Article
Public, Environmental & Occupational Health
Jelena Filipovic Trickovic, Ana Valenta Sobot, Ivana Joksic, Gordana Joksic
Summary: In this study, telomere length and structure, biomolecule oxidation, and chromosome aberrations were examined in hospital workers exposed to X-rays. The results showed that continuous exposure to low radiation doses led to increased telomere fragility and oxidative base damage of guanine, as indicated by higher levels of lipid peroxidation product and 8-oxo-dG.
ARHIV ZA HIGIJENU RADA I TOKSIKOLOGIJU-ARCHIVES OF INDUSTRIAL HYGIENE AND TOXICOLOGY
(2022)
Article
Engineering, Environmental
Preeti Singh, Prasenjit Mitra, Taru Goyal, Shailja Sharma, Praveen Sharma
Summary: Occupational exposure to heavy metals like lead and cadmium may result in increased oxidative DNA damage and impaired expression of the DNA repair gene.
ENVIRONMENTAL GEOCHEMISTRY AND HEALTH
(2021)
Article
Nuclear Science & Technology
Tae Young Kong, Si Young Kim, Yoonhee Jung, Jeong Mi Kim, Moonhyung Cho
Summary: This paper provides a comprehensive overview of administrative dose control for occupationally-exposed workers in Korean nuclear power plants (NPPs), focusing on how dose limits and administrative dose constraints are implemented to resolve inequity of radiation exposure. The analysis results show how the implementation of administrative dose constraints impacted the occupational dose distributions in Korean NPPs during the years 2009-2018.
NUCLEAR ENGINEERING AND TECHNOLOGY
(2021)
Article
Environmental Sciences
Nihal Kilinc, Mehmet Onbasilar, Akin Cayir
Summary: This study investigated the plasma concentration of cell-free nucleic acids in radiology workers and found that the concentration of ccfRNA was significantly correlated with working time and imaging number, while total working time was significantly associated with total ccfRNA concentration. These findings suggest that total RNA can be used to predict radiation exposure risk and that working time and imaging parameters can alter the level of free nucleic acids.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Neurosciences
Gehad Ahmed Abo-El-Ata, Fatma Hossni Abdellatif Abdelghany, Marwa Farghaly Ahmed, Marwa Abdelgwad, Mona Abdallah Ramadan
Summary: This study investigated the impact of occupational exposure to air pollutants on the neuropsychiatric health. The results showed that the exposed workers demonstrated impaired neuropsychological functions and increased serum levels of 4HNE compared to the control group. This suggests that occupational exposure to air pollutants can have detrimental effects on the neuropsychiatric health of pottery workers.
Article
Environmental Sciences
Mona Mohamed Taha, Nagat Mohamed Amer, Safia Beshir, Heba Mahdy-Abdallah
Summary: The study investigated the relationship between hearing loss and blood pressure variation in textile workers, finding an association between HSP70 genotypes and hypertension, with smoking also influencing the results.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Taru Goyal, Prasenjit Mitra, Preeti Singh, Raghumoy Ghosh, Malavika Lingeswaran, Shailja Sharma, Praveen Sharma
Summary: Occupational exposure to lead has a significant impact on workers' immune system and parameters, leading to immune cell dysfunction and increased pro-inflammatory response.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2021)
Article
Environmental Sciences
Bruna Gauer, Elisa Sauer, Sabrina Nascimento, Gabriela Goethel, Caroline Peruzzi, Ingrid Flesch, Nuryan Fao, Larissa Cestonaro, Tatiana Sant'Pierre, Adriana Gioda, Ursula Matte, Natalia Brucker, Solange Cristina Garcia
Summary: This study evaluated the potential effects of chronic exposure to chemical agents from air pollution on the expressions of peripheral biomarkers and tumor-related proteins. Results showed increased levels of urinary 1-hydroxypyrene and blood As and Ni in taxi drivers, associated with inflammatory and oxidative stress biomarkers, suggesting a common source of exposure. Furthermore, gene expression of p53, CD26 and ICAM-1 were decreased in taxi drivers, indicating a commom regulation point. Antioxidants were negatively associated with inflammatory biomarkers, maybe regulating the immune-response.
Article
Toxicology
Changmao Long, Guiping Hu, Pai Zheng, Tian Chen, Zekang Su, Yali Zhang, Chunguang Ding, Fangda Peng, Shanfa Yu, Tiancheng Wang, Guang Jia
Summary: This study utilized UPLC-MS non-targeted metabolomics to analyze serum metabolic changes in chromate exposure workers and controls, revealing decreases in 13 metabolites and increases in 41 metabolites related to arginine, proline, and glycerophospholipid metabolism. Additionally, significant negative correlations were found between blood Cr level and certain metabolites, primarily among male subgroups. The potential influence of diet as a confounding factor was highlighted, requiring further verification in future research.
TOXICOLOGY LETTERS
(2021)
Article
Food Science & Technology
David Lozano-Paniagua, Tesifon Parron, Raquel Alarcon, Mar Requena, Olga Lopez-Guarnido, Marina Lacasana, Antonio F. Hernandez
Summary: A study was conducted on greenhouse workers regularly exposed to pesticides compared to controls, showing a slight increase in AST levels in workers suggestive of subtle hepatocellular toxicity, while other markers like ALP, ARG1, and GST-alpha were decreased possibly due to a regulatory mechanism. These findings do not conclusively demonstrate liver dysfunction due to low-toxicity pesticides used by greenhouse workers.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Article
Oncology
Ravindra M. M. Samarth, Puneet Gandhi, Nabo Kumar Chaudhury
Summary: The complexity and correlation of acrocentric chromosome association (ACA) with dicentric chromosomes (DC) were studied in lymphocytes exposed to gamma radiation. The results showed that the complexity and frequency of ACA increased with increasing radiation dose, and the co-occurrence of ACA and DC was confirmed in the same cells.
STRAHLENTHERAPIE UND ONKOLOGIE
(2023)
Article
Environmental Sciences
Changaiz Khan, Muhammad Yasir Abdur Rehman, Riffat Naseem Malik
Summary: Exposure to heavy metals can result in oxidative stress, with dust in the workplace being a significant source of metal exposure. A study on chromite mine workers found elevated levels of metals in dust-exposed workers, correlating with increased oxidative stress.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Environmental Sciences
Tuanwei Wang, Yu Meng, Yuting Tu, Guanghui Zhang, Kan Wang, Shiyang Gong, Yunxia Zhang, Tongshuai Wang, Anqi Li, David C. Christiani, William Au, Zhao-lin Xia
Summary: Studies have shown that lead exposure can cause genotoxicity, and one possible mechanism is through DNA methylation. This study aimed to investigate the association between DNA methylation, lead exposure, and genotoxicity. Blood lead levels and genotoxic biomarkers were analyzed in lead-exposed workers, and the methylation levels of specific genes were measured. The results showed that lead exposure induced changes in DNA methylation, which mediated lead-induced genotoxicity.
ENVIRONMENTAL POLLUTION
(2023)
Article
Environmental Sciences
Prasenjit Mitra, Taru Goyal, Preeti Singh, Shailja Sharma, Praveen Sharma
Summary: The study found that miR-155 and miR-221 were significantly upregulated in occupationally lead-exposed workers, while miR-20b showed no significant difference. These miRNAs have the potential to trigger various genes and cellular pathways, highlighting the importance of miRNA dysregulation in the systemic effects of lead toxicity.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Taru Goyal, Prasenjit Mitra, Preeti Singh, Raghumoy Ghosh, Malavika Lingeswaran, Shailja Sharma, Purvi Purohit, Praveen Sharma
Summary: Occupational exposure to Cd leads to alterations in immune parameters, characterized by changes in immune cell subsets and elevated levels of pro-inflammatory cytokines, indicating a predominant pro-inflammatory immune response. These changes may predispose individuals to other systemic abnormalities.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Claudio Luparello, Mariangela Librizzi, Dalia M. L. Asaro, Ilenia Cruciata, Fabio Caradonna
Article
Biochemistry & Molecular Biology
Claudio Luparello, Dalia Maria Lucia Asaro, Ilenia Cruciata, Storm Hassell-Hart, Supojjanee Sansook, John Spencer, Fabio Caradonna
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Article
Biochemistry & Molecular Biology
Giuseppe Mannino, Carla Gentile, Alessandra Porcu, Chiara Agliassa, Fabio Caradonna, Cinzia Margherita Bertea
Review
Nutrition & Dietetics
Fabio Caradonna, Ornella Consiglio, Claudio Luparello, Carla Gentile
Review
Food Science & Technology
Fabio Caradonna, Ilenia Cruciata, Claudio Luparello
Summary: The intake of alcoholic beverages may have negative effects on genetic and epigenetic regulation, leading to different risks of cancer in populations based on genotypes. This review summarizes selected studies on the impact of low-dose alcohol consumption on tumorigenic pathways, including the relationship between dietary compounds and alcohol, the effects of other components in alcoholic drinks on oncogenes and oncosuppressors, and the role of alcohol within specific dietary regimens.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Article
Genetics & Heredity
Fabio Caradonna, Gabriella Schiera, Carlo Maria Di Liegro, Vincenzo Vitale, Ilenia Cruciata, Tiziana Ferrara, Pietro D'Oca, Riccardo Mormino, Simona Maria Angela Rizzo, Italia Di Liegro
Review
Endocrinology & Metabolism
Daniele Bellavia, Eufrosina Dimarco, Viviana Costa, Valeria Carina, Angela De Luca, Lavinia Raimondi, Milena Fini, Carla Gentile, Fabio Caradonna, Gianluca Giavaresi
Summary: This article provides comprehensive information on flavonoids with potential anti-resorptive and pro-osteogenic effects, highlighting their molecular mechanisms, often epigenetic, and emphasizing their potential pharmacological use in the prevention and treatment of osteoporosis.
TRENDS IN ENDOCRINOLOGY AND METABOLISM
(2021)
Article
Biochemistry & Molecular Biology
Claudio Luparello, Ilenia Cruciata, Andreas C. Joerger, Cory A. Ocasio, Rhiannon Jones, Raysa Khan Tareque, Mark C. Bagley, John Spencer, Martin Walker, Carol Austin, Tiziana Ferrara, Pietro D' Oca, Rossella Bellina, Rossella Branni, Fabio Caradonna
Summary: Carbazole compounds PK9320 and PK9323, as second-generation analogues of PK083, have been shown to restore p53 signaling in cancer cells by binding to mutation-induced surface crevices. The study demonstrates that small modifications in carbazole substitution patterns can significantly impact their genotoxic and epigenetic properties, with PK9320 and PK9323 being potential candidates for anticancer and epi-compounds.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Endocrinology & Metabolism
Daniele Bellavia, Fabio Caradonna, Eufrosina Dimarco, Viviana Costa, Valeria Carina, Angela De Luca, Lavinia Raimondi, Milena Fini, Carla Gentile, Gianluca Giavaresi
Summary: Progressive osteopenia and osteoporosis are caused by the imbalance between bone resorption and formation, leading to lower bone resistance and increased risk of fractures. Flavonoids have been extensively studied for their therapeutic activities, and now attention is shifting towards other polyphenolic compounds for potential use in the treatment and prevention of OP.
TRENDS IN ENDOCRINOLOGY AND METABOLISM
(2021)
Review
Endocrinology & Metabolism
Daniele Bellavia, Fabio Caradonna, Eufrosina Dimarco, Viviana Costa, Valeria Carina, Angela De Luca, Lavinia Raimondi, Carla Gentile, Riccardo Alessandro, Milena Fini, Gianluca Giavaresi
Summary: It has been found that bone density decreases due to the imbalance of bone homeostasis, leading to excessive bone resorption. Terpenoids, with their anti-resorptive effects, have the potential for long-term use in preventing and treating osteoporosis. This suggests a possible pharmacological application of terpenoids in osteoporosis management, focusing on molecular mechanisms and epigenetic factors.
TRENDS IN ENDOCRINOLOGY AND METABOLISM
(2021)
Article
Biochemistry & Molecular Biology
Daniele Bellavia, Viviana Costa, Angela De Luca, Aurora Cordaro, Milena Fini, Gianluca Giavaresi, Fabio Caradonna, Lavinia Raimondi
Summary: Research has shown a tight relationship between inflammation and epigenetics, which can lead to tumor progression and bone metastasis in primary breast tumor cells. The induction of tumor progression and bone metastasis by Interleukin-1 beta is dependent on the demethylating actions of TETs. Inhibition of TETs activity can modulate the epithelial-mesenchymal transition process and reduce the expression of bone metastasis markers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Sara Volpes, Ilenia Cruciata, Federica Ceraulo, Chiara Schimmenti, Flores Naselli, Cecilia Pinna, Maurizio Mauro, Pasquale Picone, Sabrina Dallavalle, Domenico Nuzzo, Andrea Pinto, Fabio Caradonna
Summary: The aim of this study was to evaluate the biological effects of natural stilbenoids found in Vitis vinifera, with a focus on their activity as epigenetic modulators. Resveratrol, pterostilbene, and (+/-)-trans-pterostilbene dehydrodimer showed no toxic effects and were effective in reversing arsenic damage in Caco-2 cell lines. Further studies are needed to clarify the mode of action of (+/-)-trans-delta-viniferin.
SCIENTIFIC REPORTS
(2023)
Article
Genetics & Heredity
Gabriella Schiera, Patrizia Cancemi, Carlo Maria Di Liegro, Flores Naselli, Sara Volpes, Ilenia Cruciata, Paola Sofia Cardinale, Fabiola Vaglica, Matteo Calligaris, Anna Paola Carreca, Roberto Chiarelli, Simone Dario Scilabra, Olga Leone, Fabio Caradonna, Italia Di Liegro
Summary: Gliomas, especially astrocytomas, are the most frequent brain cancers, derived from glial cells. Astrocytes play essential roles in brain functions, but when they become cancerous, their functions are altered and they invade the brain tissue. Studying the molecular properties of transformed astrocytes is crucial for better understanding of this cancer.
Article
Nutrition & Dietetics
Maria Antonietta Ragusa, Flores Naselli, Ilenia Cruciata, Sara Volpes, Chiara Schimmenti, Graziella Serio, Maurizio Mauro, Mariangela Librizzi, Claudio Luparello, Roberto Chiarelli, Chiara La Rosa, Antonino Lauria, Carla Gentile, Fabio Caradonna
Summary: This study discovered the pro-autophagic potential of indicaxanthin, extracted from prickly pear fruit, in human colorectal cancer cells. Indicaxanthin induced the up-regulation of autophagic markers and increased autophagolysosome production. It also caused epigenetic changes in autophagy-related genes, particularly those involved in the late stages of autophagy. This research provides insights into the anti-cancer effects of indicaxanthin and its potential impact on gastrointestinal health.
Review
Biology
Mariangela Librizzi, Flores Naselli, Giulia Abruscato, Claudio Luparello, Fabio Caradonna
Summary: This review focuses on the detection of molecular markers of exposure to PTHrP and the implications in various normal and pathological cellular and tissue models. It highlights the changes related to hepatic fibrosis, pancreatitis, and diabetes, and briefly summarizes the biological significance of gene and/or pathway activation or inactivation.