology
Feng Zhang, Wenhui Zhong, Honghao Li, Kaijun Huang, Min Yu, Yubin Liu
Summary: TP53 mutation is a critical driver mutation in pancreatic cancer, and a prognostic TP53-associated signature based on differentially expressed genes has been developed and validated in multiple patient cohorts. Patients in the low-risk group of the signature have better prognosis and lower immune activity, while those in the high-risk group show poor survival and enhanced response to certain chemotherapeutic agents. Overall, the TP53-associated signature is a novel prognostic biomarker and predictive indicator of pancreatic cancer.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Byungkyu Park, Jinho Im, Kyungsook Han
Summary: Breast cancer is a common and deadly cancer among females. Basal-like breast cancer, one of its subtypes, has the lowest survival rate with no effective treatments available. This study aimed to identify gene correlations and potential prognostic gene pairs for breast cancer patients. Comparative analysis revealed several new gene pairs with opposing correlations and prognostic genes for patients with a wild-type TP53 gene. Findings from this study provide important insights for prognosis and drug target selection in breast cancer, especially in basal-like breast cancer.
Article
Environmental Sciences
Daniele Luce, Julien Dugas, Amandine Vaidie, Leah Michineau, Mounia El-Yamani, Luc Multigner
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2020)
Article
Public, Environmental & Occupational Health
Amy L. Hall, Hans Kromhout, Joachim Schuz, Susan Peters, Lutzen Portengen, Roel Vermeulen, Antonio Agudo, Wolfgang Ahrens, Paolo Boffetta, Paul Brennan, Cristina Canova, David Conway, Maria Paula Curado, Alexander W. Daudt, Leticia Fernandez, Mia Hashibe, Claire M. Healy, Ivana Holcatova, Kristina Kjaerheim, Rosalina Koifman, Pagona Lagiou, Daniele Luce, Gary J. Macfarlane, Ana Menezes, Gwenn Menvielle, Jerry Polesel, Heribert Ramroth, Lorenzo Richiardi, Isabelle Stucker, Peter Thomson, Marta Vilensky, Victor Wunsch-Filho, Amy Lee Yuan-Chin, Ariana Znaor, Kurt Straif, Ann Olsson
Article
Public, Environmental & Occupational Health
Christine Barul, Mireille Matrat, Aviane Auguste, Julien Dugas, Loredana Radoi, Gwenn Menvielle, Joelle Fevotte, Anne-Valerie Guizard, Isabelle Stucker, Daniele Luce
OCCUPATIONAL AND ENVIRONMENTAL MEDICINE
(2020)
Review
Dentistry, Oral Surgery & Medicine
Francesca Bravi, Yuan-Chin Amy Lee, Mia Hashibe, Paolo Boffetta, David I. Conway, Monica Ferraroni, Carlo La Vecchia, Valeria Edefonti
Summary: The INHANCE consortium's research findings have revealed the association of head and neck cancer with smoking, alcohol consumption, and occupational exposure, as well as the benefits of good oral health, hormonal factors, and fruit and vegetable consumption in reducing the incidence of head and neck cancer. The studies also provide insights into the survival rates and recurrence rates of head and neck cancer.
Article
Multidisciplinary Sciences
Emilie Leveque, Aude Lacourt, Viviane Philipps, Daniele Luce, Pascal Guenel, Isabelle Stucker, Cecile Proust-Lima, Karen Leffondre
Article
Oncology
Aviane Auguste, Jacqueline Deloumeaux, Clarisse Joachim, Stanie Gaete, Leah Michineau, Cecile Herrmann-Storck, Suzy Duflo, Daniele Luce
Article
Oncology
Gioia Di Credico, Jerry Polesel, Luigino Dal Maso, Francesco Pauli, Nicola Torelli, Daniele Luce, Loredana Radoi, Keitaro Matsuo, Diego Serraino, Paul Brennan, Ivana Holcatova, Wolfgang Ahrens, Pagona Lagiou, Cristina Canova, Lorenzo Richiardi, Claire M. Healy, Kristina Kjaerheim, David I. Conway, Gary J. Macfarlane, Peter Thomson, Antonio Agudo, Ariana Znaor, Silvia Franceschi, Rolando Herrero, Tatiana N. Toporcov, Raquel A. Moyses, Joshua Muscat, Eva Negri, Marta Vilensky, Leticia Fernandez, Maria Paula Curado, Ana Menezes, Alexander W. Daudt, Rosalina Koifman, Victor Wunsch-Filho, Andrew F. Olshan, Jose P. Zevallos, Erich M. Sturgis, Guojun Li, Fabio Levi, Zuo-Feng Zhang, Hal Morgenstern, Elaine Smith, Philip Lazarus, Carlo La Vecchia, Werner Garavello, Chu Chen, Stephen M. Schwartz, Tongzhang Zheng, Thomas L. Vaughan, Karl Kelsey, Michael McClean, Simone Benhamou, Richard B. Hayes, Mark P. Purdue, Maura Gillison, Stimson Schantz, Guo-Pei Yu, Shu-Chun Chuang, Paolo Boffetta, Mia Hashibe, Amy Lee Yuan-Chin, Valeria Edefonti
BRITISH JOURNAL OF CANCER
(2020)
Article
Medicine, Research & Experimental
Leila Cabrera, Aviane Auguste, Leah Michineau, Jacqueline Deloumeaux, Clarisse Joachim, Daniele Luce
M S-MEDECINE SCIENCES
(2020)
Article
Public, Environmental & Occupational Health
David Conway, Jan Hovanec, Wolfgang Ahrens, Alastair Ross, Ivana Holcatova, Pagona Lagiou, Diego Serraino, Cristina Canova, Lorenzo Richiardi, Claire Healy, Kristina Kjaerheim, Gary J. Macfarlane, Peter Thomson, Antonio Agudo, Ariana Znaor, Paul Brennan, Daniele Luce, Gwenn Menvielle, Isabelle Stucker, Simone Benhamou, Heribert Ramroth, Paolo Boffetta, Marta Vilensky, Leticia Fernandez, Maria Paula Curado, Ana Menezes, Alexander Daudt, Rosalina Koifman, Victor Wunsch-Filho, Amy Lee Yuan-Chin, Mia Hashibe, Thomas Behrens, Alex D. McMahon
Summary: Low occupational socioeconomic prestige, position, and manual work are associated with head and neck cancer risk, which is only partially explained by smoking, alcohol, and occupational exposures. Perceptual occupational psychosocial status (SIOPS) appears to be the strongest socioeconomic factor relative to socioeconomic position and manual/non-manual work in relation to head and neck cancer risk.
JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH
(2021)
Letter
Public, Environmental & Occupational Health
Irina Guseva Canu, Daniele Luce, Kurt Straif
OCCUPATIONAL AND ENVIRONMENTAL MEDICINE
(2021)
Article
Oncology
Ilmo Leivo, Reetta Holmila, Daniele Luce, Torben Steiniche, Michael Dictor, Pirjo Heikkila, Kirsti Husgafvel-Pursiainen, Henrik Wolff
Summary: Wood dust exposure is a known factor for sinonasal intestinal-type adenocarcinoma, with France having a higher occurrence of this cancer type compared to Finland due to different wood usage patterns. This study highlights the importance of source of wood dust in the pathogenesis of sinonasal adenocarcinomas.
Article
Public, Environmental & Occupational Health
Irina Guseva Canu, Alan Gaillen-Guedy, Ahti Antilla, Sandrine Charles, Sandrine Fraize-Frontier, Daniele Luce, Damien Martin McElvenny, Franco Merletti, Cecile Michel, Eero Pukkala, Mary K. Schubauer-Berigan, Kurt Straif, Pascal Wild, David B. Richardson
Summary: This study reanalyzed the data on respirable titanium dioxide (TiO2) dust exposure and lung cancer mortality among TiO2 workers, considering different hypothetical interventions. The results indicate that the healthy worker survivor effect (HWSE) can mask the exposure-response relationship and suggest that appropriate analysis of TiO2 epidemiological data can demonstrate this relationship. More epidemiological studies and reanalyses of existing cohort studies are needed to support the carcinogenicity of TiO2.
OCCUPATIONAL AND ENVIRONMENTAL MEDICINE
(2022)
Article
Environmental Sciences
Leila Cabrera, Aviane Auguste, Leah Michineau, Clarisse Joachim, Jacqueline Deloumeaux, Daniele Luce
Summary: This study aimed to investigate the impact of occupational exposures on lung cancer risk in the French West Indies, with a specific focus on activities such as sugarcane work. The results showed that occupational exposures related to sugarcane farming and rum production were associated with an increased risk of lung cancer.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Biochemistry & Molecular Biology
Emmeli Mikkelsen, Berthold Huppertz, Ripudaman Singh, Katarina Ravn, Lotte Hatt, Mogens Kruhoffer, Rheanna Urrabaz-Garza, Niels Uldbjerg, Ramkumar Menon, Torben Steiniche
Summary: Unique markers in fetal membrane cells may be key in the search for biomarkers for preterm prelabor rupture of the fetal membranes (pPROM) in maternal blood. Through transcriptomic analysis and immunohistochemistry, markers exclusively expressed in fetal membranes were identified and their localization confirmed. These findings contribute to the understanding of the biological significance of these markers in the maternal circulation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Public, Environmental & Occupational Health
Neela Guha, Liacine Bouaoun, Hans Kromhout, Roel Vermeulen, Thomas Bruening, Thomas Behrens, Susan Peters, Veronique Luzon, Jack Siemiatycki, Mengting Xu, Benjamin Kendzia, Pascal Guenel, Daniele Luce, Stefan Karrasch, Heinz-Erich Wichmann, Dario Consonni, Maria Teresa Landi, Neil E. Caporaso, Per Gustavsson, Nils Plato, Franco Merletti, Dario Mirabelli, Lorenzo Richiardi, Karl-Heinz Jockel, Wolfgang Ahrens, Hermann Pohlabeln, Lap Ah Tse, Ignatius Tak-Sun Yu, Adonina Tardon, Paolo Boffetta, David Zaridze, Andrea't Mannetje, Neil Pearce, Michael P. A. Davies, Jolanta Lissowska, Beata swiatkowska, John McLaughlin, Paul A. Demers, Vladimir Bencko, Lenka Foretova, Vladimir Janout, Tamas Pandics, Eleonora Fabianova, Dana Mates, Francesco Forastiere, Bas Bueno-de-Mesquita, Joachim Schuz, Kurt Straif, Ann Olsson
Summary: Our study found that working as a painter is associated with an increased risk of lung cancer in men, especially for construction and repair painters. The risk was elevated for all histological subtypes and there was evidence of interaction between smoking and employment as a painter.
OCCUPATIONAL AND ENVIRONMENTAL MEDICINE
(2021)