Article
Behavioral Sciences
Richard Shek-kwan Chang, Eric H. Y. Lau, Elaine Yuen Ling Au, William C. Y. Leung, Yu Hin Ian Leung
Summary: In this study, it was found that the incidence of AGS peaks in the spring season, particularly from March to April, which is consistent with the peak of GBS and slightly lags behind the peak of CJI by about one month. The seasonal pattern of AGS occurrence was confirmed.
BRAIN AND BEHAVIOR
(2021)
Article
Pediatrics
Lianhong Cai, Zhanqi Hu, Jianxiang Liao, Siqi Hong, Lingyu Kong, Li Chen, Yetao Luo, Tingsong Li, Li Jiang
Summary: The most common phenotypes of anti-GQ1b antibody syndrome in childhood are acute ophthalmoparesis and classic Miller Fisher syndrome. The majority of patients show good response to immunotherapy and have favorable prognosis.
FRONTIERS IN PEDIATRICS
(2021)
Article
Immunology
Shuwen Deng, Lihong Yin, Wei Lu, Song Ouyang, Weifan Yin
Summary: This case report describes a new clinical presentation of Guillain-Barre syndrome (GBS), characterized by involvement of only the facial and trigeminal nerves in a female patient, with positive serum antibodies secondary to Mycoplasma pneumoniae infection. Treatment resulted in significant symptom improvement.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, Research & Experimental
Ming Chi, Lu Han, Zilong Zhu
Summary: This article describes a 53-year-old woman who presented with acute bulbar palsy as the first symptom of overlapping MFS/GBS accompanied by severe headache. Early identification of these overlapping syndromes is important for the management of patients, to avoid respiratory failure or severe weakness with axonal degeneration.
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
(2023)
Article
Neurosciences
Qing Zeng, Juan Li, Shu-Xing Feng, Pei-Yao Xiao, Yi-Fan Zheng, Cheng Zhang, Song-Jie Liao
Summary: This study describes the clinical characteristics of anti-GQ1b antibody syndrome with visual impairment, expanding the clinical spectrum of this syndrome. It emphasizes the importance of physical and ophthalmological examination in exploring the pathogenesis and treatment of anti-GQ1b antibody syndrome.
JOURNAL OF INTEGRATIVE NEUROSCIENCE
(2022)
Article
Clinical Neurology
Lotte S. Levison, Reimar W. Thomsen, Henning Andersen
Summary: This nationwide study aimed to investigate the association between hospital-diagnosed morbidity, recent surgery, and subsequent Guillain-Barre syndrome (GBS) development. The results showed that individuals with pre-existing hospital-diagnosed morbidity had a 1.6-fold increased risk of GBS compared to controls. The risk was highest for morbidities newly diagnosed within the past 5 months (4.1-fold increase). Additionally, individuals who had undergone surgical procedures within 5 months prior had a 2.2-fold increased risk of GBS, with the highest risk observed within the first month following surgery (3.7-fold increase).
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Lotte Sahin Levison, Reimar Wernich Thomsen, Henning Andersen
Summary: This study found a slightly increased risk of Guillain-Barre syndrome (GBS) within one month after influenza vaccination, based on a retrospective nationwide population-based case-control study in Denmark. However, only 1.5% of GBS cases were associated with recent influenza vaccination. Therefore, the benefits of influenza vaccines in preventing influenza infections and associated morbidity and mortality need to be evaluated against the small absolute risk of GBS.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Review
Clinical Neurology
Susumu Kusunoki, Hugh J. Willison, Bart C. Jacobs
Summary: Guillain-Barre syndrome and Fisher syndrome are acute autoimmune neuropathies often triggered by infection, with antiglycolipid antibody titres elevated in acute-phase patients, particularly for diagnosis in FS. These antibodies are mainly found in acute motor axonal neuropathy GBS and FS, suggesting the need for further research and standardisation in antibody detection methods.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2021)
Article
Clinical Neurology
Jing Sun, Yu Gao, Lumei Chi, Qingyang Cao, Zhijie Ning, Guangxian Nan
Summary: Atypical presentations of GBS can be mistaken for stroke, leading to delayed diagnosis. This case serves as a reminder that symptoms mimicking stroke could be indicative of GBS, and timely diagnosis is crucial for successful management. Neuroimaging plays a key role in distinguishing between stroke and GBS.
FRONTIERS IN NEUROLOGY
(2021)
Article
Clinical Neurology
Jiting Zhu, Yuanyuan Zhang, Runyun Li, Yi Lin, Ying Fu, Yaping Yan, Wenli Zhu, Ning Wang, Zaiqiang Zhang, Guorong Xu
Summary: This study investigated the diagnostic efficiency of a novel immunoblotting detection assay for anti-ganglioside antibodies (AGAs) in Guillain-Barre syndrome (GBS). The results showed a high detection rate of AGAs in GBS patients, with specific assistance in diagnosing the AMAN subtype.
FRONTIERS IN NEUROLOGY
(2021)
Article
Medicine, General & Internal
Limei Zhang, Linqing Ma, Lihua Zhou, Lu Sun, Chunru Han, Qi Fang
Summary: We present a case of Miller-Fisher syndrome (MFS) in a 48-year-old male patient with positive anti-GD1b and anti-GM1 antibodies combined with multiple autoimmune antibodies. The patient experienced symptoms of dizziness, visual rotation, nausea, and vomiting accompanied by unsteady gait and diplopia. Treatment with immunoglobulins and hormones led to symptom improvement.
Article
Neurosciences
Sachendra Badal, Prashant Jauhari, Sonali Singh, Gautam Kamilla, Biswaroop Chakrabarty, Sheffali Gulati
Summary: Acute-onset ophthalmoplegia in young children is a challenging diagnosis. Miller-Fisher syndrome, a variant of Guillain-Barre syndrome, is commonly associated with complete ophthalmoplegia, ataxia, and areflexia. However, the etiology of isolated external ophthalmoplegia is diverse and lacks research. This case report emphasizes the possibility of anti-GQ1b antibody syndrome even in young children with acute-onset external ophthalmoplegia.
Article
Gastroenterology & Hepatology
Ankit Malik, Jean M. Brudvig, Barbie J. Gadsden, Alexander D. Ethridge, Linda S. Mansfield
Summary: This study demonstrates the link between Campylobacter jejuni and the autoimmune disease Guillain-Barré syndrome and identifies the roles of Siglec-1 and IL-4 in its development. The mouse model developed in this study provides potential therapeutic interventions for this disease.
Review
Clinical Neurology
Ciro Maria Noioso, Liliana Bevilacqua, Gabriella Maria Acerra, Paola Della Valle, Marina Serio, Claudia Vinciguerra, Giuseppe Piscosquito, Antonella Toriello, Paolo Barone, Aniello Iovino
Summary: Miller Fisher syndrome (MFS) is a rare variant of Guillain-Barre syndrome (GBS), characterized by ataxia, areflexia, and ophthalmoparesis. This review provides a comprehensive overview of MFS, including its clinical characteristics, neurophysiology, treatment, and prognosis, with a focus on recent developments related to COVID-19.
FRONTIERS IN NEUROLOGY
(2023)
Article
Clinical Neurology
Johanna I. Hamel, Eric L. Logigian
Summary: This study retrospectively reviewed cases from 1999 to 2020 to describe the clinical, micronutrient, and electrophysiologic spectra and prognosis of acute nutritional axonal neuropathy (ANAN). The results showed that ANAN has a wide spectrum of manifestations and specific micronutrient deficiencies or risk factors do not predict neuropathy subtype. The prognosis of ANAN is guarded due to slow recovery of independent ambulation and residual neuropathic pain.