Article
Engineering, Biomedical
Shurun Wang, Hao Tang, Bin Wang, Jia Mo
Summary: The study introduced the rapid refined composite multiscale sample entropy (R2CMSE) method and successfully applied it to analyze muscle fatigue, showing that R2CMSE is faster and more robust compared to other multiscale entropy algorithms. By constructing a three-dimensional map of scale-length-entropy, appropriate time scales and data lengths were determined, revealing significant differences between non-fatigue and fatigue conditions under all algorithms.
BIOMEDICAL SIGNAL PROCESSING AND CONTROL
(2021)
Article
Nutrition & Dietetics
Michael T. Paris, Alexander M. Zero, Charles L. Rice
Summary: The test-retest repeatability of plantar flexion isometric torque and isotonic power evoked using brief tetanic trains at 10 and 50 Hz was evaluated in this study. Both torque and power showed excellent repeatability at low and high frequencies. Similar to isometric torque, electrically evoked isotonic power is a stable measure for studying dynamic muscle function.
APPLIED PHYSIOLOGY NUTRITION AND METABOLISM
(2023)
Article
Computer Science, Interdisciplinary Applications
Anna J. Sosnowska, Aleksandra Vuckovic, Henrik Gollee
Summary: This study introduces a computationally inexpensive algorithm for ultrasound imaging biofeedback that can accurately detect muscle contractions. In offline and online experiments, the algorithm showed good consistency with EMG and force measurements, as well as reliability and efficiency in real-time applications.
MEDICAL & BIOLOGICAL ENGINEERING & COMPUTING
(2021)
Article
Biology
Kosuke Oku, Daisuke Kimura, Tomotaka Ito, Akiyoshi Matsugi, Tatsuya Sugioka, Yusuke Kobayashi, Hayato Satake, Tsukasa Kumai
Summary: This study aimed to investigate the effect of increasing flexor hallucis longus (FHL) muscle activity on ground reaction force during landing in healthy subjects. Results showed that flexion of the metatarsophalangeal (MTP) joint at the moment of landing reduces ground reaction force by dissipating force in the foot through increased FHL muscle activity, potentially contributing to injury prevention.
Article
Biochemistry & Molecular Biology
Clara Bernard, Charline Jomard, Benedicte Chazaud, Julien Gondin
Summary: Post-injury skeletal muscle regeneration requires interactions between myogenic and non-myogenic cells. The kinetics of changes in muscle stem cells, endothelial cells, fibro-adipogenic progenitors, and macrophages in the regenerating muscle were similar in mild and severe injury models. However, the magnitude of changes in the number of differentiating muscle stem cells, hematopoietic cells, and fibro-adipogenic progenitors was higher in severe muscle damage.
Article
Biotechnology & Applied Microbiology
Geng Li, Mohammad S. Shourijeh, Di Ao, Carolynn Patten, Benjamin J. Fregly
Summary: Muscle co-contractions can enhance stability and accuracy during limb movement but come with higher energy cost. This study investigated the feasibility of using two common Co-Contraction Index (CCI) formulations to approximate lower limb joint stiffness trends during gait. The correlations between CCI formulations and joint stiffness were found to be highly influenced by methodological choices in CCI computation.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Engineering, Electrical & Electronic
Alok Prakash, Neeraj Sharma, Anurag Kumar Katiyar, Satya Kesh Dubey, Shiru Sharma
Summary: In this study, a novel magnetic-based Hall myography (HMG) technique was introduced for precise measurement of muscular contractions in the upper-limb. The sensor showed better signal stability and similar dynamic behavior compared to the traditional electromyography (EMG) sensor.
SENSORS AND ACTUATORS A-PHYSICAL
(2022)
Article
Chemistry, Analytical
Anthony Bawa, Konstantinos Banitsas
Summary: This study validates the consistency of our designed low-cost EMG sensor with a commercial system in measuring muscle activity and fatigue assessment. Through dynamic exercises performed by volunteers, the evaluation shows good agreement between the two systems and confirms the reliability of our design. The low-cost sensor is also suitable for muscle fatigue assessment.
Article
Biotechnology & Applied Microbiology
Xiaohan Wang, Zichong Luo, Mingxia Zhang, Weihua Zhao, Songyun Xie, Seng Fat Wong, Huijing Hu, Le Li
Summary: This study investigated the relationship between muscle activation and cerebral cortical activity during motor tasks. The results showed that effective connectivity between brain regions was higher in the dominant side compared to the non-dominant side. Graph theory analysis revealed significant differences in clustering coefficient and node-local efficiency of the contralateral motor cortex under different contractions. The non-linear characteristics of the muscle activation signals were also found to be correlated with brain activity. These findings provide valuable insights into the interaction between brain activity and motor task execution.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Health Care Sciences & Services
Jung-Ha Sung, Woosung Jung, Junsig Wang, Jung-Hyun Kim
Summary: The purpose of this study was to investigate the impact of different body positions and humeral abduction angles on shoulder muscle activity during ER exercises. The findings suggest that body positions and angles can affect muscle activity, which has implications for restoring muscle imbalances.
Article
Sport Sciences
Ralph J. F. H. Gordon, Christopher J. Tyler, Federico Castelli, Ceri E. Diss, Neale A. Tillin
Summary: The study investigates the impact of progressive whole-body hyperthermia on maximal and rapid voluntary torque production, indicating that late-phase voluntary rate of torque development is reduced under hyperthermic conditions, likely due to decreased neural drive and reduced maximum voluntary torque. In contrast, early-and middle-phase voluntary rate of torque development are unaffected by hyperthermia due to conflicting effects of reduced neural drive and faster intrinsic contractile properties.
JOURNAL OF SCIENCE AND MEDICINE IN SPORT
(2021)
Article
Neurosciences
Nipaporn Wannaprom, Gwendolen Jull, Julia Treleaven, Martin B. Warner, Sureeporn Uthaikhup
Summary: Patients with neck pain often exhibit scapular downward rotation (SDR) and altered muscle behavior during isometric shoulder tasks. Specifically, patients with scapular dysfunction and SDR show increased upper trapezius (UT) activity and UT/ lower trapezius (LT) and UT/serratus anterior (SA) ratios during low force tasks. Neck pain patients also demonstrate higher activity of neck extensor (NE) muscles. Therefore, it is important to consider changes in NE and UT behavior when managing neck pain patients with observable SDR.
Article
Physiology
Joel A. Walsh, Darryl J. McAndrew, Douglas J. Henness, Jonathan Shemmell, Dominic Cuicuri, Paul J. Stapley
Summary: This article introduces a custom-built semi-recumbent ECC cycle designed to limit lower limb muscle activity by monitoring voltage production. It can precisely target muscle contraction mode for rehabilitation or training studies.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Engineering, Biomedical
K. Kubota, H. Hanawa, M. Yokoyama, S. Kita, K. Hirata, T. Fujino, T. Kokubun, T. Ishibashi, N. Kanemura
Summary: The study aimed to investigate muscle synergy changes in individuals with knee osteoarthritis, showing that the number of muscle modules was significantly lower in knee osteoarthritis patients and elderly controls, with a noticeable merging of early and late stance modules in knee osteoarthritis patients.
IEEE TRANSACTIONS ON NEURAL SYSTEMS AND REHABILITATION ENGINEERING
(2021)
Article
Sport Sciences
Shigeru Sato, Riku Yoshida, Fu Murakoshi, Yuto Sasaki, Kaoru Yahata, Kazunori Nosaka, Masatoshi Nakamura
Summary: The study compared the effects of 3-s isometric maximal voluntary contraction (MVC), concentric MVC, and eccentric MVC on muscle strength and thickness. It found that performing one 3-s MVC a day can increase muscle strength, with eccentric MVC producing more potent effects than isometric or concentric MVC.
SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS
(2022)
Review
Genetics & Heredity
Masashi Ogasawara, Ichizo Nishino
Summary: This review focuses on congenital myopathies, a genetically heterogeneous group of hereditary muscle diseases. Recent advances in molecular genetics have increased the number of known causative genes, and promising findings have indicated the potential for therapy development for certain types of congenital myopathies.
JOURNAL OF HUMAN GENETICS
(2023)
Article
Genetics & Heredity
Mariko Okubo, Satoru Noguchi, Tomonari Awaya, Motoyasu Hosokawa, Nobue Tsukui, Megumu Ogawa, Shinichiro Hayashi, Hirofumi Komaki, Madoka Mori-Yoshimura, Yasushi Oya, Yuji Takahashi, Tetsuhiro Fukuyama, Michinori Funato, Yousuke Hosokawa, Satoru Kinoshita, Tsuyoshi Matsumura, Sadao Nakamura, Azusa Oshiro, Hiroshi Terashima, Tetsuro Nagasawa, Tatsuharu Sato, Yumi Shimada, Yasuko Tokita, Masatoshi Hagiwara, Katsuhisa Ogata, Ichizo Nishino
Summary: Dystrophinopathy is a disease caused by alterations in the DMD gene. In this study, a combined laboratory and computational analysis approach was used to identify disease-causing genomic variants and regulatory mechanisms underlying abnormal DMD transcript generation in genetically undiagnosed patients. Abnormal DMD transcripts were detected in the majority of cases, with exonization of intronic sequences, exon skipping, aberrant splicing, polyadenylation, and transcription termination identified as the underlying mechanisms. The findings of this study have important implications for therapeutic options for patients with Dystrophinopathy.
Article
Genetics & Heredity
Takashi Kurashige, Hiroyuki Morino, Hiroki Ueno, Tomomi Murao, Tomoaki Watanabe, Takao Hinoi, Ichizo Nishino, Tsuyoshi Torii, Hirofumi Maruyama
Summary: This study investigated clinical manifestations in 31 FSHD1 patients and 30 non-affected individuals. The results showed that gastrointestinal cancers, specifically gastric and colorectal cancers, increased after the age of 40 in FSHD1 patients and were more frequent compared to non-affected individuals, but were not dependent on D4Z4 repeat number.
JOURNAL OF HUMAN GENETICS
(2023)
Article
Clinical Neurology
Ryo Sasaki, Taijun Yunoki, Yumiko Nakano, Yusuke Fukui, Mami Takemoto, Ryuta Morihara, Eri Katsuyama, Ichizo Nishino, Toru Yamashita
Summary: This case report describes a young asymptomatic patient with anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase immune-mediated necrotizing myopathy (anti-HMGCR IMNM). The patient, a 17-year-old woman, presented with elevated creatine kinase (CK) levels without any muscular symptoms. After further examinations and antibody testing, she was diagnosed with anti-HMGCR IMNM and showed positive response to methotrexate and continuous intravenous immunoglobulin treatment. This is an uncommon case of asymptomatic anti-HMGCR IMNM in a young patient, and early diagnosis allowed for timely treatment. The findings suggest that antibody testing could be a diagnostic option for rhabdomyolysis.
NEUROMUSCULAR DISORDERS
(2023)
Article
Clinical Neurology
Kenichiro Taira, Madoka Mori-Yoshimura, Toshiyuki Yamamoto, Yasushi Oya, Ichizo Nishino, Yuji Takahashi
Summary: This study compared the swallowing function and muscle magnetic resonance imaging data between dysphagic patients with inclusion body myositis (IBM) with cricopharyngeal bar (CPB) (IBM-CPB(+), n=17) and IBM patients without CPB (IBM-CPB(-), n=28). The study found that IBM-CPB(+) patients were older at diagnosis, had more frequent obstruction-related dysphagia, stronger knee extension, and less intramuscular fatty infiltration in limb muscles compared to IBM-CPB(-) patients. These findings provide valuable information on the clinical heterogeneity of IBM and the subset of IBM-CPB(+) patients.
NEUROMUSCULAR DISORDERS
(2023)
Article
Clinical Neurology
Olivier Rossel, Felix Schlosser-Perrin, Hugues Duffau, Riki Matsumoto, Emmanuel Mandonnet, Francois Bonnetblanc
Summary: This study aimed to identify criteria for determining direct neurophysiological connections in intraoperative measurement of axono-cortical evoked potentials (ACEP). Through analysis of recorded results, specific characteristics of evoked responses were identified, allowing for differentiation between hotspot activity with direct connectivity to the stimulated site and neighboring activity.
CLINICAL NEUROPHYSIOLOGY
(2023)
Article
Clinical Neurology
Raffaele Dubbioso, Antonio Suppa, Marina A. J. Tijssen, Akio Ikeda
Summary: FAME/BAFME is a high-penetrant autosomal dominant condition characterized by cortical myoclonus and occasional/rare convulsive seizures. Neurophysiological findings suggest that cortical hyperexcitability in FAME/BAFME may be caused by abnormal neuronal network activity involving both cortical and subcortical structures, particularly the cerebellum. Advanced transcranial magnetic stimulation (TMS) protocols could be used to evaluate the functional connectivity between the cerebellum and cortical structures, and non-invasive brain stimulation techniques may be potential therapeutic tools to improve cortical excitability in FAME/BAFME.
Article
Clinical Neurology
Beatriz G. Giraldez, Jose M. Serratosa, Salvatore Striano, Akio Ikeda, Pasquale Striano, Antonietta Coppola
Summary: Familial adult myoclonus epilepsy (FAME) is an autosomal dominant condition characterized by myoclonic tremor and epilepsy, mainly occurring in adulthood. The clinical course is generally non-progressive or slowly progressive, and epilepsy can be controlled with appropriate medication, allowing individuals to have a normal life expectancy. However, the severity of myoclonus increases with age and can lead to disability in elderly individuals. Since routine genetic tests cannot detect the non-coding repeat expansions responsible for FAME, a clinical diagnosis accompanied by neurophysiological testing is essential for guiding the selection of specific genetic techniques by geneticists.
Article
Clinical Neurology
Takeshi Yoshida, Hiroki Yamazaki, Yukako Nishimori, Naoko Takamatsu, Koji Fukushima, Yusuke Osaki, Yoshinori Taniguchi, Taiki Nozaki, Yoshitaka Kumon, Jemima Albayda, Ichizo Nishino, Yuishin Izumi
Summary: This study aims to investigate the change in muscle echogenicity and its histopathological basis in patients with idiopathic inflammatory myopathies (IIMs). The results show that muscle echointensity is significantly higher in patients with IIMs compared to controls, and it correlates with creatine kinase and muscle strength. Muscle echointensity may serve as a surrogate marker of muscle inflammation in non-IBM IIMs.
Article
Clinical Neurology
Haruhiko Motegi, Yohei Kirino, Ryoji Morishita, Ichizo Nishino, Shigeaki Suzuki
Summary: Overlap syndrome refers to the presence of myositis in conjunction with one or more collagen diseases such as systemic lupus erythematosus, systemic sclerosis, and/or rheumatoid arthritis. It is unclear whether the myopathy of overlap syndrome is specific to a particular disease or falls into one of the four major subsets: inclusion body myositis, immune-mediated necrotizing myopathy, dermatomyositis, and antisynthetase syndrome. This case report highlights a patient with overlap syndrome who exhibited autoantibodies against multiple transfer-RNA components, suggesting the presence of antisynthetase syndrome. The findings suggest that the myopathological features of overlap syndrome may include antisynthetase syndrome.
NEUROMUSCULAR DISORDERS
(2023)
Article
Clinical Neurology
Satoshi Yamashita, Akihito Nagatoshi, Yosuke Takeuchi, Ichizo Nishino, Mitsuharu Ueda
Summary: Spinal muscular atrophy (SMA), an autosomal-recessive lower motor neuron disease, leads to progressive muscle wasting and weakness. A patient with adult-onset SMA was found to have myopathic changes, characterized by accumulation of phosphorylated p62 and TDP-43 in muscle cells. This suggests that abnormal protein aggregation may play a role in the myopathic pathology of SMA.
Article
Clinical Neurology
Yoshiaki Takahashi, Nobutoshi Morimoto, Tomoaki Nada, Mizuki Morimoto, Nobuyuki Eura, Narihiro Minami, Ichizo Nishino
Summary: This article describes a novel gene mutation that causes oculopharyngeal muscular dystrophy (OPMD), not through the expansion or elongation of the alanine stretch. The clinical and pathological findings of a 77-year-old male patient are consistent with OPMD, suggesting that OPMD may be caused by point mutations in addition to triplet repeats.
JOURNAL OF NEUROMUSCULAR DISEASES
(2023)
Article
Cardiac & Cardiovascular Systems
Maya Ishiguro, Yuji Nagatomo, Kanki Inoue, Tsutomu Yoshikawa, Saeko Yoshizawa, Yasushi Oya, Ichizo Nishino, Mitsuaki Isobe
Summary: This article reports a case of AMA-associated myopathy in which bradycardia-related symptoms preceded skeletal muscle symptoms. Blood tests showed elevated CK and hepatic enzymes. The patient was diagnosed with AMA-associated myopathy and received steroid pulse therapy.
EUROPEAN HEART JOURNAL-CASE REPORTS
(2023)
Meeting Abstract
Rheumatology
Satoko Ota, Akinori Uruha, Rui Shimazaki, Masako Mukai, Tomoya Kawazoe, Daisuke Nakashima, Yasuhiro Nakata, Ichizo Nishino, Kazushi Takahashi
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2023)
Article
Rheumatology
Mariko Mouri, Toru Kanamori, Eriko Tanaka, Kanako Hiratoko, Mariko Okubo, Michio Inoue, Tomohiro Morio, Masaki Shimizu, Ichizo Nishino, Naoko Okiyama, Masaaki Mori
Summary: This report describes a case of a child with juvenile dermatomyositis (JDM) who developed veno-occlusive disease (VOD) and thrombotic microangiopathy (TMA) during treatment. The patient experienced various complications related to the treatment of JDM and macrophage activation syndrome (MAS). However, with adjustments to the treatment and discontinuation of specific medications, the patient's VOD and TMA improved.
MODERN RHEUMATOLOGY CASE REPORTS
(2023)
