期刊
SENSORS
卷 15, 期 10, 页码 25313-25335出版社
MDPI
DOI: 10.3390/s151025313
关键词
Low-Noise Amplifier; neural spike recording; biomedical circuit; circuit sizing
资金
- Spanish Ministry of Economy and Competitiveness [TEC2012-33634]
- FEDER Program
This paper presents a Low Noise Amplifier (LNA) for neural spike recording applications. The proposed topology, based on a capacitive feedback network using a two-stage OTA, efficiently solves the triple trade-off between power, area and noise. Additionally, this work introduces a novel transistor-level synthesis methodology for LNAs tailored for the minimization of their noise efficiency factor under area and noise constraints. The proposed LNA has been implemented in a 130 nm CMOS technology and occupies 0.053 mm-sq. Experimental results show that the LNA offers a noise efficiency factor of 2.16 and an input referred noise of 3.8 Vrms for 1.2 V power supply. It provides a gain of 46 dB over a nominal bandwidth of 192 Hz-7.4 kHz and consumes 1.92 W. The performance of the proposed LNA has been validated through in vivo experiments with animal models.
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