Review
Orthopedics
Henrik C. Baecker, John T. Richards, Arne Kienzle, John Cunningham, Karl F. Braun
Summary: Exertional rhabdomyolysis is a condition in which skeletal muscle cells break down after intense exercise, leading to increased levels of creatine kinase (CK) or myoglobin, as well as blood in the urine, and potentially kidney insufficiency. This study aimed to outline the current perspectives on exertional rhabdomyolysis in athletes and the subsequent treatment options based on existing literature.
CLINICAL JOURNAL OF SPORT MEDICINE
(2023)
Article
Biochemical Research Methods
Andreia Carneiro, Janaina Macedo-da-Silva, Veronica Feijoli Santiago, Gilberto Santos de Oliveira, Thiago Guimaraes, Clarissa Ferolla Mendonca, Jessica Lais de Oliveira Branquinho, Cintia Verdan Lucena, Juliana Osorio, Eduardo Pernambuco, Josino Costa Moreira, Joao Bosco Pesquero, Marcos Dias Pereira, Giuseppe Palmisano
Summary: This study analyzed the blood and urine samples of marine soldiers during a special training program, and identified changes in proteins related to immune system and cell adhesion after strenuous physical exercise. The study also found associations between genetic polymorphisms and protein abundance, as well as identified six proteins as potential markers for early non-invasive diagnosis of ERM.
JOURNAL OF PROTEOMICS
(2022)
Article
Genetics & Heredity
Federica Invernizzi, Rossella Izzo, Isabel Colangelo, Andrea Legati, Nadia Zanetti, Barbara Garavaglia, Eleonora Lamantea, Lorenzo Peverelli, Anna Ardissone, Isabella Moroni, Lorenzo Maggi, Silvia Bonanno, Laura Fiori, Daniele Velardo, Francesca Magri, Giacomo P. Comi, Dario Ronchi, Daniele Ghezzi, Costanza Lamperti
Summary: This study aimed to investigate the possible genetic causes of recurrent hyperCKemia or clinical suspicion of inherited metabolic myopathy. A cohort of 139 patients was analyzed and a genetic diagnosis was obtained in 15.1% of cases, while candidate variants or variants of uncertain significance were found in a further 39.5%. The results confirmed the high genetic heterogeneity of hyperCKemia and metabolic myopathies, suggesting the existence of additional genes associated with this condition and the possibility of cases being caused by extrinsic factors.
Article
Neurosciences
Beatrice Labella, Gaetana Lanzi, Stefano Cotti Piccinelli, Filomena Caria, Simona Damioli, Barbara Risi, Enrica Bertella, Loris Poli, Alessandro Padovani, Massimiliano Filosto
Summary: This article discusses a rare genetic disorder called Very long-chain acyl-CoA dehydrogenase (VLCAD) deficiency, caused by mutations in the ACADVL gene. A case study of a 17-year-old boy with exercise-induced muscle pain and fatigue, as well as other symptoms, is reported. Various tests confirmed the diagnosis of VLCAD deficiency, and early dietary treatment is crucial for minimizing muscle damage and slowing disease progression.
Article
Clinical Neurology
Han-ding Mao, Xin Li, Shu-yuan Liu, Ling Xing, Jin-bao Zhao, Zhi-jun Tan, Hai-long Sun, Qing Song
Summary: Exertional rhabdomyolysis (ER) frequently occurs during prolonged intense exercise in hot conditions, posing a health threat to military personnel. This study identified risk factors for ER, including shorter length of service, higher BMI, lack of physical exercise, previous heat injury, and protective factors such as frequent fruit consumption and proper hydration habits. Preventative measures include gradual training adaptation for recruits, proper fluid intake before exercise, increased fruit consumption, and adequate potassium supplementation.
Article
Medicine, General & Internal
Joann M. Butkus, Mackenzie Kramer, Vincent Chan, Eunha Kim
Summary: This article presents a rare case of non-traumatic rhabdomyolysis with hyperCKemia and transaminitis, without myoglobinuria or acute kidney injury. It highlights the need for further research on the protective characteristics against rhabdomyolysis-associated acute kidney injury, the association between creatine kinase and myoglobinuria, and the diagnostic criteria for psychosis-associated hyperCKemia.
AMERICAN JOURNAL OF CASE REPORTS
(2022)
Article
Orthopedics
Michelle Meyer, Sneha Sundaram, Ingeborg Schafhalter-Zoppoth
Summary: This report illustrates a case of exercise-induced rhabdomyolysis in a 31-year-old female after a CrossFit workout, resulting in hospitalization and IV fluid administration. Rhabdomyolysis can be triggered by high-intensity exercises like CrossFit, sometimes with symptoms that may be underestimated and underreported.
CLINICAL JOURNAL OF SPORT MEDICINE
(2021)
Article
Veterinary Sciences
Mario Cervone, Alexandra Nectoux, Celine Pouzot-Nevoret
Summary: This article reports a case of rhabdomyolysis and myoglobinuria in a dog following anesthesia with propofol. The dog developed clinical symptoms a few hours after recovery from anesthesia and returned to normal after IV fluid therapy.
JOURNAL OF VETERINARY EMERGENCY AND CRITICAL CARE
(2023)
Review
Sport Sciences
Zidong Li, Zachary J. McKenna, Matthew R. Kuennen, Flavio de Castro Magalhaes, Christine M. Mermier, Fabiano T. Amorim
Summary: Exertional heat stroke is a life-threatening condition that mainly affects athletes, military personnel, firefighters, and occupational workers. It can be caused by prolonged and strenuous physical activities in high heat conditions, with exercise-induced muscle damage being a potential predisposing factor for EHS and AKI. Understanding this relationship may help to minimize the risks of EHS and AKI for individuals engaging in physical work in hot environments.
Article
Medicine, General & Internal
Abdulrashid Hashi Mohamed, Abdirahman Abdikadir Osman, Abdulkamil Abdullahi Adani, Marian Muse Osman
Summary: Acute kidney injury (AKI) is a severe complication of rhabdomyolysis, a clinical syndrome characterized by the damage of skeletal muscle and the subsequent release of its breakdown products into the bloodstream. A case is presented of a previously healthy male who developed exercise-induced rhabdomyolysis with AKI after a vigorous workout, but he recovered fully with isotonic fluid therapy without renal replacement therapy.
ANNALS OF MEDICINE AND SURGERY
(2023)
Article
Pediatrics
Chon In Kuok, Winnie Kwai Yu Chan
Summary: The prevalence of acute kidney injury (AKI) in pediatric non-traumatic rhabdomyolysis was 18.5%. Factors associated with AKI development included positive urine tests, high white cell count, lower serum bicarbonate on admission, and high peak serum CK levels.
PEDIATRIC NEPHROLOGY
(2021)
Article
Medicine, General & Internal
Andy K. H. Lim, Ajinkya Bhonsle, Karen Zhang, Joy Hong, Kuo L. C. Huang, Joseph Nim
Summary: This study found an association between hyponatremia and the severity of rhabdomyolysis, even after adjusting for confounders. The study also found that patients with psychotic and alcohol use disorders were more likely to develop hyponatremia and rhabdomyolysis compared to the general population.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Naram Khalayli, Raghad Ibrahim, Rahaf Ibrahim, Maysoun Kudsi
Summary: A fatal case of rhabdomyolysis caused by COVID-19 infection in a 48-year-old female was presented. This study suggests that severe rhabdomyolysis can occur in COVID-19 patients, and further research is needed to understand the mechanism and optimize treatment.
ANNALS OF MEDICINE AND SURGERY
(2023)
Article
Neurosciences
Dean Minnock, Giosue Annibalini, Giacomo Valli, Roberta Saltarelli, Mauricio Krause, Elena Barbieri, Giuseppe De Vito
Summary: Growing evidence suggests that people with type 1 diabetes have impaired skeletal muscle health, but this condition is not well characterized. This study found that a combined resistance and aerobic training intervention improved muscle function in type 1 diabetes patients, but to a lesser extent compared to healthy controls.
JOURNAL OF PHYSIOLOGY-LONDON
(2022)
Article
Medicine, General & Internal
Sajad Ahmad, Muhammad Anees, Irfan Elahi, Fazal-e-Mateen
Summary: Rhabdomyolysis is an uncommon cause of acute kidney injury, often caused by crush syndrome and unaccustomed physical exertion. In local cases studied, most patients were young males with elevated creatine phosphokinase levels, treated conservatively with fluid replacement or dialysis, resulting in resolution of AKI in all patients over time.
JCPSP-JOURNAL OF THE COLLEGE OF PHYSICIANS AND SURGEONS PAKISTAN
(2021)