Article
Cell Biology
Maria Donatella Semeraro, Gunter Almer, Wilfried Renner, Hans-Juergen Gruber, Markus Herrmann
Summary: Obesity and exercise may modify age-related telomere shortening by regulating telomerase and shelterins, but existing studies are inconsistent and limited in scope.
Editorial Material
Cell Biology
Pawel Kordowitzki
Summary: Research has shown that the pool of oocytes in females starts to decline before birth, and as women age, characteristics such as chromosomal abnormalities, decreased mitochondrial function, and telomere shortening become more common. This may contribute to higher rates of miscarriage and chromosomal non-disjunction in older women who choose to delay pregnancy.
Article
Cell Biology
Xin Zhang, Mengting Shi, Xi Zhao, Ennan Bin, Yucheng Hu, Nan Tang, Huaping Dai, Chen Wang
Summary: This study aimed to investigate the regeneration capacity of AT2 cells with short telomeres. It was found that short telomeres in AT2 cells result in reduced expression level of TPPP3, thereby limiting the differentiation and regeneration capacity of AT2 cells.
CELL PROLIFERATION
(2022)
Article
Cell Biology
Jue Lin, Elissa Epel
Summary: Short telomeres may increase the risk of degenerative diseases, with stress-induced telomere damage being an important pathway. The initial setting point of telomere length at birth appears to be influential, possibly affected by stress. Intergenerational stress effects on telomeres include prenatal stress and direct inheritance of short telomeres.
AGEING RESEARCH REVIEWS
(2022)
Article
Chemistry, Multidisciplinary
Yi-Yun Lin, Min-Hsuan Li, Yen-Chan Chang, Peng-Yu Fu, Ryosuke L. Ohniwa, Hung-Wen Li, Jing-Jer Lin
Summary: Telomeres are crucial for chromosome maintenance, and Cdc13 is an essential telomeric DNA binding protein that caps telomeres and regulates telomerase function. Research shows that specific binding of Cdc13 on single-stranded telomeric DNA can shorten duplex DNA into distinct states, and this shortening is dynamic and independent of duplex DNA sequences or length. Moreover, the inability of Pif1 helicase to remove Cdc13 from the shortened DNA-Cdc13 complex suggests a structurally stable complex formation through shortening of bound DNA.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Article
Biochemistry & Molecular Biology
Christina Bauch, Jelle J. Boonekamp, Peter Korsten, Ellis Mulder, Simon Verhulst
Summary: The study investigated the genetic and environmental contributions to variation in telomere length in jackdaws, finding that telomere length variation is primarily influenced by additive genetic effects with a heritability estimated at 0.74 on average. Additionally, they observed low heritable variation for telomere shortening and some impact of year effects on telomere length variation.
Review
Cell Biology
Pedro A. Pousa, Raquel M. Souza, Paulo Henrique M. Melo, Bernardo H. M. Correa, Tamires S. C. Mendonca, Ana Cristina Simoes-e-Silva, Debora M. Miranda
Summary: Through a systematic review of 56 studies, it was found that mental disorders related to psychological distress are negatively associated with telomere length, indicating a potential link between psychological stress and physiological aging. The possible underlying molecular mechanisms causing telomere shortening in psychiatric diseases include oxidative stress, inflammation, and mitochondrial dysfunction.
Article
Biochemistry & Molecular Biology
Manassanan Jitjumnong, Pornpan Chalermkitpanit, Tanyawan Suantawee, Sinsuda Dechsupa, Ladawan Vajarintarangoon, Sittisak Honsawek
Summary: This study found that patients with lumbar disc degeneration (LDD) had shorter telomeres, increased oxidative stress, and decreased antioxidant levels. The telomere length was negatively correlated with the severity of LDD, while oxidative stress markers (MDA and 8-OHdG) showed positive correlations with severity. These findings suggest that telomere length, as well as MDA and 8-OHdG levels, may be potential non-invasive biomarkers for assessing the severity of LDD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Obstetrics & Gynecology
Radhia M'kacher, Bruno Colicchio, Valentine Marquet, Claire Borie, Wala Najar, William M. Hempel, Leonhard Heidingsfelder, Noufissa Oudrhiri, Mustafa Al Jawhari, Nadege Wilhelm-Murer, Marguerite Miguet, Alain Dieterlen, Georges Deschenes, Anne-Claude Tabet, Steffen Junker, Michael Grynberg, Michael Fenech, Annelise Bennaceur-Griscelli, Philippe Voisin, Patrice Carde, Eric Jeandidier, Catherine Yardin
Summary: The study found that telomere length of patients with infertility was significantly shorter than healthy donors, and patients with infertility showed more pronounced telomere shortening and abnormalities, especially in patients with structural chromosomal aberrations.
FERTILITY AND STERILITY
(2021)
Review
Biochemistry & Molecular Biology
Andy Ruiz, Julio Flores-Gonzalez, Ivette Buendia-Roldan, Leslie Chavez-Galan
Summary: This article discusses the important role of telomere shortening (TS) in lung diseases. In addition to age, other factors can induce TS and increase the risk of lung diseases. In an infectious environment, immune cells with TS are associated with severe lymphopenia and death, while in a non-infectious context, naive T cells with TS are related to cancer progression and enhanced inflammatory processes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Editorial Material
Biochemical Research Methods
Yafei Mao, Guojie Zhang
Summary: The release of the first telomere-to-telomere human genome sequence is a significant milestone in human genomics research, offering potential insights for evolutionary genomics. This article describes the advances of this new genome assembly and discusses the challenges of applying this sequencing strategy to various extant species.
Article
Cell Biology
Jeong-Hwa Jin, Hyuk Sung Kwon, Seong Hye Choi, Seong-Ho Koh, Eun-Hye Lee, Jee Hyang Jeong, Jae-Won Jang, Kyung Won Park, Eun-Joo Kim, Hee Jin Kim, Jin Yong Hong, Soo Jin Yoon, Bora Yoon, Hyun-Hee Park, Jungsoon Ha, Jong Eun Park, Myung Hoon Han
Summary: This study found a relationship between sleep parameters and longitudinal shortening of leukocyte telomere length (LTL). Poor sleep quality, specifically short sleep duration, long sleep latency, and low sleep efficiency were associated with faster longitudinal shortening of LTL.
Article
Medicine, Research & Experimental
Seung-Hwan Seo, Ji-Hun Shin, Do-Won Ham, Eun-Hee Shin
Summary: This study investigated the molecular mechanism of GRA16, a dense granule protein of Toxoplasma gondii, in inducing cancer cell apoptosis and telomere shortening. It was found that GRA16 directly downregulated hTERT expression and phosphorylation, leading to decreased telomerase activity and telomere shortening. The activation of tumor suppressor PTEN was involved in the molecular mechanism of GRA16-mediated hTERT inactivation.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Biology
Pablo Salmon, Caroline Millet, Colin Selman, Pat Monaghan
Summary: This study found that accelerated growth can influence telomere length in nestling zebra finches, but only when individuals show accelerated growth in response to environmental circumstances.
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2021)
Article
Multidisciplinary Sciences
Lisa M. Schneper, Amanda J. Drake, Taylor Dunstan, Iulia Kotenko, Daniel A. Notterman, Chinthika Piyasena
Summary: This study examined the association between gestational age, telomere length (TL), and the rate of shortening in newborns. Telomere length was measured in buccal samples from 39 term infants and 32 preterm infants at various time points. The results showed that preterm infants had longer telomeres at birth but experienced a greater rate of telomere shortening compared to term infants. Additionally, other factors such as sex, fetal growth restriction, maternal age, and socioeconomic status differed between the two groups.
Article
Cardiac & Cardiovascular Systems
Barrak Alahmad, Haitham Khraishah, Dominic Roye, Ana Maria Vicedo-Cabrera, Yuming Guo, Stefania I. Papatheodorou, Souzana Achilleos, Fiorella Acquaotta, Ben Armstrong, Michelle L. Bell, Shih-Chun Pan, Micheline de Sousa Zanotti Stagliorio Coelho, Valentina Colistro, Tran Ngoc Dang, Do Van Dung, Francesca K. De Donato, Alireza Entezari, Yue-Liang Leon Guo, Masahiro Hashizume, Yasushi Honda, Ene Indermitte, Carmen Iniguez, Jouni J. K. Jaakkola, Ho Kim, Eric Lavigne, Whanhee Lee, Shanshan Li, Joana Madureira, Fatemeh Mayvaneh, Hans Orru, Ala Overcenco, Martina S. Ragettli, Niilo R. I. Ryti, Paulo Hilario Nascimento Saldiva, Noah Scovronick, Xerxes Seposo, Francesco Sera, Susana Pereira Silva, Massimo Stafoggia, Aurelio Tobias, Eric Garshick, Aaron S. Bernstein, Antonella Zanobetti, Joel Schwartz, Antonio Gasparrini, Petros Koutrakis
Summary: A study found that exposure to extreme hot and cold temperatures is associated with an increased risk of cardiovascular disease mortality. The study used data from 567 cities in 27 countries and found a positive correlation between high and low temperatures and mortality from various cardiovascular diseases. The highest risks were observed for heart attacks and stroke during exposure to extreme temperatures.
Article
Environmental Sciences
Luise Nottmeyer, Ben Armstrong, Rachel Lowe, Sam Abbott, Sophie Meakin, Kathleen M. O'Reilly, Rosa von Borries, Rochelle Schneider, Dominic Roye, Masahiro Hashizume, Mathilde Pascal, Aurelio Tobias, Ana Maria Vicedo-Cabrera, Eric Lavigne, Patricia Matus Correa, Nicolas Valdes Ortega, Jan Kyncl, Ales Urban, Hans Orru, Niilo Ryti, Jouni Jaakkola, Marco Dallavalle, Alexandra Schneider, Yasushi Honda, Chris Fook Sheng Ng, Barrak Alahmad, Gabriel Carrasco-Escobar, Iulian Horia Holobac, Ho Kim, Whanhee Lee, Carmen iniguez, Michelle L. Bell, Antonella Zanobetti, Joel Schwartz, Noah Scovronick, Micheline de Sousa Zanotti Stagliorio Coelho, Paulo Hilario Nascimento Saldiva, Magali Hurtado Diaz, Antonio Gasparrini, Francesco Sera
Summary: This study aimed to quantify the associations between COVID-19 incidence and meteorological variables globally. The findings showed that low temperatures and low absolute humidity were associated with increased risks of COVID-19 incidence, highlighting the regional heterogeneity of weather-related effects on COVID-19 transmission.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Correction
Medicine, General & Internal
Hayon Michelle Choi, Whanhee Lee, Dominic Roye, Seulkee Heo, Ales Urban, Alireza Entezari, Ana Maria Vicedo-Cabrera, Antonella Zanobetti, Antonio Gasparrini, Antonis Analitis, Aurelio Tobias, Ben Armstrong, Bertil Forsberg, Carmen Iniguez, Christofer Astrom, Chris Fook Sheng Ng, Ene Indermitte, Eric Lavigne, Fatemeh Mayvaneh, Fiorella Acquaotta, Francesco Sera, Hans Orru, Ho Kim, Jan Kysely, Joana Madueira, Joel Schwartz, Jouni J. K. Jaakkola, Klea Katsouyanni, Magali Hurtado Diaz, Martina S. Ragettli, Masahiro Hashizume, Mathilde Pascal, Niilo Ryti, Noah Scovronick, Samuel Osorio, Shilu Tong, Xerxes Seposo, Yasushi Honda, Yoonhee Kim, Yue-Liang Guo, Yuming Guo, Michelle L. Bell
Article
Environmental Sciences
Masna Rai, Massimo Stafoggia, Francesca de'Donato, Matteo Scortichini, Sofia Zafeiratou, Liliana Vazquez Fernandez, Siqi Zhang, Klea Katsouyanni, Evangelia Samoli, Shilpa Rao, Eric Lavigne, Yuming Guo, Haidong Kan, Samuel Osorio, Jan Kysely, Ales Urban, Hans Orru, Marek Maasikmets, Jouni J. K. Jaakkola, Niilo Ryti, Mathilde Pascal, Masahiro Hashizume, Chris Fook Sheng Ng, Barrak Alahmad, Magali Hurtado Diaz, Cesar De la Cruz Valencia, Baltazar Nuness, Joana Madureira, Noah Scovronick, Rebecca M. Garland, Ho Kim, Whanhee Lee, Aurelio Tobias, Carmen Iniguez, Bertil Forsberg, Christofer Astrom, Ana Maria Vicedo-Cabrera, Martina S. Ragettli, Yue-Liang Leon Guo, Shih-Chun Pan, Shanshan Li, Antonio Gasparrini, Francesco Sera, Pierre Masselot, Joel Schwartz, Antonella Zanobetti, Michelle L. Bell, Alexandra Schneider, Susanne Breitner
Summary: A study conducted in 482 locations across 24 countries found that heat has an impact on cardiovascular and respiratory mortality, and air pollution exacerbates this effect. The effect on respiratory mortality is stronger than on cardiovascular mortality. Therefore, it is crucial to implement mitigation measures based on the new WHO Air Quality Guidelines to improve health and promote sustainable development.
ENVIRONMENT INTERNATIONAL
(2023)
Article
Environmental Sciences
Edward O'Brien, Pierre Masselot, Francesco Sera, Dominic Roye, Susanne Breitner, Chris Fook Sheng Ng, Micheline de Sousa Zanotti Stagliorio Coelho, Joana Madureira, Aurelio Tobias, Ana Maria Vicedo-Cabrera, Michelle L. Bell, Eric Lavigne, Haidong Kan, Antonio Gasparrini
Summary: A study on the short-term association between exposure to sulfur dioxide (SO2) and daily mortality found that even at low concentrations, there is a risk of excess mortality. This suggests that stricter air quality standards could have potential benefits.
ENVIRONMENTAL HEALTH PERSPECTIVES
(2023)
Article
Environmental Sciences
Afshin Maleki, Omid Aboubakri, Reza Rezaee, Barrak Alahmad, Francesco Sera
Summary: In this study, the impact of satellite-based Land Surface Temperature (LST) and Air Temperature (AT) on covid-19 was assessed. The epidemic shape, timing, and size were compared before and after adjusting for the predictors. A semi-parametric regression model was used to account for the non-linear behavior of the pandemic. The findings suggest that temperature may have changed the seasonal variation of covid-19, but conclusive evidence was difficult to provide due to large uncertainty after adjusting for the variables.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL HEALTH RESEARCH
(2023)
Article
Oncology
Xiaoshuang Feng, Wendy Yi-Ying Wu, Justina Ucheojor Onwuka, Zahra Haider, Karine Alcala, Karl Smith-Byrne, Hana Zahed, Florence Guida, Renwei Wang, Julie K. Bassett, Victoria Stevens, Ying Wang, Stephanie Weinstein, Neal D. Freedman, Chu Chen, Lesley Tinker, Therese Haugdahl Nost, Woon-Puay Koh, David Muller, Sandra M. Colorado-Yohar, Rosario Tumino, Rayjean J. Hung, Christopher Amos, Xihong Lin, Xuehong Zhang, Alan A. Arslan, Maria-Jose Sanchez, Elin Pettersen Sorgjerd, Gianluca Severi, Kristian Hveem, Paul Brennan, Arnulf Langhammer, Roger L. Milne, Jian-Min Yuan, Beatrice Melin, Mikael Johansson, Hilary A. Robbins, Mattias Johansson
Summary: This study aimed to develop a proteomics-based risk model for lung cancer and compare its performance with a smoking-based risk model and a commercially available autoantibody biomarker test. We conducted a case-control study in 6 prospective cohorts, involving 624 lung cancer participants and 624 smoking-matched cancer free participants. The protein-based risk model showed promise in predicting incident lung cancer and outperformed the standard risk prediction model and the commercialized EarlyCDT-Lung.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2023)
Review
Nutrition & Dietetics
Luca Colangeli, David Israel Escobar Marcillo, Valeria Simonelli, Egidio Iorio, Tommaso Rinaldi, Paolo Sbraccia, Paola Fortini, Valeria Guglielmi
Summary: Adipose tissue dysregulation is a critical process in obesity and its related complications, but the molecular basis of this dysfunction is still not fully understood. Recent research suggests that mitochondria, the cellular organelles responsible for energy production, play an important role in adipose tissue metabolism and function. Additionally, the dysregulation of gut microbiota and its metabolites in obesity may directly and indirectly affect adipose tissue metabolism through its impact on mitochondria. This review explores the connections between gut microbiota and adipose tissue mitochondria and provides insights into their molecular interactions.
Article
Nutrition & Dietetics
Giulia Collatuzzo, Eva Negri, Claudio Pelucchi, Rossella Bonzi, Federica Turati, Charles S. Rabkin, Linda M. Liao, Rashmi Sinha, Domenico Palli, Monica Ferraroni, Lizbeth Lopez-Carrillo, Nuno Lunet, Samantha Morais, Demetrius Albanes, Stephanie J. Weinstein, Dominick Parisi, David Zaridze, Dmitry Maximovitch, Trinidad Dierssen-Sotos, Jose Juan Jimenez-Moleon, Jesus Vioque, Manoli Garcia de la Hera, Maria Paula Curado, Emmanuel Dias-Neto, Raul Ulises Hernandez-Ramirez, Malaquias Lopez-Cervantes, Mary H. Ward, Shoichiro Tsugane, Akihisa Hidaka, Areti Lagiou, Pagona Lagiou, Zuo-Feng Zhang, Antonia Trichopoulou, Anna Karakatsani, Maria Constanza Camargo, Carlo La Vecchia, Paolo Boffetta
Summary: A meta-analysis of 16 studies found no significant association between yoghurt consumption and gastric cancer risk.
Article
Medicine, General & Internal
Silvia Mancini, Lauro Bucchi, Federica Zamagni, Flavia Baldacchini, Emanuele Crocetti, Orietta Giuliani, Alessandra Ravaioli, Rosa Vattiato, Mario Preti, Rosario Tumino, Stefano Ferretti, Annibale Biggeri, Paola Ballotari, Lorenza Boschetti, Angelita Brustolin, Adele Caldarella, Rossella Cavallo, Claudia Cirilli, Annarita Citarella, Maria L. Contrino, Luigino Dal Maso, Rosa A. Filiberti, Mario Fusco, Rocco Galasso, Fernanda L. Lotti, Michele Magoni, Lucia Mangone, Giuseppe Masanotti, Guido Mazzoleni, Walter Mazzucco, Anna Melcarne, Maria Michiara, Paola Pesce, Angela Pinto, Daniela Piras, Roberto V. Rizzello, Magda Rognoni, Stefano Rosso, Massimo Rugge, Giuseppe Sampietro, Santo Scalzi, Tiziana Scuderi, Giovanna Tagliabue, Federica Toffolutti, Susanna Vitarelli, Fabio Falcini
Summary: Survival rates for vulvar squamous cell carcinoma in Italy have shown no significant improvement from 1990 to 2015. It is necessary to reassess strategies for controlling vulvar squamous cell carcinoma in Italy and globally.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Oncology
Hasmik Grigoryan, Partow Imani, Carlotta Sacerdote, Giovanna Masala, Sara Grioni, Rosario Tumino, Paolo Chiodini, Sandrine Dudoit, Paolo Vineis, Stephen M. Rappaport
Summary: Using untargeted adductomics, researchers identified features associated with non-Hodgkin lymphoma (NHL) by studying stable reactive oxygen species (ROS) adducts in human serum albumin. The results suggest that altered ROS homeostasis may contribute to NHL incidence, with differences observed between males and females.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2023)
Review
Cell Biology
Francesca Marcon, Simona Giunta, Margherita Bignami
Summary: Satellite DNA sequences are a crucial part of centromeres, which are essential for the accurate segregation of chromosomes during cell division. Due to their complex repetitive structure, satellite DNA can hinder DNA replication and other DNA-based processes, potentially leading to chromosome breakage. In recent years, several DNA repair proteins have been found to interact with and function at centromeres, contributing to the maintenance of their structure and function. While the importance of these repair factors has been demonstrated by chromosome aberrations resulting from their inactivation, their roles in satellite DNA replication and repair are still being explored. Recent studies have also linked specific DNA repair factors at centromeres to age-related increase in chromosomal instability under physiological and pathological conditions.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Article
Nutrition & Dietetics
Inge Huybrechts, Inarie Jacobs, Elom K. Aglago, Sahar Yammine, Michele Matta, Julie A. Schmidt, Corinne Casagrande, Genevieve Nicolas, Carine Biessy, Heleen Van Puyvelde, Augustin Scalbert, Jeroen W. G. Derksen, Yvonne T. van der Schouw, Sara Grioni, Pilar Amiano, Jytte Halkjaer, Anne Tjonneland, Jose M. Huerta, Leila Lujan-Barroso, Domenico Palli, Marc J. Gunter, Aurora Perez-Cornago, Veronique Chajes
Summary: This study aims to investigate the relationship between dietary fatty acid (FA) intake and plasma phospholipid (PL) FA levels in the EPIC cohort. Dietary intake of 60 individual FAs was estimated using validated questionnaires, and plasma PL FA concentrations were measured in non-fasting venous plasma samples. The results showed moderate positive correlations between FA intakes and plasma PL FA levels for certain FAs, especially for health-enhancing long-chain polyunsaturated FAs and health-deteriorating trans-FA.
Article
Oncology
Elisabetta Casalone, Giovanni Birolo, Barbara Pardini, Alessandra Allione, Alessia Russo, Chiara Catalano, Manlio Mencoboni, Daniela Ferrante, Corrado Magnani, Marika Sculco, Irma Dianzani, Federica Grosso, Dario Mirabelli, Rosa Angela Filiberti, Ottavio Rena, Carlotta Sacerdote, Miguel Rodriguez-Barranco, Karl Smith-Byrne, Salvatore Panico, Claudia Agnoli, Theron Johnson, Rudolf Kaaks, Rosario Tumino, Jose Maria Huerta, Elio Riboli, Alicia K. Heath, Camino Trobajo-Sanmartin, Matthias B. Schulze, Calogero Saieva, Pilar Amiano, Antonio Agudo, Elisabete Weiderpass, Paolo Vineis, Giuseppe Matullo
Summary: This study identified a miRNA signature in preclinical MPM patients, which can be detected up to five years before diagnosis, providing potential non-invasive markers for early detection and intervention.
Article
Oncology
Pier Vitale Nuzzo, Francesco Ravera, Calogero Saieva, Elisa Zanardi, Giuseppe Fotia, Andrea Malgeri, Sabrina Rossetti, Loana Bueno Valenca, Thiago Martins Oliveira, Charles Vauchier, Ricardo Pereira Mestre, Mikol Modesti, Anna Patrikidou, Sandro Pignata, Giuseppe Procopio, Giuseppe Fornarini, Ugo De Giorgi, Antonio Russo, Edoardo Francini
Summary: This study evaluated the impact of disease volume on the effectiveness of first-line treatments for metastatic castration-resistant prostate cancer (mCRPC). The results showed that for patients with low disease volume, treatment with enzalutamide (Enza) provided better overall survival and radiographic progression-free survival compared to abiraterone acetate (AA). However, there was no significant difference in outcomes between AA and Enza for patients with high disease volume.
THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY
(2023)