Article
Clinical Neurology
Alexander Peter Murphy, Elizabeth Greally, Dara O'Hogain, Andrew Blamire, Peter Caravan, Volker Straub
Summary: As putative treatments are developed for Duchenne muscular dystrophy (DMD), it is increasingly important to have sensitive, non-invasive measures to quantify disease progression. EP3533, a novel contrast agent with an affinity to collagen 1, has shown significant correlation to ex vivo fibrosis quantification. Halofuginone, an established anti-fibrotic compound, can reduce collagen skeletal muscle fibrosis in murine models of DMD. This experiment explored the use of EP3533 in detecting signal change in skeletal muscle of mdx mice before and after a 12-week course of halofuginone, showing potential for quantifying treatment effects. Further studies are needed to evaluate the use of EP3533 in humans.
FRONTIERS IN NEUROLOGY
(2021)
Article
Multidisciplinary Sciences
Michael Ziemba, Molly Barkhouse, Kitipong Uaesoontrachoon, Mamta Giri, Yetrib Hathout, Utkarsh J. Dang, Heather Gordish-Dressman, Kanneboyina Nagaraju, Eric P. Hoffman
Summary: Duchenne muscular dystrophy is caused by dystrophin deficiency, leading to downstream pathophysiological pathways that drive disability. Dystrophin replacement strategies may trigger these pathways, so combination therapies targeting multiple downstream pathways are crucial. Blood biomarkers could be used to assess drug combinations for treating DMD in both mouse models and human studies.
Article
Biochemistry & Molecular Biology
Keryn G. Woodman, Chantal A. Coles, Shireen R. Lamande, Jason D. White
Summary: Resveratrol at a lower dosage showed potential efficacy in reducing muscle damage and inflammatory cell markers associated with Duchenne muscular dystrophy, suggesting it as a candidate drug for treating DMD.
Article
Cell Biology
Jiqing Zheng, Jing Lou, Yanfang Li, Panting Qian, Wei He, Yingxue Hao, Ting Xue, Yangxin Li, Yao-Hua Song
Summary: Misregulation of satellite cell fate and function influences the severity of DMD. CIPC is a negative regulator of satellite cell function, and its deficiency promotes muscle regeneration.
Article
Biochemistry & Molecular Biology
Angus Lindsay, John Holm, Maria Razzoli, Alessandro Bartolomucci, James M. Ervasti, Dawn A. Lowe
Summary: Research shows that mdx mice do not habituate to mild stress, and daily exposure to mild stress for weeks exacerbates phenotypes associated with dystrophinopathy in mdx mice.
Article
Materials Science, Multidisciplinary
Giovana Zerbo Martinez, Bruna Alexia Cristofoletti Grillo, Lara Caetano Rocha, Carolina dos Santos Jacob, Jurandyr Pimentel Neto, Andre Neri Tomiate, Gabriela Klein Barbosa, Ii-sei Watanabe, Adriano Polican Ciena
Summary: The study revealed that mdx mice demonstrated extensive impairment in the myotendinous junction (MTJ) region, with shorter sarcomeres, fewer sarcoplasmic projections, and increased deposition of type III collagen.
MICROSCOPY AND MICROANALYSIS
(2021)
Article
Biophysics
Christopher Lopez, Abhinandan Batra, Zahra Moslemi, Andrew Rennick, Kimberly Guice, Huadong Zeng, Glenn A. Walter, Sean C. Forbes
Summary: This study demonstrates that P-31-MRS markers of energetic status and sarcolemma integrity are altered in young mdx mice compared with wild-type mice, and these indices are exacerbated following downhill running.
NMR IN BIOMEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Arkady Uryash, Alfredo Mijares, Eric Esteve, Jose A. A. Adams, Jose R. R. Lopez
Summary: Duchenne muscular dystrophy (DMD) is a genetic muscular disorder caused by mutations in the dystrophin gene. This study found anomalous regulation of resting intracellular Ca2+ in vascular smooth muscle cells (VSMCs) from a mouse model of DMD. Hypoxia leads to Ca2+ overload in VSMCs, and the lack of dystrophin makes them more susceptible to this overload.
Article
Cell Biology
Rekha Balakrishnan, Satvik Mareedu, Gopal J. Babu
Summary: The reduction or elimination of sarcolipin (SLN) expression improves muscle metabolism, reduces oxidative stress, improves muscle pathology, and protects mdx mice from glucose intolerance in the Duchenne muscular dystrophy (DMD) mouse model.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
Article
Genetics & Heredity
Nicole M. Ralbovsky, Paromita Dey, Andrew Galfano, Bijan K. Dey, Igor K. Lednev
Summary: Duchenne muscular dystrophy (DMD) is a common form of muscular dystrophy that primarily affects males in infancy. Diagnosing DMD currently requires invasive and laborious methods, making early detection difficult. There is a need for a simple and non-invasive method to accurately detect DMD as early as possible.
Article
Biochemistry & Molecular Biology
Yusuke Kawamura, Tetsuro Hida, Bisei Ohkawara, Masaki Matsushita, Takeshi Kobayashi, Shinya Ishizuka, Hideki Hiraiwa, Satoshi Tanaka, Mikito Tsushima, Hiroaki Nakashima, Kenyu Ito, Shiro Imagama, Mikako Ito, Akio Masuda, Naoki Ishiguro, Kinji Ohno
Summary: The anti-histamine drug meclozine promotes the proliferation and survival of human myogenic progenitor cells but inhibits myotube formation. In a mouse model of muscular dystrophy, meclozine improves muscle mass, exercise performance, and reduces ERK1/2 phosphorylation.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Nutrition & Dietetics
Kristy Swiderski, Suzannah J. Read, Audrey S. Chan, Jin D. Chung, Jennifer Trieu, Timur Naim, Rene Koopman, Gordon S. Lynch
Summary: Gastrointestinal dysfunction is a common but understudied condition in DMD patients, with potential for SFN to improve GI function, yet further research is needed to confirm its effectiveness.
Article
Biochemistry & Molecular Biology
Paul Ritter, Stefanie Nuebler, Andreas Buttgereit, Lucas R. Smith, Alexander Muhlberg, Julian Bauer, Mena Michael, Lucas Kreiss, Michael Haug, Elisabeth Barton, Oliver Friedrich
Summary: This study found that the mdx Cmah (-/-) genotype replicated DMD-like fibrosis but was not associated with changes in passive visco-elastic muscle stiffness. Detriments in active isometric force were compatible with the pronounced myofibrillar disarray of the dystrophic background.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Mikhail Dubinin, Vlada S. Starinets, Eugeny Yu Talanov, Irina B. Mikheeva, Natalia Belosludtseva, Konstantin N. Belosludtsev
Summary: The study demonstrates that the calcium-dependent mitochondrial permeability transition (MPT) pore inhibitor alisporivir can alleviate inflammation in mdx mice, improve muscle function, improve mitochondrial ultrastructure, normalize respiration and oxidative phosphorylation. The therapy suppresses MPT pore opening, improves calcium homeostasis, but also inhibits mitochondrial biogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cardiac & Cardiovascular Systems
Satvik Mareedu, Ronald Pachon, Jayapalraj Thilagavathi, Nadezhda Fefelova, Rekha Balakrishnan, Nandita Niranjan, Lai-Hua Xie, Gopal J. Babu
Summary: Reducing SLN expression improves cardiac SERCA function and Ca(2+)i cycling, prevents cardiomyopathy in mdx mice, activates apelin-mediated cardioprotective signaling pathways, and enhances cardiac function.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2021)
Article
Rehabilitation
Kim-Ly Bui, Nathalia Maia, Didier Saey, Gail Dechman, Francois Maltais, Pat G. Camp, Sunita Mathur
Summary: This study investigated the test-retest reliability of quadriceps power using computerized dynamometry in COPD patients, and explored the associations between quadriceps strength and power, and functional capacity. The results showed that average power had the strongest correlation with functional capacity, highlighting its significance in determining physical function.
PHYSIOTHERAPY THEORY AND PRACTICE
(2021)
Article
Rehabilitation
Lisa Wickerson, Dina Brooks, John Granton, W. Darlene Reid, Dmitry Rozenberg, Lianne G. Singer, Sunita Mathur
Summary: In patients with ILD, interval exercise is preferred and showed lower peak heart rate and trends towards less oxygen desaturation compared to continuous exercise, indicating potential benefits for lung transplant candidates.
PHYSIOTHERAPY THEORY AND PRACTICE
(2021)
Article
Rehabilitation
Nadia Keshwani, Sunita Mathur, Linda McLean
Summary: This study explored the feasibility of abdominal binding and targeted trunk exercises for managing diastasis recti abdominis. The interventions showed positive effects on body image and trunk flexion strength, suggesting that physiotherapy interventions can be effective in improving these outcomes. Further investigation through a clinical trial is recommended to confirm these findings.
PHYSIOTHERAPY THEORY AND PRACTICE
(2021)
Article
Physiology
Sunita Mathur, Dmitry Rozenberg, Lee Verweel, Camila E. Orsso, Lianne G. Singer
CLINICAL PHYSIOLOGY AND FUNCTIONAL IMAGING
(2020)
Review
Biochemistry & Molecular Biology
Heta Lad, Tyler M. Saumur, Margaret S. Herridge, Claudia C. dos Santos, Sunita Mathur, Jane Batt, Penney M. Gilbert
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Biophysics
Tyler M. Saumur, Sunita Mathur, Jacqueline Nestico, Stephen D. Perry, George Mochizuki, Avril Mansfield
Summary: The study aimed to determine the test-retest reliability of various force plate-derived measures of reactive stepping, finding that foot-off and swing times had higher reliability compared to step onset and restabilization times. The between-session reliability was higher than within-session reliability for all measures, with time to restabilization showing the worst absolute reliability. Multiple baseline sessions are recommended for measuring restabilization and step onset times, and the minimal detectable changes reported provide an index for measuring meaningful change due to intervention.
JOURNAL OF BIOMECHANICS
(2021)
Review
Allergy
Kenneth Wu, Anna Michalski, Daniel Cortes, Dmitry Rozenberg, Sunita Mathur
Summary: The current literature on glucocorticoid-induced myopathy in asthma patients shows inconsistent results, suggesting the need for future studies to use a consistent operational definition, employ a cohort study design, and consider possible confounding factors.
Article
Surgery
Sunita Mathur, Tania Janaudis-Ferreira, Julia Hemphill, Joseph A. Cafazzo, Donna Hart, Sandra Holdsworth, Mike Lovas, Lisa Wickerson
Summary: This study found that solid organ transplant recipients face barriers to physical activity but are motivated by a desire for long-term health. They desire digital health tools with features such as a reward system, affordability, integration of multiple functions, and the ability to selectively share information.
CLINICAL TRANSPLANTATION
(2021)
Article
Oncology
Ravneet Vohra, Yak-Nam Wang, Helena Son, Stephanie Totten, Akshit Arora, Adam Maxwell, Donghoon Lee
Summary: Pancreatic ductal adenocarcinoma is characterized by a complex tumor microenvironment, and magnetic resonance imaging can be used as a non-invasive tool to monitor it.
Article
Surgery
Tathiana Santana Shiguemoto, Tania Janaudis-Ferreira, Neha Dewan, Sunita Mathur
Summary: This study used the Delphi approach to explore the perspectives of transplant patients and healthcare professionals on key outcome domains related to exercise in clinical trials. Although consensus was not reached on the core outcome domains, the study provides preliminary information on domains that are prioritized by patients and professionals.
PROGRESS IN TRANSPLANTATION
(2023)
Editorial Material
Rehabilitation
Sunita Mathur, Tania Janaudis-Ferreira, Manoela de Paula Ferreira, Nicholas Bourgeois, Tom Blydt-Hansen, Tracy Fuller, Robin Deliva, Lorraine Hamiwka
PHYSIOTHERAPY CANADA
(2023)
Editorial Material
Rehabilitation
Sunita Mathur, Tania Janaudis-Ferreira, Manoela de Paula Ferreira, Nicholas Bourgeois, Tom Blydt-Hansen, Tracy Fuller, Robin Deliva, Lorraine Hamiwka
PHYSIOTHERAPY CANADA
(2023)
Article
Surgery
Matheus de Paiva Azevedo, Patricia Angelica de Miranda Silva Nogueira, Lorna D'Souza, Betty Cheung, Karen Uy, John Patcai, Sunita Mathur, Tania Janaudis-Ferreira
Summary: Inpatient rehabilitation programs can significantly improve functional outcomes and health-related quality of life in transplant recipients with a complicated postoperative course.
PROGRESS IN TRANSPLANTATION
(2023)
Article
Critical Care Medicine
Luciana Vieira, Paulo Eugenio Silva, Priscilla Flavia de Melo, Vinicius Maldaner, Joao Q. Durigan, Rita de Cassia Marqueti, Otavio Nobrega, Sunita Mathur, Chris Burtin, Fabricio Barin, Wilcelly Machado-Silva, Sergio Ramalho, Gaspar R. Chiappa, Nadia Oliveira Gomes, Celso R. F. Carvalho, Graziella F. B. Cipriano, Gerson Cipriano
Summary: This study aimed to investigate the effects of early neuromuscular electrical stimulation (NMES) on muscle quality and size in patients with traumatic brain injury (TBI). The results showed that NMES intervention preserved muscle size and quality and maintained normal levels of signaling mediators of muscle growth and inflammation in TBI patients. Therefore, early NMES can be beneficial for TBI patients.
CRITICAL CARE RESEARCH AND PRACTICE
(2023)
Article
Geriatrics & Gerontology
Konstantina Katsoulis, Sunita Mathur, Catherine E. Amara
Summary: The study evaluated the long-term reliability of muscle power and functional performance tests in healthy older women, showing consistent and stable results over a period of up to 15 weeks, with no clinically meaningful changes observed during this time frame.
JOURNAL OF AGING RESEARCH
(2021)
